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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3375
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppp1ca
Name: protein phosphatase 1 catalytic subunit alpha
Acc ID: CHEBI:40303
Term: lovastatin
Definition: A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
Chemical ID: MESH:D008148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppp1cadecreases expressionISOPpp1ca (Mus musculus)6480464CTDLovastatin results in decreased expression of PPP1CA mRNAPMID:20493250
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