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Gene: Lmna (lamin A/C) Rattus norvegicus
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Symbol: Lmna
Name: lamin A/C
Description: Exhibits protein phosphatase 1 binding activity. Involved in several processes, including cellular senescence; negative regulation of adipose tissue development; and positive regulation of osteoblast differentiation. Localizes to the nuclear matrix. Used to study transient cerebral ischemia. Biomarker of arteriosclerosis. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C); PARTICIPATES IN atherosclerosis pathway; arrhythmogenic right ventricular cardiomyopathy pathway; dilated cardiomyopathy pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: lamin A; lamin C2; lamin-A; prelamin-A/C
Orthologs:
Homo sapiens (human) : LMNA (lamin A/C)  HGNC  Alliance
Mus musculus (house mouse) : Lmna (lamin A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lmna (lamin A/C)
Pan paniscus (bonobo/pygmy chimpanzee) : LMNA (lamin A/C)
Canis lupus familiaris (dog) : LMNA (lamin A/C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lmna (lamin A/C)
Sus scrofa (pig) : LMNA (lamin A/C)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02187,842,884 - 187,863,552 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,842,885 - 187,863,516 (-)Ensembl
Rnor_5.02207,245,237 - 207,265,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,595,724 - 180,616,354 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12180,545,829 - 180,566,460 (-)NCBI
Celera2167,884,341 - 167,905,010 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Lmna
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620456
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.