Lmna (lamin A/C) - Rat Genome Database
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Gene: Lmna (lamin A/C) Rattus norvegicus
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Symbol: Lmna
Name: lamin A/C
RGD ID: 620456
Description: Exhibits protein phosphatase 1 binding activity. Involved in several processes, including cellular senescence; negative regulation of adipose tissue development; and positive regulation of osteoblast differentiation. Localizes to nuclear matrix. Used to study transient cerebral ischemia. Biomarker of arteriosclerosis. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C); PARTICIPATES IN atherosclerosis pathway; arrhythmogenic right ventricular cardiomyopathy pathway; dilated cardiomyopathy pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: lamin A; lamin C2; lamin-A; prelamin-A/C
Orthologs:
Homo sapiens (human) : LMNA (lamin A/C)  HGNC  Alliance
Mus musculus (house mouse) : Lmna (lamin A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lmna (lamin A/C)
Pan paniscus (bonobo/pygmy chimpanzee) : LMNA (lamin A/C)
Canis lupus familiaris (dog) : LMNA (lamin A/C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lmna (lamin A/C)
Sus scrofa (pig) : LMNA (lamin A/C)
Chlorocebus sabaeus (African green monkey) : LMNA (lamin A/C)
Heterocephalus glaber (naked mole-rat) : Lmna (lamin A/C)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02187,842,884 - 187,863,552 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,842,885 - 187,863,516 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,245,237 - 207,265,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,595,724 - 180,616,354 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12180,545,829 - 180,566,460 (-)NCBI
Celera2167,884,341 - 167,905,010 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model