Lmna (lamin A/C) - Rat Genome Database

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Gene: Lmna (lamin A/C) Rattus norvegicus
Analyze
Symbol: Lmna
Name: lamin A/C
RGD ID: 620456
Description: Enables protein phosphatase 1 binding activity. Involved in several processes, including cellular senescence; negative regulation of adipose tissue development; and positive regulation of osteoblast differentiation. Located in nuclear matrix. Used to study transient cerebral ischemia. Biomarker of arteriosclerosis. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C); PARTICIPATES IN atherosclerosis pathway; arrhythmogenic right ventricular cardiomyopathy pathway; dilated cardiomyopathy pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lamin A; lamin C2; lamin-A; prelamin-A/C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22173,939,751 - 173,960,423 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2173,939,751 - 173,960,423 (-)Ensembl
Rnor_6.02187,842,884 - 187,863,552 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,842,885 - 187,863,516 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,245,237 - 207,265,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,595,724 - 180,616,354 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12180,545,829 - 180,566,460 (-)NCBI
Celera2167,884,341 - 167,905,010 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
achalasia  (ISS)
aortic valve disease 2  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 9  (ISO)
arteriosclerosis  (IEP)
atrioventricular block  (ISO)
autosomal dominant distal hereditary motor neuronopathy  (ISO)
autosomal dominant Emery-Dreifuss muscular dystrophy 2  (ISO)
autosomal recessive Emery-Dreifuss muscular dystrophy 3  (ISO)
autosomal recessive limb-girdle muscular dystrophy  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2B  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Conduction Disease with or without Dilated Cardiomyopathy  (ISO)
cardiomyopathy  (ISO)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
catecholaminergic polymorphic ventricular tachycardia 1  (ISO)
cerebrovascular disease  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Charcot-Marie-Tooth disease type 2B1  (ISO)
Congenital Foot Deformities  (ISO)
Congenital Hand Deformities  (ISO)
Congenital Microtia  (ISO)
congenital muscular dystrophy  (ISO)
congenital muscular dystrophy due to LMNA mutation  (ISO)
Craniofacial Abnormalities  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1H  (ISO)
dilated cardiomyopathy 1S  (ISO)
dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome  (ISO)
disease of metabolism  (ISO)
Dwarfism  (ISO)
dyschromatosis symmetrica hereditaria  (ISO)
Emery-Dreifuss muscular dystrophy  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
familial partial lipodystrophy  (ISO)
familial partial lipodystrophy type 2  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
Heart-Hand Syndrome, Slovenian Type  (ISO)
Hereditary Motor Neuropathy with Myopathic Features  (ISO)
hereditary neuropathy with liability to pressure palsies  (ISO)
HIV-Associated Lipodystrophy Syndrome  (ISO)
Hypercholesterolemia  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
immunodeficiency 42  (ISO)
Insulin Resistance  (ISO)
Insulin-Resistant Diabetes Mellitus, with Acanthosis Nigricans  (ISO)
Laminopathies  (ISO)
left ventricular noncompaction  (ISO)
lethal restrictive dermopathy  (ISO)
limb-girdle muscular dystrophy  (ISO)
lipoatrophic diabetes mellitus  (ISO)
lipodystrophy  (ISO)
localized scleroderma  (ISO)
long QT syndrome  (ISO)
lung adenocarcinoma  (ISO)
Mandibuloacral Dysplasia with Type A Lipodystrophy  (ISO)
Metabolic Syndrome  (ISO)
MHC class II deficiency  (ISO)
muscular dystrophy  (ISO)
neuromuscular disease  (ISO)
neuropathy  (ISO)
Noonan syndrome 8  (ISO)
otitis media  (ISS)
parathyroid carcinoma  (ISO)
Paroxysmal Ventricular Fibrillation  (ISO)
peripheral nervous system disease  (ISO)
polycystic ovary syndrome  (ISO)
polyneuropathy  (ISO)
progeria  (ISO)
Progeria Syndrome, Childhood-Onset  (ISO)
severe congenital neutropenia 5  (ISO)
Sinoatrial Block  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
transient cerebral ischemia  (IDA)
type 2 diabetes mellitus  (ISO)
Ventricular Tachycardia  (ISO)
Werner syndrome  (ISO)
Wolff-Parkinson-White syndrome  (ISO)
X-linked Emery-Dreifuss muscular dystrophy 1  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+)-Tetrandrine  (ISO)
(-)-demecolcine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
aminoglutethimide  (ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bortezomib  (ISO)
Brodifacoum  (EXP)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chelerythrine  (ISO)
chloromethylisothiazolinone  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
fluoxetine  (EXP)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
isoflavones  (EXP)
ivermectin  (ISO)
leflunomide  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
lonafarnib  (ISO)
lopinavir  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
microcystin RR  (ISO)
mitomycin C  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-D-aspartic acid  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
quinoline  (ISO)
resveratrol  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (EXP)
Soman  (EXP)
staurosporine  (ISO)
sunitinib  (ISO)
suramin  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to hypoxia  (IEA,ISO)
cellular senescence  (IEA,IEP,ISO,ISS)
DNA double-strand break attachment to nuclear envelope  (IEA,ISO,ISS)
establishment or maintenance of microtubule cytoskeleton polarity  (IEA,ISO)
heterochromatin assembly  (IBA)
muscle organ development  (ISO)
negative regulation of adipose tissue development  (IMP)
negative regulation of cardiac muscle hypertrophy in response to stress  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of mesenchymal cell proliferation  (IEA,ISO)
negative regulation of release of cytochrome c from mitochondria  (IEA,ISO)
nuclear envelope organization  (IBA,IEA,ISO)
nuclear migration  (IBA)
nuclear pore localization  (IBA)
nucleus organization  (ISO)
obsolete positive regulation of cell aging  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of histone H3-K9 trimethylation  (IEA,ISO)
positive regulation of osteoblast differentiation  (IMP)
protein import into nucleus  (IEA,ISO)
protein localization  (ISO)
protein localization to nuclear envelope  (IBA)
protein localization to nucleus  (ISO,ISS)
regulation of cell migration  (IEA,ISO)
regulation of protein localization to nucleus  (IEA,ISO)
regulation of protein stability  (IEA,ISO)
regulation of telomere maintenance  (ISO)
response to mechanical stimulus  (IEP)
spermatogenesis  (IEP)
ventricular cardiac muscle cell development  (IEA,ISO)

Cellular Component

Molecular Function

References

References - curated
1. Al-Shali KZ and Hegele RA, Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1591-5. Epub 2004 Jun 17.
2. Almofti MR, etal., Clin Exp Pharmacol Physiol. 2006 Apr;33(4):305-9.
3. Alsheimer M and Benavente R, Exp Cell Res 1996 Nov 1;228(2):181-8.
4. Barboro P, etal., Exp Cell Res. 2002 Oct 1;279(2):202-18.
5. Bonne G, etal., Nat Genet. 1999 Mar;21(3):285-8.
6. Cao H and Hegele RA, Hum Mol Genet. 2000 Jan 1;9(1):109-12.
7. Cao H and Hegele RA, J Hum Genet. 2003;48(5):271-4. Epub 2003 Apr 3.
8. Chen L, etal., Lancet. 2003 Aug 9;362(9382):440-5.
9. Cid C, etal., Proteomics. 2007 Sep;7(17):3207-18.
10. Davidson EH, etal., J Craniofac Surg. 2013 Sep;24(5):1558-64. doi: 10.1097/SCS.0b013e31828f2060.
11. De Sandre-Giovannoli A, etal., Science. 2003 Jun 27;300(5628):2055. Epub 2003 Apr 17.
12. Fatkin D, etal., N Engl J Med. 1999 Dec 2;341(23):1715-24.
13. Filesi I, etal., Physiol Genomics. 2005 Oct 17;23(2):150-8. Epub 2005 Jul 26.
14. Fong LG, etal., Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18111-6. Epub 2004 Dec 17.
15. Forleo C, etal., PLoS One. 2015 Apr 2;10(4):e0121723. doi: 10.1371/journal.pone.0121723. eCollection 2015.
16. Garg A, etal., J Clin Endocrinol Metab. 2009 Dec;94(12):4971-83. doi: 10.1210/jc.2009-0472. Epub 2009 Oct 29.
17. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Grewal N, etal., J Thorac Cardiovasc Surg. 2014 Oct;148(4):1583-90. doi: 10.1016/j.jtcvs.2014.01.027. Epub 2014 Jan 25.
19. Hegele RA, etal., Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):111-6.
20. Krejci P, etal., Bone. 2010 Jul;47(1):102-10. doi: 10.1016/j.bone.2010.03.021. Epub 2010 Mar 31.
21. Liang H, etal., Clin Endocrinol (Oxf). 2005 Sep;63(3):317-22.
22. Maioli MA, etal., Muscle Nerve. 2007 Dec;36(6):828-32.
23. McClintock D, etal., Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2154-9. Epub 2006 Feb 6.
24. Mesa JL, etal., Diabetes. 2007 Mar;56(3):884-9.
25. MGD data from the GO Consortium
26. Mikula M, etal., Proteomics. 2006 Apr;6(8):2395-406.
27. Mounkes LC, etal., Nature 2003 May 15;423(6937):298-301.
28. Muchir A, etal., Hum Mol Genet. 2000 May 22;9(9):1453-9.
29. Muchir A, etal., J Clin Invest. 2007 May;117(5):1282-93. Epub 2007 Apr 19.
30. Naito M, etal., Histochem Cell Biol. 2012 Feb;137(2):235-47. doi: 10.1007/s00418-011-0890-3. Epub 2011 Nov 27.
31. NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. OMIM Disease Annotation Pipeline
33. Ozaki T and Sakiyama S, FEBS Lett 1992 Nov 9;312(2-3):165-8.
34. Pasotti M, etal., J Am Coll Cardiol. 2008 Oct 7;52(15):1250-60.
35. Pasqualin LM, etal., Pediatr Neurol. 2014 Apr;50(4):400-6. doi: 10.1016/j.pediatrneurol.2013.11.010. Epub 2013 Nov 21.
36. Pipeline to import KEGG annotations from KEGG into RGD
37. Plasilova M, etal., J Med Genet. 2004 Aug;41(8):609-14.
38. RGD automated data pipeline
39. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. RGD automated import pipeline for gene-chemical interactions
41. Segawa M, etal., FEBS J. 2005 Sep;272(17):4327-38.
42. Shackleton S, etal., Nat Genet. 2000 Feb;24(2):153-6.
43. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
44. Stallmeyer B, etal., Genet Test Mol Biomarkers. 2012 Jun;16(6):543-9. doi: 10.1089/gtmb.2011.0214. Epub 2012 Jan 6.
45. Steinle NI, etal., Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1708-13. Epub 2004 Jun 17.
46. Taylor MR, etal., J Am Coll Cardiol. 2003 Mar 5;41(5):771-80.
47. Tazir M, etal., Brain 2004 Jan;127(Pt 1):154-63. Epub 2003 Nov 7.
48. van der Kooi AJ, etal., Neurology. 2002 Aug 27;59(4):620-3.
49. Villa F, etal., Immun Ageing. 2014 Nov 26;11(1):19. doi: 10.1186/s12979-014-0019-3. eCollection 2014.
50. Wegner L, etal., Diabetes. 2007 Mar;56(3):694-8.
51. Wolf CM, etal., J Mol Cell Cardiol. 2008 Feb;44(2):293-303. Epub 2007 Dec 3.
Additional References at PubMed
PMID:8032679   PMID:11092755   PMID:11739632   PMID:12477932   PMID:14755333   PMID:16339967   PMID:16511604   PMID:16641100   PMID:16731532   PMID:16791210   PMID:16904066   PMID:17164264  
PMID:17631533   PMID:18606848   PMID:18664494   PMID:18809582   PMID:19915186   PMID:20457914   PMID:20458013   PMID:20581439   PMID:20810912   PMID:21111849   PMID:21151901   PMID:21498514  
PMID:21610090   PMID:21842415   PMID:22082260   PMID:22349700   PMID:22871113   PMID:22886301   PMID:23686339   PMID:23695662   PMID:23979707   PMID:24327345   PMID:25399868   PMID:25721888  
PMID:25910212   PMID:26436652   PMID:26657864   PMID:26769003   PMID:27114541   PMID:27534416   PMID:29040816   PMID:29476059   PMID:31495066   PMID:32083564   PMID:32926941   PMID:34502098  


Genomics

Comparative Map Data
Lmna
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22173,939,751 - 173,960,423 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2173,939,751 - 173,960,423 (-)Ensembl
Rnor_6.02187,842,884 - 187,863,552 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,842,885 - 187,863,516 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,245,237 - 207,265,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,595,724 - 180,616,354 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12180,545,829 - 180,566,460 (-)NCBI
Celera2167,884,341 - 167,905,010 (-)NCBICelera
Cytogenetic Map2q34NCBI
LMNA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,082,573 - 156,140,081 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1156,082,573 - 156,140,081 (+)EnsemblGRCh38hg38GRCh38
GRCh371156,052,364 - 156,109,872 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,351,085 - 154,376,502 (+)NCBINCBI36hg18NCBI36
Build 341152,897,570 - 152,922,944NCBI
Celera1129,157,453 - 129,182,870 (+)NCBI
Cytogenetic Map1q22NCBI
HuRef1127,414,589 - 127,472,062 (+)NCBIHuRef
CHM1_11157,448,481 - 157,505,990 (+)NCBICHM1_1
Lmna
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,388,455 - 88,413,842 (-)NCBIGRCm39mm39
GRCm39 Ensembl388,387,454 - 88,417,263 (-)Ensembl
GRCm38388,481,148 - 88,509,932 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,480,147 - 88,509,956 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,285,071 - 88,307,254 (-)NCBIGRCm37mm9NCBIm37
MGSCv36388,567,076 - 88,589,234 (-)NCBImm8
Celera388,521,102 - 88,543,289 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.84NCBI
Lmna
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,290,037 - 2,313,033 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,290,076 - 2,310,982 (+)NCBIChiLan1.0ChiLan1.0
LMNA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11135,253,700 - 135,311,542 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,253,700 - 135,311,539 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01131,456,819 - 131,482,275 (+)NCBIMhudiblu_PPA_v0panPan3
LMNA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,702,491 - 41,719,870 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,508,450 - 41,746,931 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,192,089 - 41,209,467 (-)NCBI
ROS_Cfam_1.0741,569,142 - 41,586,514 (-)NCBI
ROS_Cfam_1.0 Ensembl741,568,716 - 41,586,490 (-)Ensembl
UMICH_Zoey_3.1741,349,981 - 41,367,355 (-)NCBI
UNSW_CanFamBas_1.0741,403,350 - 41,420,721 (-)NCBI
UU_Cfam_GSD_1.0741,687,512 - 41,704,901 (-)NCBI
Lmna
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,343,835 - 26,365,060 (+)NCBI
SpeTri2.0NW_0049365805,374,208 - 5,395,442 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LMNA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,899,026 - 93,949,398 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,899,019 - 93,927,255 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,641,459 - 102,668,722 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4qNCBI
LMNA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,723,059 - 7,748,799 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl207,723,477 - 7,748,780 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660387,017,993 - 7,044,309 (-)NCBIVero_WHO_p1.0
Lmna
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248851,423,563 - 1,466,657 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
BI277711  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,941,924 - 173,942,457 (+)MAPPERmRatBN7.2
Rnor_6.02187,845,058 - 187,845,590NCBIRnor6.0
Rnor_5.02207,247,410 - 207,247,942UniSTSRnor5.0
RGSC_v3.42180,597,895 - 180,598,427UniSTSRGSC3.4
Celera2167,886,515 - 167,887,047UniSTS
RH 3.4 Map21165.5UniSTS
Cytogenetic Map2q31-q34UniSTS
RH141321  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,939,759 - 173,939,956 (+)MAPPERmRatBN7.2
Rnor_6.02187,842,893 - 187,843,089NCBIRnor6.0
Rnor_5.02207,245,245 - 207,245,441UniSTSRnor5.0
RGSC_v3.42180,595,730 - 180,595,926UniSTSRGSC3.4
Celera2167,884,350 - 167,884,546UniSTS
RH 3.4 Map21153.5UniSTS
Cytogenetic Map2q31-q34UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:113
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000026705
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 50 35 39 11 8
Low 24 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026705   ⟹   ENSRNOP00000026705
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,939,751 - 173,960,423 (-)Ensembl
Rnor_6.0 Ensembl2187,842,885 - 187,863,516 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082174   ⟹   ENSRNOP00000068655
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,939,752 - 173,960,423 (-)Ensembl
Rnor_6.0 Ensembl2187,842,887 - 187,863,516 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084455   ⟹   ENSRNOP00000072742
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,939,752 - 173,960,220 (-)Ensembl
Rnor_6.0 Ensembl2187,845,024 - 187,863,349 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092993   ⟹   ENSRNOP00000076028
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,941,802 - 173,951,235 (-)Ensembl
Rnor_6.0 Ensembl2187,844,935 - 187,854,363 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093036   ⟹   ENSRNOP00000076022
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,844,934 - 187,863,503 (-)Ensembl
RefSeq Acc Id: NM_001002016   ⟹   NP_001002016
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22173,939,751 - 173,960,423 (-)NCBI
Rnor_6.02187,842,884 - 187,863,552 (-)NCBI
Rnor_5.02207,245,237 - 207,265,928 (-)NCBI
RGSC_v3.42180,595,724 - 180,616,354 (-)RGD
Celera2167,884,341 - 167,905,010 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001002016   ⟸   NM_001002016
- UniProtKB: G3V8L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068655   ⟸   ENSRNOT00000082174
RefSeq Acc Id: ENSRNOP00000072742   ⟸   ENSRNOT00000084455
RefSeq Acc Id: ENSRNOP00000026705   ⟸   ENSRNOT00000026705
RefSeq Acc Id: ENSRNOP00000076028   ⟸   ENSRNOT00000092993
RefSeq Acc Id: ENSRNOP00000076022   ⟸   ENSRNOT00000093036
Protein Domains
IF rod   LTD

Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
AF-P48679-F1-model_v2 AlphaFold P48679 1-665 view protein structure  

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691442
Promoter ID:EPDNEW_R1967
Type:initiation region
Name:Lmna_1
Description:lamin A/C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,863,552 - 187,863,612EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620456 AgrOrtholog
BioCyc Gene G2FUF-52481 BioCyc
Ensembl Genes ENSRNOG00000019638 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000026705 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000068655 UniProtKB/TrEMBL
  ENSRNOP00000072742 UniProtKB/TrEMBL
  ENSRNOP00000076022 UniProtKB/TrEMBL
  ENSRNOP00000076028 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026705 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000082174 UniProtKB/TrEMBL
  ENSRNOT00000084455 UniProtKB/TrEMBL
  ENSRNOT00000092993 UniProtKB/TrEMBL
  ENSRNOT00000093036 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.1260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621637 IMAGE-MGC_LOAD
InterPro IF_conserved UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lamin_tail_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lamin_tail_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60374 UniProtKB/TrEMBL
MGC_CLONE MGC:72422 IMAGE-MGC_LOAD
NCBI Gene 60374 ENTREZGENE
Pfam Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LTD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB LMNA RGD
PhenoGen Lmna PhenoGen
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LTD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF74853 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JTC5_RAT UniProtKB/TrEMBL
  A0A0G2K3R2_RAT UniProtKB/TrEMBL
  A0A1B0GWU9_RAT UniProtKB/TrEMBL
  G3V8L3 ENTREZGENE, UniProtKB/TrEMBL
  LMNA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P6U3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-29 Lmna  lamin A/C  Lmna  lamin A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Lmna  lamin A      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Lmna        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 665 amino acid residues 729133