Lmna (lamin A/C) - Rat Genome Database

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Gene: Lmna (lamin A/C) Rattus norvegicus
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Symbol: Lmna
Name: lamin A/C
RGD ID: 620456
Description: Enables protein phosphatase 1 binding activity. Involved in several processes, including cellular senescence; negative regulation of adipose tissue development; and positive regulation of osteoblast differentiation. Located in nuclear matrix. Used to study transient cerebral ischemia. Biomarker of arteriosclerosis. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C); PARTICIPATES IN atherosclerosis pathway; arrhythmogenic right ventricular cardiomyopathy pathway; dilated cardiomyopathy pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: lamin A; lamin C2; lamin-A; prelamin-A/C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22173,939,751 - 173,960,423 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2173,939,751 - 173,960,423 (-)Ensembl
Rnor_6.02187,842,884 - 187,863,552 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,842,885 - 187,863,516 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,245,237 - 207,265,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,595,724 - 180,616,354 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12180,545,829 - 180,566,460 (-)NCBI
Celera2167,884,341 - 167,905,010 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
achalasia  (ISS)
aortic valve disease 2  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 9  (ISO)
arteriosclerosis  (IEP)
atrioventricular block  (ISO)
autosomal dominant distal hereditary motor neuronopathy  (ISO)
autosomal dominant Emery-Dreifuss muscular dystrophy 2  (ISO)
autosomal recessive Emery-Dreifuss muscular dystrophy 3  (ISO)
autosomal recessive limb-girdle muscular dystrophy  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2B  (ISO)
autosomal recessive nonsyndromic deafness 4  (ISO)
autosomal recessive nonsyndromic deafness 77  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Conduction Disease with or without Dilated Cardiomyopathy  (ISO)
cardiomyopathy  (ISO)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
catecholaminergic polymorphic ventricular tachycardia 1  (ISO)
cerebrovascular disease  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Charcot-Marie-Tooth disease type 2B1  (ISO)
Congenital Foot Deformities  (ISO)
Congenital Hand Deformities  (ISO)
congenital muscular dystrophy  (ISO)
congenital muscular dystrophy due to LMNA mutation  (ISO)
Craniofacial Abnormalities  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1H  (ISO)
dilated cardiomyopathy 1S  (ISO)
dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome  (ISO)
disease of metabolism  (ISO)
Emery-Dreifuss muscular dystrophy  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
familial partial lipodystrophy  (ISO)
familial partial lipodystrophy type 2  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
Heart-Hand Syndrome, Slovenian Type  (ISO)
hereditary neuropathy with liability to pressure palsies  (ISO)
HIV-Associated Lipodystrophy Syndrome  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
Insulin Resistance  (ISO)
Insulin-Resistant Diabetes Mellitus, with Acanthosis Nigricans  (ISO)
Laminopathies  (ISO)
left ventricular noncompaction  (ISO)
lethal restrictive dermopathy  (ISO)
limb-girdle muscular dystrophy  (ISO)
lipoatrophic diabetes mellitus  (ISO)
lipodystrophy  (ISO)
localized scleroderma  (ISO)
long QT syndrome  (ISO)
lung adenocarcinoma  (ISO)
Mandibuloacral Dysplasia with Type A Lipodystrophy  (ISO)
Metabolic Syndrome  (ISO)
muscular dystrophy  (ISO)
neuritis  (ISO)
neuromuscular disease  (ISO)
neuropathy  (ISO)
Noonan syndrome 8  (ISO)
otitis media  (ISS)
parathyroid carcinoma  (ISO)
Paroxysmal Ventricular Fibrillation  (ISO)
peripheral nervous system disease  (ISO)
polycystic ovary syndrome  (ISO)
polyneuropathy  (ISO)
progeria  (ISO)
Progeria Syndrome, Childhood-Onset  (ISO)
Sinoatrial Block  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
transient cerebral ischemia  (IDA)
type 2 diabetes mellitus  (ISO)
Ventricular Tachycardia  (ISO)
Werner syndrome  (ISO)
Wolff-Parkinson-White syndrome  (ISO)
X-linked Emery-Dreifuss muscular dystrophy 1  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+)-Tetrandrine  (ISO)
(-)-demecolcine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
aminoglutethimide  (ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bortezomib  (ISO)
Brodifacoum  (EXP)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chelerythrine  (ISO)
chloromethylisothiazolinone  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
fluoxetine  (EXP)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
isoflavones  (EXP)
ivermectin  (ISO)
leflunomide  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
lonafarnib  (ISO)
lopinavir  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
microcystin RR  (ISO)
mitomycin C  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
quinoline  (ISO)
resveratrol  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (EXP)
Soman  (EXP)
staurosporine  (ISO)
sunitinib  (ISO)
suramin  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Al-Shali KZ and Hegele RA, Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1591-5. Epub 2004 Jun 17.
2. Almofti MR, etal., Clin Exp Pharmacol Physiol. 2006 Apr;33(4):305-9.
3. Alsheimer M and Benavente R, Exp Cell Res 1996 Nov 1;228(2):181-8.
4. Barboro P, etal., Exp Cell Res. 2002 Oct 1;279(2):202-18.
5. Bonne G, etal., Nat Genet. 1999 Mar;21(3):285-8.
6. Cao H and Hegele RA, Hum Mol Genet. 2000 Jan 1;9(1):109-12.
7. Cao H and Hegele RA, J Hum Genet. 2003;48(5):271-4. Epub 2003 Apr 3.
8. Chen L, etal., Lancet. 2003 Aug 9;362(9382):440-5.
9. Cid C, etal., Proteomics. 2007 Sep;7(17):3207-18.
10. Davidson EH, etal., J Craniofac Surg. 2013 Sep;24(5):1558-64. doi: 10.1097/SCS.0b013e31828f2060.
11. De Sandre-Giovannoli A, etal., Science. 2003 Jun 27;300(5628):2055. Epub 2003 Apr 17.
12. Fatkin D, etal., N Engl J Med. 1999 Dec 2;341(23):1715-24.
13. Filesi I, etal., Physiol Genomics. 2005 Oct 17;23(2):150-8. Epub 2005 Jul 26.
14. Fong LG, etal., Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18111-6. Epub 2004 Dec 17.
15. Forleo C, etal., PLoS One. 2015 Apr 2;10(4):e0121723. doi: 10.1371/journal.pone.0121723. eCollection 2015.
16. Garg A, etal., J Clin Endocrinol Metab. 2009 Dec;94(12):4971-83. doi: 10.1210/jc.2009-0472. Epub 2009 Oct 29.
17. Grewal N, etal., J Thorac Cardiovasc Surg. 2014 Oct;148(4):1583-90. doi: 10.1016/j.jtcvs.2014.01.027. Epub 2014 Jan 25.
18. Hegele RA, etal., Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):111-6.
19. Krejci P, etal., Bone. 2010 Jul;47(1):102-10. doi: 10.1016/j.bone.2010.03.021. Epub 2010 Mar 31.
20. Liang H, etal., Clin Endocrinol (Oxf). 2005 Sep;63(3):317-22.
21. Maioli MA, etal., Muscle Nerve. 2007 Dec;36(6):828-32.
22. McClintock D, etal., Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2154-9. Epub 2006 Feb 6.
23. Mesa JL, etal., Diabetes. 2007 Mar;56(3):884-9.
24. MGD data from the GO Consortium
25. Mikula M, etal., Proteomics. 2006 Apr;6(8):2395-406.
26. Mounkes LC, etal., Nature 2003 May 15;423(6937):298-301.
27. Muchir A, etal., Hum Mol Genet. 2000 May 22;9(9):1453-9.
28. Muchir A, etal., J Clin Invest. 2007 May;117(5):1282-93. Epub 2007 Apr 19.
29. Naito M, etal., Histochem Cell Biol. 2012 Feb;137(2):235-47. doi: 10.1007/s00418-011-0890-3. Epub 2011 Nov 27.
30. NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. OMIM Disease Annotation Pipeline
32. Ozaki T and Sakiyama S, FEBS Lett 1992 Nov 9;312(2-3):165-8.
33. Pasotti M, etal., J Am Coll Cardiol. 2008 Oct 7;52(15):1250-60.
34. Pasqualin LM, etal., Pediatr Neurol. 2014 Apr;50(4):400-6. doi: 10.1016/j.pediatrneurol.2013.11.010. Epub 2013 Nov 21.
35. Pipeline to import KEGG annotations from KEGG into RGD
36. Plasilova M, etal., J Med Genet. 2004 Aug;41(8):609-14.
37. RGD automated data pipeline
38. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39. RGD automated import pipeline for gene-chemical interactions
40. Segawa M, etal., FEBS J. 2005 Sep;272(17):4327-38.
41. Shackleton S, etal., Nat Genet. 2000 Feb;24(2):153-6.
42. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
43. Stallmeyer B, etal., Genet Test Mol Biomarkers. 2012 Jun;16(6):543-9. doi: 10.1089/gtmb.2011.0214. Epub 2012 Jan 6.
44. Steinle NI, etal., Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1708-13. Epub 2004 Jun 17.
45. Taylor MR, etal., J Am Coll Cardiol. 2003 Mar 5;41(5):771-80.
46. Tazir M, etal., Brain 2004 Jan;127(Pt 1):154-63. Epub 2003 Nov 7.
47. van der Kooi AJ, etal., Neurology. 2002 Aug 27;59(4):620-3.
48. Villa F, etal., Immun Ageing. 2014 Nov 26;11(1):19. doi: 10.1186/s12979-014-0019-3. eCollection 2014.
49. Wegner L, etal., Diabetes. 2007 Mar;56(3):694-8.
50. Wolf CM, etal., J Mol Cell Cardiol. 2008 Feb;44(2):293-303. Epub 2007 Dec 3.
Additional References at PubMed
PMID:8032679   PMID:11092755   PMID:11739632   PMID:12477932   PMID:14755333   PMID:16339967   PMID:16511604   PMID:16641100   PMID:16731532   PMID:16791210   PMID:16904066   PMID:17164264  
PMID:17631533   PMID:18606848   PMID:18664494   PMID:18809582   PMID:19915186   PMID:20457914   PMID:20458013   PMID:20581439   PMID:20810912   PMID:21111849   PMID:21151901   PMID:21498514  
PMID:21610090   PMID:21842415   PMID:22082260   PMID:22349700   PMID:22871113   PMID:22886301   PMID:23686339   PMID:23695662   PMID:23979707   PMID:24327345   PMID:25399868   PMID:25721888  
PMID:25910212   PMID:26436652   PMID:26657864   PMID:26769003   PMID:27114541   PMID:27534416   PMID:29040816   PMID:29476059   PMID:31495066   PMID:32083564   PMID:32926941  


Genomics

Comparative Map Data
Lmna
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22173,939,751 - 173,960,423 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2173,939,751 - 173,960,423 (-)Ensembl
Rnor_6.02187,842,884 - 187,863,552 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,842,885 - 187,863,516 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,245,237 - 207,265,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,595,724 - 180,616,354 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12180,545,829 - 180,566,460 (-)NCBI
Celera2167,884,341 - 167,905,010 (-)NCBICelera
Cytogenetic Map2q34NCBI
LMNA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1156,082,573 - 156,140,081 (+)EnsemblGRCh38hg38GRCh38
GRCh381156,082,573 - 156,140,081 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371156,052,364 - 156,109,872 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,351,085 - 154,376,502 (+)NCBINCBI36hg18NCBI36
Build 341152,897,570 - 152,922,944NCBI
Celera1129,157,453 - 129,182,870 (+)NCBI
Cytogenetic Map1q22NCBI
HuRef1127,414,589 - 127,472,062 (+)NCBIHuRef
CHM1_11157,448,481 - 157,505,990 (+)NCBICHM1_1
Lmna
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,388,455 - 88,413,842 (-)NCBIGRCm39mm39
GRCm39 Ensembl388,387,454 - 88,417,263 (-)Ensembl
GRCm38388,481,148 - 88,509,932 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,480,147 - 88,509,956 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,285,071 - 88,307,254 (-)NCBIGRCm37mm9NCBIm37
MGSCv36388,567,076 - 88,589,234 (-)NCBImm8
Celera388,521,102 - 88,543,289 (-)NCBI