Lmna (lamin A/C) - Rat Genome Database

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Gene: Lmna (lamin A/C) Rattus norvegicus
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Symbol: Lmna
Name: lamin A/C
RGD ID: 620456
Description: Enables protein phosphatase 1 binding activity. Involved in several processes, including cellular senescence; negative regulation of adipose tissue development; and positive regulation of osteoblast differentiation. Located in nuclear envelope and nuclear matrix. Used to study transient cerebral ischemia. Biomarker of arteriosclerosis. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C); PARTICIPATES IN atherosclerosis pathway; arrhythmogenic right ventricular cardiomyopathy pathway; dilated cardiomyopathy pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lamin A; lamin C2; lamin-A; prelamin-A/C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,237,564 - 176,265,301 (-)NCBIGRCr8
mRatBN7.22173,939,751 - 173,960,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,939,751 - 173,960,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,083,809 - 181,104,527 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,106,174 - 179,126,892 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,706,353 - 173,727,003 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,842,884 - 187,863,552 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,842,885 - 187,863,516 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,245,237 - 207,265,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,595,724 - 180,616,354 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12180,545,829 - 180,566,460 (-)NCBI
Celera2167,884,341 - 167,905,010 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
achalasia  (ISS)
aortic valve disease 2  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 9  (ISO)
arteriosclerosis  (IEP)
atrioventricular block  (ISO)
autosomal dominant distal hereditary motor neuronopathy  (ISO)
autosomal dominant Emery-Dreifuss muscular dystrophy 2  (ISO)
autosomal recessive Emery-Dreifuss muscular dystrophy 3  (ISO)
autosomal recessive limb-girdle muscular dystrophy  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2B  (ISO)
autosomal recessive nonsyndromic deafness 4  (ISO)
Bethlem Myopathy 1A  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Conduction Disease with or without Dilated Cardiomyopathy  (ISO)
cardiomyopathy  (ISO)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
catecholaminergic polymorphic ventricular tachycardia 1  (ISO)
cerebrovascular disease  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Charcot-Marie-Tooth disease type 2B1  (ISO,ISS)
Congenital Foot Deformities  (ISO)
Congenital Hand Deformities  (ISO)
Congenital Microtia  (ISO)
congenital muscular dystrophy  (ISO)
congenital muscular dystrophy due to LMNA mutation  (ISO,ISS)
Craniofacial Abnormalities  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO,ISS)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1S  (ISO)
dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome  (ISO)
disease of metabolism  (ISO)
Dwarfism  (ISO)
Emery-Dreifuss muscular dystrophy  (ISO,ISS)
familial hypertrophic cardiomyopathy  (ISO)
familial partial lipodystrophy  (ISO)
familial partial lipodystrophy type 2  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
Heart-Hand Syndrome, Slovenian Type  (ISO)
hereditary neuropathy with liability to pressure palsies  (ISO)
HIV-Associated Lipodystrophy Syndrome  (ISO)
Hypercholesterolemia  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
hypertrophic cardiomyopathy 2  (ISO)
immunodeficiency 42  (ISO)
Insulin Resistance  (ISO)
Insulin-Resistant Diabetes Mellitus, with Acanthosis Nigricans  (ISO)
Laminopathies  (ISO)
left ventricular noncompaction  (ISO)
limb-girdle muscular dystrophy  (ISO)
lipoatrophic diabetes mellitus  (ISO)
lipodystrophy  (ISO)
localized scleroderma  (ISO)
long QT syndrome  (ISO)
lung adenocarcinoma  (ISO)
mandibuloacral dysplasia  (ISO)
mandibuloacral dysplasia type A lipodystrophy  (ISO)
maturity-onset diabetes of the young  (ISO)
Metabolic Syndrome  (ISO)
MHC class II deficiency  (ISO)
muscular dystrophy  (ISO)
neuromuscular disease  (ISO)
neuropathy  (ISO)
Noonan syndrome 8  (ISO)
otitis media  (ISS)
parathyroid carcinoma  (ISO)
Paroxysmal Ventricular Fibrillation  (ISO)
peripheral nervous system disease  (ISO)
polycystic ovary syndrome  (ISO)
polyneuropathy  (ISO)
progeria  (ISO,ISS)
Progeria Syndrome, Childhood-Onset  (ISO)
restrictive dermopathy  (ISO)
restrictive dermopathy 2  (ISO)
severe congenital neutropenia 3  (ISO)
severe congenital neutropenia 5  (ISO)
sick sinus syndrome  (ISO)
Sinoatrial Block  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
transient cerebral ischemia  (IDA)
type 2 diabetes mellitus  (ISO)
Ventricular Tachycardia  (ISO)
Werner syndrome  (ISO)
Wolff-Parkinson-White syndrome  (ISO)
X-linked Emery-Dreifuss muscular dystrophy 1  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+)-Tetrandrine  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
aminoglutethimide  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bortezomib  (ISO)
Brodifacoum  (EXP)
butyric acid  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chelerythrine  (ISO)
chloromethylisothiazolinone  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
fluoxetine  (EXP)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
isoflavones  (EXP)
ivermectin  (ISO)
leflunomide  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
lonafarnib  (ISO)
lopinavir  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
microcystin RR  (ISO)
mitomycin C  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-D-aspartic acid  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
quinoline  (ISO)
resveratrol  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (EXP)
Soman  (EXP)
staurosporine  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
suramin  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
intermediate filament  (IEA)
lamin filament  (ISO)
nuclear envelope  (IBA,IDA,IEA,ISO,ISS)
nuclear lamina  (IBA,IEA,ISO,ISS)
nuclear matrix  (IDA,IEA,ISO)
nuclear membrane  (ISO)
nuclear periphery  (IEA)
nuclear speck  (IEA,ISO)
nucleoplasm  (IEA,ISO,ISS)
nucleus  (IEA,ISO)
perinuclear region of cytoplasm  (ISO)
site of double-strand break  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Laminopathies and atherosclerosis. Al-Shali KZ and Hegele RA, Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1591-5. Epub 2004 Jun 17.
2. Proteomic analysis of rat aorta during atherosclerosis induced by high cholesterol diet and injection of vitamin D3. Almofti MR, etal., Clin Exp Pharmacol Physiol. 2006 Apr;33(4):305-9.
3. Change of karyoskeleton during mammalian spermatogenesis: expression pattern of nuclear lamin C2 and its regulation. Alsheimer M and Benavente R, Exp Cell Res 1996 Nov 1;228(2):181-8.
4. Unraveling the organization of the internal nuclear matrix: RNA-dependent anchoring of NuMA to a lamin scaffold. Barboro P, etal., Exp Cell Res. 2002 Oct 1;279(2):202-18.
5. Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy. Bonne G, etal., Nat Genet. 1999 Mar;21(3):285-8.
6. Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy. Cao H and Hegele RA, Hum Mol Genet. 2000 Jan 1;9(1):109-12.
7. LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090). Cao H and Hegele RA, J Hum Genet. 2003;48(5):271-4. Epub 2003 Apr 3.
8. LMNA mutations in atypical Werner's syndrome. Chen L, etal., Lancet. 2003 Aug 9;362(9382):440-5.
9. Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance. Cid C, etal., Proteomics. 2007 Sep;7(17):3207-18.
10. Lacunocanalicular fluid flow transduces mechanical tension stress during distraction osteogenesis. Davidson EH, etal., J Craniofac Surg. 2013 Sep;24(5):1558-64. doi: 10.1097/SCS.0b013e31828f2060.
11. Lamin a truncation in Hutchinson-Gilford progeria. De Sandre-Giovannoli A, etal., Science. 2003 Jun 27;300(5628):2055. Epub 2003 Apr 17.
12. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. Fatkin D, etal., N Engl J Med. 1999 Dec 2;341(23):1715-24.
13. Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy. Filesi I, etal., Physiol Genomics. 2005 Oct 17;23(2):150-8. Epub 2005 Jul 26.
14. Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Fong LG, etal., Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18111-6. Epub 2004 Dec 17.
15. Clinical and functional characterization of a novel mutation in lamin a/c gene in a multigenerational family with arrhythmogenic cardiac laminopathy. Forleo C, etal., PLoS One. 2015 Apr 2;10(4):e0121723. doi: 10.1371/journal.pone.0121723. eCollection 2015.
16. Atypical progeroid syndrome due to heterozygous missense LMNA mutations. Garg A, etal., J Clin Endocrinol Metab. 2009 Dec;94(12):4971-83. doi: 10.1210/jc.2009-0472. Epub 2009 Oct 29.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Ascending aorta dilation in association with bicuspid aortic valve: a maturation defect of the aortic wall. Grewal N, etal., J Thorac Cardiovasc Surg. 2014 Oct;148(4):1583-90. doi: 10.1016/j.jtcvs.2014.01.027. Epub 2014 Jan 25.
19. Elevated serum C-reactive protein and free fatty acids among nondiabetic carriers of missense mutations in the gene encoding lamin A/C (LMNA) with partial lipodystrophy. Hegele RA, etal., Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):111-6.
20. FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence. Krejci P, etal., Bone. 2010 Jul;47(1):102-10. doi: 10.1016/j.bone.2010.03.021. Epub 2010 Mar 31.
21. Association of LMNA 1908C/T polymorphism with cerebral vascular disease and diabetic nephropathy in Japanese men with type 2 diabetes. Liang H, etal., Clin Endocrinol (Oxf). 2005 Sep;63(3):317-22.
22. A novel mutation in the central rod domain of lamin A/C producing a phenotype resembling the Emery-Dreifuss muscular dystrophy phenotype. Maioli MA, etal., Muscle Nerve. 2007 Dec;36(6):828-32.
23. Sequestration of pRb by cyclin D3 causes intranuclear reorganization of lamin A/C during muscle cell differentiation. Mariappan I and Parnaik VK, Mol Biol Cell. 2005 Apr;16(4):1948-60. doi: 10.1091/mbc.e04-02-0154. Epub 2005 Feb 9.
24. Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody. McClintock D, etal., Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2154-9. Epub 2006 Feb 6.
25. Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies. Mesa JL, etal., Diabetes. 2007 Mar;56(3):884-9.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Landscape of the hnRNP K protein-protein interactome. Mikula M, etal., Proteomics. 2006 Apr;6(8):2395-406.
28. A progeroid syndrome in mice is caused by defects in A-type lamins. Mounkes LC, etal., Nature 2003 May 15;423(6937):298-301.
29. Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B). Muchir A, etal., Hum Mol Genet. 2000 May 22;9(9):1453-9.
30. Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy. Muchir A, etal., J Clin Invest. 2007 May;117(5):1282-93. Epub 2007 Apr 19.
31. Suppression of lamin A/C by short hairpin RNAs promotes adipocyte lineage commitment in mesenchymal progenitor cell line, ROB-C26. Naito M, etal., Histochem Cell Biol. 2012 Feb;137(2):235-47. doi: 10.1007/s00418-011-0890-3. Epub 2011 Nov 27.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. Lamin A gene expression is specifically suppressed in v-src-transformed cells. Ozaki T and Sakiyama S, FEBS Lett 1992 Nov 9;312(2-3):165-8.
35. Long-term outcome and risk stratification in dilated cardiolaminopathies. Pasotti M, etal., J Am Coll Cardiol. 2008 Oct 7;52(15):1250-60.
36. Congenital muscular dystrophy with dropped head linked to the LMNA gene in a Brazilian cohort. Pasqualin LM, etal., Pediatr Neurol. 2014 Apr;50(4):400-6. doi: 10.1016/j.pediatrneurol.2013.11.010. Epub 2013 Nov 21.
37. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
38. Homozygous missense mutation in the lamin A/C gene causes autosomal recessive Hutchinson-Gilford progeria syndrome. Plasilova M, etal., J Med Genet. 2004 Aug;41(8):609-14.
39. GOA pipeline RGD automated data pipeline
40. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Proteome analysis of a rat liver nuclear insoluble protein fraction and localization of a novel protein, ISP36, to compartments in the interchromatin space. Segawa M, etal., FEBS J. 2005 Sep;272(17):4327-38.
43. LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. Shackleton S, etal., Nat Genet. 2000 Feb;24(2):153-6.
44. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
45. Identification of novel mutations in LMNA associated with familial forms of dilated cardiomyopathy. Stallmeyer B, etal., Genet Test Mol Biomarkers. 2012 Jun;16(6):543-9. doi: 10.1089/gtmb.2011.0214. Epub 2012 Jan 6.
46. Variation in the lamin A/C gene: associations with metabolic syndrome. Steinle NI, etal., Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1708-13. Epub 2004 Jun 17.
47. Natural history of dilated cardiomyopathy due to lamin A/C gene mutations. Taylor MR, etal., J Am Coll Cardiol. 2003 Mar 5;41(5):771-80.
48. Phenotypic variability in autosomal recessive axonal Charcot-Marie-Tooth disease due to the R298C mutation in lamin A/C. Tazir M, etal., Brain 2004 Jan;127(Pt 1):154-63. Epub 2003 Nov 7.
49. Lamin A/C mutations with lipodystrophy, cardiac abnormalities, and muscular dystrophy. van der Kooi AJ, etal., Neurology. 2002 Aug 27;59(4):620-3.
50. A G613A missense in the Hutchinson's progeria lamin A/C gene causes a lone, autosomal dominant atrioventricular block. Villa F, etal., Immun Ageing. 2014 Nov 26;11(1):19. doi: 10.1186/s12979-014-0019-3. eCollection 2014.
51. Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites. Wegner L, etal., Diabetes. 2007 Mar;56(3):694-8.
52. Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease. Wolf CM, etal., J Mol Cell Cardiol. 2008 Feb;44(2):293-303. Epub 2007 Dec 3.
Additional References at PubMed
PMID:8032679   PMID:11092755   PMID:11739632   PMID:12477932   PMID:14755333   PMID:16339967   PMID:16511604   PMID:16641100   PMID:16731532   PMID:16791210   PMID:16904066   PMID:17164264  
PMID:17631533   PMID:18606848   PMID:18664494   PMID:18809582   PMID:19915186   PMID:20457914   PMID:20458013   PMID:20581439   PMID:20810912   PMID:21111849   PMID:21151901   PMID:21498514  
PMID:21610090   PMID:21842415   PMID:22082260   PMID:22349700   PMID:22871113   PMID:22886301   PMID:23686339   PMID:23695662   PMID:23979707   PMID:24327345   PMID:25399868   PMID:25721888  
PMID:25910212   PMID:26436652   PMID:26769003   PMID:27114541   PMID:27534416   PMID:29040816   PMID:29476059   PMID:31495066   PMID:32083564   PMID:32926941   PMID:34502098   PMID:35352799  


Genomics

Comparative Map Data
Lmna
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,237,564 - 176,265,301 (-)NCBIGRCr8
mRatBN7.22173,939,751 - 173,960,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,939,751 - 173,960,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,083,809 - 181,104,527 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,106,174 - 179,126,892 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,706,353 - 173,727,003 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,842,884 - 187,863,552 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,842,885 - 187,863,516 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,245,237 - 207,265,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,595,724 - 180,616,354 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12180,545,829 - 180,566,460 (-)NCBI
Celera2167,884,341 - 167,905,010 (-)NCBICelera
Cytogenetic Map2q34NCBI
LMNA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,082,573 - 156,140,081 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,082,572 - 156,140,081 (+)EnsemblGRCh38hg38GRCh38
GRCh371156,052,364 - 156,109,872 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,351,085 - 154,376,502 (+)NCBINCBI36Build 36hg18NCBI36
Build 341152,897,570 - 152,922,944NCBI
Celera1129,157,453 - 129,182,870 (+)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,414,589 - 127,472,062 (+)NCBIHuRef
CHM1_11157,448,481 - 157,505,990 (+)NCBICHM1_1
T2T-CHM13v2.01155,221,038 - 155,278,530 (+)NCBIT2T-CHM13v2.0
Lmna
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,388,455 - 88,413,842 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,387,454 - 88,417,263 (-)EnsemblGRCm39 Ensembl
GRCm38388,481,148 - 88,509,932 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,480,147 - 88,509,956 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,285,071 - 88,307,254 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,567,076 - 88,589,234 (-)NCBIMGSCv36mm8
Celera388,521,102 - 88,543,289 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.84NCBI
Lmna
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,290,037 - 2,313,033 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,290,076 - 2,310,982 (+)NCBIChiLan1.0ChiLan1.0
LMNA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,706,163 - 93,763,674 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,438,136 - 93,463,558 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01131,456,819 - 131,482,275 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,253,700 - 135,311,542 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,253,700 - 135,311,539 (+)Ensemblpanpan1.1panPan2
LMNA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,702,491 - 41,719,870 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,508,450 - 41,746,931 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,192,089 - 41,209,467 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,569,142 - 41,586,514 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,568,716 - 41,586,490 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,349,981 - 41,367,355 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,403,350 - 41,420,721 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,687,512 - 41,704,901 (-)NCBIUU_Cfam_GSD_1.0
Lmna
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,343,835 - 26,365,060 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,373,974 - 5,395,468 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,374,208 - 5,395,442 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LMNA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,899,019 - 93,926,320 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,899,019 - 93,927,255 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,641,459 - 102,668,722 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4qNCBI
LMNA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,723,059 - 7,748,799 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,723,477 - 7,748,780 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660387,017,993 - 7,044,309 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lmna
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,447,395 - 1,467,554 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,423,563 - 1,466,657 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lmna
92 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:113
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000026705
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
BI277711  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82176,239,737 - 176,240,270 (+)Marker Load Pipeline
mRatBN7.22173,941,924 - 173,942,457 (+)MAPPERmRatBN7.2
Rnor_6.02187,845,058 - 187,845,590NCBIRnor6.0
Rnor_5.02207,247,410 - 207,247,942UniSTSRnor5.0
RGSC_v3.42180,597,895 - 180,598,427UniSTSRGSC3.4
Celera2167,886,515 - 167,887,047UniSTS
RH 3.4 Map21165.5UniSTS
Cytogenetic Map2q31-q34UniSTS
RH141321  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82176,237,572 - 176,237,769 (+)Marker Load Pipeline
mRatBN7.22173,939,759 - 173,939,956 (+)MAPPERmRatBN7.2
Rnor_6.02187,842,893 - 187,843,089NCBIRnor6.0
Rnor_5.02207,245,245 - 207,245,441UniSTSRnor5.0
RGSC_v3.42180,595,730 - 180,595,926UniSTSRGSC3.4
Celera2167,884,350 - 167,884,546UniSTS
RH 3.4 Map21153.5UniSTS
Cytogenetic Map2q31-q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026705   ⟹   ENSRNOP00000026705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,939,751 - 173,960,423 (-)Ensembl
Rnor_6.0 Ensembl2187,842,885 - 187,863,516 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082174   ⟹   ENSRNOP00000068655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,939,752 - 173,960,423 (-)Ensembl
Rnor_6.0 Ensembl2187,842,887 - 187,863,516 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084455   ⟹   ENSRNOP00000072742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,939,752 - 173,960,220 (-)Ensembl
Rnor_6.0 Ensembl2187,845,024 - 187,863,349 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092993   ⟹   ENSRNOP00000076028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,941,802 - 173,951,235 (-)Ensembl
Rnor_6.0 Ensembl2187,844,935 - 187,854,363 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093036   ⟹   ENSRNOP00000076022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,844,934 - 187,863,503 (-)Ensembl
RefSeq Acc Id: NM_001002016   ⟹   NP_001002016
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,237,564 - 176,258,235 (-)NCBI
mRatBN7.22173,939,751 - 173,960,423 (-)NCBI
Rnor_6.02187,842,884 - 187,863,552 (-)NCBI
Rnor_5.02207,245,237 - 207,265,928 (-)NCBI
RGSC_v3.42180,595,724 - 180,616,354 (-)RGD
Celera2167,884,341 - 167,905,010 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063282429   ⟹   XP_063138499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,237,565 - 176,265,301 (-)NCBI
RefSeq Acc Id: NP_001002016   ⟸   NM_001002016
- UniProtKB: P48679 (UniProtKB/Swiss-Prot),   G3V8L3 (UniProtKB/TrEMBL),   A6J680 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068655   ⟸   ENSRNOT00000082174
Ensembl Acc Id: ENSRNOP00000072742   ⟸   ENSRNOT00000084455
Ensembl Acc Id: ENSRNOP00000026705   ⟸   ENSRNOT00000026705
Ensembl Acc Id: ENSRNOP00000076028   ⟸   ENSRNOT00000092993
Ensembl Acc Id: ENSRNOP00000076022   ⟸   ENSRNOT00000093036
RefSeq Acc Id: XP_063138499   ⟸   XM_063282429
- Peptide Label: isoform X1
- UniProtKB: P48679 (UniProtKB/Swiss-Prot),   A6J680 (UniProtKB/TrEMBL),   G3V8L3 (UniProtKB/TrEMBL)
Protein Domains
IF rod   LTD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48679-F1-model_v2 AlphaFold P48679 1-665 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691442
Promoter ID:EPDNEW_R1967
Type:initiation region
Name:Lmna_1
Description:lamin A/C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,863,552 - 187,863,612EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620456 AgrOrtholog
BioCyc Gene G2FUF-52481 BioCyc
Ensembl Genes ENSRNOG00000019638 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000026705 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  2.60.40.1260 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5621637 IMAGE-MGC_LOAD
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Lamin_tail_dom UniProtKB/Swiss-Prot
  Lamin_tail_dom_sf UniProtKB/Swiss-Prot
MGC_CLONE MGC:72422 IMAGE-MGC_LOAD
NCBI Gene 60374 ENTREZGENE
PANTHER LAMIN DM0-RELATED UniProtKB/Swiss-Prot
  PRELAMIN-A/C UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
  LTD UniProtKB/Swiss-Prot
PharmGKB LMNA RGD
PhenoGen Lmna PhenoGen
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
  LTD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019638 RatGTEx
SMART Filament UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
  SSF74853 UniProtKB/Swiss-Prot
UniProt A0A0G2JTC5_RAT UniProtKB/TrEMBL
  A0A0G2K3R2_RAT UniProtKB/TrEMBL
  A0A1B0GWU9_RAT UniProtKB/TrEMBL
  A6J680 ENTREZGENE, UniProtKB/TrEMBL
  A6J681_RAT UniProtKB/TrEMBL
  A6J682_RAT UniProtKB/TrEMBL
  G3V8L3 ENTREZGENE, UniProtKB/TrEMBL
  LMNA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P6U3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-29 Lmna  lamin A/C  Lmna  lamin A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Lmna  lamin A      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Lmna        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 665 amino acid residues 729133