Hpd (4-hydroxyphenylpyruvate dioxygenase) - Rat Genome Database

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Gene: Hpd (4-hydroxyphenylpyruvate dioxygenase) Rattus norvegicus
Analyze
Symbol: Hpd
Name: 4-hydroxyphenylpyruvate dioxygenase
RGD ID: 61974
Description: Enables 4-hydroxyphenylpyruvate dioxygenase activity; iron ion binding activity; and protein homodimerization activity. Involved in tyrosine catabolic process. Located in Golgi membrane and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 4-hydroxyphenylpyruvic acid dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; f Alloantigen; f protein; HPPDase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21233,381,397 - 33,392,750 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,381,231 - 33,392,766 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1234,560,040 - 34,571,400 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01235,171,415 - 35,182,771 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01234,223,280 - 34,234,640 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01238,828,606 - 38,839,956 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1238,828,444 - 38,839,969 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01240,729,052 - 40,740,668 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,548,320 - 34,558,371 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11234,411,707 - 34,421,759 (+)NCBI
Celera1235,063,212 - 35,073,637 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diquat  (ISO)
doramapimod  (EXP)
folic acid  (EXP,ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
glycidol  (EXP)
L-methionine  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (EXP)
nitisinone  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
propanal  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tamibarotene  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
tremolite asbestos  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Molecular cloning of the liver-specific rat F antigen. Gershwin ME, etal., J Immunol 1987 Dec 1;139(11):3828-33.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. The C-terminal of rat 4-hydroxyphenylpyruvate dioxygenase is indispensable for enzyme activity. Lee MH, etal., FEBS Lett. 1996 Sep 16;393(2-3):269-72.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Tissue distribution, intracellular localization and proteolytic processing of rat 4-hydroxyphenylpyruvate dioxygenase. Neve S, etal., Cell Biol Int 2003;27(8):611-24.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Structural basis for herbicidal inhibitor selectivity revealed by comparison of crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases. Yang C, etal., Biochemistry. 2004 Aug 17;43(32):10414-23. doi: 10.1021/bi049323o.
Additional References at PubMed
PMID:10942115   PMID:15489334   PMID:19056867   PMID:20677779   PMID:22872058   PMID:23376485  


Genomics

Comparative Map Data
Hpd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21233,381,397 - 33,392,750 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,381,231 - 33,392,766 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1234,560,040 - 34,571,400 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01235,171,415 - 35,182,771 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01234,223,280 - 34,234,640 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01238,828,606 - 38,839,956 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1238,828,444 - 38,839,969 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01240,729,052 - 40,740,668 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,548,320 - 34,558,371 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11234,411,707 - 34,421,759 (+)NCBI
Celera1235,063,212 - 35,073,637 (+)NCBICelera
Cytogenetic Map12q16NCBI
HPD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812121,839,527 - 121,888,611 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12121,839,527 - 121,863,596 (-)EnsemblGRCh38hg38GRCh38
GRCh3712122,277,433 - 122,326,517 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612120,761,816 - 120,781,152 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412120,740,154 - 120,759,489NCBI
Celera12121,913,690 - 121,962,455 (-)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12119,289,545 - 119,337,791 (-)NCBIHuRef
CHM1_112122,245,145 - 122,294,160 (-)NCBICHM1_1
T2T-CHM13v2.012121,836,201 - 121,884,910 (-)NCBIT2T-CHM13v2.0
Hpd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395123,309,870 - 123,320,786 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5123,309,870 - 123,320,790 (-)EnsemblGRCm39 Ensembl
GRCm385123,171,807 - 123,182,723 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5123,171,807 - 123,182,727 (-)EnsemblGRCm38mm10GRCm38
MGSCv375123,621,816 - 123,632,695 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365123,432,425 - 123,443,305 (-)NCBIMGSCv36mm8
Celera5120,267,078 - 120,277,955 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map562.82NCBI
Hpd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554826,586,975 - 6,595,034 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554826,586,975 - 6,595,034 (+)NCBIChiLan1.0ChiLan1.0
HPD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan112129,924,008 - 129,973,639 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012119,442,893 - 119,462,171 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112122,813,141 - 122,859,815 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12122,813,141 - 122,831,701 (-)Ensemblpanpan1.1panPan2
HPD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1267,430,891 - 7,440,643 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl267,430,933 - 7,440,611 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha267,590,591 - 7,600,332 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0267,682,482 - 7,692,423 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl267,682,506 - 7,692,441 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1267,614,559 - 7,624,300 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0267,704,925 - 7,714,660 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0267,660,824 - 7,670,565 (+)NCBIUU_Cfam_GSD_1.0
HPD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1430,845,613 - 30,857,667 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11430,845,608 - 30,857,658 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21432,650,996 - 32,662,746 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HPD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111117,203,844 - 117,246,249 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11117,203,307 - 117,224,038 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366613630,819 - 51,286 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hpd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474722,209,009 - 22,217,841 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474722,209,191 - 22,217,665 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hpd
57 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:83
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000001809
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122860752637691617Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

Markers in Region
RH141029  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,392,472 - 33,392,665 (+)MAPPERmRatBN7.2
Rnor_6.01238,839,679 - 38,839,871NCBIRnor6.0
Rnor_5.01240,740,391 - 40,740,583UniSTSRnor5.0
RGSC_v3.41234,558,094 - 34,558,286UniSTSRGSC3.4
Celera1235,073,360 - 35,073,552UniSTS
Cytogenetic Map12q16UniSTS
GDB:455130  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,386,550 - 33,386,634 (+)MAPPERmRatBN7.2
mRatBN7.24175,792,841 - 175,793,184 (+)MAPPERmRatBN7.2
Rnor_6.04177,068,161 - 177,068,503NCBIRnor6.0
Rnor_6.01238,833,759 - 38,833,842NCBIRnor6.0
Rnor_5.01240,734,471 - 40,734,554UniSTSRnor5.0
Rnor_5.04241,276,967 - 241,277,309UniSTSRnor5.0
RGSC_v3.44180,725,277 - 180,725,619UniSTSRGSC3.4
RGSC_v3.41234,552,174 - 34,552,257UniSTSRGSC3.4
Celera1235,067,439 - 35,067,522UniSTS
Celera4164,323,553 - 164,323,938UniSTS
Cytogenetic Map12q16UniSTS
Cytogenetic Map4q44UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 22 22 22 4
Medium 2 21 19 19 25 7 1
Low 23 14 17 8 9 23 6 26 7 8
Below cutoff 3 14 2 2 37 6 3

Sequence


RefSeq Acc Id: ENSRNOT00000001809   ⟹   ENSRNOP00000001809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,381,231 - 33,392,766 (+)Ensembl
Rnor_6.0 Ensembl1238,828,444 - 38,839,969 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000120179   ⟹   ENSRNOP00000085869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,381,389 - 33,392,766 (+)Ensembl
RefSeq Acc Id: NM_017233   ⟹   NP_058929
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21233,381,397 - 33,392,750 (+)NCBI
Rnor_6.01238,828,606 - 38,839,956 (+)NCBI
Rnor_5.01240,729,052 - 40,740,668 (+)NCBI
RGSC_v3.41234,548,320 - 34,558,371 (+)RGD
Celera1235,063,212 - 35,073,637 (+)RGD
Sequence:
RefSeq Acc Id: NP_058929   ⟸   NM_017233
- UniProtKB: O88655 (UniProtKB/Swiss-Prot),   P32755 (UniProtKB/Swiss-Prot),   A0A8L2Q085 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001809   ⟸   ENSRNOT00000001809
RefSeq Acc Id: ENSRNOP00000085869   ⟸   ENSRNOT00000120179
Protein Domains
VOC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P32755-F1-model_v2 AlphaFold P32755 1-393 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698633
Promoter ID:EPDNEW_R9157
Type:multiple initiation site
Name:Hpd_1
Description:4-hydroxyphenylpyruvate dioxygenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01238,828,598 - 38,828,658EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61974 AgrOrtholog
BioCyc Gene G2FUF-19291 BioCyc
BioCyc Pathway PWY-6318 [L-phenylalanine degradation IV (mammalian, via side chain)] BioCyc
  TYRFUMCAT-PWY [L-tyrosine degradation I] BioCyc
BioCyc Pathway Image PWY-6318 BioCyc
  TYRFUMCAT-PWY BioCyc
Ensembl Genes ENSRNOG00000001338 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055015643 UniProtKB/Swiss-Prot
  ENSRNOG00060003174 UniProtKB/Swiss-Prot
  ENSRNOG00065006407 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001809.7 UniProtKB/TrEMBL
  ENSRNOT00000120179 ENTREZGENE
  ENSRNOT00000120179.1 UniProtKB/Swiss-Prot
  ENSRNOT00055026676 UniProtKB/Swiss-Prot
  ENSRNOT00060005212 UniProtKB/Swiss-Prot
  ENSRNOT00065009858 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.180.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7107086 IMAGE-MGC_LOAD
InterPro 4OHPhenylPyrv_dOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4OHPhenylPyrv_dOase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4OHPhenylPyrv_dOase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyas_Bleomycin-R_OHBP_Dase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyas_Fos-R_dOase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VOC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29531 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93530 IMAGE-MGC_LOAD
NCBI Gene 29531 ENTREZGENE
PANTHER 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyoxalase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hpd PhenoGen
PIRSF HPP_dOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE VOC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001338 RatGTEx
  ENSRNOG00055015643 RatGTEx
  ENSRNOG00060003174 RatGTEx
  ENSRNOG00065006407 RatGTEx
Superfamily-SCOP SSF54593 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2Q085 ENTREZGENE, UniProtKB/TrEMBL
  A6J162_RAT UniProtKB/TrEMBL
  HPPD_RAT UniProtKB/Swiss-Prot
  O88655 ENTREZGENE
  P32755 ENTREZGENE
UniProt Secondary O88655 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-24 Hpd  4-hydroxyphenylpyruvate dioxygenase  Hpd  4-hydroxyphenylpyruvic acid dioxygenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hpd  4-hydroxyphenylpyruvic acid dioxygenase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to membranes of the endoplasmic reticulum and Golgi apparatus 632936
gene_expression expressed in liver  
gene_expression expressed in liver, kidney, and in neurons of various regions of the brain 632936
gene_product 43kDa