Crybb1 (crystallin, beta B1) - Rat Genome Database

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Gene: Crybb1 (crystallin, beta B1) Rattus norvegicus
Analyze
Symbol: Crybb1
Name: crystallin, beta B1
RGD ID: 2416
Description: A structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Human ortholog(s) of this gene implicated in cataract and cataract 17 multiple types. Orthologous to human CRYBB1 (crystallin beta B1); INTERACTS WITH acrylamide; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-B1 crystallin; beta-crystallin B1; CRYB1; CRYB11; crystallin beta B1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81250,030,146 - 50,043,756 (-)NCBIGRCr8
mRatBN7.21244,369,734 - 44,383,344 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1244,369,735 - 44,383,344 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1245,538,591 - 45,552,345 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01246,149,005 - 46,162,615 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01245,209,536 - 45,223,146 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01250,390,939 - 50,404,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1250,390,940 - 50,404,550 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01252,147,268 - 52,160,879 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1245,952,784 - 45,966,534 (-)NCBICelera
RH 3.4 Map12776.72RGD
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat lens beta-crystallins are internally duplicated and homologous to gamma-crystallins. den Dunnen JT, etal., Biochim Biophys Acta 1985 Apr 19;824(4):295-303.
2. Intron insertions and deletions in the beta/gamma-crystallin gene family: the rat beta B1 gene. den Dunnen JT, etal., Proc Natl Acad Sci U S A 1986 May;83(9):2855-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
6. Lens proteomics: analysis of rat crystallin sequences and two-dimensional electrophoresis map. Lampi KJ, etal., Invest Ophthalmol Vis Sci 2002 Jan;43(1):216-24.
7. A nonsense mutation in CRYBB1 associated with autosomal dominant cataract linked to human chromosome 22q. Mackay DS, etal., Am J Hum Genet 2002 Nov;71(5):1216-21.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8405363   PMID:12477932  


Genomics

Comparative Map Data
Crybb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81250,030,146 - 50,043,756 (-)NCBIGRCr8
mRatBN7.21244,369,734 - 44,383,344 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1244,369,735 - 44,383,344 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1245,538,591 - 45,552,345 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01246,149,005 - 46,162,615 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01245,209,536 - 45,223,146 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01250,390,939 - 50,404,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1250,390,940 - 50,404,550 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01252,147,268 - 52,160,879 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1245,952,784 - 45,966,534 (-)NCBICelera
RH 3.4 Map12776.72RGD
Cytogenetic Map12q16NCBI
CRYBB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382226,599,278 - 26,618,027 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2226,599,278 - 26,618,027 (-)EnsemblGRCh38hg38GRCh38
GRCh372226,995,242 - 27,013,991 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362225,325,362 - 25,343,991 (-)NCBINCBI36Build 36hg18NCBI36
Build 342225,319,915 - 25,338,545NCBI
Celera2210,799,161 - 10,817,792 (-)NCBICelera
Cytogenetic Map22q12.1ENTREZGENE
HuRef229,942,881 - 9,961,511 (-)NCBIHuRef
CHM1_12226,954,881 - 26,973,527 (-)NCBICHM1_1
T2T-CHM13v2.02227,061,628 - 27,080,697 (-)NCBIT2T-CHM13v2.0
Crybb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395112,403,686 - 112,417,451 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5112,403,681 - 112,417,451 (+)EnsemblGRCm39 Ensembl
GRCm385112,254,563 - 112,269,585 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5112,255,815 - 112,269,585 (+)EnsemblGRCm38mm10GRCm38
MGSCv375112,684,841 - 112,698,602 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365112,496,124 - 112,509,885 (+)NCBIMGSCv36mm8
Celera5109,375,405 - 109,389,151 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map554.63NCBI
Crybb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554551,165,048 - 1,180,826 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554551,165,048 - 1,180,826 (-)NCBIChiLan1.0ChiLan1.0
CRYBB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22336,604,824 - 36,623,396 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12239,303,287 - 39,321,857 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0227,661,085 - 7,679,640 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12225,383,681 - 25,402,158 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2225,383,681 - 25,402,158 (-)Ensemblpanpan1.1panPan2
CRYBB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12620,258,873 - 20,269,647 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2620,258,877 - 20,287,217 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2620,122,587 - 20,133,372 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02620,622,023 - 20,632,822 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2620,622,027 - 20,650,377 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12620,343,574 - 20,354,371 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02620,594,199 - 20,605,216 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02620,664,547 - 20,675,365 (-)NCBIUU_Cfam_GSD_1.0
Crybb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118114,660,332 - 114,676,677 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366571,193,474 - 1,210,443 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366571,194,030 - 1,210,345 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRYBB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1444,194,199 - 44,208,154 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11444,194,268 - 44,206,057 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21447,074,156 - 47,085,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRYBB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1199,500,341 - 9,517,178 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl199,500,431 - 9,515,068 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045116,585,561 - 116,602,261 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crybb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247473,125,168 - 3,137,576 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247473,125,168 - 3,137,576 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Crybb1
62 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:94
Interacting mature miRNAs:105
Transcripts:ENSRNOT00000071613, ENSRNOT00000073072
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat

Markers in Region
RH94677  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21244,369,748 - 44,370,007 (+)MAPPERmRatBN7.2
Rnor_6.01250,390,954 - 50,391,212NCBIRnor6.0
Rnor_5.01252,147,283 - 52,147,541UniSTSRnor5.0
Celera1245,952,799 - 45,953,057UniSTS
RH 3.4 Map12776.72UniSTS
GDB:362766  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21244,369,820 - 44,370,003 (+)MAPPERmRatBN7.2
Rnor_6.01250,391,026 - 50,391,208NCBIRnor6.0
Rnor_5.01252,147,355 - 52,147,537UniSTSRnor5.0
Celera1245,952,871 - 45,953,053UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 10 39 104 33 28 3 14 3 5 125 76 85 31 52 25

Sequence


Ensembl Acc Id: ENSRNOT00000071613   ⟹   ENSRNOP00000064652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1250,391,083 - 50,400,765 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000073072   ⟹   ENSRNOP00000064741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1244,369,735 - 44,383,344 (-)Ensembl
Rnor_6.0 Ensembl1250,390,940 - 50,404,550 (-)Ensembl
RefSeq Acc Id: NM_012936   ⟹   NP_037068
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81250,030,146 - 50,043,756 (-)NCBI
mRatBN7.21244,369,734 - 44,383,344 (-)NCBI
Rnor_6.01250,390,939 - 50,404,550 (-)NCBI
Rnor_5.01252,147,268 - 52,160,879 (-)NCBI
Celera1245,952,784 - 45,966,534 (-)RGD
Sequence:
RefSeq Acc Id: NP_037068   ⟸   NM_012936
- UniProtKB: A0JN26 (UniProtKB/Swiss-Prot),   Q9JHV9 (UniProtKB/Swiss-Prot),   P02523 (UniProtKB/Swiss-Prot),   A6J266 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064741   ⟸   ENSRNOT00000073072
Ensembl Acc Id: ENSRNOP00000064652   ⟸   ENSRNOT00000071613
Protein Domains
Beta/gamma crystallin 'Greek key'

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02523-F1-model_v2 AlphaFold P02523 1-250 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2416 AgrOrtholog
BioCyc Gene G2FUF-18864 BioCyc
Ensembl Genes ENSRNOG00000047653 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055002197 UniProtKB/Swiss-Prot
  ENSRNOG00065006027 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073072.3 UniProtKB/Swiss-Prot
  ENSRNOT00055003484 UniProtKB/Swiss-Prot
  ENSRNOT00065009112 UniProtKB/Swiss-Prot
Gene3D-CATH Crystallins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8364407 IMAGE-MGC_LOAD
InterPro Beta/Gamma-Crystallin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta/gamma_crystallin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_crystallin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25421 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:156675 IMAGE-MGC_LOAD
NCBI Gene 25421 ENTREZGENE
PANTHER BETA-CRYSTALLIN B1 UniProtKB/TrEMBL
  BETA/GAMMA CRYSTALLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11818:SF12 UniProtKB/Swiss-Prot
Pfam Crystall UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Crybb1 PhenoGen
PRINTS BGCRYSTALLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CRYSTALLIN_BETA_GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047653 RatGTEx
  ENSRNOG00055002197 RatGTEx
  ENSRNOG00065006027 RatGTEx
SMART XTALbg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP gamma-Crystallin-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A0JN26 ENTREZGENE
  A6J266 ENTREZGENE, UniProtKB/TrEMBL
  CRBB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9JHV9 ENTREZGENE
UniProt Secondary A0JN26 UniProtKB/Swiss-Prot
  Q9JHV9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Crybb1  crystallin, beta B1    crystallin beta B1  Name updated 1299863 APPROVED
2002-06-10 Crybb1  crystallin beta B1      Name updated 70584 APPROVED