Prkar1b (protein kinase cAMP-dependent type I regulatory subunit beta) - Rat Genome Database

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Gene: Prkar1b (protein kinase cAMP-dependent type I regulatory subunit beta) Rattus norvegicus
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Symbol: Prkar1b
Name: protein kinase cAMP-dependent type I regulatory subunit beta
RGD ID: 3392
Description: Enables cAMP binding activity and cAMP-dependent protein kinase regulator activity. Involved in positive regulation of excitatory postsynaptic potential; positive regulation of fear response; and positive regulation of long-term synaptic potentiation. Part of cAMP-dependent protein kinase complex. Orthologous to human PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta); PARTICIPATES IN protein kinase A (PKA) signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cAMP dependent protein kinase, subunit type 1 beta; cAMP-dependent protein kinase type I-beta regulatory subunit; LOC360774; MGC125243; Prkar1b_mapped; protein kinase cAMP-dependent type 1 regulatory subunit beta; protein kinase, cAMP dependent regulatory, type 1 beta; protein kinase, cAMP dependent regulatory, type I, beta; protein kinase, camp dependent regulatory, type i, beta (mapped); protein kinase, cAMP-dependent, regulatory subunit type I beta; RGD1563094; RIbeta; similar to cAMP-dependent protein kinase type I-beta regulatory subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Prkar1bem1Tua   Prkar1bem2Tua  
Genetic Models: F344-Prkar1bem2Tua F344-Prkar1bem1Tua
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81220,606,066 - 20,738,766 (+)NCBIGRCr8
mRatBN7.21215,492,233 - 15,624,942 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,511,801 - 15,624,942 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,336,888 - 16,436,081 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,960,627 - 17,059,817 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,984,377 - 16,082,381 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,614,536 - 17,713,567 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,614,632 - 17,712,373 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,611,694 - 19,708,682 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41216,025,867 - 16,131,129 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1217,279,498 - 17,377,254 (+)NCBICelera
Cytogenetic Map12q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
caffeine  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlormequat chloride  (EXP)
cisplatin  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
fulvestrant  (ISO)
gentamycin  (EXP)
ketoconazole  (ISO)
lead(0)  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
O-methyleugenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
pyrethrins  (EXP)
quercetin  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential effects of haloperidol and clozapine on cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain. Dwivedi Y, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):197-209.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats. Hoang Trung H, etal., Sci Rep. 2021 Jan 21;11(1):2039. doi: 10.1038/s41598-021-81515-x.
4. An active protein kinase A (PKA) is involved in meiotic arrest of rat growing oocytes. Kovo M, etal., Reproduction. 2006 Jul;132(1):33-43.
5. Rat RI beta isoform of type I regulatory subunit of cyclic adenosine monophosphate-dependent protein kinase: cDNA sequence analysis, mRNA tissue specificity, and rat/mouse difference in expression in testis. Massa JS, etal., Mol Reprod Dev 1990 Jun;26(2):129-33.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Clustered distribution of cAMP-dependent protein kinase regulatory isoform RI alpha during the development of the rat brain. Mucignat-Caretta C and Caretta A, J Comp Neurol. 2002 Sep 30;451(4):324-33.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Sugiyama F, etal., Genomics 2001 Jan 1;71(1):70-7.
12. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
Additional References at PubMed
PMID:7568030   PMID:8548807   PMID:9054501   PMID:12477932   PMID:21502359   PMID:21812984   PMID:24413018   PMID:30053369  


Genomics

Comparative Map Data
Prkar1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81220,606,066 - 20,738,766 (+)NCBIGRCr8
mRatBN7.21215,492,233 - 15,624,942 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,511,801 - 15,624,942 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,336,888 - 16,436,081 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,960,627 - 17,059,817 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,984,377 - 16,082,381 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,614,536 - 17,713,567 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,614,632 - 17,712,373 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,611,694 - 19,708,682 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41216,025,867 - 16,131,129 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1217,279,498 - 17,377,254 (+)NCBICelera
Cytogenetic Map12q11NCBI
PRKAR1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387549,197 - 728,934 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7549,197 - 727,650 (-)EnsemblGRCh38hg38GRCh38
GRCh377588,834 - 767,313 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367555,913 - 718,659 (-)NCBINCBI36Build 36hg18NCBI36
Celera7558,390 - 735,169 (-)NCBICelera
Cytogenetic Map7p22.3NCBI
HuRef7507,400 - 685,578 (-)NCBIHuRef
CHM1_17588,428 - 766,905 (-)NCBICHM1_1
T2T-CHM13v2.07650,161 - 832,029 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27650,549 - 825,534 (-)NCBI
Prkar1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,003,059 - 139,136,458 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5139,003,061 - 139,135,756 (-)EnsemblGRCm39 Ensembl
GRCm385139,017,304 - 139,150,703 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,017,306 - 139,150,001 (-)EnsemblGRCm38mm10GRCm38
MGSCv375139,493,258 - 139,605,706 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,270,948 - 139,383,333 (-)NCBIMGSCv36mm8
Celera5136,072,385 - 136,181,556 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map577.74NCBI
Prkar1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,357,637 - 8,460,396 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,357,890 - 8,479,875 (-)NCBIChiLan1.0ChiLan1.0
PRKAR1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v265,484,409 - 5,661,348 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1753,809,101 - 53,986,014 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07700,691 - 876,497 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17923,668 - 1,097,792 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7923,668 - 1,097,456 (-)Ensemblpanpan1.1panPan2
PRKAR1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1616,135,406 - 16,248,567 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl616,135,715 - 16,247,465 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,607,212 - 17,720,355 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,264,735 - 16,377,921 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,265,043 - 16,382,743 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,067,389 - 16,180,517 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0615,993,837 - 16,106,858 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,283,599 - 16,396,577 (+)NCBIUU_Cfam_GSD_1.0
Prkar1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344144,047,325 - 144,167,636 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936754842,343 - 963,024 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936754842,697 - 963,002 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAR1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3343,139 - 425,165 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13343,124 - 425,154 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23190,914 - 227,592 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKAR1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12820,838,247 - 21,016,196 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2820,853,763 - 21,016,257 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666090658,653 - 842,505 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkar1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474026,202,375 - 26,315,352 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474026,202,882 - 26,315,987 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkar1b
1040 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:504
Count of miRNA genes:230
Interacting mature miRNAs:286
Transcripts:ENSRNOT00000031896
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121300829619212979Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat

Markers in Region
RH132420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21215,624,642 - 15,624,850 (+)MAPPERmRatBN7.2
Rnor_6.01217,713,268 - 17,713,475NCBIRnor6.0
Rnor_5.01219,708,394 - 19,708,601UniSTSRnor5.0
RGSC_v3.41216,130,841 - 16,131,048UniSTSRGSC3.4
Celera1217,376,966 - 17,377,173UniSTS
RH 3.4 Map12245.9UniSTS
Cytogenetic Map12q11UniSTS
Prkar1b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21215,624,102 - 15,624,853 (+)MAPPERmRatBN7.2
Rnor_6.01217,712,728 - 17,713,478NCBIRnor6.0
Rnor_5.01219,707,854 - 19,708,604UniSTSRnor5.0
RGSC_v3.41216,130,301 - 16,131,051UniSTSRGSC3.4
Celera1217,376,426 - 17,377,176UniSTS
Cytogenetic Map12q11UniSTS


Genetic Models
This gene Prkar1b is modified in the following models/strains:
F344-Prkar1bem2Tua     F344-Prkar1bem1Tua    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 31 13 13 224 61 103
Low 13 126 127 83 51 83 30 30 18 54 42 55 18
Below cutoff 15 69 51 18 51 6 15 6

Sequence


Ensembl Acc Id: ENSRNOT00000031896   ⟹   ENSRNOP00000033202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1215,526,431 - 15,624,926 (+)Ensembl
Rnor_6.0 Ensembl1217,614,632 - 17,712,373 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100560   ⟹   ENSRNOP00000097684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1215,528,188 - 15,624,938 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101865   ⟹   ENSRNOP00000083988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1215,511,801 - 15,624,933 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117175   ⟹   ENSRNOP00000085372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1215,528,061 - 15,624,942 (+)Ensembl
RefSeq Acc Id: NM_001033679   ⟹   NP_001028851
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81220,640,241 - 20,738,766 (+)NCBI
mRatBN7.21215,526,403 - 15,624,942 (+)NCBI
Rnor_6.01217,614,565 - 17,713,556 (+)NCBI
Rnor_5.01219,611,694 - 19,708,682 (+)NCBI
RGSC_v3.41216,025,867 - 16,131,129 (+)RGD
Celera1217,279,498 - 17,377,254 (+)RGD
Sequence:
RefSeq Acc Id: NM_001418675   ⟹   NP_001405604
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81220,625,924 - 20,738,766 (+)NCBI
mRatBN7.21215,512,085 - 15,624,942 (+)NCBI
RefSeq Acc Id: XM_039089115   ⟹   XP_038945043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81220,625,584 - 20,738,766 (+)NCBI
mRatBN7.21215,511,751 - 15,624,942 (+)NCBI
RefSeq Acc Id: XM_039089116   ⟹   XP_038945044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81220,624,811 - 20,738,766 (+)NCBI
mRatBN7.21215,511,310 - 15,624,942 (+)NCBI
RefSeq Acc Id: XM_039089117   ⟹   XP_038945045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81220,606,066 - 20,738,766 (+)NCBI
mRatBN7.21215,492,233 - 15,624,942 (+)NCBI
RefSeq Acc Id: XM_039089118   ⟹   XP_038945046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81220,692,276 - 20,738,766 (+)NCBI
mRatBN7.21215,578,440 - 15,624,942 (+)NCBI
RefSeq Acc Id: NP_001028851   ⟸   NM_001033679
- Peptide Label: isoform 2
- UniProtKB: Q3SWU5 (UniProtKB/TrEMBL),   F1M9X5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000033202   ⟸   ENSRNOT00000031896
RefSeq Acc Id: XP_038945045   ⟸   XM_039089117
- Peptide Label: isoform X1
- UniProtKB: P81377 (UniProtKB/Swiss-Prot),   A0A8I6A184 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945044   ⟸   XM_039089116
- Peptide Label: isoform X1
- UniProtKB: P81377 (UniProtKB/Swiss-Prot),   A0A8I6A184 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945043   ⟸   XM_039089115
- Peptide Label: isoform X1
- UniProtKB: P81377 (UniProtKB/Swiss-Prot),   A0A8I6A184 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945046   ⟸   XM_039089118
- Peptide Label: isoform X2
- UniProtKB: Q5BJR2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085372   ⟸   ENSRNOT00000117175
Ensembl Acc Id: ENSRNOP00000097684   ⟸   ENSRNOT00000100560
Ensembl Acc Id: ENSRNOP00000083988   ⟸   ENSRNOT00000101865
RefSeq Acc Id: NP_001405604   ⟸   NM_001418675
- Peptide Label: isoform 1
- UniProtKB: P81377 (UniProtKB/Swiss-Prot),   A0A8I6A184 (UniProtKB/TrEMBL)
Protein Domains
Cyclic nucleotide-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P81377-F1-model_v2 AlphaFold P81377 1-381 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698474
Promoter ID:EPDNEW_R8997
Type:multiple initiation site
Name:Prkar1b_1
Description:protein kinase cAMP-dependent type 1 regulatory subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01217,614,537 - 17,614,597EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3392 AgrOrtholog
BioCyc Gene G2FUF-19879 BioCyc
Ensembl Genes ENSRNOG00000028733 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055011650 UniProtKB/Swiss-Prot
  ENSRNOG00060026437 UniProtKB/Swiss-Prot
  ENSRNOG00065000188 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000031896.7 UniProtKB/TrEMBL
  ENSRNOT00000100560.1 UniProtKB/TrEMBL
  ENSRNOT00000101865.1 UniProtKB/Swiss-Prot
  ENSRNOT00000117175.1 UniProtKB/TrEMBL
  ENSRNOT00055019810 UniProtKB/Swiss-Prot
  ENSRNOT00060045975 UniProtKB/Swiss-Prot
  ENSRNOT00065000331 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7319686 IMAGE-MGC_LOAD
  IMAGE:7456971 IMAGE-MGC_LOAD
InterPro cAMP-dep_kinase_reg_chain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cAMP_dep_PK_reg_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cAMP_dep_PK_reg_su_I/II_a/b UniProtKB/Swiss-Prot
  cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIbeta_DD UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25521 UniProtKB/TrEMBL
MGC_CLONE MGC:109438 IMAGE-MGC_LOAD
  MGC:125243 IMAGE-MGC_LOAD
NCBI Gene 25521 ENTREZGENE
PANTHER CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIIa UniProtKB/Swiss-Prot
PhenoGen Prkar1b PhenoGen
PIRSF PK_regulatory UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CAMPKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028733 RatGTEx
  ENSRNOG00055011650 RatGTEx
  ENSRNOG00060026437 RatGTEx
  ENSRNOG00065000188 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIIa UniProtKB/Swiss-Prot
Superfamily-SCOP Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit UniProtKB/Swiss-Prot
  SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A184 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AUR5_RAT UniProtKB/TrEMBL
  F1M9X5 ENTREZGENE, UniProtKB/TrEMBL
  KAP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q3SWU5 ENTREZGENE, UniProtKB/TrEMBL
  Q5BJR2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-03 Prkar1b  protein kinase cAMP-dependent type I regulatory subunit beta  Prkar1b  protein kinase cAMP-dependent type 1 regulatory subunit beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Prkar1b  protein kinase cAMP-dependent type 1 regulatory subunit beta  Prkar1b  protein kinase, cAMP-dependent, regulatory subunit type I beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-30 Prkar1b  protein kinase, cAMP-dependent, regulatory subunit type I beta  Prkar1b  protein kinase, cAMP dependent regulatory, type I, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-02-05 Prkar1b  protein kinase, cAMP dependent regulatory, type I, beta  RGD1563094_predicted  similar to cAMP-dependent protein kinase type I-beta regulatory subunit (predicted)  Data merged from RGD:1563094 737654 APPROVED
2007-02-05 Prkar1b  protein kinase, cAMP dependent regulatory, type I, beta  Prkar1b_mapped  protein kinase, cAMP dependent regulatory, type I, beta (mapped)  gene upgraded from "mapped" status 1299863 APPROVED
2006-11-19 Prkar1b  protein kinase, cAMP dependent regulatory, type I, beta      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 Prkar1b_mapped  protein kinase, cAMP dependent regulatory, type I, beta(mapped)  Prkar1b  protein kinase, cAMP dependent regulatory, type I, beta  Symbol set to symbol_mapped, name set to name (mapped) 1582166 APPROVED
2006-03-07 RGD1563094_predicted  similar to cAMP-dependent protein kinase type I-beta regulatory subunit (predicted)  LOC360774  similar to cAMP-dependent protein kinase type I-beta regulatory subunit  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC360774  similar to cAMP-dependent protein kinase type I-beta regulatory subunit      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Prkar1b  protein kinase, cAMP dependent regulatory, type I, beta    protein kinase, cAMP dependent regulatory, type 1 beta  Name updated 629478 APPROVED
2001-10-24 Prkar1b  protein kinase, cAMP dependent regulatory, type 1 beta      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED