PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta) - Rat Genome Database

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Gene: PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta) Chlorocebus sabaeus
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Symbol: PRKAR1B
Name: protein kinase cAMP-dependent type I regulatory subunit beta
RGD ID: 18682325
Description: ENCODES a protein that exhibits cAMP binding (ortholog); cAMP-dependent protein kinase regulator activity (ortholog); INVOLVED IN learning or memory (ortholog); positive regulation of excitatory postsynaptic potential (ortholog); positive regulation of fear response (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH genetic disease (ortholog); hypertension (ortholog); MARBACH-SCHAAF NEURODEVELOPMENTAL SYNDROME (ortholog); FOUND IN cAMP-dependent protein kinase complex (ortholog); glutamatergic synapse (ortholog); hippocampal mossy fiber to CA3 synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cAMP-dependent protein kinase type I-beta regulatory subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12820,838,247 - 21,016,196 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2820,853,763 - 21,016,257 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666090658,653 - 842,505 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
PRKAR1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12820,838,247 - 21,016,196 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2820,853,763 - 21,016,257 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666090658,653 - 842,505 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PRKAR1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387549,197 - 728,934 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7549,197 - 727,650 (-)EnsemblGRCh38hg38GRCh38
GRCh377588,834 - 767,313 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367555,913 - 718,659 (-)NCBINCBI36Build 36hg18NCBI36
Celera7558,390 - 735,169 (-)NCBICelera
Cytogenetic Map7p22.3NCBI
HuRef7507,400 - 685,578 (-)NCBIHuRef
CHM1_17588,428 - 766,905 (-)NCBICHM1_1
T2T-CHM13v2.07650,161 - 832,029 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27650,549 - 825,534 (-)NCBI
Prkar1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,003,059 - 139,136,458 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5139,003,061 - 139,135,756 (-)EnsemblGRCm39 Ensembl
GRCm385139,017,304 - 139,150,703 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,017,306 - 139,150,001 (-)EnsemblGRCm38mm10GRCm38
MGSCv375139,493,258 - 139,605,706 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,270,948 - 139,383,333 (-)NCBIMGSCv36mm8
Celera5136,072,385 - 136,181,556 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map577.74NCBI
Prkar1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81220,606,066 - 20,738,766 (+)NCBIGRCr8
mRatBN7.21215,492,233 - 15,624,942 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,511,801 - 15,624,942 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,336,888 - 16,436,081 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,960,627 - 17,059,817 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,984,377 - 16,082,381 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,614,536 - 17,713,567 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,614,632 - 17,712,373 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,611,694 - 19,708,682 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41216,025,867 - 16,131,129 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1217,279,498 - 17,377,254 (+)NCBICelera
Cytogenetic Map12q11NCBI
Prkar1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,357,637 - 8,460,396 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,357,890 - 8,479,875 (-)NCBIChiLan1.0ChiLan1.0
PRKAR1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v265,484,409 - 5,661,348 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1753,809,101 - 53,986,014 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07700,691 - 876,497 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17923,668 - 1,097,792 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7923,668 - 1,097,456 (-)Ensemblpanpan1.1panPan2
PRKAR1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1616,135,406 - 16,248,567 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl616,135,715 - 16,247,465 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,607,212 - 17,720,355 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,264,735 - 16,377,921 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,265,043 - 16,382,743 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,067,389 - 16,180,517 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0615,993,837 - 16,106,858 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,283,599 - 16,396,577 (+)NCBIUU_Cfam_GSD_1.0
Prkar1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344144,047,325 - 144,167,636 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936754842,343 - 963,024 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936754842,697 - 963,002 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAR1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3343,139 - 425,165 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13343,124 - 425,154 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23190,914 - 227,592 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Prkar1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474026,202,375 - 26,315,352 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474026,202,882 - 26,315,987 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 20 60
Low 16 16
Below cutoff 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000015630   ⟹   ENSCSAP00000013563
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2820,853,763 - 21,016,257 (+)Ensembl
RefSeq Acc Id: XM_008018915   ⟹   XP_008017106
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12820,853,034 - 21,016,196 (+)NCBI
Vero_WHO_p1.0NW_023666090658,653 - 827,757 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008018916   ⟹   XP_008017107
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12820,838,247 - 21,016,196 (+)NCBI
Vero_WHO_p1.0NW_023666090658,653 - 842,505 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008018917   ⟹   XP_008017108
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12820,838,564 - 21,016,196 (+)NCBI
Vero_WHO_p1.0NW_023666090658,667 - 842,175 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008018918   ⟹   XP_008017109
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12820,851,659 - 21,016,196 (+)NCBI
Vero_WHO_p1.0NW_023666090658,653 - 828,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008018920   ⟹   XP_008017111
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12820,852,574 - 21,016,196 (+)NCBI
Vero_WHO_p1.0NW_023666090658,653 - 828,111 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_008017107   ⟸   XM_008018916
- UniProtKB: A0A0D9RY74 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008017108   ⟸   XM_008018917
- UniProtKB: A0A0D9RY74 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008017109   ⟸   XM_008018918
- UniProtKB: A0A0D9RY74 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008017111   ⟸   XM_008018920
- UniProtKB: A0A0D9RY74 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008017106   ⟸   XM_008018915
- UniProtKB: A0A0D9RY74 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000013563   ⟸   ENSCSAT00000015630


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017535 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015630.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/TrEMBL
  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain UniProtKB/TrEMBL
InterPro cAMP_dep_PK_reg_su UniProtKB/TrEMBL
  cAMP_dep_PK_reg_su_I/II_a/b UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  RIbeta_DD UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
KEGG Report csab:103246902 UniProtKB/TrEMBL
NCBI Gene PRKAR1B ENTREZGENE
PANTHER CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN UniProtKB/TrEMBL
  CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  RIIa UniProtKB/TrEMBL
PIRSF PK_regulatory UniProtKB/TrEMBL
PRINTS CAMPKINASE UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
  RIIa UniProtKB/TrEMBL
Superfamily-SCOP Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit UniProtKB/TrEMBL
  SSF51206 UniProtKB/TrEMBL
UniProt A0A0D9RY74 ENTREZGENE, UniProtKB/TrEMBL