Strain Report - Rat Genome Database

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Strain: F344-Prkar1bem2Tua

Symbol: F344-Prkar1bem2Tua
Strain: F344-Prkar1bem2
Substrain: Tua
RGD ID: 150519901
Citation ID: RRID:RGD_150519901
Ontology ID: RS:0005071
Alleles: Prkar1bem2Tua
Also Known As: F344-Prkar1bem2/Tua; F344-Prkar1b^[em2Tua]
Type: mutant
Available Source: Not Available
Origination: Department of Animal Science Faculty of Agriculture Tokyo University of Agriculture 1737 Funako Atsugi Kanagawa 243-0034 Japan
Description: CRISPR/Cas9 system containing guide RNAs targeting exon 2 and intron 2 were introduced into the F344/Stm embryos using a super electroporator NEPA 2. This mutant strain F344-Prkar1bem2Tua carried a 13-bp frameshift deletion in exon2 creating a premature stop codon in the Prkar1b transcripts. Expression levels of Prkar1b transcripts and protein are significantly decreased in the mutants.
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21215,492,233 - 15,624,942RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01217,614,536 - 17,713,567RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01219,611,694 - 19,708,682RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41216,025,867 - 16,131,129RGD_MAPPER_PIPELINERGSC3.4

Disease Annotations     Click to see Annotation Detail View
Tremor  (IMP)

Phenotype Annotations     Click to see Annotation Detail View


References - curated
# Reference Title Reference Citation
1. Deficiency of the RI╬▓ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats. Hoang Trung H, etal., Sci Rep. 2021 Jan 21;11(1):2039. doi: 10.1038/s41598-021-81515-x.


Additional Information