Arpc3 (actin related protein 2/3 complex, subunit 3) - Rat Genome Database

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Gene: Arpc3 (actin related protein 2/3 complex, subunit 3) Rattus norvegicus
Analyze
Symbol: Arpc3
Name: actin related protein 2/3 complex, subunit 3
RGD ID: 1311985
Description: Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to actin filament binding activity. Involved in cellular response to nerve growth factor stimulus. Located in growth cone leading edge. Part of filamentous actin. Used to study Parkinson's disease. Orthologous to human ARPC3 (actin related protein 2/3 complex subunit 3); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: actin-related protein 2/3 complex subunit 3; LOC288669
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81239,833,569 - 39,847,436 (-)NCBIGRCr8
mRatBN7.21234,172,780 - 34,186,651 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,172,780 - 34,186,651 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,345,197 - 35,359,072 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01235,956,610 - 35,970,481 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,008,933 - 35,022,805 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,653,951 - 39,667,817 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,653,953 - 39,667,849 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01241,533,346 - 41,548,335 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,366,969 - 35,377,111 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,230,356 - 35,240,663 (-)NCBI
Celera1235,843,695 - 35,857,566 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Arpc3Ratdiabetes mellitus  ISORGD:132372811049459associated with Obesity, Morbid;mRNA:decreased expression:omentum, adipose tissue (human)RGD 
Arpc3RatParkinson's disease treatmentIDA 11049454 RGD 

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Arpc3Rat1,2-dimethylhydrazine multiple interactionsISORGD:13237296480464Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of ARPC3 mRNA]CTDPMID:22206623
Arpc3Rat1,2-dimethylhydrazine increases expressionISORGD:132372964804641,2-Dimethylhydrazine results in increased expression of ARPC3 mRNACTDPMID:22206623
Arpc3Rat1-chloro-2,4-dinitrobenzene affects bindingISORGD:13237286480464Dinitrochlorobenzene binds to ARPC3 proteinCTDPMID:32991956
Arpc3Rat17alpha-ethynylestradiol affects expressionISORGD:13237296480464Ethinyl Estradiol affects the expression of ARPC3 mRNACTDPMID:17555576
Arpc3Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of ARPC3 mRNACTDPMID:29097150
Arpc3Rat17alpha-ethynylestradiol multiple interactionsISORGD:13237296480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARPC3 mRNACTDPMID:17942748
Arpc3Rat17alpha-ethynylestradiol increases expressionISORGD:13237296480464Ethinyl Estradiol results in increased expression of ARPC3 mRNACTDPMID:17942748
Arpc3Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of ARPC3 mRNACTDPMID:17557909
Arpc3Rat2,3',4,4',5-Pentachlorobiphenyl increases expressionISORGD:132372964804642,3',4,4',5-pentachlorobiphenyl results in increased expression of ARPC3 mRNACTDPMID:31388691
Arpc3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:13237296480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARPC3 mRNACTDPMID:17942748
Arpc3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of ARPC3 mRNACTDPMID:34747641
Arpc3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:13237296480464Tetrachlorodibenzodioxin affects the expression of ARPC3 mRNACTDPMID:21570461
Arpc3Rat2,6-dimethoxyphenol multiple interactionsISORGD:13237286480464[Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether] results in decreased expression of and affects the more ...CTDPMID:38598786
Arpc3Rat2,6-dinitrotoluene affects expressionEXP 64804642,6-dinitrotoluene affects the expression of ARPC3 mRNACTDPMID:21346803
Arpc3Rat3,4-methylenedioxymethamphetamine decreases expressionEXP 6480464N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ARPC3 mRNACTDPMID:30071829
Arpc3Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISORGD:13237286480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...CTDPMID:28628672
Arpc3Rat4,4'-sulfonyldiphenol increases expressionISORGD:13237296480464bisphenol S results in increased expression of ARPC3 mRNACTDPMID:39298647
Arpc3Rat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ...CTDPMID:36041667
Arpc3Rat5-fluorouracil decreases expressionISORGD:13237286480464Fluorouracil results in decreased expression of ARPC3 mRNACTDPMID:16709241
Arpc3Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of ARPC3 mRNACTDPMID:30047161

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Biological Process

  
Object Symbol
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Reference
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Source
Original Reference(s)
Arpc3RatArp2/3 complex-mediated actin nucleation involved_inISORGD:13237281624291 PMID:11741539RGDPMID:11741539
Arpc3RatArp2/3 complex-mediated actin nucleation involved_inIEAUniRule:UR0001264831600115GO_REF:0000104UniProtGO_REF:0000104
Arpc3RatArp2/3 complex-mediated actin nucleation involved_inIBAPANTHER:PTN000273425|PomBase:SPBC1778.08c|UniProtKB:O151451600115GO_REF:0000033GO_CentralGO_REF:0000033
Arpc3RatArp2/3 complex-mediated actin nucleation involved_inIEAUniProtKB:O15145|ensembl:ENSP000002288251600115GO_REF:0000107EnsemblGO_REF:0000107
Arpc3RatArp2/3 complex-mediated actin nucleation involved_inIEAInterPro:IPR007204|InterPro:IPR0367531600115GO_REF:0000002InterProGO_REF:0000002
Arpc3Ratcellular response to nerve growth factor stimulus  IEP 11049163 RGD 
Arpc3Ratregulation of actin filament polymerization involved_inIEAInterPro:IPR0367531600115GO_REF:0000002InterProGO_REF:0000002
Arpc3Ratregulation of synaptic vesicle endocytosis involved_inISORGD:13237291624291 PMID:34269176RGDPMID:34269176

Cellular Component
1 to 16 of 16 rows

  
Object Symbol
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Term
Qualifier
Evidence
With
Reference
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Source
Original Reference(s)
Arpc3RatArp2/3 protein complex part_ofISORGD:13237281624291 PMID:11741539RGDPMID:11741539
Arpc3RatArp2/3 protein complex part_ofIBAPANTHER:PTN000273425|PomBase:SPBC1778.08c|SGD:S000004362|UniProtKB:O15145|dictyBase:DDB_G02928041600115GO_REF:0000033GO_CentralGO_REF:0000033
Arpc3RatArp2/3 protein complex part_ofIEAUniRule:UR0001264831600115GO_REF:0000104UniProtGO_REF:0000104
Arpc3RatArp2/3 protein complex part_ofIEAUniProtKB:O15145|ensembl:ENSP000002288251600115GO_REF:0000107EnsemblGO_REF:0000107
Arpc3RatArp2/3 protein complex part_ofIEAInterPro:IPR007204|InterPro:IPR0367531600115GO_REF:0000002InterProGO_REF:0000002
Arpc3Ratcell leading edge  IDA 2306208 RGD 
Arpc3Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Arpc3Ratcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
Arpc3Ratcytoskeleton located_inIEAInterPro:IPR007204|InterPro:IPR0367531600115GO_REF:0000002InterProGO_REF:0000002
Arpc3Ratcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Arpc3Ratfilamentous actin  IDA 11049163 RGD 
Arpc3Ratgrowth cone leading edge  IDA 11049163 RGD 
Arpc3Ratlamellipodium located_inISORGD:13237281624291 PMID:9230079RGDPMID:9230079
Arpc3Ratlamellipodium located_inIEAUniProtKB:O15145|ensembl:ENSP000002288251600115GO_REF:0000107EnsemblGO_REF:0000107
Arpc3Ratlamellipodium located_inISORGD:13237291624291 PMID:15294161RGDPMID:15294161
Arpc3Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function

  
Object Symbol
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Term
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Reference
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Source
Original Reference(s)
Arpc3Ratactin binding enablesIEAUniProtKB-KW:KW-00091600115GO_REF:0000043UniProtGO_REF:0000043
Arpc3Ratactin filament binding contributes_toISORGD:13237281624291 PMID:11741539RGDPMID:11741539
Arpc3Ratactin filament binding contributes_toIEAUniProtKB:O15145|ensembl:ENSP000002288251600115GO_REF:0000107EnsemblGO_REF:0000107
Arpc3Ratactin filament binding contributes_toIBAPANTHER:PTN000273425|UniProtKB:O151451600115GO_REF:0000033GO_CentralGO_REF:0000033
Arpc3Ratprotein binding enablesISORGD:13237281624291UniProtKB:A2RTX5|UniProtKB:O00401|UniProtKB:O43365|UniProtKB:O95835-2|UniProtKB:P0DTC9|UniProtKB:P14859-6|UniProtKB:P46092|UniProtKB:P48552|UniProtKB:P59998|UniProtKB:Q08379|UniProtKB:Q68J44|UniProtKB:Q86VR2|UniProtKB:Q8IZU1|UniProtKB:Q8NC74|UniProtKB:Q9H609|UniProtKB:Q9NX95-5 PMID:11162547, PMID:24981860, PMID:25416956, PMID:32296183, PMID:33961781, PMID:35271311, PMID:36217029, PMID:36217030RGDPMID:11162547|PMID:24981860|PMID:25416956|PMID:32296183|PMID:33961781|PMID:35271311|PMID:36217029|PMID:36217030
Arpc3Ratprotein binding enablesISORGD:13237291624291PR:Q9JLI7 PMID:31146259RGDPMID:31146259
Arpc3Ratstructural constituent of cytoskeleton enablesISORGD:13237281624291 PMID:11741539RGDPMID:11741539
Arpc3Ratstructural constituent of cytoskeleton enablesIEAUniProtKB:O15145|ensembl:ENSP000002288251600115GO_REF:0000107EnsemblGO_REF:0000107

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Source
Original Reference(s)
Arpc3Ratinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORGD:132372810054052 RGD 
Arpc3RatRab family mediated signaling pathway  ISORGD:132372810054052 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Source
Original Reference(s)
Arpc3RatFc gamma receptor mediated signaling pathway  IEA 6907045 KEGGrno:04666

Imported Annotations - PID (archival)

Object Symbol
Species
Term
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Reference
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Source
Original Reference(s)
Arpc3Ratplatelet-derived growth factor signaling pathway  ISORGD:13237286484113 PIDPID:200149

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#
Reference Title
Reference Citation
1. Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation. Bailly M, etal., J Cell Biol. 1999 Apr 19;145(2):331-45.
2. Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells. Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
3. Global Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans. Doumatey AP, etal., J Endocrinol Metab. 2015 Jun;5(3):199-210.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Recruitment of the Arp2/3 complex and mena for the stimulation of actin polymerization in growth cones by nerve growth factor. Goldberg DJ, etal., J Neurosci Res. 2000 May 15;60(4):458-67.
7. Antiparkinsonian trophic action of glial cell line-derived neurotrophic factor and transforming growth factor beta1 is enhanced after co-infusion in rats. Gonzalez-Aparicio R, etal., Exp Neurol. 2010 Nov;226(1):136-47. doi: 10.1016/j.expneurol.2010.08.016. Epub 2010 Aug 14.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
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PMID:9230079   PMID:11741539   PMID:12477932   PMID:15252126   PMID:15294161   PMID:18509026   PMID:19056867   PMID:19946888   PMID:20458337   PMID:21423176   PMID:23376485   PMID:23533145  



Arpc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81239,833,569 - 39,847,436 (-)NCBIGRCr8
mRatBN7.21234,172,780 - 34,186,651 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,172,780 - 34,186,651 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,345,197 - 35,359,072 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01235,956,610 - 35,970,481 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,008,933 - 35,022,805 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,653,951 - 39,667,817 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,653,953 - 39,667,849 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01241,533,346 - 41,548,335 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,366,969 - 35,377,111 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,230,356 - 35,240,663 (-)NCBI
Celera1235,843,695 - 35,857,566 (-)NCBICelera
Cytogenetic Map12q16NCBI
ARPC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812110,434,823 - 110,450,337 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12110,434,823 - 110,450,422 (-)EnsemblGRCh38hg38GRCh38
GRCh3712110,872,628 - 110,888,142 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612109,357,089 - 109,372,541 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412109,335,426 - 109,350,878NCBI
Celera12110,499,460 - 110,514,921 (-)NCBICelera
Cytogenetic Map12q24.11NCBI
HuRef12107,890,831 - 107,906,550 (-)NCBIHuRef
CHM1_112110,840,525 - 110,856,046 (-)NCBICHM1_1
T2T-CHM13v2.012110,412,518 - 110,428,033 (-)NCBIT2T-CHM13v2.0
Arpc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395122,529,941 - 122,544,244 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5122,529,941 - 122,552,247 (+)EnsemblGRCm39 Ensembl
GRCm385122,391,878 - 122,406,181 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5122,391,878 - 122,414,184 (+)EnsemblGRCm38mm10GRCm38
MGSCv375122,841,937 - 122,856,187 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365122,652,545 - 122,666,795 (+)NCBIMGSCv36mm8
Celera5119,470,471 - 119,484,714 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map562.34NCBI
Arpc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554827,350,456 - 7,364,266 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554827,350,456 - 7,364,266 (-)NCBIChiLan1.0ChiLan1.0
ARPC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210118,498,814 - 118,514,420 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112118,495,217 - 118,510,697 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012108,007,884 - 108,023,386 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112111,395,800 - 111,415,170 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12111,399,433 - 111,415,156 (-)Ensemblpanpan1.1panPan2
ARPC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,267,123 - 8,277,779 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,267,196 - 8,277,688 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,430,745 - 8,441,421 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0268,524,788 - 8,535,469 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl268,524,794 - 8,535,367 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1268,484,142 - 8,494,810 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0268,542,697 - 8,553,529 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,497,864 - 8,508,751 (-)NCBIUU_Cfam_GSD_1.0
LOC101978301
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118156,057,681 - 156,061,635 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365583,418,664 - 3,421,693 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARPC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1431,814,151 - 31,826,855 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11431,814,382 - 31,823,452 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21433,736,371 - 33,745,205 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARPC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111105,670,798 - 105,685,911 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037139,433,833 - 139,450,140 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arpc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474721,438,612 - 21,454,753 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474721,438,602 - 21,451,154 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Arpc3
81 total Variants

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:25
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000011499
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 51 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat

1 to 10 of 51 rows
RH133976  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,182,468 - 34,182,663 (+)MAPPERmRatBN7.2
Rnor_6.01239,663,639 - 39,663,833NCBIRnor6.0
Rnor_5.01241,544,156 - 41,544,350UniSTSRnor5.0
RGSC_v3.41235,376,657 - 35,376,851UniSTSRGSC3.4
Celera1235,853,390 - 35,853,584UniSTS
RH 3.4 Map12605.8UniSTS
Cytogenetic Map12q16UniSTS
BF412122  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,179,199 - 34,179,350 (+)MAPPERmRatBN7.2
Rnor_6.01239,660,371 - 39,660,521NCBIRnor6.0
Rnor_5.01241,539,766 - 41,539,916UniSTSRnor5.0
RGSC_v3.41235,373,389 - 35,373,539UniSTSRGSC3.4
Celera1235,850,122 - 35,850,272UniSTS
RH 3.4 Map12596.2UniSTS
Cytogenetic Map12q16UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000011499   ⟹   ENSRNOP00000011499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,172,780 - 34,186,651 (-)Ensembl
Rnor_6.0 Ensembl1239,653,953 - 39,667,849 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099673   ⟹   ENSRNOP00000082825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,172,780 - 34,183,407 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108586   ⟹   ENSRNOP00000096174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,173,698 - 34,186,651 (-)Ensembl
RefSeq Acc Id: NM_001105933   ⟹   NP_001099403
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81239,833,569 - 39,847,436 (-)NCBI
mRatBN7.21234,172,780 - 34,186,651 (-)NCBI
Rnor_6.01239,653,951 - 39,667,817 (-)NCBI
Rnor_5.01241,533,346 - 41,548,335 (-)NCBI
RGSC_v3.41235,366,969 - 35,377,111 (-)RGD
Celera1235,843,695 - 35,857,566 (-)RGD
Sequence:
Protein RefSeqs NP_001099403 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66554 (Get FASTA)   NCBI Sequence Viewer  
  EDM13686 (Get FASTA)   NCBI Sequence Viewer  
  EDM13687 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011499
  ENSRNOP00000011499.5
  ENSRNOP00000082825.1
  ENSRNOP00000096174.1
RefSeq Acc Id: NP_001099403   ⟸   NM_001105933
- UniProtKB: B2GV73 (UniProtKB/TrEMBL),   F1LRL8 (UniProtKB/TrEMBL),   A0A9K3Y7C4 (UniProtKB/TrEMBL),   A0A8I5ZU90 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011499   ⟸   ENSRNOT00000011499
Ensembl Acc Id: ENSRNOP00000082825   ⟸   ENSRNOT00000099673
Ensembl Acc Id: ENSRNOP00000096174   ⟸   ENSRNOT00000108586

Name Modeler Protein Id AA Range Protein Structure
AF-B2GV73-F1-model_v2 AlphaFold B2GV73 1-178 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698645
Promoter ID:EPDNEW_R9169
Type:initiation region
Name:Arpc3_1
Description:actin related protein 2/3 complex, subunit 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01239,667,791 - 39,667,851EPDNEW


1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-19253 BioCyc
Ensembl Genes ENSRNOG00000008673 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011499 ENTREZGENE
  ENSRNOT00000011499.8 UniProtKB/TrEMBL
  ENSRNOT00000099673.1 UniProtKB/TrEMBL
  ENSRNOT00000108586.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1760.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7311069 IMAGE-MGC_LOAD
InterPro ARP2/3_p21-Arc UniProtKB/TrEMBL
  ARPC3_sf UniProtKB/TrEMBL
KEGG Report rno:288669 UniProtKB/TrEMBL
MGC_CLONE MGC:188163 IMAGE-MGC_LOAD
NCBI Gene 288669 ENTREZGENE
PANTHER P21-Arc UniProtKB/TrEMBL
Pfam P21-Arc UniProtKB/TrEMBL
PhenoGen Arpc3 PhenoGen
PIRSF ARP2/3_P21-Arc UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008673 RatGTEx
Superfamily-SCOP ARP2/3_P21-Arc UniProtKB/TrEMBL
UniProt A0A8I5ZU90 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AL89_RAT UniProtKB/TrEMBL
  A0A9K3Y7C4 ENTREZGENE, UniProtKB/TrEMBL
  B2GV73 ENTREZGENE, UniProtKB/TrEMBL
  F1LRL8 ENTREZGENE
UniProt Secondary F1LRL8 UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Arpc3  actin related protein 2/3 complex, subunit 3   Arpc3_predicted  actin related protein 2/3 complex, subunit 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Arpc3_predicted  actin related protein 2/3 complex, subunit 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED