Arpc3 (actin related protein 2/3 complex subunit 3)

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Gene: Arpc3 (actin related protein 2/3 complex subunit 3) Chinchilla lanigera

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Symbol:

Arpc3

Name:

actin related protein 2/3 complex subunit 3

RGD ID:

8722909

Description:

ENCODES a protein that exhibits actin filament binding (ortholog); structural constituent of cytoskeleton (ortholog); INVOLVED IN Arp2/3 complex-mediated actin nucleation (ortholog); cellular response to nerve growth factor stimulus (ortholog); regulation of synaptic vesicle endocytosis (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH diabetes mellitus (ortholog); Parkinson's disease (ortholog); FOUND IN Arp2/3 protein complex (ortholog); cell leading edge (ortholog); filamentous actin (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

actin related protein 2/3 complex, subunit 3, 21kDa; actin-related protein 2/3 complex subunit 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	7,350,456 - 7,364,266 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955482	7,350,456 - 7,364,266 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

diabetes mellitus (ISO)

Parkinson's disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Arp2/3 complex-mediated actin nucleation (ISO)

cellular response to nerve growth factor stimulus (ISO)

regulation of synaptic vesicle endocytosis (ISO)

Cellular Component

Arp2/3 protein complex (ISO)

cell leading edge (ISO)

filamentous actin (ISO)

growth cone leading edge (ISO)

lamellipodium (ISO)

Molecular Function

actin filament binding (ISO)

protein binding (ISO)

structural constituent of cytoskeleton (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

insulin responsive facilitative sugar transporter mediated glucose transport pathway (ISO)

platelet-derived growth factor signaling pathway (ISO)

Rab family mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Arpc3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	7,350,456 - 7,364,266 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955482	7,350,456 - 7,364,266 (-)	NCBI	ChiLan1.0	ChiLan1.0

ARPC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	110,434,823 - 110,450,337 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	110,434,823 - 110,450,422 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	110,872,628 - 110,888,142 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	109,357,089 - 109,372,541 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	109,335,426 - 109,350,878	NCBI
Celera	12	110,499,460 - 110,514,921 (-)	NCBI		Celera
Cytogenetic Map	12	q24.11	NCBI
HuRef	12	107,890,831 - 107,906,550 (-)	NCBI		HuRef
CHM1_1	12	110,840,525 - 110,856,046 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	110,412,518 - 110,428,033 (-)	NCBI		T2T-CHM13v2.0

Arpc3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	122,529,941 - 122,544,244 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	122,529,941 - 122,552,247 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	122,391,878 - 122,406,181 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	122,391,878 - 122,414,184 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	122,841,937 - 122,856,187 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	122,652,545 - 122,666,795 (+)	NCBI		MGSCv36	mm8
Celera	5	119,470,471 - 119,484,714 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	62.34	NCBI

Arpc3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	39,833,569 - 39,847,436 (-)	NCBI		GRCr8
mRatBN7.2	12	34,172,780 - 34,186,651 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	34,172,780 - 34,186,651 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	35,345,197 - 35,359,072 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	35,956,610 - 35,970,481 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	35,008,933 - 35,022,805 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	39,653,951 - 39,667,817 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	39,653,953 - 39,667,849 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	41,533,346 - 41,548,335 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	35,366,969 - 35,377,111 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	35,230,356 - 35,240,663 (-)	NCBI
Celera	12	35,843,695 - 35,857,566 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

ARPC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	118,498,814 - 118,514,420 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	118,495,217 - 118,510,697 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	108,007,884 - 108,023,386 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	111,395,800 - 111,415,170 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	111,399,433 - 111,415,156 (-)	Ensembl	panpan1.1		panPan2

ARPC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	8,267,123 - 8,277,779 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	8,267,196 - 8,277,688 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	8,430,745 - 8,441,421 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	8,524,788 - 8,535,469 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	8,524,794 - 8,535,367 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	8,484,142 - 8,494,810 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	8,542,697 - 8,553,529 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	8,497,864 - 8,508,751 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101978301
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	156,057,681 - 156,061,635 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936558	3,418,664 - 3,421,693 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ARPC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	31,814,151 - 31,826,855 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	31,814,382 - 31,823,452 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	33,736,371 - 33,745,205 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ARPC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	105,670,798 - 105,685,911 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	139,433,833 - 139,450,140 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Arpc3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	21,438,612 - 21,454,753 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	21,438,602 - 21,451,154 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005403143	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01057459	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01057460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01029082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000019309 ⟹ ENSCLAP00000019124

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955482	7,350,456 - 7,364,266 (-)	Ensembl

RefSeq Acc Id:

XM_005403143 ⟹ XP_005403200

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955482	7,350,456 - 7,364,266 (-)	NCBI

Sequence:

show sequence

AAAAACAAAGGAAGCGATTAATCACATTCCCTCTTGCGCGCGTGTTGCGCATGCGCGAGCCTCG
CGCCCTCCGCTTGGAGTTCGCGCGCCCCCTGGCGCTCCTTCAGATCTGCGCAGCCGCAGCAGCG
GGCGCAGTGACAGCGAGCGGGAGGGGCCGCGTCCTCCCGTCTCCTCCCCTTCCGACTCACTTCC
GCCCACTGCGCCGGAGCCCCCGCCCGGAAGGGTCGCGTTCGGACCGGGTCCTGCTCGTCTGTGT
TGGAACCCCGACCCCGCCAGAATGCCGGCCTACCACTCTTCTCTCATGGACCCCGACACCAAAC
TCATTGGAAACATGGCACTGCTGCCCATCAGGAGTCAGTTCAAAGGACCCGCCCCTAGAGAGAC
AAAAGATACAGATATTGTGGATGAAGCCATCTATTACTTCAAGGCCAATGTATTCTTCAAAAAT
TACGAAATTAAGAATGAAGCAGACAGGACTTTGATATATATAACTCTCTACATTTCTGAGTGTC
TGAAGAAACTCCAAAAGTGCAATTCCAAAAGCCAAGGAGAGAAAGAAATGTATACACTGGGAAT
CACTAATTTTCCCATTCCTGGAGAGCCTGGTTTTCCACTAAATGCCATTTATGCCAAACCTGCA
AACAAACAGGAAGATGAGGTGATGAGAGCCTACCTGCAGCAGCTAAGGCAAGAGACTGGACTGA
GACTTTGTGAAAAAGTTTTTGACCCTCAGAATGATAAACCCAGCAAGTGGTGGACGTGCTTTGT
GAAGAGACAGTTCATGAACAAGAGTCTGTCAGGACCCGGGCAGTGAGCAGCACCCGGCGGCCGT
GTCCAGACCCCGGCGGCACTTCACGGCCCCTTGCGCACAGTCCCTGGCCTGTGTTTCCTAAAGT
TTGTAGAGAAGCAAGAAGGAAGCCTGTCTGCCTGAAAAGTTCTTGGTTACGTTCGGGTACGGGA
GGGGGAAGTGGGCTATCCAAGGGTGATGTGAACATTTCTGCAGTATTAAGCTGGTGCTTAATAA
TAATAATAATTAATAAATTTCTAATAACTTTGTTGCTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005403200	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000019124
	ENSCLAP00000019124.1

RefSeq Acc Id:	XP_005403200 ⟸ XM_005403143
- UniProtKB:	A0A8C2VXY9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPAYHSSLMDPDTKLIGNMALLPIRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEIKNEA DRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPANKQEDEV MRAYLQQLRQETGLRLCEKVFDPQNDKPSKWWTCFVKRQFMNKSLSGPGQ hide sequence

Ensembl Acc Id:

ENSCLAP00000019124 ⟸ ENSCLAT00000019309

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000013105	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000019309	ENTREZGENE
	ENSCLAT00000019309.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1760.10	UniProtKB/TrEMBL
InterPro	ARPC3	UniProtKB/TrEMBL
	ARPC3_sf	UniProtKB/TrEMBL
NCBI Gene	Arpc3	ENTREZGENE
PANTHER	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3	UniProtKB/TrEMBL
	PTHR12391	UniProtKB/TrEMBL
Pfam	P21-Arc	UniProtKB/TrEMBL
PIRSF	ARP2/3_P21-Arc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF69060	UniProtKB/TrEMBL
UniProt	A0A8C2VXY9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Arpc3	actin related protein 2/3 complex subunit 3		actin related protein 2/3 complex, subunit 3, 21kDa	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - PID (archival)

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RGD Manual Annotations

Imported Annotations - PID (archival)