Gene: Tpcn1 (two pore segment channel 1) Rattus norvegicus
Symbol: Tpcn1
Name: two pore segment channel 1
Description: ENCODES a protein that exhibits identical protein binding (ortholog); NAADP-sensitive calcium-release channel activity (ortholog); INVOLVED IN positive regulation of autophagy (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH oligospermia (ortholog); FOUND IN endosome membrane (ortholog); lysosomal membrane (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; C60 fullerene
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC246215; two pore calcium channel protein 1; two pore channel 1; voltage-dependent calcium channel protein TPC1; voltage-gated Ca channel
Homo sapiens (human) : TPCN1 (two pore segment channel 1)  HGNC  Alliance
Mus musculus (house mouse) : Tpcn1 (two pore channel 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tpcn1 (two pore segment channel 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TPCN1 (two pore segment channel 1)
Canis lupus familiaris (dog) : TPCN1 (two pore segment channel 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tpcn1 (two pore segment channel 1)
Sus scrofa (pig) : TPCN1 (two pore segment channel 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01241,507,784 - 41,566,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01243,365,885 - 43,421,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41237,140,428 - 37,227,711 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11237,003,822 - 37,091,098 (+)NCBI
Celera1237,634,250 - 37,689,810 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tpcn1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 708494
Created: 2003-09-23
Species: Rattus norvegicus
Last Modified: 2019-01-30
Status: ACTIVE