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Gene: Tpcn1 (two pore segment channel 1) Rattus norvegicus
Symbol: Tpcn1
Name: two pore segment channel 1
Description: Predicted to have cation channel activity; phosphatidylinositol-3,5-bisphosphate binding activity; and protein homodimerization activity. Predicted to be involved in positive regulation of autophagy and sodium ion transmembrane transport. Predicted to localize to endosome membrane; integral component of membrane; and lysosomal membrane. Orthologous to human TPCN1 (two pore segment channel 1); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC246215; two pore calcium channel protein 1; two pore channel 1; voltage-dependent calcium channel protein TPC1; voltage-gated Ca channel
Homo sapiens (human) : TPCN1 (two pore segment channel 1)  HGNC  Alliance
Mus musculus (house mouse) : Tpcn1 (two pore channel 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tpcn1 (two pore segment channel 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TPCN1 (two pore segment channel 1)
Canis lupus familiaris (dog) : TPCN1 (two pore segment channel 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tpcn1 (two pore segment channel 1)
Sus scrofa (pig) : TPCN1 (two pore segment channel 1)
Chlorocebus sabaeus (African green monkey) : TPCN1 (two pore segment channel 1)
Heterocephalus glaber (naked mole-rat) : Tpcn1 (two pore segment channel 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01241,507,784 - 41,566,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,543,696 - 41,566,847 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,365,885 - 43,421,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41237,140,428 - 37,227,711 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11237,003,822 - 37,091,098 (+)NCBI
Celera1237,634,250 - 37,689,810 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tpcn1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 708494
Created: 2003-09-23
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.