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Gene: Dtx1 (deltex E3 ubiquitin ligase 1) Rattus norvegicus
Symbol: Dtx1
Name: deltex E3 ubiquitin ligase 1
Description: Predicted to have Notch binding activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cellular response to leukemia inhibitory factor; negative regulation of cell differentiation; and regulation of Notch signaling pathway. Predicted to localize to cytosol and nuclear body. Orthologous to human DTX1 (deltex E3 ubiquitin ligase 1); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH bisphenol A; manganese(II) chloride; N-methyl-4-phenylpyridinium.
Type: protein-coding
RefSeq Status: MODEL
Also known as: deltex 1; deltex 1, E3 ubiquitin ligase; deltex homolog 1; deltex homolog 1 (Drosophila); E3 ubiquitin-protein ligase DTX1; LOC687424; similar to Protein deltex-1 (Deltex-1) (Deltex1) (mDTX1) (FXI-T1)
Homo sapiens (human) : DTX1 (deltex E3 ubiquitin ligase 1)  HGNC  Alliance
Mus musculus (house mouse) : Dtx1 (deltex 1, E3 ubiquitin ligase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dtx1 (deltex E3 ubiquitin ligase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DTX1 (deltex E3 ubiquitin ligase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dtx1 (deltex E3 ubiquitin ligase 1)
Sus scrofa (pig) : DTX1 (deltex E3 ubiquitin ligase 1)
Chlorocebus sabaeus (African green monkey) : DTX1 (deltex E3 ubiquitin ligase 1)
Heterocephalus glaber (naked mole-rat) : Dtx1 (deltex E3 ubiquitin ligase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01241,383,885 - 41,415,783 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,385,241 - 41,414,754 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,243,009 - 43,274,204 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1237,511,093 - 37,542,318 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Dtx1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1585380
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.