Asl (argininosuccinate lyase) - Rat Genome Database

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Gene: Asl (argininosuccinate lyase) Rattus norvegicus
Analyze
Symbol: Asl
Name: argininosuccinate lyase
RGD ID: 619974
Description: Enables argininosuccinate lyase activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to organic cyclic compound; and response to peptide hormone. Located in several cellular components, including cell body fiber; mitochondrial outer membrane; and perikaryon. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase); PARTICIPATES IN urea cycle pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: arginosuccinase; ASAL
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,295,779 - 32,313,257 (+)NCBIGRCr8
mRatBN7.21226,659,664 - 26,677,136 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,659,565 - 26,679,662 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1227,807,557 - 27,824,901 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01228,418,086 - 28,435,430 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01227,479,553 - 27,496,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01230,160,922 - 30,178,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1230,165,694 - 30,178,341 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,097,760 - 32,115,110 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41227,702,882 - 27,720,230 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11227,570,168 - 27,583,445 (+)NCBI
Celera1228,373,639 - 28,390,987 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroform  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
indometacin  (ISO)
isoniazide  (EXP)
ivermectin  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP)
metformin  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
N-nitrosomorpholine  (EXP)
nickel dichloride  (EXP)
ochratoxin A  (EXP)
oxycodone  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (EXP)
silibinin  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
theophylline  (EXP)
thioacetamide  (EXP)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zidovudine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Amino acid sequence of rat argininosuccinate lyase deduced from cDNA. Amaya Y, etal., J Biochem (Tokyo) 1988 Jan;103(1):177-81.
2. Decreased urea synthesis in cafeteria-diet-induced obesity in the rat. Barber T, etal., Biochem J. 1985 Sep 15;230(3):675-81.
3. Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons. Bizzoco E, etal., Exp Neurol. 2006 Dec 30;.
4. Activated microglia cells express argininosuccinate synthetase and argininosuccinate lyase in the rat brain after transient ischemia. Bizzoco E, etal., Exp Neurol. 2007 Nov;208(1):100-9. Epub 2007 Aug 17.
5. Measurement of nitric oxide-related enzymes in the brain by in situ hybridization. Braissant O Methods Mol Biol. 2004;279:113-24.
6. Hyperammonemia: regulation of argininosuccinate synthetase and argininosuccinate lyase genes in aggregating cell cultures of fetal rat brain. Braissant O, etal., Neurosci Lett. 1999 May 7;266(2):89-92.
7. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, etal., J Proteome Res. 2019 May 3;18(5):2032-2044. doi: 10.1021/acs.jproteome.8b00921. Epub 2019 Mar 29.
8. Argininosuccinate synthetase and argininosuccinate lyase are localized around mitochondria: an immunocytochemical study. Cohen NS and Kuda A, J Cell Biochem. 1996 Mar 1;60(3):334-40.
9. Arginine-metabolizing enzymes in the developing rat small intestine. De Jonge WJ, etal., Pediatr Res. 1998 Apr;43(4 Pt 1):442-51.
10. Ontogenesis of nitric oxide synthases in the ventilatory muscles. El Dwairi Q, etal., Am J Respir Cell Mol Biol. 1998 Jun;18(6):844-52.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Modulation of intestinal urea cycle by dietary spermine in suckling rat. Gharbi M, etal., Biochem Biophys Res Commun. 2005 Nov 4;336(4):1119-24.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Expression of the genes of arginine-synthesizing enzymes in the rat kidney during development. Goutal I, etal., Biol Neonate. 1999 Oct;76(4):253-60.
15. Effects of growth hormone on steroid-induced increase in ability of urea synthesis and urea enzyme mRNA levels. Grofte T, etal., Am J Physiol. 1998 Jul;275(1 Pt 1):E79-86.
16. Induction of astrocyte argininosuccinate synthetase and argininosuccinate lyase by dibutyryl cyclic AMP and dexamethasone. Jackson MJ, etal., Neurochem Res. 1996 Oct;21(10):1161-5.
17. Structural analysis of an extremely long 5'-noncoding region of rat brain argininosuccinate lyase mRNA: presence of multiple B1 repeats and multiple upstream AUG codons, and a possibility of translational control. Kawamoto S, etal., Biochim Biophys Acta 1993 Apr 29;1173(1):111-4.
18. Molecular cloning and nucleotide sequence of rat brain argininosuccinate lyase cDNA with an extremely long 5'-untranslated sequence: evidence for the identity of the brain and liver enzymes. Kawamoto S, etal., Brain Res Mol Brain Res 1989 May;5(3):235-41.
19. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
20. Clinical, enzymatic, and molecular genetic characterization of a biochemical variant type of argininosuccinic aciduria: prenatal and postnatal diagnosis in five unrelated families. Kleijer WJ, etal., J Inherit Metab Dis 2002 Sep;25(5):399-410.
21. Identification of argininosuccinate lyase as a hypoxia-responsive gene in rat hepatocytes. Latasa MU, etal., J Hepatol. 2000 Nov;33(5):709-15.
22. Structure of the rat argininosuccinate lyase gene: close similarity to chicken delta-crystallin genes. Matsubasa T, etal., Proc Natl Acad Sci U S A 1989 Jan;86(2):592-6.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. The 'intestinal-renal' arginine biosynthetic axis in the aging rat. Mistry SK, etal., Mech Ageing Dev. 2002 Apr 30;123(8):1159-65.
25. Nutritional and hormonal regulation of mRNA abundance for arginine biosynthetic enzymes in kidney. Morris SM Jr, etal., Arch Biochem Biophys. 1989 Aug 15;273(1):230-7.
26. Coinduction of nitric oxide synthase, argininosuccinate synthetase, and argininosuccinate lyase in lipopolysaccharide-treated rats. RNA blot, immunoblot, and immunohistochemical analyses. Nagasaki A, etal., J Biol Chem. 1996 Feb 2;271(5):2658-62.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus. Rao PV, etal., J Assoc Physicians India. 2005 Jun;53:521-6.
32. Changes in levels of argininosuccinate lyase mRNA during induction by glucagon and cyclic AMP in cultured foetal-rat hepatocytes. Renouf S, etal., Biochem J. 1993 Apr 15;291 ( Pt 2):609-13.
33. Developmental control of argininosuccinate lyase gene by methylation. Renouf S, etal., Biol Neonate. 1998;73(3):190-7.
34. GOA pipeline RGD automated data pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Journal of animal physiology and animal nutrition Roth VH J Anim Physiol Anim Nutr (Berl). 2001 Feb;85(1-2):45-52.
38. Molecular basis of enzyme abnormalities in urea cycle disorders. With special reference to citrullinemia and argininosuccinic aciduria. Saheki T, etal., Enzyme. 1987;38(1-4):227-32.
39. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
40. Nitric oxide (no), citrulline - no cycle enzymes, glutamine synthetase and oxidative stress in anoxia (hypobaric hypoxia) and reperfusion in rat brain. Swamy M, etal., Int J Med Sci. 2010 May 31;7(3):147-54.
41. Regulation of genes for inducible nitric oxide synthase and urea cycle enzymes in rat liver in endotoxin shock. Tabuchi S, etal., Biochem Biophys Res Commun. 2000 Feb 5;268(1):221-4.
42. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
43. L-Citrulline attenuates arrested alveolar growth and pulmonary hypertension in oxygen-induced lung injury in newborn rats. Vadivel A, etal., Pediatr Res. 2010 Aug 27.
44. L-citrulline recycling by argininosuccinate synthetase and lyase in rat gastric fundus. Van Geldre LA, etal., Eur J Pharmacol. 2002 Nov 29;455(2-3):149-60.
45. Molecular analysis of human argininosuccinate lyase: mutant characterization and alternative splicing of the coding region. Walker DC, etal., Proc Natl Acad Sci U S A 1990 Dec;87(24):9625-9.
46. Urea cycle gene expression is suppressed by PFOA treatment in rats. Walters MW and Wallace KB, Toxicol Lett. 2010 Aug 1;197(1):46-50. Epub 2010 May 7.
47. Preparation of recombinant argininosuccinate synthetase and argininosuccinate lyase: expression of the enzymes in rat tissues. Yu Y, etal., J Biochem (Tokyo). 1995 May;117(5):952-7.
48. Coinduction of inducible nitric oxide synthase and arginine recycling enzymes in cytokine-stimulated PC12 cells and high output production of nitric oxide. Zhang WY, etal., Brain Res Mol Brain Res. 2000 Nov 10;83(1-2):1-8.
Additional References at PubMed
PMID:12559843   PMID:15489334   PMID:19056867   PMID:21988832   PMID:24904080   PMID:25416956   PMID:25502805   PMID:31515488  


Genomics

Comparative Map Data
Asl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,295,779 - 32,313,257 (+)NCBIGRCr8
mRatBN7.21226,659,664 - 26,677,136 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,659,565 - 26,679,662 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1227,807,557 - 27,824,901 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01228,418,086 - 28,435,430 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01227,479,553 - 27,496,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01230,160,922 - 30,178,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1230,165,694 - 30,178,341 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,097,760 - 32,115,110 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41227,702,882 - 27,720,230 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11227,570,168 - 27,583,445 (+)NCBI
Celera1228,373,639 - 28,390,987 (+)NCBICelera
Cytogenetic Map12q12NCBI
ASL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38766,075,819 - 66,093,576 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl766,075,800 - 66,094,697 (+)EnsemblGRCh38hg38GRCh38
GRCh37765,540,806 - 65,558,563 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36765,178,211 - 65,195,765 (+)NCBINCBI36Build 36hg18NCBI36
Build 34764,984,963 - 65,002,090NCBI
Celera766,555,388 - 66,572,941 (-)NCBICelera
Cytogenetic Map7q11.21ENTREZGENE
HuRef761,727,625 - 61,745,174 (+)NCBIHuRef
CHM1_1765,636,440 - 65,653,994 (+)NCBICHM1_1
T2T-CHM13v2.0767,297,906 - 67,315,665 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2764,878,281 - 64,895,827 (+)NCBI
Asl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395130,040,099 - 130,053,222 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5130,040,099 - 130,058,088 (-)EnsemblGRCm39 Ensembl
GRCm385130,011,258 - 130,024,381 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5130,011,258 - 130,029,247 (-)EnsemblGRCm38mm10GRCm38
MGSCv375130,487,373 - 130,500,201 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365130,296,206 - 130,309,034 (-)NCBIMGSCv36mm8
Celera5127,015,654 - 127,028,488 (-)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map568.37NCBI
Asl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554568,411,220 - 8,416,992 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554568,409,767 - 8,419,915 (-)NCBIChiLan1.0ChiLan1.0
ASL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.16768,522 - 779,144 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl6730,358 - 779,424 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha62,468,962 - 2,479,644 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.06573,409 - 584,014 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl6565,544 - 584,326 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.16517,146 - 527,808 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.06511,138 - 521,729 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.06682,422 - 693,029 (-)NCBIUU_Cfam_GSD_1.0
Asl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344126,336,725 - 126,347,816 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365437,688,741 - 7,699,851 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365437,688,788 - 7,699,842 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl316,637,481 - 16,646,867 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1316,637,481 - 16,646,869 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2316,889,701 - 16,899,549 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1281,782,434 - 1,800,581 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl281,782,553 - 1,802,517 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607014,846,508 - 14,865,029 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247408,414,733 - 8,423,777 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247408,414,664 - 8,423,797 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Asl
83 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:60
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000001211
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)122423477731894213Rat

Markers in Region
BF388305  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21226,661,399 - 26,661,549 (+)MAPPERmRatBN7.2
Rnor_6.01230,162,607 - 30,162,756NCBIRnor6.0
Rnor_5.01232,099,369 - 32,099,518UniSTSRnor5.0
RGSC_v3.41227,704,491 - 27,704,640UniSTSRGSC3.4
Celera1228,375,248 - 28,375,397UniSTS
RH 3.4 Map12454.3UniSTS
Cytogenetic Map12q13UniSTS
AA818673  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21226,676,740 - 26,677,034 (+)MAPPERmRatBN7.2
Rnor_6.01230,177,953 - 30,178,246NCBIRnor6.0
Rnor_5.01232,114,715 - 32,115,008UniSTSRnor5.0
RGSC_v3.41227,719,837 - 27,720,130UniSTSRGSC3.4
Celera1228,390,594 - 28,390,887UniSTS
RH 3.4 Map12449.1UniSTS
Cytogenetic Map12q13UniSTS
ASL  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21226,675,167 - 26,675,631 (+)MAPPERmRatBN7.2
Rnor_6.01230,176,380 - 30,176,843NCBIRnor6.0
Rnor_5.01232,113,142 - 32,113,605UniSTSRnor5.0
RGSC_v3.41227,718,264 - 27,718,727UniSTSRGSC3.4
Celera1228,389,021 - 28,389,484UniSTS
Cytogenetic Map12q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 57 41 19 41 1 1 67 35 41 11 1
Low 1 17 7 10 7 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC097270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D13978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000001211   ⟹   ENSRNOP00000001211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1226,667,915 - 26,677,132 (+)Ensembl
Rnor_6.0 Ensembl1230,165,694 - 30,178,341 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103968   ⟹   ENSRNOP00000095504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1226,659,565 - 26,677,132 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110317   ⟹   ENSRNOP00000089055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1226,659,565 - 26,679,662 (+)Ensembl
RefSeq Acc Id: NM_021577   ⟹   NP_067588
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,295,908 - 32,313,255 (+)NCBI
mRatBN7.21226,659,791 - 26,677,134 (+)NCBI
Rnor_6.01230,160,998 - 30,178,346 (+)NCBI
Rnor_5.01232,097,760 - 32,115,110 (+)NCBI
RGSC_v3.41227,702,882 - 27,720,230 (+)RGD
Celera1228,373,639 - 28,390,987 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249245   ⟹   XP_006249307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,295,782 - 32,313,257 (+)NCBI
mRatBN7.21226,659,665 - 26,677,136 (+)NCBI
Rnor_6.01230,160,923 - 30,178,348 (+)NCBI
Rnor_5.01232,097,760 - 32,115,110 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089715   ⟹   XP_038945643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,296,029 - 32,313,257 (+)NCBI
mRatBN7.21226,660,104 - 26,677,136 (+)NCBI
RefSeq Acc Id: XM_063271607   ⟹   XP_063127677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,295,779 - 32,313,257 (+)NCBI
RefSeq Acc Id: XM_063271608   ⟹   XP_063127678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,295,787 - 32,313,257 (+)NCBI
RefSeq Acc Id: XM_063271609   ⟹   XP_063127679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,296,029 - 32,313,257 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_067588   ⟸   NM_021577
- UniProtKB: Q6AZ85 (UniProtKB/Swiss-Prot),   P20673 (UniProtKB/Swiss-Prot),   Q4QRB8 (UniProtKB/TrEMBL),   Z4YND9 (UniProtKB/TrEMBL),   A6J0N5 (UniProtKB/TrEMBL),   A0A8J8XG16 (UniProtKB/TrEMBL),   A0A8I6ARJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249307   ⟸   XM_006249245
- Peptide Label: isoform X1
- UniProtKB: Q6AZ85 (UniProtKB/Swiss-Prot),   P20673 (UniProtKB/Swiss-Prot),   Q4QRB8 (UniProtKB/TrEMBL),   Z4YND9 (UniProtKB/TrEMBL),   A6J0N5 (UniProtKB/TrEMBL),   A0A8J8XG16 (UniProtKB/TrEMBL),   A0A8I6ARJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001211   ⟸   ENSRNOT00000001211
RefSeq Acc Id: XP_038945643   ⟸   XM_039089715
- Peptide Label: isoform X1
- UniProtKB: Q6AZ85 (UniProtKB/Swiss-Prot),   P20673 (UniProtKB/Swiss-Prot),   Z4YND9 (UniProtKB/TrEMBL),   Q4QRB8 (UniProtKB/TrEMBL),   A6J0N5 (UniProtKB/TrEMBL),   A0A8J8XG16 (UniProtKB/TrEMBL),   A0A8I6ARJ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000089055   ⟸   ENSRNOT00000110317
RefSeq Acc Id: ENSRNOP00000095504   ⟸   ENSRNOT00000103968
RefSeq Acc Id: XP_063127677   ⟸   XM_063271607
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARJ8 (UniProtKB/TrEMBL),   A6J0N5 (UniProtKB/TrEMBL),   Q4QRB8 (UniProtKB/TrEMBL),   Z4YND9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127678   ⟸   XM_063271608
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARJ8 (UniProtKB/TrEMBL),   A6J0N5 (UniProtKB/TrEMBL),   Q4QRB8 (UniProtKB/TrEMBL),   Z4YND9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127679   ⟸   XM_063271609
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARJ8 (UniProtKB/TrEMBL),   A6J0N5 (UniProtKB/TrEMBL),   Q4QRB8 (UniProtKB/TrEMBL),   Z4YND9 (UniProtKB/TrEMBL)
Protein Domains
Argininosuccinate lyase C-terminal   Fumarate lyase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20673-F1-model_v2 AlphaFold P20673 1-461 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698579
Promoter ID:EPDNEW_R9104
Type:multiple initiation site
Name:Asl_1
Description:argininosuccinate lyase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01230,165,757 - 30,165,817EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619974 AgrOrtholog
BioCyc Gene G2FUF-19522 BioCyc
BioCyc Pathway PWY-4983 [nitric oxide biosynthesis II (mammals)] BioCyc
  PWY-4984 [urea cycle] BioCyc
BioCyc Pathway Image PWY-4983 BioCyc
  PWY-4984 BioCyc
Ensembl Genes ENSRNOG00000000903 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001211.8 UniProtKB/TrEMBL
  ENSRNOT00000103968 ENTREZGENE
  ENSRNOT00000103968.1 UniProtKB/TrEMBL
  ENSRNOT00000110317.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.275.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarase/aspartase (C-terminal domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarase/aspartase (Central domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109106 IMAGE-MGC_LOAD
  IMAGE:7455735 IMAGE-MGC_LOAD
InterPro Arg_succ_lyase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Argininosuccinate_lyase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarase/histidase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarate_lyase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarate_lyase_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarate_lyase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L-Aspartase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59085 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114244 IMAGE-MGC_LOAD
  MGC:93044 IMAGE-MGC_LOAD
NCBI Gene 59085 ENTREZGENE
PANTHER ARGININOSUCCINATE LYASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ASL_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lyase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Asl PhenoGen
PRINTS ARGSUCLYASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FUMRATELYASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FUMARATE_LYASES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000903 RatGTEx
Superfamily-SCOP SSF48557 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AB44_RAT UniProtKB/TrEMBL
  A0A8I6ARJ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8XG16 ENTREZGENE, UniProtKB/TrEMBL
  A6J0N5 ENTREZGENE, UniProtKB/TrEMBL
  ARLY_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4QRB8 ENTREZGENE
  Q6AZ85 ENTREZGENE
  Z4YND9 ENTREZGENE
UniProt Secondary Q4QRB8 UniProtKB/TrEMBL
  Q6AZ85 UniProtKB/Swiss-Prot
  Z4YND9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Asl  argininosuccinate lyase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Asl  argininosuccinate lyase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression may be induced in high levels after some types of lethal liver damage 70249