RGD Reference Report - Decreased urea synthesis in cafeteria-diet-induced obesity in the rat. - Rat Genome Database

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Decreased urea synthesis in cafeteria-diet-induced obesity in the rat.

Authors: Barber, T  Vina, JR  Vina, J  Cabo, J 
Citation: Barber T, etal., Biochem J. 1985 Sep 15;230(3):675-81.
RGD ID: 2300098
Pubmed: PMID:4062872   (View Abstract at PubMed)
PMCID: PMC1152671   (View Article at PubMed Central)

Feeding rats with a cafeteria diet resulted in increases in total body weight and in epididymal-adipose-tissue weight. Those rats excreted significantly less N than did controls. The amount of N ingested by cafeteria-diet-fed rats was kept equal to that of controls. This decrease in N excretion is explained by a decrease in urinary excretion of urea. This may be due to the following facts. The rate of synthesis of urea from precursors by isolated hepatocytes from cafeteria-diet-fed rats was lower than in controls. In cafeteria-diet-fed rats the activities of all the enzymes of the urea cycle are decreased. The major percentage decreases are those of carbamoylphosphate synthetase (EC and of argininosuccinate synthetase (EC, the enzymes probably involved in the regulation of the overall rate of the cycle. When rats are switched to normal chow diet, the enzyme activities return to normal values. The uptake of amino acids by liver of cafeteria-diet-fed rats is lower than in controls. These results contrast with those obtained previously by using other models of obesity in rat (i.e. genetic or hypothalamic), in which N excretion was increased.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
arginine metabolic process  IDA 2300098 RGD 
argininosuccinate metabolic process  IDA 2300098; 2300098 RGD 
monoatomic anion homeostasis  IDA 2300098Carbamoyl phosphate RGD 
monoatomic anion homeostasis  IDA 2300098Carbamoyl phosphateRGD 
ornithine metabolic process  IDA 2300098 RGD 
urea cycle  IDA 2300098; 2300098; 2300098; 2300098; 2300098 RGD 

Molecular Function

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Arg1  (arginase 1)
Asl  (argininosuccinate lyase)
Ass1  (argininosuccinate synthase 1)
Cps1  (carbamoyl-phosphate synthase 1)
Otc  (ornithine transcarbamylase)

Genes (Mus musculus)
Arg1  (arginase, liver)
Asl  (argininosuccinate lyase)
Ass1  (argininosuccinate synthetase 1)
Cps1  (carbamoyl-phosphate synthetase 1)
Otc  (ornithine transcarbamylase)

Genes (Homo sapiens)
ARG1  (arginase 1)
ASL  (argininosuccinate lyase)
ASS1  (argininosuccinate synthase 1)
CPS1  (carbamoyl-phosphate synthase 1)
OTC  (ornithine transcarbamylase)

Additional Information