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Gene: ASS1 (argininosuccinate synthase 1) Homo sapiens
Symbol: ASS1
Name: argininosuccinate synthase 1
Description: Exhibits amino acid binding activity; argininosuccinate synthase activity; and identical protein binding activity. Involved in several processes, including alpha-amino acid metabolic process; positive regulation of nitric oxide biosynthetic process; and urea cycle. Localizes to cytosol. Implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: argininosuccinate synthase; argininosuccinate synthetase 1; arginosuccinate synthetase; ASS; citrulline--aspartate ligase; citrulline-aspartate ligase; CTLN1
Mus musculus (house mouse) : Ass1 (argininosuccinate synthetase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ass1 (argininosuccinate synthase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ass1 (argininosuccinate synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ASS1 (argininosuccinate synthase 1)
Canis lupus familiaris (dog) : ASS1 (argininosuccinate synthase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ass1 (argininosuccinate synthase 1)
Sus scrofa (pig) : ASS1 (argininosuccinate synthase 1)
Chlorocebus sabaeus (African green monkey) : ASS1 (argininosuccinate synthase 1)
Heterocephalus glaber (naked mole-rat) : Ass1 (argininosuccinate synthase 1)
more info ...
Related Pseudogenes: AC003989.1   ASS1P1   ASS1P10   ASS1P11   ASS1P12   ASS1P13   ASS1P14   ASS1P2   ASS1P3   ASS1P4   ASS1P5   ASS1P6   ASS1P7   ASS1P8   ASS1P9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl9130,444,961 - 130,501,274 (+)EnsemblGRCh38hg38GRCh38
GRCh389130,444,707 - 130,501,274 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379133,320,094 - 133,376,661 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369132,309,915 - 132,366,482 (+)NCBINCBI36hg18NCBI36
Build 349130,355,212 - 130,406,214NCBI
Celera9103,858,652 - 103,915,182 (+)NCBI
Cytogenetic Map9q34.11NCBI
HuRef9102,805,927 - 102,862,325 (+)NCBIHuRef
CHM1_19133,469,032 - 133,525,591 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ASS1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736136
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.