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Gene: Otc (ornithine carbamoyltransferase) Rattus norvegicus
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Symbol: Otc
Name: ornithine carbamoyltransferase
Description: Exhibits anion binding activity; identical protein binding activity; and ornithine carbamoyltransferase activity. Involved in several processes, including alpha-amino acid metabolic process; response to biotin; and urea cycle. Localizes to the mitochondrial inner membrane. Used to study ornithine carbamoyltransferase deficiency. Biomarker of cholestasis; fatty liver disease; and obesity. Human ortholog(s) of this gene implicated in ornithine carbamoyltransferase deficiency. Orthologous to human OTC (ornithine carbamoyltransferase); PARTICIPATES IN urea cycle pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC108742; ornithine carbamoyltransferase, mitochondrial; ornithine transcarbamylase; OTCase
Orthologs:
Homo sapiens (human) : OTC (ornithine carbamoyltransferase)  HGNC  Alliance
Mus musculus (house mouse) : Otc (ornithine transcarbamylase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Otc (ornithine carbamoyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : OTC (ornithine carbamoyltransferase)
Canis lupus familiaris (dog) : OTC (ornithine carbamoyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Otc (ornithine carbamoyltransferase)
Sus scrofa (pig) : OTC (ornithine carbamoyltransferase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X13,524,804 - 13,601,074 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX13,524,607 - 13,601,069 (-)Ensembl
Rnor_5.0X14,314,381 - 14,390,615 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X24,609,141 - 24,685,341 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X24,662,538 - 24,738,739 (-)NCBI
CeleraX13,066,848 - 13,142,959 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Otc
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3236
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.