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Gene: Arg1 (arginase, liver) Mus musculus
Symbol: Arg1
Name: arginase, liver
Description: Exhibits arginase activity. Involved in defense response to protozoan; negative regulation of T-helper 2 cell cytokine production; and negative regulation of activated T cell proliferation. Predicted to localize to several cellular components, including extracellular space; mitochondrial outer membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study hyperargininemia. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; argininosuccinic aciduria pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrabromodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI; AI256583; Arg-1; arginase 1, liver; arginase I; arginase-1; liver-type arginase; PGIF; type I arginase
Homo sapiens (human) : ARG1 (arginase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Arg1 (arginase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arg1 (arginase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ARG1 (arginase 1)
Canis lupus familiaris (dog) : ARG1 (arginase 1)
Sus scrofa (pig) : ARG1 (arginase 1)
Chlorocebus sabaeus (African green monkey) : ARG1 (arginase 1)
Heterocephalus glaber (naked mole-rat) : Arg1 (arginase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1024,915,221 - 24,927,484 (-)EnsemblGRCm38mm10GRCm38
GRCm381024,915,207 - 24,927,470 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371024,635,013 - 24,647,276 (-)NCBIGRCm37mm9NCBIm37
MGSCv361024,604,637 - 24,617,896 (-)NCBImm8
Celera1025,846,180 - 25,858,528 (-)NCBICelera
Cytogenetic Map10A4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Arg1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736430
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.