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Gene: OTC (ornithine carbamoyltransferase) Homo sapiens
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Symbol: OTC
Name: ornithine carbamoyltransferase
Description: Exhibits ornithine carbamoyltransferase activity. Involved in alpha-amino acid metabolic process; ammonia homeostasis; and urea cycle. Localizes to the mitochondrion. Implicated in ornithine carbamoyltransferase deficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC129967; MGC129968; MGC138856; OCTD; ornithine carbamoyltransferase, mitochondrial; ornithine transcarbamylase; OTCase
Orthologs:
Mus musculus (house mouse) : Otc (ornithine transcarbamylase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Otc (ornithine carbamoyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Otc (ornithine carbamoyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : OTC (ornithine carbamoyltransferase)
Canis lupus familiaris (dog) : OTC (ornithine carbamoyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Otc (ornithine carbamoyltransferase)
Sus scrofa (pig) : OTC (ornithine carbamoyltransferase)
Chlorocebus sabaeus (green monkey) : OTC (ornithine carbamoyltransferase)
Heterocephalus glaber (naked mole-rat) : Otc (ornithine carbamoyltransferase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX38,352,586 - 38,421,446 (+)Ensembl
GRCh38X38,352,528 - 38,421,446 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X38,211,736 - 38,280,703 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X38,096,680 - 38,165,647 (+)NCBINCBI36hg18NCBI36
Build 34X37,967,574 - 38,036,826NCBI
CeleraX42,349,386 - 42,418,351 (+)NCBI
Cytogenetic MapXp11.4NCBI
HuRefX35,956,917 - 36,026,112 (+)NCBIHuRef
CHM1_1X38,242,780 - 38,311,752 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on OTC
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732939
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.