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Gene: Arg1 (arginase 1) Rattus norvegicus
Symbol: Arg1
Name: arginase 1
Description: Exhibits arginase activity; identical protein binding activity; and manganese ion binding activity. Involved in several processes, including cellular response to lipid; gland development; and response to vitamin. Localizes to several cellular components, including extracellular space; mitochondrial outer membrane; and neuronal cell body. Used to study hypertension. Biomarker of several diseases, including acute kidney failure; cholestasis; silicosis; ureteral obstruction; and uveitis. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1); PARTICIPATES IN urea cycle pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-bromopropane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI type I arginase; AI, type I arginase; arginase 1 liver; Arginase 1, liver; arginase, liver; arginase-1; liver-type arginase; type I arginase
Homo sapiens (human) : ARG1 (arginase 1)  HGNC  Alliance
Mus musculus (house mouse) : Arg1 (arginase, liver)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arg1 (arginase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ARG1 (arginase 1)
Canis lupus familiaris (dog) : ARG1 (arginase 1)
Sus scrofa (pig) : ARG1 (arginase 1)
Chlorocebus sabaeus (African green monkey) : ARG1 (arginase 1)
Heterocephalus glaber (naked mole-rat) : Arg1 (arginase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0121,525,421 - 21,537,872 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,525,421 - 21,537,863 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,005,260 - 23,017,714 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4120,998,894 - 21,011,275 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1120,999,006 - 21,011,333 (+)NCBI
Celera119,228,309 - 19,241,078 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Arg1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2150
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.