Arg1 (arginase 1) - Rat Genome Database

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Gene: Arg1 (arginase 1) Rattus norvegicus
Analyze
Symbol: Arg1
Name: arginase 1
RGD ID: 2150
Description: Enables arginase activity; identical protein binding activity; and manganese ion binding activity. Involved in several processes, including cellular response to hormone stimulus; gland development; and response to vitamin. Located in several cellular components, including extracellular space; mitochondrial outer membrane; and neuronal cell body. Used to study hypertension. Biomarker of several diseases, including acute kidney failure; cholestasis; silicosis; ureteral obstruction; and uveitis. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1); PARTICIPATES IN urea cycle pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-bromopropane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI type I arginase; AI, type I arginase; arginase 1 liver; Arginase 1, liver; arginase, liver; arginase-1; liver-type arginase; type I arginase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2120,475,878 - 20,488,422 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl120,475,968 - 20,488,422 (+)Ensembl
Rnor_6.0121,525,421 - 21,537,872 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,525,421 - 21,537,863 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,005,260 - 23,017,714 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4120,998,894 - 21,011,275 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1120,999,006 - 21,011,333 (+)NCBI
Celera119,228,309 - 19,241,078 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-thiamethoxam  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1-bromopropane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,5-hexanedione  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-(1,4-diazepane-1-sulfonyl)isoquinoline  (EXP)
5-aminoimidazole-4-carboxamide  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
agathisflavone  (EXP)
AICA ribonucleotide  (EXP)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
amlexanox  (ISO)
ammonium chloride  (EXP)
ampicillin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azithromycin  (ISO)
azoxystrobin  (ISO)
Bardoxolone methyl  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-amyrin  (ISO)
bexarotene  (EXP)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
bromobenzene  (EXP)
calciol  (ISO)
calcitriol  (ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cortisol  (EXP)
coumarin  (EXP)
crocidolite asbestos  (ISO)
Cyclopamine  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cyproconazole  (EXP)
cyprodinil  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dichlorine  (EXP,ISO)
diethylstilbestrol  (ISO)
difenoconazole  (ISO)
dimethomorph  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
diuron  (EXP)
donepezil hydrochloride  (ISO)
dopamine  (EXP)
dorsomorphin  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
ethoprophos  (ISO)
excitatory amino acid agonist  (EXP)
fasudil hydrochloride  (EXP)
fenhexamid  (ISO)
fenpyroximate  (ISO)
fipronil  (ISO)
flavonoids  (EXP)
fludioxonil  (ISO)
flurbiprofen  (ISO)
flusilazole  (EXP,ISO)
flutamide  (EXP)
fluxapyroxad  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
glyburide  (EXP)
glycidol  (EXP)
graphene oxide  (ISO)
graphite  (EXP)
hexadecanoic acid  (EXP,ISO)
HU-308  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
imipramine  (ISO)
iodide salt  (EXP)
isoliquiritigenin  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
Lasiocarpine  (ISO)
leflunomide  (ISO)
limonene  (EXP)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP)
MeIQx  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
mifepristone  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nickel dichloride  (EXP)
nitrofen  (EXP)
NS-398  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
ozone  (EXP)
paeoniflorin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
prochloraz  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quartz  (EXP)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (ISO)
salicylic acid  (EXP)
SB 203580  (ISO)
selenium atom  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
streptozocin  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
tebuconazole  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thiamethoxam  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trans-caffeic acid  (ISO)
tremolite asbestos  (ISO)
triadimefon  (EXP)
trimethyltin  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
trypanothione  (ISO)
trypanothione disulfide  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
WIN 55212-2  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
aging  (IEP)
arginine catabolic process to ornithine  (IBA,IDA)
arginine metabolic process  (IDA)
cellular response to dexamethasone stimulus  (IEP)
cellular response to glucagon stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to interleukin-4  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
collagen biosynthetic process  (IMP)
defense response to protozoan  (ISO)
female pregnancy  (IEP)
innate immune response  (IEA)
liver development  (IEP)
lung development  (IEP)
mammary gland involution  (IEP)
maternal process involved in female pregnancy  (IEP)
negative regulation of activated T cell proliferation  (ISO)
negative regulation of interferon-gamma-mediated signaling pathway  (ISO)
negative regulation of T cell proliferation  (ISO)
negative regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of endothelial cell proliferation  (IDA)
positive regulation of neutrophil mediated killing of fungus  (ISO)
regulation of L-arginine import  (IDA)
response to amine  (IEP)
response to amino acid  (IEP)
response to axon injury  (IEP)
response to cadmium ion  (IEP)
response to herbicide  (IEP)
response to lipopolysaccharide  (IEP)
response to manganese ion  (IEP)
response to methylmercury  (IEP)
response to peptide hormone  (IEP)
response to selenium ion  (IEP)
response to steroid hormone  (IEP)
response to vitamin A  (IEP)
response to vitamin E  (IEP)
response to wounding  (IEP)
response to xenobiotic stimulus  (IEP)
response to zinc ion  (IEP)
urea cycle  (IDA,IEA)

Cellular Component

Molecular Function

References

References - curated
1. Alarcon-Corredor OM and Alfonso R, Arch Latinoam Nutr. 2007 Sep;57(3):224-30.
2. Bagnost T, etal., J Hypertens. 2008 Jun;26(6):1110-8.
3. Barber T, etal., Biochem J. 1985 Sep 15;230(3):675-81.
4. Beck B, etal., J Surg Res. 2005 Jun 1;126(1):19-26.
5. Belik J, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Mar;294(3):L498-504. Epub 2008 Jan 11.
6. Belik J, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L777-84. Epub 2009 Aug 7.
7. Biczo G, etal., Pancreas. 2010 Aug;39(6):868-74.
8. Cama E, etal., Biochemistry. 2003 Jul 1;42(25):7748-58.
9. Cheng PN, etal., Cancer Res. 2007 Jan 1;67(1):309-17.
10. Demougeot C, etal., Life Sci. 2007 Feb 27;80(12):1128-34. Epub 2006 Dec 14.
11. Dingemanse MA, etal., Hepatology. 1996 Aug;24(2):407-11.
12. Ensunsa JL, etal., Exp Biol Med (Maywood). 2004 Dec;229(11):1143-53.
13. Erbas H, etal., Pharmacol Res. 2004 Nov;50(5):523-7.
14. Erisir M, etal., Cell Biochem Funct. 2003 Dec;21(4):331-5.
15. Estevez AG, etal., J Neurosci. 2006 Aug 16;26(33):8512-6.
16. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Grandvuillemin I, etal., Am J Physiol Regul Integr Comp Physiol. 2018 Sep 1;315(3):R509-R520. doi: 10.1152/ajpregu.00354.2017. Epub 2018 May 9.
18. Grofte T, etal., Am J Physiol. 1998 Jul;275(1 Pt 1):E79-86.
19. Hirata M, etal., Mol Hum Reprod. 2006 Aug;12(8):513-8. Epub 2006 May 30.
20. Hultstrom M, etal., Am J Physiol Renal Physiol. 2009 Jul;297(1):F163-8. Epub 2009 Apr 22.
21. Iyer RK, etal., Mol Genet Metab 1998 Mar;63(3):168-75.
22. Kanda H, etal., Arch Toxicol. 2008 Nov;82(11):803-8. Epub 2008 May 17.
23. Kanyo ZF, etal., J Mol Biol. 1992 Apr 20;224(4):1175-7.
24. Kawamoto S, etal., J Biol Chem 1987 May 5;262(13):6280-3.
25. KEGG
26. Kerem M, etal., Liver Int. 2008 Aug;28(7):972-81. Epub 2008 Apr 23.
27. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
28. Klasen S, etal., Br J Pharmacol. 2001 Mar;132(6):1349-57.
29. Koga T, etal., Exp Eye Res 2002 Dec;75(6):659-67.
30. Li H, etal., Am J Physiol Endocrinol Metab. 2001 Jan;280(1):E75-82.
31. Li H, etal., Am J Physiol Regul Integr Comp Physiol. 2002 Jan;282(1):R64-9.
32. Li H, etal., J Allergy Clin Immunol. 2006 Jan;117(1):119-26. Epub 2005 Nov 28.
33. Lindemann D and Racke K, Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):546-50. Epub 2003 Nov 15.
34. Liu H, etal., Am J Transplant. 2005 Jun;5(6):1256-63.
35. Liu P, etal., J Vestib Res. 2004;14(6):411-7.
36. Matthiesen S, etal., Eur J Pharmacol. 2008 Jan 28;579(1-3):403-10. Epub 2007 Oct 25.
37. Mendez JD, etal., Biomed Pharmacother. 2006 Feb;60(2):82-5. Epub 2005 Dec 27.
38. MGD data from the GO Consortium
39. Moran JM, etal., Nitric Oxide. 2010 Apr 11.
40. Mori M, etal., J Inherit Metab Dis. 1998;21 Suppl 1:59-71.
41. Murayama H, etal., Clin Chim Acta. 2007 Jan;375(1-2):63-8. Epub 2006 Jun 21.
42. NCBI rat LocusLink and RefSeq merged data July 26, 2002
43. Nissim I, et al., J Biol Chem. 2005 May 6;280(18):17715-24. Epub 2005 Mar 7.
44. O'Brien J, etal., Am J Pathol. 2010 Mar;176(3):1241-55. Epub 2010 Jan 28.
45. OMIM Disease Annotation Pipeline
46. Pipeline to import KEGG annotations from KEGG into RGD
47. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
48. Pipeline to import SMPDB annotations from SMPDB into RGD
49. Poljakovic M, etal., J Toxicol Environ Health A. 2007 Jan 15;70(2):118-27.
50. Pooranaperundevi M, etal., Singapore Med J. 2010 May;51(5):389-98.
51. Que LG, etal., Am J Physiol. 1998 Jul;275(1 Pt 1):L96-102.
52. Que LG, etal., Nitric Oxide 2002 Feb;6(1):1-8.
53. Reid KM, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Feb;292(2):G512-7. Epub 2006 Oct 5.
54. RGD automated data pipeline
55. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
56. RGD automated import pipeline for gene-chemical interactions
57. Romero MJ, etal., Circ Res. 2008 Jan 4;102(1):95-102. Epub 2007 Oct 25.
58. Roth VH J Anim Physiol Anim Nutr (Berl). 2001 Feb;85(1-2):45-52.
59. Santhanam L, et al., Circ Res. 2007 Sep 28;101(7):692-702. Epub 2007 Aug 17.
60. Schwartz IF, etal., Kidney Blood Press Res. 2008;31(3):210-6. Epub 2008 Jun 14.
61. Schwartz IF, etal., Kidney Int 2002 Nov;62(5):1700-6.
62. Sonoki T, etal., J Biol Chem. 1997 Feb 7;272(6):3689-93.
63. Tabuchi S, etal., Biochem Biophys Res Commun. 2000 Feb 5;268(1):221-4.
64. Tormanen CD J Enzyme Inhib Med Chem. 2006 Feb;21(1):119-23.
65. Tu L, etal., Oncotarget. 2017 Apr 25;8(17):27704-27714. doi: 10.18632/oncotarget.15984.
66. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
67. Uchino T, etal., Hum Genet. 1995 Sep;96(3):255-60.
68. Ulbright C and Snodgrass PJ, Arch Biochem Biophys. 1993 Mar;301(2):237-43.
69. Vonk JM, etal., Pharmacogenet Genomics. 2010 Mar;20(3):179-86.
70. Warnken M, etal., Naunyn Schmiedebergs Arch Pharmacol. 2010 Apr;381(4):297-304. Epub 2010 Jan 28.
71. Wei CL, etal., Biochem Pharmacol. 2002 Mar 15;63(6):1043-50.
72. Witte MB, etal., J Gastrointest Surg. 2003 Mar-Apr;7(3):378-85.
73. Witte MB, etal., J Surg Res 2002 Jun 1;105(1):35-42.
74. Yagi Y, etal., Am J Clin Pathol. 1988 Jun;89(6):735-41.
75. Zimmermann N, etal., J Clin Invest. 2003 Jun;111(12):1863-74.
Additional References at PubMed
PMID:2026618   PMID:2892837   PMID:8849731   PMID:9179379   PMID:9265637   PMID:9502196   PMID:10542097   PMID:11883902   PMID:12020133   PMID:12194870   PMID:12477932   PMID:15013576  
PMID:15248756   PMID:15489334   PMID:15546957   PMID:16141327   PMID:16380531   PMID:16709924   PMID:16794538   PMID:17418108   PMID:19164802   PMID:19182904   PMID:19360123   PMID:19641117  
PMID:19661445   PMID:19763131   PMID:20032511   PMID:21408057   PMID:21630459   PMID:21952491   PMID:21975054   PMID:22182949   PMID:22325098   PMID:22483960   PMID:22507752   PMID:22872058  
PMID:23232640   PMID:23376485   PMID:23665321   PMID:23691079   PMID:25490411   PMID:25557182   PMID:25872571   PMID:25931508   PMID:26140333   PMID:28259758  


Genomics

Comparative Map Data
Arg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2120,475,878 - 20,488,422 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl120,475,968 - 20,488,422 (+)Ensembl
Rnor_6.0121,525,421 - 21,537,872 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,525,421 - 21,537,863 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,005,260 - 23,017,714 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4120,998,894 - 21,011,275 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1120,999,006 - 21,011,333 (+)NCBI
Celera119,228,309 - 19,241,078 (+)NCBICelera
Cytogenetic Map1p12NCBI
ARG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6131,470,832 - 131,584,332 (+)EnsemblGRCh38hg38GRCh38
GRCh386131,573,226 - 131,584,329 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376131,894,366 - 131,905,469 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366131,936,058 - 131,947,161 (+)NCBINCBI36hg18NCBI36
Build 346131,936,057 - 131,947,161NCBI
Celera6132,641,003 - 132,652,108 (+)NCBI
Cytogenetic Map6q23.2NCBI
HuRef6129,475,527 - 129,486,657 (+)NCBIHuRef
CHM1_16132,158,130 - 132,169,259 (+)NCBICHM1_1
Arg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391024,791,105 - 24,803,368 (-)NCBIGRCm39mm39
GRCm39 Ensembl1024,791,119 - 24,803,382 (-)Ensembl
GRCm381024,915,207 - 24,927,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1024,915,221 - 24,927,484 (-)EnsemblGRCm38mm10GRCm38
MGSCv371024,635,013 - 24,647,276 (-)NCBIGRCm37mm9NCBIm37
MGSCv361024,604,637 - 24,617,896 (-)NCBImm8
Celera1025,846,180 - 25,858,528 (-)NCBICelera
Cytogenetic Map10A4NCBI
Arg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543612,235,767 - 12,251,972 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543612,235,767 - 12,247,817 (+)NCBIChiLan1.0ChiLan1.0
ARG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16133,479,966 - 133,491,162 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6133,479,966 - 133,491,162 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06129,372,747 - 129,383,880 (+)NCBIMhudiblu_PPA_v0panPan3
ARG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112242,717 - 255,736 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12242,714 - 255,305 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12380,548 - 393,575 (-)NCBI
ROS_Cfam_1.012386,327 - 399,472 (-)NCBI
UMICH_Zoey_3.112243,210 - 256,371 (-)NCBI
UNSW_CanFamBas_1.012313,845 - 327,006 (-)NCBI
UU_Cfam_GSD_1.012384,828 - 398,005 (-)NCBI
ARG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl132,006,038 - 32,028,986 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1132,006,035 - 32,028,983 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2135,580,471 - 35,603,458 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11341,971,955 - 41,983,372 (-)NCBI
ChlSab1.1 Ensembl1341,971,802 - 41,983,049 (-)Ensembl
Vero_WHO_p1.0NW_02366604014,133,035 - 14,144,266 (-)NCBI
Arg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247535,737,720 - 5,749,313 (+)NCBI

Position Markers
RH134303  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2120,488,177 - 20,488,361 (+)MAPPERmRatBN7.2
Rnor_6.0121,537,628 - 21,537,811NCBIRnor6.0
Rnor_5.0123,017,470 - 23,017,653UniSTSRnor5.0
RGSC_v3.4121,011,031 - 21,011,214UniSTSRGSC3.4
Celera119,240,834 - 19,241,017UniSTS
RH 3.4 Map1193.0UniSTS
Cytogenetic Map1p12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:31
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000017911
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 7 7 1
Medium 40 40 40 6 4 10 9
Low 3 43 16 18 8 9 68 31 27 2 8
Below cutoff 1 2 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017911   ⟹   ENSRNOP00000017911
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl120,475,968 - 20,488,422 (+)Ensembl
Rnor_6.0 Ensembl121,525,421 - 21,537,863 (+)Ensembl
RefSeq Acc Id: NM_017134   ⟹   NP_058830
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2120,475,968 - 20,488,422 (+)NCBI
Rnor_6.0121,525,421 - 21,537,872 (+)NCBI
Rnor_5.0123,005,260 - 23,017,714 (+)NCBI
RGSC_v3.4120,998,894 - 21,011,275 (+)RGD
Celera119,228,309 - 19,241,078 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103358   ⟹   XP_038959286
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2120,475,878 - 20,488,422 (+)NCBI
RefSeq Acc Id: XM_039103360   ⟹   XP_038959288
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2120,476,223 - 20,488,422 (+)NCBI
RefSeq Acc Id: XM_039103362   ⟹   XP_038959290
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2120,476,044 - 20,488,422 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058830   ⟸   NM_017134
- UniProtKB: P07824 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017911   ⟸   ENSRNOT00000017911
RefSeq Acc Id: XP_038959286   ⟸   XM_039103358
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038959290   ⟸   XM_039103362
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038959288   ⟸   XM_039103360
- Peptide Label: isoform X2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689524
Promoter ID:EPDNEW_R48
Type:multiple initiation site
Name:Arg1_1
Description:arginase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0121,525,474 - 21,525,534EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2150 AgrOrtholog
Ensembl Genes ENSRNOG00000013304 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000017911 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017911 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7368991 IMAGE-MGC_LOAD
InterPro Arginase UniProtKB/Swiss-Prot
  Ureohydrolase UniProtKB/Swiss-Prot
  Ureohydrolase_dom_sf UniProtKB/Swiss-Prot
  Ureohydrolase_Mn_BS UniProtKB/Swiss-Prot
KEGG Report rno:29221 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108729 IMAGE-MGC_LOAD
NCBI Gene 29221 ENTREZGENE
Pfam Arginase UniProtKB/Swiss-Prot
PhenoGen Arg1 PhenoGen
PIRSF Arginase UniProtKB/Swiss-Prot
PRINTS ARGINASE UniProtKB/Swiss-Prot
PROSITE ARGINASE_1 UniProtKB/Swiss-Prot
  ARGINASE_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52768 UniProtKB/Swiss-Prot
TIGRFAMs rocF_arginase UniProtKB/Swiss-Prot
UniProt ARGI1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q5BK93 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-31 Arg1  arginase 1  Arg1  arginase, liver  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Arg1  arginase, liver  Arg1  arginase 1, liver  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-14 Arg1  arginase 1, liver  Arg1  arginase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-14 Arg1  arginase 1, liver  Arg1  arginase 1, liver  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Arg1  arginase 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the hydrolysis of arginine to ornithine and urea 634666
gene_process plays a role in arginine metabolism 634666
gene_process may play a role in recovery from wounding 634666
gene_process regulates nitric oxide production 634667
gene_regulation increased expression is detected in fibroblasts after wounding 634666