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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2150
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arg1
Name: arginase 1
Acc ID: CHEBI:6482
Term: linuron
Definition: A member of the class of phenylureas that is N-methyl urea substituted by a methoxy group at position 1 and a 3,4-dichlorophenyl group at position 3.
Chemical ID: MESH:D008044
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arg1increases expressionISOArg1 (Mus musculus)6480464CTDLinuron results in increased expression of ARG1 mRNAPMID:30661753
Arg1multiple interactionsISOArg1 (Mus musculus)6480464CTDSIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of ARG1 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of ARG1 mRNA]PMID:30661753
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