Arg1 (arginase 1) - Rat Genome Database

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Gene: Arg1 (arginase 1) Heterocephalus glaber
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Symbol: Arg1
Name: arginase 1
RGD ID: 18915263
Description: ENCODES a protein that exhibits arginase activity (ortholog); identical protein binding (ortholog); manganese ion binding (ortholog); INVOLVED IN arginine catabolic process to ornithine (ortholog); arginine metabolic process (ortholog); cellular response to dexamethasone stimulus (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; argininosuccinic aciduria pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute necrotizing pancreatitis (ortholog); amino acid metabolic disorder (ortholog); FOUND IN extracellular space (ortholog); mitochondrial outer membrane (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: arginase, liver; arginase-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247535,737,237 - 5,752,966 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247535,737,720 - 5,749,313 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arginine catabolic process to ornithine  (IEA,ISO)
arginine metabolic process  (IEA,ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucagon stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-4  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
collagen biosynthetic process  (ISO)
defense response to protozoan  (ISO)
female pregnancy  (ISO)
liver development  (ISO)
lung development  (ISO)
mammary gland involution  (ISO)
maternal process involved in female pregnancy  (ISO)
negative regulation of activated T cell proliferation  (ISO)
negative regulation of T cell proliferation  (ISO)
negative regulation of T-helper 2 cell cytokine production  (ISO)
negative regulation of type II interferon-mediated signaling pathway  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of neutrophil mediated killing of fungus  (ISO)
regulation of L-arginine import across plasma membrane  (ISO)
response to amine  (ISO)
response to amino acid  (ISO)
response to axon injury  (ISO)
response to cadmium ion  (ISO)
response to herbicide  (ISO)
response to lipopolysaccharide  (ISO)
response to manganese ion  (ISO)
response to methylmercury  (ISO)
response to peptide hormone  (ISO)
response to selenium ion  (ISO)
response to steroid hormone  (ISO)
response to vitamin A  (ISO)
response to vitamin E  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
urea cycle  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Arg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247535,737,237 - 5,752,966 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247535,737,720 - 5,749,313 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ARG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386131,573,226 - 131,584,329 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6131,470,832 - 131,584,332 (+)EnsemblGRCh38hg38GRCh38
GRCh376131,894,366 - 131,905,469 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366131,936,058 - 131,947,161 (+)NCBINCBI36Build 36hg18NCBI36
Build 346131,936,057 - 131,947,161NCBI
Celera6132,641,003 - 132,652,108 (+)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6129,475,527 - 129,486,657 (+)NCBIHuRef
CHM1_16132,158,130 - 132,169,259 (+)NCBICHM1_1
T2T-CHM13v2.06132,767,703 - 132,778,804 (+)NCBIT2T-CHM13v2.0
Arg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391024,791,105 - 24,803,368 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1024,791,119 - 24,803,382 (-)EnsemblGRCm39 Ensembl
GRCm381024,915,207 - 24,927,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1024,915,221 - 24,927,484 (-)EnsemblGRCm38mm10GRCm38
MGSCv371024,635,013 - 24,647,276 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361024,604,637 - 24,617,896 (-)NCBIMGSCv36mm8
Celera1025,846,180 - 25,858,528 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1012.26NCBI
Arg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8122,295,093 - 22,307,720 (+)NCBIGRCr8
mRatBN7.2120,475,878 - 20,488,422 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl120,475,968 - 20,488,422 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx120,252,638 - 20,265,091 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,252,577 - 26,265,080 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0120,452,538 - 20,464,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0121,525,421 - 21,537,872 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,525,421 - 21,537,863 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,005,260 - 23,017,714 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4120,998,894 - 21,011,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1120,999,006 - 21,011,333 (+)NCBI
Celera119,228,309 - 19,241,078 (+)NCBICelera
Cytogenetic Map1p12NCBI
Arg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543612,235,767 - 12,251,972 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543612,235,767 - 12,247,817 (+)NCBIChiLan1.0ChiLan1.0
ARG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25151,578,718 - 151,592,958 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16149,485,403 - 149,496,465 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06129,372,747 - 129,383,880 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16133,479,966 - 133,491,162 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6133,479,966 - 133,491,162 (+)Ensemblpanpan1.1panPan2
ARG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112242,717 - 255,736 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12242,714 - 255,305 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12380,548 - 393,575 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.012386,327 - 399,472 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.112243,210 - 256,371 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012313,845 - 327,006 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.012384,828 - 398,005 (-)NCBIUU_Cfam_GSD_1.0
ARG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl132,006,046 - 32,028,988 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1132,006,035 - 32,028,983 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2135,580,471 - 35,603,458 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11341,971,955 - 41,983,372 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1341,971,802 - 41,983,049 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604014,133,035 - 14,144,266 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


RefSeq Acc Id: ENSHGLT00000022466   ⟹   ENSHGLP00000022255
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247535,737,237 - 5,752,966 (+)Ensembl
RefSeq Acc Id: XM_004845992   ⟹   XP_004846049
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247535,737,720 - 5,749,313 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004846049 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000022255
  ENSHGLP00000038366
  ENSHGLP00100054611
GenBank Protein JAO03512 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004846049   ⟸   XM_004845992
- UniProtKB: A0A0P6JN26 (UniProtKB/TrEMBL),   G5C776 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000022255   ⟸   ENSHGLT00000022466


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015864 Ensembl, ENTREZGENE
  ENSHGLG00000043532 UniProtKB/TrEMBL
  ENSHGLG00100049246 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000022466 ENTREZGENE
  ENSHGLT00000081915 UniProtKB/TrEMBL
  ENSHGLT00100063161 UniProtKB/TrEMBL
Gene3D-CATH Ureohydrolase domain UniProtKB/TrEMBL
InterPro Arginase UniProtKB/TrEMBL
  Ureohydrolase UniProtKB/TrEMBL
  Ureohydrolase_dom_sf UniProtKB/TrEMBL
  Ureohydrolase_Mn_BS UniProtKB/TrEMBL
KEGG Report hgl:101703947 UniProtKB/TrEMBL
NCBI Gene Arg1 ENTREZGENE
PANTHER ARGINASE-1 UniProtKB/TrEMBL
  PTHR43782 UniProtKB/TrEMBL
Pfam Arginase UniProtKB/TrEMBL
PIRSF Arginase UniProtKB/TrEMBL
PRINTS ARGINASE UniProtKB/TrEMBL
PROSITE ARGINASE_1 UniProtKB/TrEMBL
  ARGINASE_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52768 UniProtKB/TrEMBL
UniProt A0A0P6JN26 ENTREZGENE, UniProtKB/TrEMBL
  G5C776 ENTREZGENE, UniProtKB/TrEMBL