ARG1 (arginase 1) - Rat Genome Database

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Gene: ARG1 (arginase 1) Sus scrofa
Analyze
Symbol: ARG1
Name: arginase 1
RGD ID: 14112549
Description: ENCODES a protein that exhibits arginase activity (ortholog); identical protein binding (ortholog); manganese ion binding (ortholog); INVOLVED IN arginine catabolic process to ornithine (ortholog); arginine metabolic process (ortholog); cellular response to dexamethasone stimulus (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; argininosuccinic aciduria pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute necrotizing pancreatitis (ortholog); amino acid metabolic disorder (ortholog); FOUND IN extracellular space (ortholog); mitochondrial outer membrane (ortholog); neuronal cell body (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide; cadmium atom; cadmium dichloride
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: arginase I; arginase, liver; arginase-1; liver-type arginase; type I arginase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl132,006,046 - 32,028,988 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1132,006,035 - 32,028,983 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2135,580,471 - 35,603,458 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arginine catabolic process to ornithine  (IBA,IEA,ISO)
arginine metabolic process  (IEA,ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucagon stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-4  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
collagen biosynthetic process  (ISO)
defense response to protozoan  (IEA)
female pregnancy  (ISO)
liver development  (ISO)
lung development  (ISO)
mammary gland involution  (ISO)
maternal process involved in female pregnancy  (ISO)
negative regulation of activated T cell proliferation  (IEA)
negative regulation of T cell proliferation  (IEA)
negative regulation of T-helper 2 cell cytokine production  (IEA)
negative regulation of type II interferon-mediated signaling pathway  (IEA)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of neutrophil mediated killing of fungus  (IEA)
regulation of L-arginine import across plasma membrane  (ISO)
response to amine  (ISO)
response to amino acid  (ISO)
response to axon injury  (ISO)
response to cadmium ion  (ISO)
response to herbicide  (ISO)
response to lipopolysaccharide  (ISO)
response to manganese ion  (ISO)
response to methylmercury  (ISO)
response to peptide hormone  (ISO)
response to selenium ion  (ISO)
response to steroid hormone  (ISO)
response to vitamin A  (ISO)
response to vitamin E  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
urea cycle  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:17379953   PMID:19293328   PMID:22301074   PMID:30032202   PMID:34206713  


Genomics

Comparative Map Data
ARG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl132,006,046 - 32,028,988 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1132,006,035 - 32,028,983 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2135,580,471 - 35,603,458 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386131,573,226 - 131,584,329 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6131,470,832 - 131,584,332 (+)EnsemblGRCh38hg38GRCh38
GRCh376131,894,366 - 131,905,469 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366131,936,058 - 131,947,161 (+)NCBINCBI36Build 36hg18NCBI36
Build 346131,936,057 - 131,947,161NCBI
Celera6132,641,003 - 132,652,108 (+)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6129,475,527 - 129,486,657 (+)NCBIHuRef
CHM1_16132,158,130 - 132,169,259 (+)NCBICHM1_1
T2T-CHM13v2.06132,767,703 - 132,778,804 (+)NCBIT2T-CHM13v2.0
Arg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391024,791,105 - 24,803,368 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1024,791,119 - 24,803,382 (-)EnsemblGRCm39 Ensembl
GRCm381024,915,207 - 24,927,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1024,915,221 - 24,927,484 (-)EnsemblGRCm38mm10GRCm38
MGSCv371024,635,013 - 24,647,276 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361024,604,637 - 24,617,896 (-)NCBIMGSCv36mm8
Celera1025,846,180 - 25,858,528 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1012.26NCBI
Arg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8122,295,093 - 22,307,720 (+)NCBIGRCr8
mRatBN7.2120,475,878 - 20,488,422 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl120,475,968 - 20,488,422 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx120,252,638 - 20,265,091 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,252,577 - 26,265,080 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0120,452,538 - 20,464,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0121,525,421 - 21,537,872 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,525,421 - 21,537,863 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,005,260 - 23,017,714 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4120,998,894 - 21,011,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1120,999,006 - 21,011,333 (+)NCBI
Celera119,228,309 - 19,241,078 (+)NCBICelera
Cytogenetic Map1p12NCBI
Arg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543612,235,767 - 12,251,972 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543612,235,767 - 12,247,817 (+)NCBIChiLan1.0ChiLan1.0
ARG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25151,578,718 - 151,592,958 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16149,485,403 - 149,496,465 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06129,372,747 - 129,383,880 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16133,479,966 - 133,491,162 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6133,479,966 - 133,491,162 (+)Ensemblpanpan1.1panPan2
ARG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112242,717 - 255,736 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12242,714 - 255,305 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12380,548 - 393,575 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.012386,327 - 399,472 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.112243,210 - 256,371 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012313,845 - 327,006 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.012384,828 - 398,005 (-)NCBIUU_Cfam_GSD_1.0
ARG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11341,971,955 - 41,983,372 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1341,971,802 - 41,983,049 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604014,133,035 - 14,144,266 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247535,737,237 - 5,752,966 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247535,737,720 - 5,749,313 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARG1
832 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2
Low 4 1 1 1 1 1
Below cutoff 6 4 2 2 2 15 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_214048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005659190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021082739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021082745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021082747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK235882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK236963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK350425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK391419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK391563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK396024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY039112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU570820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU633754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01041212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSSSCT00000004636   ⟹   ENSSSCP00000004530
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl132,006,051 - 32,028,988 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000035404   ⟹   ENSSSCP00000029011
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl132,006,046 - 32,016,114 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000098309   ⟹   ENSSSCP00000074822
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl132,006,051 - 32,028,988 (-)Ensembl
RefSeq Acc Id: NM_214048   ⟹   NP_999213
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1132,006,766 - 32,020,302 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005659190   ⟹   XP_005659247
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1132,006,035 - 32,028,983 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021082739   ⟹   XP_020938398
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1132,006,035 - 32,028,983 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021082745   ⟹   XP_020938404
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1132,006,035 - 32,020,568 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021082747   ⟹   XP_020938406
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1132,006,035 - 32,028,983 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020938406   ⟸   XM_021082747
- Peptide Label: isoform X1
- UniProtKB: Q95JC8 (UniProtKB/Swiss-Prot),   A0A480QN87 (UniProtKB/TrEMBL),   A0A8D1LX53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005659247   ⟸   XM_005659190
- Peptide Label: isoform X1
- UniProtKB: Q95JC8 (UniProtKB/Swiss-Prot),   A0A480QN87 (UniProtKB/TrEMBL),   A0A8D1LX53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938398   ⟸   XM_021082739
- Peptide Label: isoform X1
- UniProtKB: Q95JC8 (UniProtKB/Swiss-Prot),   A0A480QN87 (UniProtKB/TrEMBL),   A0A8D1LX53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938404   ⟸   XM_021082745
- Peptide Label: isoform X1
- UniProtKB: Q95JC8 (UniProtKB/Swiss-Prot),   A0A480QN87 (UniProtKB/TrEMBL),   A0A8D1LX53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999213   ⟸   NM_214048
- UniProtKB: Q95JC8 (UniProtKB/Swiss-Prot),   A0A480QN87 (UniProtKB/TrEMBL),   A0A8D1LX53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000029011   ⟸   ENSSSCT00000035404
RefSeq Acc Id: ENSSSCP00000004530   ⟸   ENSSSCT00000004636
RefSeq Acc Id: ENSSSCP00000074822   ⟸   ENSSSCT00000098309


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004195 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00005028353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00015057664 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00025000224 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00035053824 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00040053749 UniProtKB/TrEMBL
  ENSSSCG00045007689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00050026950 UniProtKB/TrEMBL
  ENSSSCG00055014125 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00065062146 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00070019904 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000004636 ENTREZGENE
  ENSSSCT00000004636.5 UniProtKB/Swiss-Prot
  ENSSSCT00000035404 ENTREZGENE
  ENSSSCT00000035404.4 UniProtKB/TrEMBL
  ENSSSCT00000098309.1 UniProtKB/TrEMBL
  ENSSSCT00005044893.1 UniProtKB/Swiss-Prot
  ENSSSCT00005044916.1 UniProtKB/Swiss-Prot
  ENSSSCT00005044927.1 UniProtKB/Swiss-Prot
  ENSSSCT00005044998.1 UniProtKB/TrEMBL
  ENSSSCT00015076899.1 UniProtKB/TrEMBL
  ENSSSCT00015077075.1 UniProtKB/Swiss-Prot
  ENSSSCT00025000287.1 UniProtKB/Swiss-Prot
  ENSSSCT00025000299.1 UniProtKB/TrEMBL
  ENSSSCT00035071810.1 UniProtKB/Swiss-Prot
  ENSSSCT00035071822.1 UniProtKB/TrEMBL
  ENSSSCT00040072706.1 UniProtKB/TrEMBL
  ENSSSCT00040072833.1 UniProtKB/TrEMBL
  ENSSSCT00045012855.1 UniProtKB/TrEMBL
  ENSSSCT00045012908.1 UniProtKB/Swiss-Prot
  ENSSSCT00050036288.1 UniProtKB/TrEMBL
  ENSSSCT00055027862.1 UniProtKB/TrEMBL
  ENSSSCT00055027949.1 UniProtKB/Swiss-Prot
  ENSSSCT00065085231.1 UniProtKB/Swiss-Prot
  ENSSSCT00065085237.1 UniProtKB/TrEMBL
  ENSSSCT00070039531.1 UniProtKB/Swiss-Prot
  ENSSSCT00070039536.1 UniProtKB/Swiss-Prot
Gene3D-CATH Ureohydrolase domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Arginase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ureohydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ureohydrolase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ureohydrolase_Mn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397115 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene ARG1 ENTREZGENE
PANTHER ARGINASE-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43782 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arginase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Arginase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ARGINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ARGINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARGINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52768 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A480QN87 ENTREZGENE, UniProtKB/TrEMBL
  A0A5S8LD81_PIG UniProtKB/TrEMBL
  A0A8D0LRA7_PIG UniProtKB/TrEMBL
  A0A8D0U7C3_PIG UniProtKB/TrEMBL
  A0A8D1F549_PIG UniProtKB/TrEMBL
  A0A8D1KF76_PIG UniProtKB/TrEMBL
  A0A8D1LX53 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4F6P6_PIG UniProtKB/TrEMBL
  ARGI1_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:85454 ENTREZGENE