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Gene: ARG1 (arginase 1) Homo sapiens
Symbol: ARG1
Name: arginase 1
Description: Predicted to have manganese ion binding activity. Involved in negative regulation of T cell proliferation; negative regulation of interferon-gamma-mediated signaling pathway; and positive regulation of neutrophil mediated killing of fungus. Localizes to extracellular space. Implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Biomarker of asthma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: arginase, liver; arginase-1; liver-type arginase; type I arginase
Mus musculus (house mouse) : Arg1 (arginase, liver)  MGI  Alliance
Rattus norvegicus (Norway rat) : Arg1 (arginase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arg1 (arginase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ARG1 (arginase 1)
Canis lupus familiaris (dog) : ARG1 (arginase 1)
Sus scrofa (pig) : ARG1 (arginase 1)
Chlorocebus sabaeus (African green monkey) : ARG1 (arginase 1)
Heterocephalus glaber (naked mole-rat) : Arg1 (arginase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl6131,470,832 - 131,584,332 (+)EnsemblGRCh38hg38GRCh38
GRCh386131,573,226 - 131,584,329 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376131,894,344 - 131,905,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366131,936,058 - 131,947,161 (+)NCBINCBI36hg18NCBI36
Build 346131,936,057 - 131,947,161NCBI
Celera6132,641,003 - 132,652,108 (+)NCBI
Cytogenetic Map6q23.2NCBI
HuRef6129,475,527 - 129,486,657 (+)NCBIHuRef
CHM1_16132,158,130 - 132,169,259 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ARG1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353986
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.