ASL (argininosuccinate lyase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: ASL (argininosuccinate lyase) Chlorocebus sabaeus
Analyze
Symbol: ASL
Name: argininosuccinate lyase
RGD ID: 18725350
Description: ENCODES a protein that exhibits argininosuccinate lyase activity (ortholog); INVOLVED IN amino acid metabolic process (ortholog); ammonia assimilation cycle (ortholog); argininosuccinate metabolic process (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; argininosuccinic aciduria pathway; ASSOCIATED WITH amino acid metabolic disorder (ortholog); argininosuccinic aciduria (ortholog); autistic disorder (ortholog); FOUND IN cell body fiber (ortholog); mitochondrial outer membrane (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1281,782,434 - 1,800,581 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl281,782,553 - 1,802,517 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607014,846,508 - 14,865,029 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ASL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1281,782,434 - 1,800,581 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl281,782,553 - 1,802,517 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607014,846,508 - 14,865,029 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ASL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38766,075,819 - 66,093,576 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl766,075,800 - 66,094,697 (+)EnsemblGRCh38hg38GRCh38
GRCh37765,540,806 - 65,558,563 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36765,178,211 - 65,195,765 (+)NCBINCBI36Build 36hg18NCBI36
Build 34764,984,963 - 65,002,090NCBI
Celera766,555,388 - 66,572,941 (-)NCBICelera
Cytogenetic Map7q11.21ENTREZGENE
HuRef761,727,625 - 61,745,174 (+)NCBIHuRef
CHM1_1765,636,440 - 65,653,994 (+)NCBICHM1_1
T2T-CHM13v2.0767,297,906 - 67,315,665 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2764,878,281 - 64,895,827 (+)NCBI
Asl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395130,040,099 - 130,053,222 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5130,040,099 - 130,058,088 (-)EnsemblGRCm39 Ensembl
GRCm385130,011,258 - 130,024,381 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5130,011,258 - 130,029,247 (-)EnsemblGRCm38mm10GRCm38
MGSCv375130,487,373 - 130,500,201 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365130,296,206 - 130,309,034 (-)NCBIMGSCv36mm8
Celera5127,015,654 - 127,028,488 (-)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map568.37NCBI
Asl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,295,779 - 32,313,257 (+)NCBIGRCr8
mRatBN7.21226,659,664 - 26,677,136 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,659,565 - 26,679,662 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1227,807,557 - 27,824,901 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01228,418,086 - 28,435,430 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01227,479,553 - 27,496,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01230,160,922 - 30,178,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1230,165,694 - 30,178,341 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,097,760 - 32,115,110 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41227,702,882 - 27,720,230 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11227,570,168 - 27,583,445 (+)NCBI
Celera1228,373,639 - 28,390,987 (+)NCBICelera
Cytogenetic Map12q12NCBI
Asl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554568,411,220 - 8,416,992 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554568,409,767 - 8,419,915 (-)NCBIChiLan1.0ChiLan1.0
ASL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.16768,522 - 779,144 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl6730,358 - 779,424 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha62,468,962 - 2,479,644 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.06573,409 - 584,014 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl6565,544 - 584,326 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.16517,146 - 527,808 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.06511,138 - 521,729 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.06682,422 - 693,029 (-)NCBIUU_Cfam_GSD_1.0
Asl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344126,336,725 - 126,347,816 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365437,688,741 - 7,699,851 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365437,688,788 - 7,699,842 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl316,637,481 - 16,646,867 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1316,637,481 - 16,646,869 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2316,889,701 - 16,899,549 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Asl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247408,414,733 - 8,423,777 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247408,414,664 - 8,423,797 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000016386   ⟹   ENSCSAP00000014301
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl281,782,553 - 1,802,517 (+)Ensembl
RefSeq Acc Id: XM_008018254   ⟹   XP_008016445
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1281,782,434 - 1,800,581 (+)NCBI
Vero_WHO_p1.0NW_02366607014,846,731 - 14,865,029 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008018255   ⟹   XP_008016446
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1281,782,529 - 1,800,581 (+)NCBI
Vero_WHO_p1.0NW_02366607014,846,731 - 14,864,945 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037990579   ⟹   XP_037846507
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607014,846,508 - 14,864,945 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008016445 (Get FASTA)   NCBI Sequence Viewer  
  XP_008016446 (Get FASTA)   NCBI Sequence Viewer  
  XP_037846507 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000014301.1
RefSeq Acc Id: XP_008016445   ⟸   XM_008018254
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S0B2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008016446   ⟸   XM_008018255
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S0B2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000014301   ⟸   ENSCSAT00000016386
RefSeq Acc Id: XP_037846507   ⟸   XM_037990579
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S0B2 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000018289 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000016386.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.275.10 UniProtKB/TrEMBL
  Fumarase/aspartase (C-terminal domain) UniProtKB/TrEMBL
  Fumarase/aspartase (Central domain) UniProtKB/TrEMBL
InterPro Arg_succ_lyase_C UniProtKB/TrEMBL
  Argininosuccinate_lyase UniProtKB/TrEMBL
  Fumarase/histidase_N UniProtKB/TrEMBL
  Fumarate_lyase_CS UniProtKB/TrEMBL
  Fumarate_lyase_fam UniProtKB/TrEMBL
  Fumarate_lyase_N UniProtKB/TrEMBL
  L-Aspartase-like UniProtKB/TrEMBL
KEGG Report csab:103246575 UniProtKB/TrEMBL
NCBI Gene ASL ENTREZGENE
PANTHER ARGININOSUCCINATE LYASE UniProtKB/TrEMBL
  PTHR43814 UniProtKB/TrEMBL
Pfam ASL_C2 UniProtKB/TrEMBL
  Lyase_1 UniProtKB/TrEMBL
PRINTS ARGSUCLYASE UniProtKB/TrEMBL
  FUMRATELYASE UniProtKB/TrEMBL
PROSITE FUMARATE_LYASES UniProtKB/TrEMBL
Superfamily-SCOP SSF48557 UniProtKB/TrEMBL
UniProt A0A0D9S0B2 ENTREZGENE, UniProtKB/TrEMBL