Gusb (glucuronidase, beta) - Rat Genome Database

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Gene: Gusb (glucuronidase, beta) Rattus norvegicus
Analyze
Symbol: Gusb
Name: glucuronidase, beta
RGD ID: 2772
Description: Enables beta-glucuronidase activity and carbohydrate binding activity. Predicted to be involved in chondroitin sulfate catabolic process; heparan sulfate proteoglycan catabolic process; and hyaluronan catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular space and lysosomal lumen. Biomarker of mucopolysaccharidosis and peritonitis. Human ortholog(s) of this gene implicated in Sly syndrome. Orthologous to human GUSB (glucuronidase beta); PARTICIPATES IN acute intermittent porphyria pathway; congenital sucrase-isomaltase deficiency pathway; erythropoietic porphyria pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ac2-223; beta-glucuronidase; Gus-s
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,337,281 - 32,350,838 (+)NCBIGRCr8
mRatBN7.21226,701,188 - 26,714,718 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,697,951 - 26,726,905 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1227,848,970 - 27,862,457 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01228,459,495 - 28,472,985 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01227,520,988 - 27,534,476 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01230,202,066 - 30,215,583 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1230,198,822 - 30,227,771 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,139,367 - 32,152,883 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41227,744,409 - 27,757,755 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11227,607,658 - 27,620,971 (+)NCBI
Celera1228,414,852 - 28,428,552 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amlodipine  (EXP)
ammonium chloride  (EXP)
anthocyanin  (EXP)
atrazine  (EXP)
benoxaprofen  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (EXP)
cis-caffeic acid  (EXP)
cobalt dichloride  (EXP)
compound 48/80  (EXP)
cumene hydroperoxide  (ISO)
Cuprizon  (EXP)
curcumin  (EXP)
cyclophosphamide  (EXP)
cytochalasin B  (EXP)
D-mannopyranose 6-phosphate  (ISO)
D-mannose 6-phosphate  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
ellagic acid  (EXP)
endosulfan  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (ISO)
ferulic acid  (EXP)
Fexofenadine hydrochloride  (ISO)
flavonoids  (EXP)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycine betaine  (EXP)
histamine  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
mangiferin  (EXP)
menadione  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
misonidazole  (EXP,ISO)
myo-inositol hexakisphosphate  (EXP)
myrtenal  (EXP)
N,O-dimethyltyramine  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
naringin  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP)
nicorandil  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
parathion-methyl  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
phenytoin  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
resveratrol  (ISO)
S-allylcysteine  (EXP)
selenic acid  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
suramin  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
trans-caffeic acid  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Actinomycin D peritonitis in the rat. Arrigoni-Martelli E, Fed Proc. 1976 Nov;35(13):2457-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Nucleotide sequence of rat preputial gland beta-glucuronidase cDNA and in vitro insertion of its encoded polypeptide into microsomal membranes. Nishimura Y, etal., Proc Natl Acad Sci U S A 1986 Oct;83(19):7292-6.
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
11. Cloning, sequencing, and expression of cDNA for human beta-glucuronidase. Oshima A, etal., Proc Natl Acad Sci U S A 1987 Feb;84(3):685-9.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. Rat liver beta-glucuronidase. cDNA cloning, sequence comparisons and expression of a chimeric protein in COS cells. Powell PP, etal., Biochem J 1988 Mar 1;250(2):547-55.
15. Alterations in certain lysosomal glycohydrolases and cathepsins in rats on dexamethasone administration. Rajashree S and Puvanakrishnan R, Mol Cell Biochem. 1996 Jan 26;154(2):165-70.
16. The suramin-treated rat as a model of mucopolysaccharidosis. Variation in the reversibility of biochemical and morphological changes among different organs. Rees S, etal., Virchows Arch B Cell Pathol Incl Mol Pathol. 1986;52(3):259-72. doi: 10.1007/BF02889967.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
21. Effect of concurrent administration of aspirin, indomethacin or hydrocortisone with gold sodium thiomalate against adjuvant-induced arthritis in the rat. Sofia DR, etal., Agents Actions. 1976 Nov;6(6):728-34. doi: 10.1007/BF02026096.
22. Reversal of pathology in murine mucopolysaccharidosis type VII by somatic cell gene transfer. Wolfe JH, etal., Nature 1992 Dec 24-31;360(6406):749-53.
Additional References at PubMed
PMID:1914521   PMID:4777306   PMID:4841576   PMID:7203014   PMID:8889548   PMID:12782150   PMID:15358052   PMID:18523484   PMID:19056867   PMID:19710420   PMID:19751987   PMID:19946888  
PMID:20028034   PMID:23376485   PMID:23533145   PMID:25645918   PMID:29078076   PMID:29514215  


Genomics

Comparative Map Data
Gusb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,337,281 - 32,350,838 (+)NCBIGRCr8
mRatBN7.21226,701,188 - 26,714,718 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,697,951 - 26,726,905 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1227,848,970 - 27,862,457 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01228,459,495 - 28,472,985 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01227,520,988 - 27,534,476 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01230,202,066 - 30,215,583 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1230,198,822 - 30,227,771 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,139,367 - 32,152,883 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41227,744,409 - 27,757,755 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11227,607,658 - 27,620,971 (+)NCBI
Celera1228,414,852 - 28,428,552 (+)NCBICelera
Cytogenetic Map12q12NCBI
GUSB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38765,960,684 - 65,982,213 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl765,960,684 - 65,982,215 (-)EnsemblGRCh38hg38GRCh38
GRCh37765,425,671 - 65,447,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36765,063,106 - 65,084,681 (-)NCBINCBI36Build 36hg18NCBI36
Build 34764,869,824 - 64,891,346NCBI
Celera766,666,375 - 66,688,005 (+)NCBICelera
Cytogenetic Map7q11.21NCBI
HuRef761,613,080 - 61,634,635 (-)NCBIHuRef
CHM1_1765,520,933 - 65,542,533 (-)NCBICHM1_1
T2T-CHM13v2.0767,182,808 - 67,204,306 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2764,763,190 - 64,784,820 (-)NCBI
Gusb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395130,011,278 - 130,031,890 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5130,017,852 - 130,031,890 (-)EnsemblGRCm39 Ensembl
GRCm385129,989,011 - 130,003,049 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5129,989,011 - 130,003,049 (-)EnsemblGRCm38mm10GRCm38
MGSCv375130,464,891 - 130,478,698 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365130,273,724 - 130,287,531 (-)NCBIMGSCv36mm8
Celera5126,991,862 - 127,006,971 (-)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map568.32NCBI
Gusb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554568,378,654 - 8,392,252 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554568,377,161 - 8,392,298 (-)NCBIChiLan1.0ChiLan1.0
GUSB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2681,270,069 - 81,293,057 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17129,597,227 - 129,619,836 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0760,087,130 - 60,109,289 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1764,724,628 - 64,745,040 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl764,724,841 - 64,744,909 (-)Ensemblpanpan1.1panPan2
GUSB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.16730,345 - 743,916 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl6730,358 - 779,424 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha62,430,980 - 2,444,321 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.06535,764 - 548,724 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl6535,765 - 549,610 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.16479,152 - 492,513 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.06473,517 - 486,454 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.06644,508 - 657,770 (-)NCBIUU_Cfam_GSD_1.0
Gusb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344126,304,099 - 126,314,709 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365437,721,763 - 7,731,897 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365437,721,273 - 7,732,468 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUSB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl316,671,389 - 16,689,203 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1316,672,071 - 16,686,520 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2316,924,697 - 16,939,444 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103246571
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1281,621,293 - 1,646,097 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl281,620,359 - 1,646,075 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607015,002,837 - 15,024,286 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gusb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247408,390,197 - 8,401,387 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247408,390,096 - 8,401,063 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gusb
128 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:230
Count of miRNA genes:159
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000001215, ENSRNOT00000041645
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134043551788Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)122423477731894213Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat

Markers in Region
D5Mit27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21226,704,113 - 26,704,326 (+)MAPPERmRatBN7.2
Rnor_6.01230,204,978 - 30,205,190NCBIRnor6.0
Rnor_5.01232,142,279 - 32,142,491UniSTSRnor5.0
RGSC_v3.41227,747,321 - 27,747,533UniSTSRGSC3.4
Celera1228,417,763 - 28,417,975UniSTS
Cytogenetic Map12q13UniSTS
Gus-s  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21226,704,111 - 26,704,346 (+)MAPPERmRatBN7.2
Rnor_6.01230,204,976 - 30,205,210NCBIRnor6.0
Rnor_5.01232,142,277 - 32,142,511UniSTSRnor5.0
RGSC_v3.41227,747,319 - 27,747,553UniSTSRGSC3.4
Celera1228,417,761 - 28,417,995UniSTS
Cytogenetic Map12q13UniSTS
RH130072  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21226,714,495 - 26,714,645 (+)MAPPERmRatBN7.2
Rnor_6.01230,215,363 - 30,215,512NCBIRnor6.0
Rnor_5.01232,152,663 - 32,152,812UniSTSRnor5.0
RGSC_v3.41227,757,535 - 27,757,684UniSTSRGSC3.4
Celera1228,428,332 - 28,428,481UniSTS
RH 3.4 Map12452.5UniSTS
Cytogenetic Map12q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000001215   ⟹   ENSRNOP00000001215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1226,701,204 - 26,714,705 (+)Ensembl
Rnor_6.0 Ensembl1230,202,055 - 30,215,581 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000041645   ⟹   ENSRNOP00000045033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1226,697,951 - 26,726,905 (+)Ensembl
Rnor_6.0 Ensembl1230,198,822 - 30,227,771 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103940   ⟹   ENSRNOP00000084597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1226,697,951 - 26,714,702 (+)Ensembl
RefSeq Acc Id: NM_017015   ⟹   NP_058711
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,337,307 - 32,350,838 (+)NCBI
mRatBN7.21226,701,188 - 26,714,718 (+)NCBI
Rnor_6.01230,202,066 - 30,215,583 (+)NCBI
Rnor_5.01232,139,367 - 32,152,883 (+)NCBI
RGSC_v3.41227,744,409 - 27,757,755 (+)RGD
Celera1228,414,852 - 28,428,552 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598255   ⟹   XP_017453744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,339,545 - 32,350,835 (+)NCBI
mRatBN7.21226,703,428 - 26,714,718 (+)NCBI
Rnor_6.01230,204,292 - 30,215,583 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063271038   ⟹   XP_063127108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,339,473 - 32,350,835 (+)NCBI
RefSeq Acc Id: XM_063271039   ⟹   XP_063127109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,337,281 - 32,341,112 (+)NCBI
RefSeq Acc Id: NP_058711   ⟸   NM_017015
- Peptide Label: precursor
- UniProtKB: P06760 (UniProtKB/Swiss-Prot),   F1LQQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453744   ⟸   XM_017598255
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000045033   ⟸   ENSRNOT00000041645
Ensembl Acc Id: ENSRNOP00000001215   ⟸   ENSRNOT00000001215
Ensembl Acc Id: ENSRNOP00000084597   ⟸   ENSRNOT00000103940
RefSeq Acc Id: XP_063127109   ⟸   XM_063271039
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZZP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127108   ⟸   XM_063271038
- Peptide Label: isoform X1
Protein Domains
Glycoside hydrolase family 2 catalytic   Glycoside hydrolase family 2 immunoglobulin-like   Glycosyl hydrolases family 2 sugar binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06760-F1-model_v2 AlphaFold P06760 1-648 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698580
Promoter ID:EPDNEW_R9105
Type:initiation region
Name:Gusb_1
Description:glucuronidase, beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01230,202,090 - 30,202,150EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2772 AgrOrtholog
BioCyc Gene G2FUF-19513 BioCyc
Ensembl Genes ENSRNOG00000000913 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001215.7 UniProtKB/TrEMBL
  ENSRNOT00000041645.5 UniProtKB/TrEMBL
  ENSRNOT00000103940.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycosidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Beta-gal/glucu_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_2_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_2_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_2_Ig-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_2_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24434 UniProtKB/Swiss-Prot
NCBI Gene 24434 ENTREZGENE
PANTHER BETA-GLUCURONIDASE UniProtKB/Swiss-Prot
  BETA-GLUCURONIDASE UniProtKB/Swiss-Prot
  BETA-GLUCURONIDASE UniProtKB/TrEMBL
  BETA-GLUCURONIDASE UniProtKB/TrEMBL
Pfam Glyco_hydro_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_2_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gusb PhenoGen
PRINTS GLHYDRLASE2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLYCOSYL_HYDROL_F2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLYCOSYL_HYDROL_F2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000913 RatGTEx
Superfamily-SCOP SSF49303 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZZP5 ENTREZGENE, UniProtKB/TrEMBL
  A6J0N6_RAT UniProtKB/TrEMBL
  A6J0N7_RAT UniProtKB/TrEMBL
  BGLR_RAT UniProtKB/Swiss-Prot
  F1LQQ8 ENTREZGENE, UniProtKB/TrEMBL
  P06760 ENTREZGENE
  Q7TPJ3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gusb  Glucuronidase, beta      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog causes mucopolysaccharidosis type VII 731201