Gene: Gusb (glucuronidase, beta) Rattus norvegicus
Analyze
Symbol:
Gusb
Name:
glucuronidase, beta
Description:
Exhibits beta-glucuronidase activity and carbohydrate binding activity. Predicted to be involved in glucuronoside catabolic process. Localizes to lysosome. Human ortholog(s) of this gene implicated in Sly syndrome. Orthologous to human GUSB (glucuronidase beta); PARTICIPATES IN acute intermittent porphyria pathway; congenital sucrase-isomaltase deficiency pathway; erythropoietic porphyria pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (R)-lipoic acid.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
Ac2-223; beta-glucuronidase; Gus-s
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
GUSB (glucuronidase beta) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Gusb (glucuronidase, beta) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Gusb (glucuronidase beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
GUSB (glucuronidase beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
GUSB (glucuronidase beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Gusb (glucuronidase beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
GUSB (glucuronidase beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
GUSB (glucuronidase beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Gusb (glucuronidase beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
GUSBP11 (GUSB pseudogene 11) HGNC
PhylomeDB
Alliance orthologs 3
Homo sapiens (human):
GUSB (glucuronidase beta)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Mus musculus (house mouse):
Gusb (glucuronidase, beta)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Danio rerio (zebrafish):
gusb (glucuronidase, beta)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Drosophila melanogaster (fruit fly):
CG15117
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|InParanoid|OrthoInspector|Hieranoid)
Caenorhabditis elegans (roundworm):
Y105E8B.9
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Drosophila melanogaster (fruit fly):
betaGlu
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|InParanoid|OrthoInspector|Hieranoid)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: suggests misassembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 12 30,202,066 - 30,215,583 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 12 30,198,822 - 30,227,771 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 12 32,139,367 - 32,152,883 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 12 27,744,409 - 27,757,755 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 12 27,607,658 - 27,620,971 (+) NCBI Celera 12 28,414,852 - 28,428,552 (+) NCBI Celera Cytogenetic Map 12 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
argininosuccinic aciduria ISO RGD:737258 8554872 ClinVar Annotator: match by term: Argininosuccinate lyase deficiency ClinVar PMID:28492532 Hydrops Fetalis ISO RGD:737258 8554872 ClinVar Annotator: match by term: Non-immune hydrops fetalis ClinVar PMID:26036949 Hydrops Fetalis ISO RGD:737258 8554872 ClinVar Annotator: match by term: Non-immune hydrops fetalis ClinVar PMID:19224584 more ... Hydrops Fetalis ISO RGD:737258 8554872 ClinVar Annotator: match by term: Non-immune hydrops fetalis ClinVar PMID:1702266 more ... mucopolysaccharidosis VI ISO RGD:737258 8554872 ClinVar Annotator: match by term: Mucopolysaccharidosis type VI ClinVar PMID:19224584 more ... mucopolysaccharidosis VI ISO RGD:737258 8554872 ClinVar Annotator: match by term: Mucopolysaccharidosis type VI ClinVar PMID:12403825 more ... pleomorphic xanthoastrocytoma ISO RGD:737258 8554872 ClinVar Annotator: match by term: Pleomorphic xanthoastrocytoma ClinVar PMID:28299358 prostate cancer ISO RGD:737258 8554872 ClinVar Annotator: match by term: Prostate cancer ClinVar PMID:23265383 Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by term: Mucopolysaccharidosis type VII ClinVar PMID:25741868 , PMID:9490302 Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by term: Sly syndrome ClinVar PMID:24260279 , PMID:28492532 Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by term: Sly syndrome ClinVar PMID:19224584 more ... Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by term: Sly syndrome ClinVar PMID:19224584 more ... Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by term: Mucopolysaccharidosis type VII ClinVar PMID:19224584 more ... Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by term: Mucopolysaccharidosis type VII ClinVar PMID:12403825 more ... Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by term: Mucopolysaccharidosis type VII ClinVar PMID:25741868 Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by term: Mucopolysaccharidosis type VII ClinVar PMID:11226217 , PMID:7680524 Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by term: Mucopolysaccharidosis type VII ClinVar PMID:1833732 , PMID:8111412 Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by term: Mucopolysaccharidosis type VII ClinVar PMID:1702266 more ... Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by term: Mucopolysaccharidosis type VII ClinVar PMID:28492532 Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by term: Mucopolysaccharidosis type VII ClinVar PMID:24033266 , PMID:25741868 Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by OMIM:253220 ClinVar PMID:12522561 , PMID:144057 Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by OMIM:253220 ClinVar PMID:8111413 Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by OMIM:253220 ClinVar PMID:9490302 Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by OMIM:253220 ClinVar PMID:1702266 Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by OMIM:253220 ClinVar PMID:6811712 , PMID:8111413 Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by OMIM:253220 ClinVar PMID:12522561 Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by OMIM:253220 ClinVar Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by OMIM:253220 ClinVar PMID:7633414 Sly syndrome ISO RGD:737258 8554872 ClinVar Annotator: match by OMIM:253220 ClinVar PMID:1992472 more ...
Imported Annotations - CTD
nervous system disease ISO RGD:737258 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:7073948 , PMID:7107415 proteinuria ISO RGD:737258 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:2880436 Imported Annotations - OMIM
Sly syndrome ISO RGD:737258 7240710 OMIM
(+)-alpha-tocopherol multiple interactions ISO RGD:1557024 6480464 alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in decreased uptake of GUSB protein], alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of GUSB protein] CTD PMID:19135433 (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of GUSB mRNA] CTD PMID:31150632 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:737258 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of GUSB mRNA, epigallocatechin gallate inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of GUSB protein] CTD PMID:11944907 , PMID:22079256 (-)-epigallocatechin 3-gallate multiple interactions EXP 6480464 epigallocatechin gallate inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:18294627 (R)-lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GUSB protein] CTD PMID:19699728 1,1-dichloroethene increases expression ISO RGD:1557024 6480464 vinylidene chloride results in increased expression of GUSB mRNA CTD PMID:26682919 17beta-estradiol increases expression ISO RGD:1557024 6480464 Estradiol results in increased expression of GUSB mRNA CTD PMID:15289156 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1557024 6480464 Tetrachlorodibenzodioxin affects the expression of GUSB mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of GUSB mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of GUSB mRNA CTD PMID:21346803 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:737258 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GUSB mRNA CTD PMID:28628672 4,4'-diaminodiphenylmethane decreases expression ISO RGD:1557024 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of GUS mRNA CTD PMID:18648102 4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid increases expression ISO RGD:737258 6480464 Am 580 results in increased expression of GUSB mRNA CTD PMID:16982809 4-hydroxyphenyl retinamide decreases expression ISO RGD:1557024 6480464 Fenretinide results in decreased expression of GUSB mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine increases expression ISO RGD:1557024 6480464 Decitabine results in increased expression of GUSB mRNA CTD PMID:27915011 acrylamide increases activity ISO RGD:1557024 6480464 Acrylamide results in increased activity of GUSB protein CTD PMID:7073948 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of GUSB mRNA CTD PMID:28959563 aflatoxin B1 decreases expression ISO RGD:1557024 6480464 Aflatoxin B1 results in decreased expression of GUSB mRNA CTD PMID:19770486 amlodipine multiple interactions EXP 6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:11829124 , PMID:14499179 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of GUSB mRNA CTD PMID:16483693 anthocyanin multiple interactions EXP 6480464 Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of GUSB protein] CTD PMID:25451569 atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of GUSB mRNA CTD PMID:22285353 benoxaprofen increases secretion ISO RGD:737258 6480464 benoxaprofen results in increased secretion of GUSB protein CTD PMID:6737371 benzene multiple interactions EXP 6480464 Benzene affects the localization of and results in decreased activity of GUSB protein, Selenic Acid inhibits the reaction [Benzene affects the localization of and results in decreased activity of GUSB protein] CTD PMID:79528 benzo[a]pyrene multiple interactions ISO RGD:1557024 6480464 [lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of GUSB mRNA more ... CTD PMID:19654925 more ... benzo[a]pyrene multiple interactions ISO RGD:737258 6480464 GUSB protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] more ... CTD PMID:26438400 benzo[a]pyrene increases expression ISO RGD:1557024 6480464 Benzo(a)pyrene results in increased expression of GUSB mRNA CTD PMID:22228805 bisphenol A increases expression ISO RGD:1557024 6480464 bisphenol A results in increased expression of GUSB mRNA CTD PMID:26063408 , PMID:30303745 bisphenol A multiple interactions ISO RGD:737258 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GUSB mRNA CTD PMID:28628672 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of GUSB mRNA CTD PMID:25181051 carbamazepine affects expression ISO RGD:737258 6480464 Carbamazepine affects the expression of GUSB mRNA CTD PMID:25979313 carbon nanotube increases expression ISO RGD:1557024 6480464 Nanotubes, Carbon analog results in increased expression of GUSB mRNA, Nanotubes, Carbon results in increased expression of GUSB mRNA CTD PMID:25554681 choline multiple interactions ISO RGD:1557024 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GUSB mRNA CTD PMID:20938992 cis-caffeic acid multiple interactions EXP 6480464 caffeic acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:20391626 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of GUSB mRNA CTD PMID:24386269 compound 48/80 increases secretion EXP 6480464 p-Methoxy-N-methylphenethylamine results in increased secretion of GUSB protein CTD PMID:9545557 cumene hydroperoxide multiple interactions ISO RGD:1557024 6480464 alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in decreased uptake of GUSB protein], alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of GUSB protein] CTD PMID:19135433 cumene hydroperoxide decreases uptake ISO RGD:1557024 6480464 cumene hydroperoxide results in decreased uptake of GUSB protein CTD PMID:19135433 cumene hydroperoxide increases secretion ISO RGD:1557024 6480464 cumene hydroperoxide results in increased secretion of GUSB protein CTD PMID:19135433 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:8534267 cyclophosphamide decreases expression EXP 6480464 Cyclophosphamide results in decreased expression of GUSB protein CTD PMID:17686619 cyclophosphamide increases activity EXP 6480464 Cyclophosphamide results in increased activity of GUSB protein CTD PMID:25451569 cyclophosphamide multiple interactions EXP 6480464 Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of GUSB protein], Plant Extracts inhibits the reaction [Cyclophosphamide results in increased activity of GUSB protein] CTD PMID:25451569 D-mannopyranose 6-phosphate multiple interactions ISO RGD:737258 6480464 mannose-6-phosphate affects the reaction [GUSB protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]] CTD PMID:26438400 D-mannose 6-phosphate multiple interactions ISO RGD:737258 6480464 mannose-6-phosphate affects the reaction [GUSB protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]] CTD PMID:26438400 dexamethasone multiple interactions ISO RGD:1557024 6480464 Dexamethasone inhibits the reaction [Misonidazole results in increased activity of GUSB protein] CTD PMID:6696821 dexamethasone multiple interactions ISO RGD:737258 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GUSB mRNA CTD PMID:28628672 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of GUSB mRNA CTD PMID:21266533 diethylstilbestrol increases expression ISO RGD:1557024 6480464 Diethylstilbestrol results in increased expression of GUSB mRNA CTD PMID:15289156 divanadium pentaoxide affects expression ISO RGD:1557024 6480464 vanadium pentoxide affects the expression of GUSB mRNA CTD PMID:26210822 doxorubicin affects response to substance ISO RGD:737258 6480464 GUSB protein affects the susceptibility to Doxorubicin CTD PMID:16217747 doxorubicin decreases expression ISO RGD:737258 6480464 Doxorubicin results in decreased expression of GUSB mRNA CTD PMID:29803840 doxorubicin decreases expression ISO RGD:1557024 6480464 Doxorubicin results in decreased expression of GUSB mRNA CTD PMID:15033991 ellagic acid multiple interactions EXP 6480464 Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:21762681 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of GUSB mRNA CTD PMID:29391264 ethanol increases expression EXP 6480464 Ethanol results in increased expression of GUSB mRNA CTD PMID:17920746 ethanol increases expression ISO RGD:1557024 6480464 Ethanol results in increased expression of GUSB mRNA CTD PMID:30319688 ethyl methanesulfonate increases expression ISO RGD:737258 6480464 Ethyl Methanesulfonate results in increased expression of GUSB mRNA CTD PMID:23649840 fenvalerate increases activity ISO RGD:1557024 6480464 fenvalerate results in increased activity of GUSB protein CTD PMID:7175102 ferulic acid multiple interactions EXP 6480464 [ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:17045618 Fexofenadine hydrochloride multiple interactions ISO RGD:737258 6480464 fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of GUSB protein], fexofenadine inhibits the reaction [Histamine results in increased expression of GUSB protein] CTD PMID:11238657 flavonoids increases expression EXP 6480464 Flavonoids results in increased expression of GUSB mRNA CTD PMID:18035473 flurbiprofen multiple interactions ISO RGD:1557024 6480464 Flurbiprofen inhibits the reaction [Misonidazole results in increased activity of GUSB protein] CTD PMID:6696821 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of GUSB mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:1557024 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GUSB mRNA CTD PMID:20938992 gamma-hexachlorocyclohexane affects activity EXP 6480464 Hexachlorocyclohexane affects the activity of GUSB protein CTD PMID:8519523 genistein increases expression ISO RGD:1557024 6480464 Genistein results in increased expression of GUSB mRNA CTD PMID:15289156 genistein decreases expression EXP 6480464 Genistein results in decreased expression of GUSB mRNA CTD PMID:17341692 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of GUSB mRNA CTD PMID:22061828 glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of GUSB mRNA CTD PMID:24136188 glycine betaine multiple interactions EXP 6480464 Betaine inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein], Betaine inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:19294532 histamine multiple interactions ISO RGD:737258 6480464 fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of GUSB protein] more ... CTD PMID:11238657 histamine increases expression ISO RGD:737258 6480464 Histamine results in increased expression of GUSB protein CTD PMID:11238657 indometacin multiple interactions ISO RGD:737258 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GUSB mRNA CTD PMID:28628672 isoprenaline multiple interactions EXP 6480464 [ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] more ... CTD PMID:11829124 more ... isoprenaline increases activity EXP 6480464 Isoproterenol results in increased activity of GUSB protein CTD PMID:11829124 more ... isoprenaline decreases activity EXP 6480464 Isoproterenol results in decreased activity of GUSB protein CTD PMID:17188415 more ... isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of GUSB mRNA CTD PMID:17182065 L-ascorbic acid multiple interactions EXP 6480464 [ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:17045618 L-methionine multiple interactions ISO RGD:1557024 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GUSB mRNA CTD PMID:20938992 lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GUSB protein] CTD PMID:19699728 lipopolysaccharide multiple interactions ISO RGD:1557024 6480464 [Lipopolysaccharides co-treated with Benzo(a)pyrene] affects the activity of GUSB protein CTD PMID:26438400 lipopolysaccharide affects activity ISO RGD:1557024 6480464 Lipopolysaccharides affects the activity of GUSB protein CTD PMID:26438400 lipopolysaccharide multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GUSB protein] CTD PMID:19699728 lipopolysaccharide decreases activity EXP 6480464 Lipopolysaccharides results in decreased activity of GUSB protein CTD PMID:19699728 mangiferin multiple interactions EXP 6480464 mangiferin inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein] CTD PMID:19172585 menadione affects expression ISO RGD:737258 6480464 Vitamin K 3 affects the expression of GUSB mRNA CTD PMID:20044591 methoxychlor decreases expression EXP 6480464 Methoxychlor results in decreased expression of GUSB mRNA CTD PMID:22285353 methoxychlor increases expression EXP 6480464 Methoxychlor results in increased expression of GUSB mRNA CTD PMID:22285353 methyl methanesulfonate increases expression ISO RGD:737258 6480464 Methyl Methanesulfonate results in increased expression of GUSB mRNA CTD PMID:23649840 myrtenal multiple interactions EXP 6480464 myrtenal inhibits the reaction [[Phenobarbital co-treated with Diethylnitrosamine] results in increased activity of GUSB protein] CTD PMID:22436021 N,O-dimethyltyramine increases secretion EXP 6480464 p-Methoxy-N-methylphenethylamine results in increased secretion of GUSB protein CTD PMID:9545557 N-formyl-L-methionyl-L-leucyl-L-phenylalanine multiple interactions ISO RGD:737258 6480464 epigallocatechin gallate inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of GUSB protein] CTD PMID:11944907 N-formyl-L-methionyl-L-leucyl-L-phenylalanine increases secretion EXP 6480464 N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of GUSB protein CTD PMID:9545557 N-formyl-L-methionyl-L-leucyl-L-phenylalanine increases secretion ISO RGD:737258 6480464 N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of GUSB protein CTD PMID:11944907 N-nitrosodiethylamine multiple interactions EXP 6480464 [Phenobarbital co-treated with Diethylnitrosamine] results in increased activity of GUSB protein, myrtenal inhibits the reaction [[Phenobarbital co-treated with Diethylnitrosamine] results in increased activity of GUSB protein] CTD PMID:22436021 naringin multiple interactions EXP 6480464 naringin inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein], naringin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:17188415 nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of GUSB mRNA CTD PMID:24136188 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of GUSB mRNA CTD PMID:22110744 nickel dichloride increases activity EXP 6480464 nickel chloride results in increased activity of GUSB protein CTD PMID:12028813 nicorandil multiple interactions EXP 6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:11829124 , PMID:14499179 paclitaxel affects response to substance ISO RGD:737258 6480464 GUSB protein affects the susceptibility to Paclitaxel CTD PMID:16217747 paracetamol affects expression ISO RGD:1557024 6480464 Acetaminophen affects the expression of GUSB mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:737258 6480464 Acetaminophen results in increased expression of GUSB mRNA, Acetaminophen results in increased expression of GUSB protein CTD PMID:17642144 , PMID:22230336 parathion-methyl decreases activity EXP 6480464 Methyl Parathion results in decreased activity of GUSB protein CTD PMID:3008131 , PMID:3008132 phenobarbital multiple interactions EXP 6480464 [Phenobarbital co-treated with Diethylnitrosamine] results in increased activity of GUSB protein, myrtenal inhibits the reaction [[Phenobarbital co-treated with Diethylnitrosamine] results in increased activity of GUSB protein] CTD PMID:22436021 phenytoin multiple interactions ISO RGD:1557024 6480464 Phenytoin inhibits the reaction [Misonidazole results in increased activity of GUSB protein] CTD PMID:6696821 phenytoin decreases activity ISO RGD:1557024 6480464 Phenytoin results in decreased activity of GUSB protein CTD PMID:6696821 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of GUSB mRNA CTD PMID:19162173 potassium chromate increases expression ISO RGD:737258 6480464 potassium chromate(VI) results in increased expression of GUSB mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:737258 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of GUSB mRNA CTD PMID:22079256 resveratrol multiple interactions ISO RGD:1557024 6480464 resveratrol inhibits the reaction [triptolide results in decreased activity of GUSB protein] CTD PMID:29723566 S-allylcysteine multiple interactions EXP 6480464 S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of GUSB mRNA] CTD PMID:17182065 selenic acid multiple interactions EXP 6480464 Selenic Acid inhibits the reaction [Benzene affects the localization of and results in decreased activity of GUSB protein] CTD PMID:79528 silver atom increases expression ISO RGD:1557024 6480464 Silver results in increased expression of GUSB mRNA CTD PMID:19429238 silver(0) increases expression ISO RGD:1557024 6480464 Silver results in increased expression of GUSB mRNA CTD PMID:19429238 Soman increases expression EXP 6480464 Soman results in increased expression of GUSB mRNA CTD PMID:19281266 sunitinib decreases expression ISO RGD:737258 6480464 Sunitinib results in decreased expression of GUSB mRNA CTD PMID:31533062 tert-butyl hydroperoxide decreases expression ISO RGD:737258 6480464 tert-Butylhydroperoxide results in decreased expression of GUSB mRNA CTD PMID:15336504 tetrachloromethane increases expression ISO RGD:1557024 6480464 Carbon Tetrachloride results in increased expression of GUSB mRNA CTD PMID:27339419 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of GUSB mRNA] CTD PMID:31150632 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of GUSB mRNA CTD PMID:31150632 titanium dioxide increases expression ISO RGD:1557024 6480464 titanium dioxide results in increased expression of GUSB mRNA CTD PMID:23409001 trans-caffeic acid multiple interactions EXP 6480464 caffeic acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:20391626 Triptolide multiple interactions ISO RGD:1557024 6480464 resveratrol inhibits the reaction [triptolide results in decreased activity of GUSB protein] CTD PMID:29723566 Triptolide decreases activity ISO RGD:1557024 6480464 triptolide results in decreased activity of GUSB protein CTD PMID:29723566 valproic acid increases expression ISO RGD:737258 6480464 Valproic Acid results in increased expression of GUSB mRNA CTD PMID:19101580 , PMID:23179753 valproic acid increases methylation ISO RGD:737258 6480464 Valproic Acid results in increased methylation of GUSB gene CTD PMID:29154799 vancomycin decreases expression ISO RGD:1557024 6480464 Vancomycin results in decreased expression of GUSB mRNA CTD PMID:18930951 vincaleukoblastine affects response to substance ISO RGD:737258 6480464 GUSB protein affects the susceptibility to Vinblastine CTD PMID:16217747 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of GUSB mRNA CTD PMID:22285353 , PMID:23034163 vitamin E multiple interactions ISO RGD:1557024 6480464 alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in decreased uptake of GUSB protein], alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of GUSB protein] CTD PMID:19135433
Gene-Chemical Interaction Annotations
