RGD Reference Report - Actinomycin D peritonitis in the rat. - Rat Genome Database

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Actinomycin D peritonitis in the rat.

Authors: Arrigoni-Martelli, E 
Citation: Arrigoni-Martelli E, Fed Proc. 1976 Nov;35(13):2457-7.
RGD ID: 42722008
Pubmed: PMID:185091   (View Abstract at PubMed)

Following intraperitoneal injection of actinomycin D rats show a decrease in number of cells present in the peritoneal cavity, reaching the lowest point after 24 hr. At the same time a highly significant increase of free beta-glucoronidase and of the intracellular concentrations of both cyclic AMP and cyclic GMP has been observed. No exudate was present at this time. Measurable quantities of exudate were present 48-72 hr after actinomycin injection concomitantly with an intense cellular immigration, the dominant cell being mononuclears. In this second phase of the reaction the free beta-glucuronidase decreases towards normal values and both the cyclic nucleotides are significantly below the control values. It is suggested that the increase of intracellular cAMP--concomitant with the maximum release of lysosomal enzymes--is a feedback mechanism preventing further release of inflammatory mediators.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
peritonitis  ISOGusb (Rattus norvegicus)42722008; 42722008protein:altered expression:peritoneal cells (rat)RGD 
peritonitis  IEP 42722008protein:altered expression:peritoneal cells (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gusb  (glucuronidase, beta)

Genes (Mus musculus)
Gusb  (glucuronidase, beta)

Genes (Homo sapiens)
GUSB  (glucuronidase beta)


Additional Information