Acacb (acetyl-CoA carboxylase beta) - Rat Genome Database

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Gene: Acacb (acetyl-CoA carboxylase beta) Rattus norvegicus
Analyze
Symbol: Acacb
Name: acetyl-CoA carboxylase beta
RGD ID: 620500
Description: Exhibits biotin binding activity. Involved in response to drug and response to organic cyclic compound. Localizes to mitochondrion. Used to study fatty liver disease. Orthologous to human ACACB (acetyl-CoA carboxylase beta); PARTICIPATES IN fatty acid biosynthetic pathway; insulin signaling pathway; propanoate metabolic pathway; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (R)-mevalonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Acc2; acetyl-CoA carboxylase 2; acetyl-Coenzyme A carboxylase 2; acetyl-Coenzyme A carboxylase beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21242,365,800 - 42,477,651 (-)NCBI
Rnor_6.0 Ensembl1248,127,149 - 48,238,887 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01248,127,149 - 48,238,969 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01249,914,427 - 50,000,957 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,388,679 - 43,492,993 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11243,252,066 - 43,356,381 (-)NCBI
Celera1243,976,897 - 44,062,163 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-schisandrin B  (EXP)
(R)-mevalonic acid  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cyclosporin A  (ISO)
D-mannitol  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
fenofibrate  (ISO)
folic acid  (ISO)
fructose  (EXP,ISO)
furan  (ISO)
genistein  (ISO)
GW 4064  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
O-methyleugenol  (ISO)
olaparib  (ISO)
oleic acid  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
puerarin  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tenofovir disoproxil fumarate  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:11283375   PMID:12764144   PMID:12920182   PMID:15579580   PMID:15590647   PMID:15677334   PMID:16854592   PMID:17210641   PMID:17956983   PMID:18255222   PMID:18487439   PMID:18614015  
PMID:19236960   PMID:19618481   PMID:20457939   PMID:20952656   PMID:25195817   PMID:26976583  


Genomics

Candidate Gene Status
Acacb is a candidate Gene for QTL Bw128
Acacb is a candidate Gene for QTL Bw132
Acacb is a candidate Gene for QTL Foco6
Acacb is a candidate Gene for QTL Foco10
Acacb is a candidate Gene for QTL Foco20
Comparative Map Data
Acacb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21242,365,800 - 42,477,651 (-)NCBI
Rnor_6.0 Ensembl1248,127,149 - 48,238,887 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01248,127,149 - 48,238,969 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01249,914,427 - 50,000,957 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,388,679 - 43,492,993 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11243,252,066 - 43,356,381 (-)NCBI
Celera1243,976,897 - 44,062,163 (-)NCBICelera
Cytogenetic Map12q16NCBI
ACACB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12109,116,595 - 109,268,226 (+)EnsemblGRCh38hg38GRCh38
GRCh3812109,112,666 - 109,268,226 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712109,554,392 - 109,706,031 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612108,061,585 - 108,190,414 (+)NCBINCBI36hg18NCBI36
Build 3412108,039,930 - 108,166,887NCBI
Celera12109,201,352 - 109,330,479 (+)NCBI
Cytogenetic Map12q24.11NCBI
HuRef12106,595,722 - 106,724,234 (+)NCBIHuRef
CHM1_112109,544,852 - 109,673,937 (+)NCBICHM1_1
Acacb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395114,284,378 - 114,388,822 (+)NCBIGRCm39mm39
GRCm39 Ensembl5114,284,596 - 114,388,822 (+)Ensembl
GRCm385114,146,321 - 114,250,761 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,146,535 - 114,250,761 (+)EnsemblGRCm38mm10GRCm38
MGSCv375114,615,527 - 114,700,767 (+)NCBIGRCm37mm9NCBIm37
MGSCv365114,426,517 - 114,510,733 (+)NCBImm8
Celera5111,267,324 - 111,357,484 (+)NCBICelera
Cytogenetic Map5FNCBI
Acacb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545510,308,192 - 10,426,076 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545510,282,308 - 10,427,439 (+)NCBIChiLan1.0ChiLan1.0
ACACB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112110,086,374 - 110,239,847 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12110,086,374 - 110,239,847 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012106,692,668 - 106,845,490 (+)NCBIMhudiblu_PPA_v0panPan3
ACACB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12617,763,531 - 17,895,319 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2617,747,362 - 17,894,400 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2617,906,250 - 18,037,960 (+)NCBI
ROS_Cfam_1.02618,106,936 - 18,239,349 (-)NCBI
UMICH_Zoey_3.12618,115,480 - 18,247,107 (+)NCBI
UNSW_CanFamBas_1.02618,097,758 - 18,229,980 (-)NCBI
UU_Cfam_GSD_1.02618,116,847 - 18,248,772 (-)NCBI
Acacb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118144,422,223 - 144,525,063 (-)NCBI
SpeTri2.0NW_004936769950,970 - 1,053,671 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACACB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11441,621,574 - 41,739,916 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21444,153,373 - 44,271,216 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACACB
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111104,325,250 - 104,488,567 (+)NCBI
ChlSab1.1 Ensembl11104,349,573 - 104,488,003 (+)Ensembl
Acacb
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474712,287,817 - 12,426,340 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12421005149210051Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6922362652716770Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922362652716770Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922362652716770Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922363052716770Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12978983452716770Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121312721150320041Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121441977552716770Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121502198652716770Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121590890052716770Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121590890052716770Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121834247752716770Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121834247752716770Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121872904352716770Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121875259352716770Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101875259352716770Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)122265070248598906Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)122265070252716770Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122490659052716770Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122609884552716770Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122911360949560679Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122911360950757185Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123172356551955754Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123172356552716770Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123752188451955754Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:202
Count of miRNA genes:86
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000000821, ENSRNOT00000067975
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 22 13 3 13 8 11 21 5 11 8
Low 3 35 28 16 28 72 14 36
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB004329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC131519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM237460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ493871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB872073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB873333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB875204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB879714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB888449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB921258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC929482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC930742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC932613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC937123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC945858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC978667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000000821   ⟹   ENSRNOP00000000821
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1248,128,408 - 48,218,955 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000067975   ⟹   ENSRNOP00000060736
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1248,128,405 - 48,218,955 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078868   ⟹   ENSRNOP00000071816
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1248,127,149 - 48,238,887 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080557   ⟹   ENSRNOP00000073473
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1248,128,405 - 48,218,955 (-)Ensembl
RefSeq Acc Id: NM_053922   ⟹   NP_446374
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21242,365,800 - 42,477,651 (-)NCBI
Rnor_6.01248,128,405 - 48,218,955 (-)NCBI
Rnor_5.01249,914,427 - 50,000,957 (-)NCBI
RGSC_v3.41243,388,679 - 43,492,993 (-)RGD
Celera1243,976,897 - 44,062,163 (-)RGD
Sequence:
RefSeq Acc Id: XM_008769309   ⟹   XP_008767531
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01248,127,149 - 48,238,968 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769313   ⟹   XP_008767535
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01248,127,149 - 48,238,968 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598242   ⟹   XP_017453731
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21242,365,800 - 42,477,509 (-)NCBI
Rnor_6.01248,127,149 - 48,238,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598243   ⟹   XP_017453732
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21242,365,800 - 42,467,804 (-)NCBI
Rnor_6.01248,127,149 - 48,229,431 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598244   ⟹   XP_017453733
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01248,127,149 - 48,238,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598245   ⟹   XP_017453734
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21242,365,800 - 42,466,946 (-)NCBI
Rnor_6.01248,127,149 - 48,228,340 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598246   ⟹   XP_017453735
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21242,365,800 - 42,477,508 (-)NCBI
Rnor_6.01248,127,149 - 48,238,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598247   ⟹   XP_017453736
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21242,365,800 - 42,448,872 (-)NCBI
Rnor_6.01248,127,149 - 48,210,393 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598248   ⟹   XP_017453737
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21242,365,800 - 42,442,942 (-)NCBI
Rnor_6.01248,127,149 - 48,205,056 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039089030   ⟹   XP_038944958
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21242,365,800 - 42,457,635 (-)NCBI
RefSeq Acc Id: XM_039089031   ⟹   XP_038944959
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21242,391,852 - 42,477,587 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446374   ⟸   NM_053922
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_008767535   ⟸   XM_008769313
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008767531   ⟸   XM_008769309
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017453735   ⟸   XM_017598246
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017453731   ⟸   XM_017598242
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017453733   ⟸   XM_017598244
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017453732   ⟸   XM_017598243
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017453734   ⟸   XM_017598245
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017453736   ⟸   XM_017598247
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017453737   ⟸   XM_017598248
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000073473   ⟸   ENSRNOT00000080557
RefSeq Acc Id: ENSRNOP00000060736   ⟸   ENSRNOT00000067975
RefSeq Acc Id: ENSRNOP00000000821   ⟸   ENSRNOT00000000821
RefSeq Acc Id: ENSRNOP00000071816   ⟸   ENSRNOT00000078868
RefSeq Acc Id: XP_038944958   ⟸   XM_039089030
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038944959   ⟸   XM_039089031
- Peptide Label: isoform X6
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
12 48218640 48218641 T G snv BBDP/Wor (RGD), LEW/NCrlBR (RGD), LEW/Crl (RGD)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620500 AgrOrtholog
Ensembl Genes ENSRNOG00000000658 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000821 UniProtKB/TrEMBL
  ENSRNOP00000060736 UniProtKB/TrEMBL
  ENSRNOP00000071816 UniProtKB/TrEMBL
  ENSRNOP00000073473 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000821 UniProtKB/TrEMBL
  ENSRNOT00000067975 UniProtKB/TrEMBL
  ENSRNOT00000078868 UniProtKB/TrEMBL
  ENSRNOT00000080557 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.1490.20 UniProtKB/TrEMBL
InterPro AcCoA_carboxyl UniProtKB/TrEMBL
  AcCoA_COase_cen UniProtKB/TrEMBL
  ATP-grasp UniProtKB/TrEMBL
  ATP_grasp_subdomain_1 UniProtKB/TrEMBL
  Biotin_carboxylation_dom UniProtKB/TrEMBL
  Biotin_COase_C UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_ATP-bd UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_N UniProtKB/TrEMBL
  ClpP/crotonase-like_dom UniProtKB/TrEMBL
  COA_CT_C UniProtKB/TrEMBL
  COA_CT_N UniProtKB/TrEMBL
  PreATP-grasp-like UniProtKB/TrEMBL
  Rudment_hybrid_motif UniProtKB/TrEMBL
  Single_hybrid_motif UniProtKB/TrEMBL
KEGG Report rno:116719 UniProtKB/TrEMBL
NCBI Gene 116719 ENTREZGENE
Pfam ACC_central UniProtKB/TrEMBL
  Biotin_carb_C UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/TrEMBL
  Carboxyl_trans UniProtKB/TrEMBL
  CPSase_L_chain UniProtKB/TrEMBL
  CPSase_L_D2 UniProtKB/TrEMBL
PhenoGen Acacb PhenoGen
PROSITE ATP_GRASP UniProtKB/TrEMBL
  BIOTINYL_LIPOYL UniProtKB/TrEMBL
  COA_CT_CTER UniProtKB/TrEMBL
  COA_CT_NTER UniProtKB/TrEMBL
  CPSASE_1 UniProtKB/TrEMBL
  CPSASE_2 UniProtKB/TrEMBL
  PS50979 UniProtKB/TrEMBL
SMART Biotin_carb_C UniProtKB/TrEMBL
Superfamily-SCOP Hybrid_motif UniProtKB/TrEMBL
  PreATP-grasp-like UniProtKB/TrEMBL
  Rudmnt_hyb_motif UniProtKB/TrEMBL
  SSF52096 UniProtKB/TrEMBL
UniProt A0A0G2K1F2_RAT UniProtKB/TrEMBL
  A0A0G2K5L6_RAT UniProtKB/TrEMBL
  B7ZDJ4_RAT UniProtKB/TrEMBL
  D3ZBE2_RAT UniProtKB/TrEMBL
  E9PSQ0_RAT UniProtKB/TrEMBL
  O70151_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Acacb  acetyl-CoA carboxylase beta  Acacb  acetyl-Coenzyme A carboxylase beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Acacb  acetyl-Coenzyme A carboxylase beta      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Acacb  acetyl-Coenzyme A carboxylase beta      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed at high levels in heart, skeletal muscle, and brown adipose tissue 631890
gene_regulation synergystically regulated by sterol regulatory element-binding protein-1 (SREBP1). 631890