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Gene: Trpv4 (transient receptor potential cation channel, subfamily V, member 4) Rattus norvegicus
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Symbol: Trpv4
Name: transient receptor potential cation channel, subfamily V, member 4
Description: Exhibits calcium channel activity; cytoskeletal protein binding activity; and protein kinase C binding activity. Involved in several processes, including actin cytoskeleton organization; calcium ion transport; and microtubule cytoskeleton organization. Localizes to several cellular components, including focal adhesion; lamellipodium; and ruffle membrane. Colocalizes with cytoplasmic microtubule. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV4 (transient receptor potential cation channel subfamily V member 4); INTERACTS WITH 3',5'-cyclic AMP; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: osm-9-like TRP channel 4; osmosensitive transient receptor potential channel 4; Otrpc4; Otrpc4-pending; transient receptor potential cation channel subfamily 5 member 4; transient receptor potential cation channel subfamily V member 4; transient receptor potential cation channel, subfamily 5, member 4; vanilloid receptor-related osmotically activated channel (Vroac); vanilloid receptor-related osmotically-activated channel; VR-OAC; Vroac
Orthologs:
Allele / Splice: Trpv4em5Mcwi   Trpv4em4Mcwi  
Genetic Models: WKY-Trpv4em5Mcwi WKY-Trpv4em4Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01247,698,915 - 47,737,902 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,698,947 - 47,737,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,492,064 - 49,529,956 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,226,933 - 43,265,889 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11243,090,320 - 43,129,277 (+)NCBI
Celera1243,552,408 - 43,590,250 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Trpv4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69337
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2020-05-19
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.