Adap1 (ArfGAP with dual PH domains 1) - Rat Genome Database

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Gene: Adap1 (ArfGAP with dual PH domains 1) Rattus norvegicus
Analyze
Symbol: Adap1
Name: ArfGAP with dual PH domains 1
RGD ID: 621418
Description: Enables inositol 1,3,4,5 tetrakisphosphate binding activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be located in cytosol; nucleus; and plasma membrane. Orthologous to human ADAP1 (ArfGAP with dual PH domains 1); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arf-GAP with dual PH domain-containing protein 1; Centa1; centaurin, alpha 1; p42IP4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81220,438,091 - 20,489,961 (+)NCBIGRCr8
mRatBN7.21215,323,913 - 15,376,110 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,324,209 - 15,380,831 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,134,353 - 16,186,232 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,758,093 - 16,809,976 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,784,243 - 15,836,094 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,416,327 - 17,468,212 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,416,327 - 17,468,212 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,402,559 - 19,454,794 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,825,017 - 15,877,643 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11215,855,021 - 15,906,562 (+)NCBI
Celera1217,078,350 - 17,130,259 (+)NCBICelera
Cytogenetic Map12q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of the brain-specific membrane adapter protein p42IP4/centaurin alpha, a Ins(1,3,4,5)P4/PtdIns(3,4,5)P3 binding protein, in developing rat brain. Aggensteiner M and Reiser G, Brain Res Dev Brain Res 2003 Apr 14;142(1):77-87.
2. Identification of rat brain p42(IP4), a high-affinity inositol(1,3,4, 5)tetrakisphosphate/phosphatidylinositol(3,4,5)trisphosphate binding protein. Aggensteiner M, etal., Biochim Biophys Acta 1998 Sep 8;1387(1-2):117-28.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Identification and cloning of centaurin-alpha. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brain. Hammonds-Odie LP, etal., J Biol Chem 1996 Aug 2;271(31):18859-68.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Oligomerization controls in tissue-specific manner ligand binding of native, affinity-purified p42(IP4)/centaurin alpha1 and cytohesins-proteins with high affinity for the messengers D-inositol 1,3,4,5-tetrakisphosphate/phosphatidylinositol 3,4,5-trisphosphate. Stricker R, etal., Biochim Biophys Acta 2003 Sep 23;1651(1-2):102-15.
Additional References at PubMed
PMID:10333475   PMID:10448098   PMID:12477932   PMID:15082226   PMID:15679100   PMID:15923660   PMID:16805830   PMID:17635995   PMID:18298663   PMID:23516302   PMID:30206251  


Genomics

Comparative Map Data
Adap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81220,438,091 - 20,489,961 (+)NCBIGRCr8
mRatBN7.21215,323,913 - 15,376,110 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,324,209 - 15,380,831 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,134,353 - 16,186,232 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,758,093 - 16,809,976 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,784,243 - 15,836,094 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,416,327 - 17,468,212 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,416,327 - 17,468,212 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,402,559 - 19,454,794 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,825,017 - 15,877,643 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11215,855,021 - 15,906,562 (+)NCBI
Celera1217,078,350 - 17,130,259 (+)NCBICelera
Cytogenetic Map12q11NCBI
ADAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387897,900 - 955,407 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7897,900 - 955,407 (-)EnsemblGRCh38hg38GRCh38
GRCh377937,537 - 995,043 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367904,066 - 960,811 (-)NCBINCBI36Build 36hg18NCBI36
Build 347710,780 - 767,508NCBI
Celera7906,136 - 962,035 (-)NCBICelera
Cytogenetic Map7p22.3NCBI
HuRef7855,527 - 893,573 (-)NCBIHuRef
CHM1_17936,645 - 993,431 (-)NCBICHM1_1
T2T-CHM13v2.071,001,683 - 1,060,405 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27992,062 - 1,048,924 (-)NCBI
Adap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,257,631 - 139,311,516 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5139,257,631 - 139,311,377 (-)EnsemblGRCm39 Ensembl
GRCm385139,271,876 - 139,325,763 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,271,876 - 139,325,622 (-)EnsemblGRCm38mm10GRCm38
MGSCv375139,747,830 - 139,801,418 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,525,518 - 139,559,961 (-)NCBIMGSCv36mm8
Celera5136,325,945 - 136,379,615 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map578.27NCBI
Adap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,635,463 - 8,674,455 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,635,463 - 8,674,455 (-)NCBIChiLan1.0ChiLan1.0
ADAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v265,841,176 - 5,899,642 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1754,165,865 - 54,224,306 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v071,054,499 - 1,112,240 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.171,269,235 - 1,316,351 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl71,269,235 - 1,326,102 (-)Ensemblpanpan1.1panPan2
ADAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1615,921,865 - 15,976,101 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl615,898,326 - 15,973,771 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,394,927 - 17,448,262 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,052,553 - 16,105,914 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,028,493 - 16,105,914 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1615,855,375 - 15,908,735 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0615,781,938 - 15,835,092 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,070,134 - 16,124,464 (+)NCBIUU_Cfam_GSD_1.0
Adap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344143,855,837 - 143,879,769 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367541,131,500 - 1,154,528 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367541,130,585 - 1,154,459 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3547,364 - 615,471 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13548,823 - 615,471 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23429,376 - 430,952 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.23695,020 - 722,372 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12820,617,948 - 20,677,848 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2820,617,995 - 20,680,628 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660901,013,133 - 1,073,527 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474026,481,054 - 26,518,469 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474026,481,036 - 26,518,315 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adap1
243 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:415
Count of miRNA genes:196
Interacting mature miRNAs:236
Transcripts:ENSRNOT00000001736
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121300829619212979Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat

Markers in Region
RH131687  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21215,375,796 - 15,376,007 (+)MAPPERmRatBN7.2
Rnor_6.01217,467,900 - 17,468,110NCBIRnor6.0
Rnor_5.01219,454,482 - 19,454,692UniSTSRnor5.0
RGSC_v3.41215,877,331 - 15,877,541UniSTSRGSC3.4
Celera1217,129,947 - 17,130,157UniSTS
RH 3.4 Map12245.9UniSTS
Cytogenetic Map12q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 62 14 1 1
Low 41 43 27 17 27 5 8 12 21 39 10 5
Below cutoff 2 14 14 14 3 3 1 3

Sequence


RefSeq Acc Id: ENSRNOT00000089590   ⟹   ENSRNOP00000075236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1215,324,237 - 15,376,109 (+)Ensembl
Rnor_6.0 Ensembl1217,416,327 - 17,468,212 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092186   ⟹   ENSRNOP00000074351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1215,324,209 - 15,380,831 (+)Ensembl
Rnor_6.0 Ensembl1217,416,411 - 17,467,184 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100857   ⟹   ENSRNOP00000080905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1215,325,407 - 15,376,109 (+)Ensembl
RefSeq Acc Id: NM_133567   ⟹   NP_598251
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81220,438,091 - 20,489,961 (+)NCBI
mRatBN7.21215,324,237 - 15,376,109 (+)NCBI
Rnor_6.01217,416,327 - 17,468,212 (+)NCBI
Rnor_5.01219,402,559 - 19,454,794 (+)NCBI
RGSC_v3.41215,825,017 - 15,877,643 (+)RGD
Celera1217,078,350 - 17,130,259 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598251   ⟹   XP_017453740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81220,439,264 - 20,489,961 (+)NCBI
mRatBN7.21215,325,596 - 15,376,110 (+)NCBI
Rnor_6.01217,417,466 - 17,468,212 (+)NCBI
Sequence:
RefSeq Acc Id: NP_598251   ⟸   NM_133567
- UniProtKB: O88768 (UniProtKB/TrEMBL),   Q9QUI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453740   ⟸   XM_017598251
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000074351   ⟸   ENSRNOT00000092186
RefSeq Acc Id: ENSRNOP00000075236   ⟸   ENSRNOT00000089590
RefSeq Acc Id: ENSRNOP00000080905   ⟸   ENSRNOT00000100857
Protein Domains
Arf-GAP   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K7U5-F1-model_v2 AlphaFold A0A0G2K7U5 1-414 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698469
Promoter ID:EPDNEW_R8993
Type:initiation region
Name:Adap1_1
Description:ArfGAP with dual PH domains 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01217,416,234 - 17,416,294EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621418 AgrOrtholog
BioCyc Gene G2FUF-19887 BioCyc
Ensembl Genes ENSRNOG00000054033 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089590 ENTREZGENE
  ENSRNOT00000089590.2 UniProtKB/TrEMBL
  ENSRNOT00000092186.2 UniProtKB/TrEMBL
  ENSRNOT00000100857.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.220.150 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7933317 IMAGE-MGC_LOAD
InterPro ArfGAP UniProtKB/TrEMBL
  ARFGAP/RecO UniProtKB/TrEMBL
  ArfGAP_dom_sf UniProtKB/TrEMBL
  PH1_ADAP UniProtKB/TrEMBL
  PH2_ADAP UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
KEGG Report rno:171097 UniProtKB/TrEMBL
MGC_CLONE MGC:124568 IMAGE-MGC_LOAD
NCBI Gene 171097 ENTREZGENE
PANTHER ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN UniProtKB/TrEMBL
Pfam ArfGap UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
PhenoGen Adap1 PhenoGen
PRINTS REVINTRACTNG UniProtKB/TrEMBL
PROSITE ARFGAP UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054033 RatGTEx
SMART ArfGap UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF57863 UniProtKB/TrEMBL
UniProt A0A0G2K7U5_RAT UniProtKB/TrEMBL
  A0A8I5ZRW6_RAT UniProtKB/TrEMBL
  A6K1X0_RAT UniProtKB/TrEMBL
  O88768 ENTREZGENE, UniProtKB/TrEMBL
  Q9QUI9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-15 Adap1  ArfGAP with dual PH domains 1  Centa1  centaurin, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Centa1  centaurin, alpha 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Centa1  centaurin, alpha 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed with various levels in the cortex, hippocampus, thalamus, striatum and Cerebellum 632412
gene_process may link the activation of phosphoinositide 3-kinase to downstream responses in the brain 632413