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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of CCT6A mRNA] | CTD | PMID:31150632 | (-)-epigallocatechin 3-gallate | decreases expression | ISO | CCT6A (Homo sapiens) | 6480464 | epigallocatechin gallate results in decreased expression of CCT6A protein | CTD | PMID:31195006 | (1->4)-beta-D-glucan | multiple interactions | ISO | Cct6a (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CCT6A mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | multiple interactions | ISO | Cct6a (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of CCT6A mRNA] | CTD | PMID:22206623 | 1,2-dimethylhydrazine | increases expression | ISO | Cct6a (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of CCT6A mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | ISO | Cct6a (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of CCT6A mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | Cct6a (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCT6A mRNA | CTD | PMID:17942748 | 17beta-estradiol | affects expression | ISO | Cct6a (Mus musculus) | 6480464 | Estradiol affects the expression of CCT6A mRNA | CTD | PMID:15598610 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of CCT6A mRNA | CTD | PMID:26496021 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Cct6a (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Cct6a (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CCT6A mRNA and [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCT6A mRNA | CTD | PMID:16214954 and PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CCT6A mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Cct6a (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of CCT6A mRNA | CTD | PMID:21570461 | 2,4,6-trinitrotoluene | affects expression | EXP | | 6480464 | Trinitrotoluene affects the expression of CCT6A mRNA | CTD | PMID:21346803 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of CCT6A mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of CCT6A mRNA | CTD | PMID:21346803 | 2-amino-14,16-dimethyloctadecan-3-ol | decreases expression | ISO | CCT6A (Homo sapiens) | 6480464 | 2-amino-14 and 16-dimethyloctadecan-3-ol results in decreased expression of CCT6A protein | CTD | PMID:32044396 | 4,4'-sulfonyldiphenol | increases expression | ISO | CCT6A (Homo sapiens) | 6480464 | bis(4-hydroxyphenyl)sulfone results in increased expression of CCT6A protein | CTD | PMID:34186270 | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2 and 6-dinitrotoluene affects the expression of CCT6A mRNA | CTD | PMID:21346803 | acrolein | multiple interactions | ISO | CCT6A (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of CCT6A mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of CCT6A mRNA | CTD | PMID:32699268 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of CCT6A mRNA | CTD | PMID:28959563 | acrylamide | increases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Acrylamide results in increased expression of CCT6A mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of CCT6A mRNA | CTD | PMID:33354967 | all-trans-retinoic acid | decreases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of CCT6A mRNA | CTD | PMID:33167477 | alpha-pinene | multiple interactions | ISO | CCT6A (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of CCT6A mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of CCT6A mRNA | CTD | PMID:32699268 | aminoglutethimide | decreases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Aminoglutethimide results in decreased expression of CCT6A protein | CTD | PMID:26102013 | arsenous acid | increases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of CCT6A protein | CTD | PMID:19364129 | benzatropine | multiple interactions | ISO | CCT6A (Homo sapiens) | 6480464 | [Cuprizone co-treated with Benztropine] results in decreased expression of CCT6A protein | CTD | PMID:34122009 | benzo[a]pyrene | increases expression | ISO | Cct6a (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of CCT6A mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases methylation | ISO | CCT6A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of CCT6A 3' UTR and Benzo(a)pyrene results in increased methylation of CCT6A promoter | CTD | PMID:27901495 | bis(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in increased expression of CCT6A mRNA | CTD | PMID:21318169 | bis(2-ethylhexyl) phthalate | increases expression | ISO | Cct6a (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in increased expression of CCT6A mRNA | CTD | PMID:21318169 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of CCT6A mRNA | CTD | PMID:26496021 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CCT6A mRNA | CTD | PMID:30816183 | bisphenol A | decreases expression | ISO | CCT6A (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of CCT6A mRNA and bisphenol A results in decreased expression of CCT6A protein | CTD | PMID:29275510 and PMID:34186270 | bisphenol A | decreases methylation | ISO | Cct6a (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of CCT6A promoter | CTD | PMID:27312807 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of CCT6A mRNA | CTD | PMID:25181051 | Bisphenol B | increases expression | ISO | CCT6A (Homo sapiens) | 6480464 | bisphenol B results in increased expression of CCT6A protein | CTD | PMID:34186270 | bisphenol F | increases expression | ISO | CCT6A (Homo sapiens) | 6480464 | bisphenol F results in increased expression of CCT6A protein | CTD | PMID:34186270 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of CCT6A mRNA | CTD | PMID:19167457 | caffeine | decreases phosphorylation | ISO | CCT6A (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of CCT6A protein | CTD | PMID:35688186 | calcium dichloride | decreases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Calcium Chloride results in decreased expression of CCT6A protein | CTD | PMID:25824407 | cannabidiol | increases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Cannabidiol results in increased expression of CCT6A protein | CTD | PMID:34122009 | cannabidiol | multiple interactions | ISO | CCT6A (Homo sapiens) | 6480464 | [Cuprizone co-treated with Cannabidiol] results in decreased expression of CCT6A protein | CTD | PMID:34122009 | captan | decreases expression | ISO | Cct6a (Mus musculus) | 6480464 | Captan results in decreased expression of CCT6A mRNA | CTD | PMID:31558096 | carbon nanotube | increases expression | ISO | Cct6a (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chromium(6+) | affects expression | ISO | Cct6a (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of CCT6A mRNA | CTD | PMID:28472532 | cisplatin | decreases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of CCT6A mRNA | CTD | PMID:27594783 | CU-O LINKAGE | increases expression | ISO | CCT6A (Homo sapiens) | 6480464 | cupric oxide results in increased expression of CCT6A protein | CTD | PMID:25470785 | Cuprizon | affects expression | EXP | | 6480464 | Cuprizone affects the expression of CCT6A mRNA | CTD | PMID:27523638 | Cuprizon | multiple interactions | ISO | CCT6A (Homo sapiens) | 6480464 | [Cuprizone co-treated with Benztropine] results in decreased expression of CCT6A protein and [Cuprizone co-treated with Cannabidiol] results in decreased expression of CCT6A protein | CTD | PMID:34122009 | Cuprizon | increases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Cuprizone results in increased expression of CCT6A protein | CTD | PMID:34122009 | cyclosporin A | increases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of CCT6A mRNA | CTD | PMID:20106945 | deguelin | increases expression | ISO | CCT6A (Homo sapiens) | 6480464 | deguelin results in increased expression of CCT6A mRNA | CTD | PMID:33512557 | diarsenic trioxide | increases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of CCT6A protein | CTD | PMID:19364129 | dicrotophos | decreases expression | ISO | CCT6A (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of CCT6A mRNA | CTD | PMID:28302478 | disodium selenite | increases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Sodium Selenite results in increased expression of CCT6A mRNA | CTD | PMID:18175754 | ethanol | affects splicing | ISO | Cct6a (Mus musculus) | 6480464 | Ethanol affects the splicing of CCT6A mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | decreases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of CCT6A mRNA | CTD | PMID:23649840 | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of CCT6A mRNA | CTD | PMID:24136188 | fipronil | decreases expression | EXP | | 6480464 | fipronil results in decreased expression of CCT6A mRNA | CTD | PMID:34044035 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of CCT6A mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Cct6a (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of CCT6A mRNA] | CTD | PMID:22206623 | folpet | decreases expression | ISO | Cct6a (Mus musculus) | 6480464 | folpet results in decreased expression of CCT6A mRNA | CTD | PMID:31558096 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of CCT6A mRNA and Gentamicins results in increased expression of CCT6A protein | CTD | PMID:22061828 and PMID:33387578 | hydrogen peroxide | affects expression | ISO | CCT6A (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of CCT6A mRNA | CTD | PMID:20044591 | irinotecan | decreases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Irinotecan analog results in decreased expression of CCT6A mRNA | CTD | PMID:18927307 | ivermectin | decreases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of CCT6A protein | CTD | PMID:32959892 | lead(0) | affects expression | ISO | CCT6A (Homo sapiens) | 6480464 | Lead affects the expression of CCT6A mRNA | CTD | PMID:28903495 | lithocholic acid | decreases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Lithocholic Acid results in decreased expression of CCT6A protein | CTD | PMID:21224350 | lovastatin | increases expression | ISO | Cct6a (Mus musculus) | 6480464 | Lovastatin results in increased expression of CCT6A mRNA | CTD | PMID:20493250 | megestrol acetate | increases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Megestrol Acetate results in increased expression of CCT6A protein | CTD | PMID:16939895 | methyl methanesulfonate | decreases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of CCT6A mRNA | CTD | PMID:23649840 | N-nitrosomorpholine | increases expression | EXP | | 6480464 | N-nitrosomorpholine results in increased expression of CCT6A protein | CTD | PMID:19716841 | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of CCT6A mRNA | CTD | PMID:24136188 | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of CCT6A mRNA | CTD | PMID:24136188 | ozone | multiple interactions | ISO | CCT6A (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of CCT6A mRNA more ... | CTD | PMID:32699268 | paracetamol | affects expression | ISO | Cct6a (Mus musculus) | 6480464 | Acetaminophen affects the expression of CCT6A mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of CCT6A mRNA | CTD | PMID:21420995 | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of CCT6A mRNA | CTD | PMID:32680482 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Cct6a (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CCT6A mRNA | CTD | PMID:36331819 | pirinixic acid | increases expression | ISO | Cct6a (Mus musculus) | 6480464 | pirinixic acid results in increased expression of CCT6A mRNA | CTD | PMID:15375163 and PMID:18301758 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of CCT6A mRNA | CTD | PMID:19162173 and PMID:21318169 | propiconazole | increases expression | ISO | Cct6a (Mus musculus) | 6480464 | propiconazole results in increased expression of CCT6A mRNA | CTD | PMID:21278054 | rotenone | increases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Rotenone results in increased expression of CCT6A mRNA | CTD | PMID:33512557 | silicon dioxide | affects secretion | ISO | CCT6A (Homo sapiens) | 6480464 | Silicon Dioxide analog affects the secretion of CCT6A protein | CTD | PMID:25895662 | sodium arsenite | decreases expression | ISO | CCT6A (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of CCT6A protein | CTD | PMID:30528433 | sodium dichromate | increases expression | EXP | | 6480464 | sodium bichromate results in increased expression of CCT6A mRNA | CTD | PMID:25993096 | sodium dichromate | decreases expression | ISO | Cct6a (Mus musculus) | 6480464 | sodium bichromate results in decreased expression of CCT6A mRNA | CTD | PMID:31558096 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of CCT6A mRNA | CTD | PMID:31150632 | tetrachloromethane | increases expression | ISO | Cct6a (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of CCT6A mRNA | CTD | PMID:31919559 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of CCT6A mRNA] | CTD | PMID:31150632 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of CCT6A mRNA | CTD | PMID:34492290 | trichloroethene | multiple interactions | ISO | Cct6a (Mus musculus) | 6480464 | PPARA protein inhibits the reaction [Trichloroethylene results in increased expression of CCT6A protein] | CTD | PMID:15363585 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of CCT6A mRNA | CTD | PMID:33387578 | trichloroethene | increases expression | ISO | Cct6a (Mus musculus) | 6480464 | Trichloroethylene results in increased expression of CCT6A mRNA | CTD | PMID:15363585 | trimellitic anhydride | increases expression | ISO | Cct6a (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of CCT6A mRNA | CTD | PMID:19042947 | tunicamycin | decreases expression | ISO | CCT6A (Homo sapiens) | 6480464 | Tunicamycin results in decreased expression of CCT6A mRNA | CTD | PMID:29453283 | valdecoxib | increases expression | EXP | | 6480464 | valdecoxib results in increased expression of CCT6A mRNA | CTD | PMID:24136188 | valproic acid | affects expression | ISO | Cct6a (Mus musculus) | 6480464 | Valproic Acid affects the expression of CCT6A mRNA | CTD | PMID:17292431 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of CCT6A mRNA | CTD | PMID:21318169 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of CCT6A mRNA | CTD | PMID:19015723 | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of CCT6A mRNA | CTD | PMID:20566332 | warfarin | increases expression | ISO | Cct6a (Mus musculus) | 6480464 | Warfarin results in increased expression of CCT6A mRNA | CTD | PMID:20493250 | zinc atom | multiple interactions | ISO | CCT6A (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of CCT6A mRNA | CTD | PMID:18593933 | zinc(0) | multiple interactions | ISO | CCT6A (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of CCT6A mRNA | CTD | PMID:18593933 | |