Spnl2 (sialophorin like 2) - Rat Genome Database

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Gene: Spnl2 (sialophorin like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Spnl2
Name: sialophorin like 2
RGD ID: 1559964
Description: Predicted to enable heat shock protein binding activity. Predicted to be involved in cell surface receptor signaling pathway; defense response to bacterium; and regulation of immune response. Predicted to be active in external side of plasma membrane. Orthologous to human SPN (sialophorin).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC498157; Leukosialin-like; MGC112692; similar to Leukosialin precursor (Leucocyte sialoglycoprotein) (Sialophorin) (CD43) (W3/13 antigen); uncharacterized protein LOC498157
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81221,239,923 - 21,244,886 (-)NCBIGRCr8
mRatBN7.21216,126,150 - 16,131,108 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1216,126,150 - 16,131,163 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,937,731 - 16,942,684 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01217,561,460 - 17,566,415 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01216,629,959 - 16,634,912 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,280,858 - 18,286,468 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,264,361 - 18,286,426 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,252,508 - 20,274,574 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41216,634,927 - 16,639,883 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1217,876,836 - 17,881,797 (-)NCBICelera
Cytogenetic Map12q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Spnl2Ratcell surface receptor signaling pathway involved_inIBAMGI:98384 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Spnl2Ratdefense response to bacterium involved_inIBAMGI:98384 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Spnl2Ratregulation of immune response involved_inIBAMGI:98384 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Spnl2Ratregulation of T cell activation involved_inIEAInterPro:IPR0388291600115GO_REF:0000002InterProGO_REF:0000002
Spnl2Ratregulation of T cell migration involved_inIEAInterPro:IPR0388291600115GO_REF:0000002InterProGO_REF:0000002

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Spnl2Ratexternal side of plasma membrane is_active_inIBAMGI:98384 and PANTHER:PTN0021739151600115GO_REF:0000033GO_CentralGO_REF:0000033
Spnl2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Spnl2Ratheat shock protein binding enablesIBAMGI:98384 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Spnl2Rattransmembrane signaling receptor activity enablesIEAInterPro:IPR0388291600115GO_REF:0000002InterProGO_REF:0000002


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.


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Variants in Spnl2
61 total Variants

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:88
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000032844, ENSRNOT00000060155
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 49 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat

1 to 10 of 49 rows



alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
1 2 18 11 12 1 8 1 13 9 17 24 11



Ensembl Acc Id: ENSRNOT00000060155   ⟹   ENSRNOP00000056899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1218,264,361 - 18,286,426 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082200   ⟹   ENSRNOP00000070827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1216,126,150 - 16,131,163 (-)Ensembl
Rnor_6.0 Ensembl1218,281,736 - 18,286,426 (-)Ensembl
RefSeq Acc Id: NM_001025759   ⟹   NP_001020930
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81221,239,923 - 21,244,879 (-)NCBI
mRatBN7.21216,126,150 - 16,131,108 (-)NCBI
Rnor_6.01218,281,455 - 18,286,426 (-)NCBI
Rnor_5.01220,252,508 - 20,274,574 (-)NCBI
RGSC_v3.41216,634,927 - 16,639,883 (-)RGD
Celera1217,876,836 - 17,881,797 (-)RGD
Sequence:
RefSeq Acc Id: XM_039089694   ⟹   XP_038945622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81221,239,923 - 21,244,886 (-)NCBI
mRatBN7.21216,126,150 - 16,131,103 (-)NCBI
Protein RefSeqs NP_001020930 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945622 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98706 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070827
  ENSRNOP00000070827.2
RefSeq Acc Id: NP_001020930   ⟸   NM_001025759
- Peptide Label: precursor
- UniProtKB: Q4KM82 (UniProtKB/TrEMBL),   A0A0G2JYX4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070827   ⟸   ENSRNOT00000082200
Ensembl Acc Id: ENSRNOP00000056899   ⟸   ENSRNOT00000060155
RefSeq Acc Id: XP_038945622   ⟸   XM_039089694
- Peptide Label: isoform X1

Name Modeler Protein Id AA Range Protein Structure
AF-F7F2T3-F1-model_v2 AlphaFold F7F2T3 1-341 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698479
Promoter ID:EPDNEW_R9004
Type:single initiation site
Name:MGC112692_2
Description:similar to Leukosialin precursor (W3/13 antigen)
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9005  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01218,282,679 - 18,282,739EPDNEW
RGD ID:13698499
Promoter ID:EPDNEW_R9005
Type:single initiation site
Name:MGC112692_1
Description:similar to Leukosialin precursor (W3/13 antigen)
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9004  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01218,286,437 - 18,286,497EPDNEW


1 to 16 of 16 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-19860 BioCyc
Ensembl Genes ENSRNOG00000039282 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082200 ENTREZGENE
  ENSRNOT00000082200.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7114401 IMAGE-MGC_LOAD
InterPro Leukosialin UniProtKB/TrEMBL
KEGG Report rno:498157 UniProtKB/TrEMBL
MGC_CLONE MGC:112692 IMAGE-MGC_LOAD
NCBI Gene 498157 ENTREZGENE
PANTHER LEUKOSIALIN UniProtKB/TrEMBL
  PTHR35265 UniProtKB/TrEMBL
PhenoGen Spnl2 PhenoGen
RatGTEx ENSRNOG00000039282 RatGTEx
UniProt A0A0G2JYX4 ENTREZGENE
  Q4KM82 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2JYX4 UniProtKB/TrEMBL
1 to 16 of 16 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Spnl2  sialophorin like 2  MGC112692  similar to Leukosialin precursor (Leucocyte sialoglycoprotein) (Sialophorin) (CD43) (W3/13 antigen)  Symbol and Name Changed 1299863 APPROVED
2006-02-09 MGC112692  similar to Leukosialin precursor (Leucocyte sialoglycoprotein) (Sialophorin) (CD43) (W3/13 antigen)      Symbol and Name status set to provisional 70820 PROVISIONAL