Mir93 (microRNA 93) - Rat Genome Database

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Gene: Mir93 (microRNA 93) Rattus norvegicus
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Symbol: Mir93
Name: microRNA 93
RGD ID: 2325459
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in negative regulation of gene expression; negative regulation of transforming growth factor beta receptor signaling pathway; and negative regulation of transporter activity. Predicted to act upstream of or within several processes, including cellular response to forskolin; long-term synaptic potentiation; and negative regulation of B cell apoptotic process. Predicted to be located in extracellular space. Biomarker of hepatocellular carcinoma. Orthologous to human MIR93 (microRNA 93); INTERACTS WITH 17beta-estradiol; 2-acetamidofluorene; 2-methoxyethanol.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-mir-93
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81222,156,844 - 22,156,930 (-)NCBIGRCr8
mRatBN7.21217,043,135 - 17,043,221 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1217,043,135 - 17,043,221 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1217,866,516 - 17,866,602 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,490,260 - 18,490,346 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,543,666 - 17,543,752 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,307,543 - 19,307,629 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,307,543 - 19,307,629 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,365,173 - 21,365,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1218,973,305 - 18,973,391 (-)NCBICelera
Cytogenetic Map12q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The miR-93 promotes proliferation by directly targeting PDCD4 in hepatocellular carcinoma. Huang H, etal., Neoplasma. 2017;64(5):770-777. doi: 10.4149/neo_2017_516.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. miR-106b promotes cancer progression in hepatitis B virus-associated hepatocellular carcinoma. Yen CS, etal., World J Gastroenterol. 2016 Jun 14;22(22):5183-92. doi: 10.3748/wjg.v22.i22.5183.
Additional References at PubMed
PMID:14691248   PMID:15345052   PMID:16381832   PMID:16682203   PMID:17604727   PMID:17613256   PMID:18329372   PMID:20403161   PMID:21216258   PMID:21993888   PMID:23646144   PMID:25858512  
PMID:26798048   PMID:28284149   PMID:29243790   PMID:29421576   PMID:29551367   PMID:30178854   PMID:30195636   PMID:31754334   PMID:33414426   PMID:34138419   PMID:34313929  


Genomics

Comparative Map Data
Mir93
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81222,156,844 - 22,156,930 (-)NCBIGRCr8
mRatBN7.21217,043,135 - 17,043,221 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1217,043,135 - 17,043,221 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1217,866,516 - 17,866,602 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,490,260 - 18,490,346 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,543,666 - 17,543,752 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,307,543 - 19,307,629 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,307,543 - 19,307,629 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,365,173 - 21,365,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1218,973,305 - 18,973,391 (-)NCBICelera
Cytogenetic Map12q11NCBI
MIR93
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,093,768 - 100,093,847 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,093,768 - 100,093,847 (-)EnsemblGRCh38hg38GRCh38
GRCh37799,691,391 - 99,691,470 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,529,326 - 99,529,405 (-)NCBINCBI36Build 36hg18NCBI36
Celera794,426,050 - 94,426,129 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,327,042 - 94,327,121 (-)NCBIHuRef
CHM1_1799,621,548 - 99,621,627 (-)NCBICHM1_1
T2T-CHM13v2.07101,333,614 - 101,333,693 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,051,511 - 99,051,590 (-)NCBI
Mir93
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395138,163,785 - 138,163,872 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5138,163,785 - 138,163,872 (-)EnsemblGRCm39 Ensembl
GRCm385138,165,523 - 138,165,610 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5138,165,523 - 138,165,610 (-)EnsemblGRCm38mm10GRCm38
MGSCv375138,606,751 - 138,606,838 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera5135,144,855 - 135,144,942 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.97NCBI
MIR93
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,498,780 - 9,498,840 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.069,435,781 - 9,435,841 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.169,285,107 - 9,285,167 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.069,265,403 - 9,265,463 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,445,018 - 9,445,078 (+)NCBIUU_Cfam_GSD_1.0

miRNA Target Status (No longer updated)

Predicted Targets
Summary Value
Count of predictions:11080
Count of gene targets:6381
Count of transcripts:6871
Interacting mature miRNAs:rno-miR-93-3p, rno-miR-93-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121300829619212979Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat

Markers in Region
AI747533  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81222,156,415 - 22,157,251 (+)Marker Load Pipeline
mRatBN7.21217,042,705 - 17,043,542 (+)MAPPERmRatBN7.2
Rnor_6.01219,307,114 - 19,307,950NCBIRnor6.0
Rnor_5.01221,364,744 - 21,365,580UniSTSRnor5.0
RGSC_v3.41217,607,744 - 17,608,580UniSTSRGSC3.4
Celera1218,972,876 - 18,973,712UniSTS
Cytogenetic Map12q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 6 28 84 41 39 18 18 18 3 109 59 70 24 39 21

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1217,043,135 - 17,043,221 (-)Ensembl
Rnor_6.0 Ensembl1219,307,543 - 19,307,629 (-)Ensembl
RefSeq Acc Id: NR_031853
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,156,844 - 22,156,930 (-)NCBI
mRatBN7.21217,043,135 - 17,043,221 (-)NCBI
Rnor_6.01219,307,543 - 19,307,629 (-)NCBI
Rnor_5.01221,365,173 - 21,365,259 (-)NCBI
Celera1218,973,305 - 18,973,391 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325459 AgrOrtholog
BioCyc Gene G2FUF-19812 BioCyc
Ensembl Genes ENSRNOG00000035485 Ensembl
miRBase MI0000880 ENTREZGENE
NCBI Gene 100314154 ENTREZGENE
PhenoGen Mir93 PhenoGen
RatGTEx ENSRNOG00000035485 RatGTEx
RNAcentral URS0000149452 RNACentral
  URS000075DD98 RNACentral
  URS000075E435 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir93  microRNA 93  Mir93  microRNA mir-93  Name updated 61478 APPROVED
2010-06-02 Mir93  microRNA mir-93      Symbol and Name status set to provisional 70820 PROVISIONAL