Mapkapk5 (MAPK activated protein kinase 5) - Rat Genome Database

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Gene: Mapkapk5 (MAPK activated protein kinase 5) Rattus norvegicus
Analyze
Symbol: Mapkapk5
Name: MAPK activated protein kinase 5
RGD ID: 1564113
Description: Predicted to enable several functions, including calmodulin binding activity; p53 binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including Ras protein signal transduction; positive regulation of telomere maintenance; and stress-induced premature senescence. Predicted to act upstream of or within positive regulation of dendritic spine development. Predicted to be located in cytosol; nucleoplasm; and septin cytoskeleton. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPKAPK5 (MAPK activated protein kinase 5); PARTICIPATES IN p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH copper atom; copper(0); cypermethrin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MAP kinase-activated protein kinase 5; MGC116327; mitogen-activated protein kinase-activated protein kinase 5; similar to MK-5 type 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,654,220 - 40,673,740 (+)NCBIGRCr8
mRatBN7.21234,993,520 - 35,013,059 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,994,092 - 35,013,052 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,166,747 - 36,185,867 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,777,956 - 36,797,075 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,830,405 - 35,849,524 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,510,378 - 40,529,332 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,510,378 - 40,529,338 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,377,614 - 42,396,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,128,538 - 36,147,493 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1236,658,764 - 36,677,720 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8889548   PMID:15538386   PMID:15577943   PMID:16973613   PMID:17254968   PMID:19166925   PMID:20640477   PMID:21329882   PMID:21336308   PMID:21531765   PMID:22508986  


Genomics

Comparative Map Data
Mapkapk5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,654,220 - 40,673,740 (+)NCBIGRCr8
mRatBN7.21234,993,520 - 35,013,059 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,994,092 - 35,013,052 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,166,747 - 36,185,867 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,777,956 - 36,797,075 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,830,405 - 35,849,524 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,510,378 - 40,529,332 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,510,378 - 40,529,338 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,377,614 - 42,396,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,128,538 - 36,147,493 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1236,658,764 - 36,677,720 (+)NCBICelera
Cytogenetic Map12q16NCBI
MAPKAPK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812111,842,228 - 111,902,222 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12111,842,013 - 111,902,222 (+)EnsemblGRCh38hg38GRCh38
GRCh3712112,280,032 - 112,340,026 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,764,662 - 110,815,611 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412110,742,998 - 110,793,947NCBI
Celera12111,905,742 - 111,956,689 (+)NCBICelera
Cytogenetic Map12q24.12-q24.13NCBI
HuRef12109,293,372 - 109,344,645 (+)NCBIHuRef
CHM1_112112,247,967 - 112,299,159 (+)NCBICHM1_1
T2T-CHM13v2.012111,819,139 - 111,879,131 (+)NCBIT2T-CHM13v2.0
Mapkapk5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,663,114 - 121,683,955 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,663,101 - 121,683,968 (-)EnsemblGRCm39 Ensembl
GRCm385121,525,051 - 121,545,892 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,525,038 - 121,545,905 (-)EnsemblGRCm38mm10GRCm38
MGSCv375121,975,060 - 121,995,901 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365121,785,668 - 121,806,509 (-)NCBIMGSCv36mm8
Celera5118,614,887 - 118,635,774 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.84NCBI
Mapkapk5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554828,409,192 - 8,434,907 (+)NCBIChiLan1.0ChiLan1.0
MAPKAPK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210119,911,213 - 119,966,539 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112119,907,604 - 119,962,960 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012109,416,610 - 109,471,729 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112112,812,764 - 112,868,846 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12112,812,769 - 112,863,595 (+)Ensemblpanpan1.1panPan2
MAPKAPK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,380,551 - 9,420,564 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,319,180 - 9,419,236 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,542,771 - 9,581,769 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,640,243 - 9,679,215 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,640,197 - 9,679,147 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,595,507 - 9,634,501 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0269,658,467 - 9,697,479 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0269,611,599 - 9,650,628 (+)NCBIUU_Cfam_GSD_1.0
Mapkapk5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118155,030,940 - 155,065,143 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365584,414,277 - 4,451,291 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365584,414,283 - 4,448,291 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPKAPK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1439,849,413 - 39,886,455 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11439,852,537 - 39,885,898 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21442,329,054 - 42,362,471 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAPKAPK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111107,084,117 - 107,126,360 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11107,084,366 - 107,124,710 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037137,965,646 - 138,009,993 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapkapk5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474720,344,078 - 20,384,894 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474720,344,078 - 20,384,880 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mapkapk5
61 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4
Count of miRNA genes:2
Interacting mature miRNAs:2
Transcripts:ENSRNOT00000001817, ENSRNOT00000065314
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122860752637691617Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

Markers in Region
RH139329  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,012,464 - 35,012,930 (+)MAPPERmRatBN7.2
Rnor_6.01240,528,751 - 40,529,216NCBIRnor6.0
Rnor_5.01242,395,987 - 42,396,452UniSTSRnor5.0
RGSC_v3.41236,146,912 - 36,147,377UniSTSRGSC3.4
Celera1236,677,133 - 36,677,598UniSTS
Cytogenetic Map12q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000001817   ⟹   ENSRNOP00000001817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,994,092 - 35,013,052 (+)Ensembl
Rnor_6.0 Ensembl1240,510,378 - 40,529,338 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000065314   ⟹   ENSRNOP00000061902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,994,259 - 35,013,052 (+)Ensembl
Rnor_6.0 Ensembl1240,517,657 - 40,529,338 (+)Ensembl
RefSeq Acc Id: NM_001025761   ⟹   NP_001020932
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,662,059 - 40,673,740 (+)NCBI
mRatBN7.21235,001,371 - 35,013,052 (+)NCBI
Rnor_6.01240,517,657 - 40,529,332 (+)NCBI
Rnor_5.01242,377,614 - 42,396,568 (+)NCBI
RGSC_v3.41236,128,538 - 36,147,493 (+)RGD
Celera1236,666,043 - 36,677,720 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001164043   ⟹   NP_001157515
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,654,780 - 40,673,740 (+)NCBI
mRatBN7.21234,994,092 - 35,013,052 (+)NCBI
Rnor_6.01240,510,378 - 40,529,332 (+)NCBI
Rnor_5.01242,377,614 - 42,396,568 (+)NCBI
RGSC_v3.41236,128,538 - 36,147,493 (+)RGD
Celera1236,658,764 - 36,677,720 (+)RGD
Sequence:
RefSeq Acc Id: XM_039089701   ⟹   XP_038945629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,654,220 - 40,673,740 (+)NCBI
mRatBN7.21234,993,523 - 35,013,055 (+)NCBI
RefSeq Acc Id: XM_039089703   ⟹   XP_038945631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,654,224 - 40,673,740 (+)NCBI
mRatBN7.21234,993,524 - 35,013,055 (+)NCBI
RefSeq Acc Id: XM_039089704   ⟹   XP_038945632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,661,254 - 40,673,740 (+)NCBI
mRatBN7.21235,000,492 - 35,013,055 (+)NCBI
RefSeq Acc Id: XM_063271585   ⟹   XP_063127655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,654,223 - 40,673,740 (+)NCBI
RefSeq Acc Id: XM_063271586   ⟹   XP_063127656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,663,934 - 40,673,740 (+)NCBI
RefSeq Acc Id: XM_063271587   ⟹   XP_063127657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,662,939 - 40,673,740 (+)NCBI
RefSeq Acc Id: XM_063271588   ⟹   XP_063127658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,654,220 - 40,673,740 (+)NCBI
RefSeq Acc Id: NP_001020932   ⟸   NM_001025761
- Peptide Label: isoform 2
- UniProtKB: Q4KLJ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157515   ⟸   NM_001164043
- Peptide Label: isoform 1
- UniProtKB: F1LN87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061902   ⟸   ENSRNOT00000065314
RefSeq Acc Id: ENSRNOP00000001817   ⟸   ENSRNOT00000001817
RefSeq Acc Id: XP_038945629   ⟸   XM_039089701
- Peptide Label: isoform X5
- UniProtKB: F1LN87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945631   ⟸   XM_039089703
- Peptide Label: isoform X1
- UniProtKB: F7FFP2 (UniProtKB/TrEMBL),   Q4KLJ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945632   ⟸   XM_039089704
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063127658   ⟸   XM_063271588
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063127655   ⟸   XM_063271585
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063127657   ⟸   XM_063271587
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063127656   ⟸   XM_063271586
- Peptide Label: isoform X3
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LN87-F1-model_v2 AlphaFold F1LN87 1-473 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564113 AgrOrtholog
BioCyc Gene G2FUF-19215 BioCyc
Ensembl Genes ENSRNOG00000001345 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001817 ENTREZGENE
  ENSRNOT00000001817.8 UniProtKB/TrEMBL
  ENSRNOT00000065314.3 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1170.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7381631 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  MAPKAPK_C UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:498183 UniProtKB/TrEMBL
MGC_CLONE MGC:116327 IMAGE-MGC_LOAD
NCBI Gene 498183 ENTREZGENE
PANTHER MAP KINASE-ACTIVATED PROTEIN KINASE 5 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Mapkapk5 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001345 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt F1LN87 ENTREZGENE, UniProtKB/TrEMBL
  F7FFP2 ENTREZGENE, UniProtKB/TrEMBL
  Q4KLJ9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Mapkapk5  MAPK activated protein kinase 5  Mapkapk5  mitogen-activated protein kinase-activated protein kinase 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-06 Mapkapk5  mitogen-activated protein kinase-activated protein kinase 5  Mapkapk5  MAP kinase-activated protein kinase 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Mapkapk5  MAP kinase-activated protein kinase 5  MGC116327  similar to MK-5 type 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 MGC116327  similar to MK-5 type 2      Symbol and Name status set to provisional 70820 PROVISIONAL