Mn1 (MN1 proto-oncogene, transcriptional regulator) - Rat Genome Database

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Gene: Mn1 (MN1 proto-oncogene, transcriptional regulator) Rattus norvegicus
Analyze
Symbol: Mn1
Name: MN1 proto-oncogene, transcriptional regulator
RGD ID: 1565571
Description: Predicted to be involved in negative regulation of osteoblast proliferation; positive regulation of vitamin D receptor signaling pathway; and regulation of cell cycle G1/S phase transition. Predicted to act upstream of or within intramembranous ossification. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in familial meningioma; meningioma; and myeloid leukemia. Orthologous to human MN1 (MN1 proto-oncogene, transcriptional regulator); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498194; meningioma 1; probable tumor suppressor protein MN1; RGD1565571; similar to meningioma 1; transcriptional activator MN1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21245,184,060 - 45,220,102 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,183,085 - 45,221,651 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1246,357,662 - 46,393,868 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01246,963,905 - 47,000,113 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01246,024,420 - 46,060,627 (-)NCBIRnor_WKY
Rnor_6.01251,214,192 - 51,250,230 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,214,192 - 51,250,230 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01252,955,948 - 52,991,986 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41245,318,155 - 45,355,115 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1246,751,609 - 46,787,208 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. Buijs A, etal., Oncogene. 1995 Apr 20;10(8):1511-9.
2. Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma. Lekanne Deprez RH, etal., Oncogene. 1995 Apr 20;10(8):1521-8.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. Molecular genetics of meningiomas. Ragel BT and Jensen RL, Neurosurg Focus. 2005 Nov 15;19(5):E9.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:15870292  


Genomics

Comparative Map Data
Mn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21245,184,060 - 45,220,102 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,183,085 - 45,221,651 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1246,357,662 - 46,393,868 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01246,963,905 - 47,000,113 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01246,024,420 - 46,060,627 (-)NCBIRnor_WKY
Rnor_6.01251,214,192 - 51,250,230 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,214,192 - 51,250,230 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01252,955,948 - 52,991,986 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41245,318,155 - 45,355,115 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1246,751,609 - 46,787,208 (-)NCBICelera
Cytogenetic Map12q16NCBI
MN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382227,748,277 - 27,801,756 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2227,748,277 - 27,801,756 (-)EnsemblGRCh38hg38GRCh38
GRCh372228,144,265 - 28,197,744 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362226,474,265 - 26,527,486 (-)NCBINCBI36Build 36hg18NCBI36
Build 342226,468,819 - 26,522,040NCBI
Celera2211,944,239 - 11,997,449 (-)NCBICelera
Cytogenetic Map22q12.1ENTREZGENE
HuRef2211,108,458 - 11,161,677 (-)NCBIHuRef
CHM1_12228,103,532 - 28,156,750 (-)NCBICHM1_1
T2T-CHM13v2.02228,209,592 - 28,263,071 (-)NCBIT2T-CHM13v2.0
Mn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395111,565,166 - 111,604,896 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5111,565,228 - 111,604,899 (+)EnsemblGRCm39 Ensembl
GRCm385111,417,300 - 111,457,030 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5111,417,362 - 111,457,033 (+)EnsemblGRCm38mm10GRCm38
MGSCv375111,847,186 - 111,886,045 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365111,657,665 - 111,697,328 (+)NCBIMGSCv36mm8
Celera5108,545,721 - 108,584,945 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.86NCBI
Mn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554552,127,377 - 2,171,850 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554552,130,104 - 2,171,868 (-)NCBIChiLan1.0ChiLan1.0
MN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12226,519,251 - 26,571,373 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0228,799,832 - 8,854,695 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12621,216,912 - 21,261,518 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2621,216,837 - 21,261,031 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2621,087,978 - 21,132,430 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02621,583,778 - 21,628,255 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2621,581,242 - 21,627,694 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12621,301,607 - 21,346,030 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02621,557,327 - 21,601,736 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02621,626,045 - 21,670,478 (-)NCBIUU_Cfam_GSD_1.0
Mn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118113,804,928 - 113,846,405 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366572,024,350 - 2,065,263 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366572,024,302 - 2,066,196 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1445,096,485 - 45,140,570 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11445,093,660 - 45,142,476 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21447,943,781 - 47,990,706 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11910,652,940 - 10,706,989 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1910,652,939 - 10,706,762 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045115,411,325 - 115,467,616 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247474,093,279 - 4,134,876 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247474,090,664 - 4,135,822 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mn1
114 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:105
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000029508
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

Markers in Region
D12Rat49  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,207,488 - 45,207,619 (+)MAPPERmRatBN7.2
Rnor_6.01251,237,617 - 51,237,747NCBIRnor6.0
Rnor_5.01252,979,373 - 52,979,503UniSTSRnor5.0
RGSC_v3.41245,342,502 - 45,342,632UniSTSRGSC3.4
RGSC_v3.41245,342,501 - 45,342,632RGDRGSC3.4
RGSC_v3.11245,205,890 - 45,206,020RGD
Celera1246,774,609 - 46,774,725UniSTS
RH 3.4 Map12802.8RGD
RH 3.4 Map12802.8UniSTS
RH 2.0 Map12566.1RGD
SHRSP x BN Map1254.0099RGD
Cytogenetic Map12q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 2 2 2 2 5 58 4 20 2
Low 3 42 24 8 19 8 6 6 16 31 15 11 6
Below cutoff 31 31 31 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000029508   ⟹   ENSRNOP00000029870
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,183,085 - 45,221,651 (-)Ensembl
Rnor_6.0 Ensembl1251,214,192 - 51,250,230 (-)Ensembl
RefSeq Acc Id: NM_001191928   ⟹   NP_001178857
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21245,184,060 - 45,220,102 (-)NCBI
Rnor_6.01251,214,192 - 51,250,230 (-)NCBI
Rnor_5.01252,955,948 - 52,991,986 (-)NCBI
Celera1246,751,609 - 46,787,208 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178857 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001178857   ⟸   NM_001191928
- UniProtKB: D4AAP6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000029870   ⟸   ENSRNOT00000029508

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAP6-F1-model_v2 AlphaFold D4AAP6 1-1304 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565571 AgrOrtholog
BioCyc Gene G2FUF-18840 BioCyc
Ensembl Genes ENSRNOG00000027489 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000029870 ENTREZGENE
  ENSRNOP00000029870.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029508 ENTREZGENE
  ENSRNOT00000029508.5 UniProtKB/TrEMBL
InterPro MN1 UniProtKB/TrEMBL
KEGG Report rno:498194 UniProtKB/TrEMBL
NCBI Gene 498194 ENTREZGENE
PANTHER PTHR15821 UniProtKB/TrEMBL
PhenoGen Mn1 PhenoGen
UniProt D4AAP6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Mn1  MN1 proto-oncogene, transcriptional regulator  Mn1  meningioma 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Mn1  meningioma 1  RGD1565571_predicted  similar to meningioma 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565571_predicted  similar to meningioma 1 (predicted)  LOC498194  similar to meningioma 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498194  similar to meningioma 1      Symbol and Name status set to provisional 70820 PROVISIONAL