Ap1s1 (adaptor related protein complex 1 subunit sigma 1) - Rat Genome Database

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Gene: Ap1s1 (adaptor related protein complex 1 subunit sigma 1) Rattus norvegicus
Analyze
Symbol: Ap1s1
Name: adaptor related protein complex 1 subunit sigma 1
RGD ID: 1305911
Description: Predicted to enable clathrin adaptor activity. Predicted to be involved in response to virus and vesicle-mediated transport. Predicted to act upstream of or within retrograde transport, endosome to Golgi. Predicted to be located in Golgi apparatus and terminal bouton. Predicted to be part of AP-1 adaptor complex. Predicted to be active in intracellular membrane-bounded organelle and presynapse. Human ortholog(s) of this gene implicated in MEDNIK syndrome. Orthologous to human AP1S1 (adaptor related protein complex 1 subunit sigma 1); INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adaptor protein complex AP-1, sigma 1; adaptor-related protein complex 1, sigma 1 subunit; E2 ubiquitin-conjugating enzyme W; LOC360785; MGC188494; N-terminal E2 ubiquitin-conjugating enzyme; N-terminus-conjugating E2; Ube2w; ubiquitin carrier protein W; ubiquitin-conjugating enzyme E2 W; ubiquitin-protein ligase W
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,261,958 - 25,272,483 (+)NCBIGRCr8
mRatBN7.21219,625,267 - 19,635,792 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,625,332 - 19,756,713 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,762,948 - 20,773,387 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,375,661 - 21,386,100 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,440,199 - 20,450,638 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,665,128 - 22,676,079 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,665,112 - 22,676,075 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,677,410 - 24,688,360 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,907,855 - 20,918,301 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11220,897,466 - 20,907,910 (-)NCBI
Celera1221,401,021 - 21,411,455 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
amitrole  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clomipramine  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
flecainide  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
levofloxacin  (EXP)
loratadine  (ISO)
methimazole  (EXP)
methoxychlor  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perhexiline  (ISO)
phenylmercury acetate  (ISO)
propanal  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
thioridazine  (ISO)
thiram  (ISO)
trovafloxacin  (EXP)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
Yessotoxin  (ISO)
zimeldine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord. Montpetit A, etal., PLoS Genet. 2008 Dec;4(12):e1000296. doi: 10.1371/journal.pgen.1000296. Epub 2008 Dec 5.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. Page LJ, etal., J Cell Biol 1999 Sep 6;146(5):993-1004.
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:16548883   PMID:19946888   PMID:20203623   PMID:23376485   PMID:24928897   PMID:25378584  


Genomics

Comparative Map Data
Ap1s1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,261,958 - 25,272,483 (+)NCBIGRCr8
mRatBN7.21219,625,267 - 19,635,792 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,625,332 - 19,756,713 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,762,948 - 20,773,387 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,375,661 - 21,386,100 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,440,199 - 20,450,638 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,665,128 - 22,676,079 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,665,112 - 22,676,075 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,677,410 - 24,688,360 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,907,855 - 20,918,301 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11220,897,466 - 20,907,910 (-)NCBI
Celera1221,401,021 - 21,411,455 (+)NCBICelera
Cytogenetic Map12q12NCBI
AP1S1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387101,154,476 - 101,161,276 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7101,154,456 - 101,161,596 (+)EnsemblGRCh38hg38GRCh38
GRCh377100,797,757 - 100,804,557 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,584,406 - 100,591,277 (+)NCBINCBI36Build 36hg18NCBI36
Build 347100,391,201 - 100,397,991NCBI
Celera795,806,042 - 95,812,913 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef795,390,854 - 95,397,722 (+)NCBIHuRef
CHM1_17100,728,140 - 100,735,019 (+)NCBICHM1_1
T2T-CHM13v2.07102,477,198 - 102,484,025 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27100,156,073 - 100,162,944 (+)NCBI
Ap1s1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,063,852 - 137,074,917 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,063,847 - 137,074,989 (-)EnsemblGRCm39 Ensembl
GRCm385137,034,993 - 137,046,108 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,034,993 - 137,046,135 (-)EnsemblGRCm38mm10GRCm38
MGSCv375137,510,864 - 137,521,930 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365137,319,621 - 137,330,687 (-)NCBIMGSCv36mm8
Celera5134,051,733 - 134,062,892 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.13NCBI
Ap1s1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545616,127,877 - 16,134,039 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545616,127,877 - 16,134,039 (-)NCBIChiLan1.0ChiLan1.0
AP1S1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26119,166,703 - 119,173,603 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17167,431,334 - 167,438,233 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0793,294,826 - 93,301,202 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,536,450 - 106,543,317 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,536,452 - 106,543,316 (+)Ensemblpanpan1.1panPan2
AP1S1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,705,294 - 8,711,285 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,705,647 - 8,711,190 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,402,619 - 10,408,611 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.068,524,828 - 8,530,831 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,524,828 - 8,530,772 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,484,889 - 8,490,882 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,455,351 - 8,461,345 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.068,620,013 - 8,626,010 (-)NCBIUU_Cfam_GSD_1.0
Ap1s1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344132,978,078 - 132,983,830 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365431,052,732 - 1,058,483 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365431,052,692 - 1,058,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP1S1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,881,107 - 8,887,566 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,880,993 - 8,887,806 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AP1S1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,022,376 - 12,029,435 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,022,201 - 12,029,181 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660704,321,127 - 4,327,918 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap1s1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,111,004 - 16,116,992 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,111,004 - 16,117,075 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ap1s1
101 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:296
Count of miRNA genes:169
Interacting mature miRNAs:186
Transcripts:ENSRNOT00000001918
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)121961087024139202Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat

Markers in Region
BI280199  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,635,251 - 19,635,402 (+)MAPPERmRatBN7.2
Rnor_6.01222,675,539 - 22,675,689NCBIRnor6.0
Rnor_5.01224,687,820 - 24,687,970UniSTSRnor5.0
RGSC_v3.41220,908,245 - 20,908,395UniSTSRGSC3.4
Celera1221,410,915 - 21,411,065UniSTS
RH 3.4 Map12277.8UniSTS
Cytogenetic Map12q12UniSTS
UniSTS:235344  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,635,431 - 19,635,637 (+)MAPPERmRatBN7.2
Rnor_6.01222,675,719 - 22,675,924NCBIRnor6.0
Rnor_5.01224,688,000 - 24,688,205UniSTSRnor5.0
RGSC_v3.41220,908,010 - 20,908,215UniSTSRGSC3.4
Celera1221,411,095 - 21,411,300UniSTS
Cytogenetic Map12q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000001918   ⟹   ENSRNOP00000001918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,625,332 - 19,635,784 (+)Ensembl
Rnor_6.0 Ensembl1222,665,112 - 22,676,075 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099813   ⟹   ENSRNOP00000096668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,625,385 - 19,756,713 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110980   ⟹   ENSRNOP00000082199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,625,332 - 19,634,424 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119520   ⟹   ENSRNOP00000082325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,625,816 - 19,634,424 (+)Ensembl
RefSeq Acc Id: NM_001108331   ⟹   NP_001101801
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,262,036 - 25,272,483 (+)NCBI
mRatBN7.21219,625,345 - 19,635,792 (+)NCBI
Rnor_6.01222,665,158 - 22,676,079 (+)NCBI
Rnor_5.01224,677,410 - 24,688,360 (+)NCBI
RGSC_v3.41220,907,855 - 20,918,301 (-)RGD
Celera1221,401,021 - 21,411,455 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249179   ⟹   XP_006249241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,261,958 - 25,272,478 (+)NCBI
mRatBN7.21219,625,267 - 19,633,551 (+)NCBI
Rnor_6.01222,665,128 - 22,673,832 (+)NCBI
Rnor_5.01224,677,410 - 24,688,360 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001101801   ⟸   NM_001108331
- UniProtKB: B5DFI3 (UniProtKB/TrEMBL),   A0A8I6ASY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249241   ⟸   XM_006249179
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZW78 (UniProtKB/TrEMBL),   A6J050 (UniProtKB/TrEMBL),   A0A8I5ZUR0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001918   ⟸   ENSRNOT00000001918
Ensembl Acc Id: ENSRNOP00000096668   ⟸   ENSRNOT00000099813
Ensembl Acc Id: ENSRNOP00000082325   ⟸   ENSRNOT00000119520
Ensembl Acc Id: ENSRNOP00000082199   ⟸   ENSRNOT00000110980
Protein Domains
AP complex mu/sigma subunit

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DFI3-F1-model_v2 AlphaFold B5DFI3 1-158 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698525
Promoter ID:EPDNEW_R9050
Type:initiation region
Name:Ap1s1_1
Description:adaptor-related protein complex 1, sigma 1 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,665,205 - 22,665,265EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305911 AgrOrtholog
BioCyc Gene G2FUF-19677 BioCyc
BioCyc Pathway PWY-7511 [protein ubiquitination] BioCyc
BioCyc Pathway Image PWY-7511 BioCyc
Ensembl Genes ENSRNOG00000001415 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001918.7 UniProtKB/TrEMBL
  ENSRNOT00000099813.1 UniProtKB/TrEMBL
  ENSRNOT00000110980.1 UniProtKB/TrEMBL
  ENSRNOT00000119520.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.60 UniProtKB/TrEMBL
InterPro AP1_sigma UniProtKB/TrEMBL
  AP_complex_ssu UniProtKB/TrEMBL
  AP_mu_sigma_su UniProtKB/TrEMBL
  Clathrin_sigma/coatomer_zeta UniProtKB/TrEMBL
  Longin-like UniProtKB/TrEMBL
KEGG Report rno:360785 UniProtKB/TrEMBL
NCBI Gene 360785 ENTREZGENE
PANTHER AP-1 COMPLEX SUBUNIT SIGMA-1A UniProtKB/TrEMBL
  PTHR11753 UniProtKB/TrEMBL
Pfam Clat_adaptor_s UniProtKB/TrEMBL
PhenoGen Ap1s1 PhenoGen
PIRSF AP_complex_sigma UniProtKB/TrEMBL
PROSITE CLAT_ADAPTOR_S UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001415 RatGTEx
Superfamily-SCOP Longin_like UniProtKB/TrEMBL
UniProt A0A8I5ZUR0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZW78 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASY6 ENTREZGENE, UniProtKB/TrEMBL
  A6J050 ENTREZGENE, UniProtKB/TrEMBL
  B5DFI3 ENTREZGENE, UniProtKB/TrEMBL
  F7EZ57_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-03 Ap1s1  adaptor related protein complex 1 subunit sigma 1  Ap1s1  adaptor-related protein complex 1, sigma 1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Ap1s1  adaptor-related protein complex 1, sigma 1 subunit  Ap1s1  adaptor protein complex AP-1, sigma 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ap1s1  adaptor protein complex AP-1, sigma 1   Ap1s1_predicted  adaptor protein complex AP-1, sigma 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ap1s1_predicted  adaptor protein complex AP-1, sigma 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED