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Gene: Ap1s1 (adaptor related protein complex 1 subunit sigma 1) Rattus norvegicus
Symbol: Ap1s1
Name: adaptor related protein complex 1 subunit sigma 1
Description: Predicted to have ubiquitin-protein transferase activity. Predicted to be involved in several processes, including cellular response to misfolded protein; protein monoubiquitination; and proteolysis involved in cellular protein catabolic process. Predicted to localize to the Golgi apparatus; nucleus; and terminal bouton. Human ortholog(s) of this gene implicated in MEDNIK syndrome. Orthologous to human AP1S1 (adaptor related protein complex 1 subunit sigma 1); INTERACTS WITH bisphenol A; C60 fullerene; flutamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adaptor protein complex AP-1, sigma 1; adaptor-related protein complex 1, sigma 1 subunit; E2 ubiquitin-conjugating enzyme W; LOC360785; MGC188494; N-terminal E2 ubiquitin-conjugating enzyme; N-terminus-conjugating E2; Ube2w; ubiquitin carrier protein W; ubiquitin-conjugating enzyme E2 W; ubiquitin-protein ligase W
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01222,665,128 - 22,676,079 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01224,677,410 - 24,688,360 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,907,855 - 20,918,301 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11220,897,466 - 20,907,910 (-)NCBI
Celera1221,401,021 - 21,411,455 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Ap1s1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305911
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-06-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.