P2rx2 (purinergic receptor P2X 2) - Rat Genome Database

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Gene: P2rx2 (purinergic receptor P2X 2) Rattus norvegicus
Analyze
Symbol: P2rx2
Name: purinergic receptor P2X 2
RGD ID: 620251
Description: Enables several functions, including anion binding activity; extracellularly ATP-gated monoatomic cation channel activity; and transition metal ion binding activity. Involved in several processes, including neuronal action potential; regulation of presynaptic cytosolic calcium ion concentration; and response to ischemia. Located in several cellular components, including dendritic spine; postsynaptic density; and presynaptic membrane. Part of receptor complex. Is active in glutamatergic synapse and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 41. Orthologous to human P2RX2 (purinergic receptor P2X 2); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 1,4-dithiothreitol; 6-propyl-2-thiouracil; 9-cis-retinoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP receptor; P2X purinoceptor 2; P2X2; purinergic receptor P2X, ligand-gated ion channel, 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21246,338,979 - 46,342,891 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,339,549 - 46,342,891 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1247,515,324 - 47,518,520 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01248,120,973 - 48,124,163 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01247,181,498 - 47,184,688 (+)NCBIRnor_WKY
Rnor_6.01252,397,666 - 52,401,005 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,397,792 - 52,401,015 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01254,133,143 - 54,136,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,485,125 - 46,488,319 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11246,352,056 - 46,355,251 (+)NCBI
Celera1247,896,140 - 47,899,334 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of P2X2/P2X4/P2X6 heterotrimeric receptors using atomic force microscopy (AFM) imaging. Antonio LS, etal., FEBS Lett. 2014 Jun 5;588(12):2125-8. doi: 10.1016/j.febslet.2014.04.048. Epub 2014 May 8.
2. Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes. Aschrafi A, etal., J Mol Biol. 2004 Sep 3;342(1):333-43.
3. P2X(2) receptor immunoreactivity in the dorsal vagal complex and area postrema of the rat. Atkinson L, etal., Neuroscience. 2000;99(4):683-96.
4. The stoichiometry of P2X2/6 receptor heteromers depends on relative subunit expression levels. Barrera NP, etal., Biophys J. 2007 Jul 15;93(2):505-12. Epub 2007 Apr 20.
5. New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Brake AJ, etal., Nature 1994 Oct 6;371(6497):519-23.
6. Up-regulation of P2X2, P2X4 receptor and ischemic cell death: prevention by P2 antagonists. Cavaliere F, etal., Neuroscience. 2003;120(1):85-98.
7. Cerebellar lesion up-regulates P2X1 and P2X2 purinergic receptors in precerebellar nuclei. Florenzano F, etal., Neuroscience 2002;115(2):425-34.
8. Regulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositides. Fujiwara Y and Kubo Y, J Physiol. 2006 Oct 1;576(Pt 1):135-49. Epub 2006 Jul 20.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Identification of a short form of the P2xR1-purinoceptor subunit produced by alternative splicing in the pituitary and cochlea. Housley GD, etal., Biochem Biophys Res Commun 1995 Jul 17;212(2):501-8.
12. Gain and loss of channel function by alanine substitutions in the transmembrane segments of the rat ATP-gated P2X2 receptor. Li Z, etal., J Neurosci. 2004 Aug 18;24(33):7378-86.
13. Extracellular histidine residues identify common structural determinants in the copper/zinc P2X2 receptor modulation. Lorca RA, etal., J Neurochem. 2005 Oct;95(2):499-512.
14. Characterization of three types of ATP-activated current in relation to P2X subunits in rat trigeminal ganglion neurons. Luo J, etal., Brain Res. 2006 Oct 18;1115(1):9-15. Epub 2006 Aug 24.
15. Fe65 interacts with P2X2 subunits at excitatory synapses and modulates receptor function. Masin M, etal., J Biol Chem. 2006 Feb 17;281(7):4100-8. Epub 2005 Dec 5.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Reconstruction of the P2X(2) receptor reveals a vase-shaped structure with lateral tunnels above the membrane. Mio K, etal., Structure. 2009 Feb 13;17(2):266-75. doi: 10.1016/j.str.2008.12.007.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. Rodrigues RJ, etal., J Neurosci. 2005 Jul 6;25(27):6286-95.
25. Distinct Localization of P2X receptors at excitatory postsynaptic specializations. Rubio ME and Soto F, J Neurosci. 2001 Jan 15;21(2):641-53.
26. P2X2 receptor subunit expression in a subpopulation of cochlear type I spiral ganglion neurones. Salih SG, etal., Neuroreport 1998 Jan 26;9(2):279-82.
27. A histidine scan to probe the flexibility of the rat P2X2 receptor zinc-binding site. Tittle RK, etal., J Biol Chem. 2007 Jul 6;282(27):19526-33. Epub 2007 May 21.
28. Evidence for three additional P2X2 purinoceptor isoforms produced by alternative splicing in the adult rat vestibular end-organs. Troyanovskaya M and Wackym PA, Hear Res 1998 Dec;126(1-2):201-9.
29. Inhibition mechanism of the recombinant rat P2X(2) receptor in glial cells by suramin and TNP-ATP. Trujillo CA, etal., Biochemistry. 2006 Jan 10;45(1):224-33.
30. Role of the domain encompassing Arg304-Ile328 in rat P2X2 receptor conformation revealed by alterations in complex glycosylation at Asn298. Young MT, etal., Biochem J. 2008 Nov 15;416(1):137-43. doi: 10.1042/BJ20081182.
Additional References at PubMed
PMID:9119082   PMID:12604087   PMID:12788520   PMID:12844512   PMID:12850289   PMID:12858039   PMID:12878756   PMID:12917379   PMID:12921863   PMID:12937291   PMID:14672995   PMID:15081800  
PMID:15107474   PMID:15126501   PMID:15228593   PMID:15456793   PMID:15572362   PMID:15657042   PMID:15899882   PMID:15905416   PMID:15947072   PMID:15961431   PMID:15973739   PMID:16033901  
PMID:16219297   PMID:16322458   PMID:16753051   PMID:17329369   PMID:17664346   PMID:17706883   PMID:17917716   PMID:17959738   PMID:18048351   PMID:18565509   PMID:19064335   PMID:19266560  
PMID:19383439   PMID:19625689   PMID:19752115   PMID:19906973   PMID:20308075   PMID:20406659   PMID:20617399   PMID:20677337   PMID:20705122   PMID:20736052   PMID:20860800   PMID:20868656  
PMID:21051571   PMID:21191044   PMID:21303687   PMID:21409380   PMID:21907716   PMID:22038573   PMID:22090499   PMID:22422599   PMID:22556417   PMID:22621423   PMID:23345450   PMID:23382219  
PMID:23936459   PMID:24515105   PMID:24798490   PMID:24863932   PMID:25172943   PMID:25680470   PMID:26808983   PMID:26843630   PMID:29608947   PMID:32145326  


Genomics

Comparative Map Data
P2rx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21246,338,979 - 46,342,891 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,339,549 - 46,342,891 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1247,515,324 - 47,518,520 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01248,120,973 - 48,124,163 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01247,181,498 - 47,184,688 (+)NCBIRnor_WKY
Rnor_6.01252,397,666 - 52,401,005 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,397,792 - 52,401,015 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01254,133,143 - 54,136,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,485,125 - 46,488,319 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11246,352,056 - 46,355,251 (+)NCBI
Celera1247,896,140 - 47,899,334 (+)NCBICelera
Cytogenetic Map12q16NCBI
P2RX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812132,618,776 - 132,622,388 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl12132,618,776 - 132,622,388 (+)EnsemblGRCh38hg38GRCh38
GRCh3712133,195,362 - 133,198,974 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612131,705,476 - 131,709,045 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412131,805,752 - 131,809,322NCBI
Celera12132,895,833 - 132,898,704 (+)NCBICelera
Cytogenetic Map12q24.33NCBI
HuRef12129,940,850 - 129,978,664 (+)NCBIHuRef
CHM1_112133,014,978 - 133,018,311 (+)NCBICHM1_1
T2T-CHM13v2.012132,668,996 - 132,672,547 (+)NCBIT2T-CHM13v2.0
P2rx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395110,487,678 - 110,491,186 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5110,487,678 - 110,491,078 (-)EnsemblGRCm39 Ensembl
GRCm385110,339,812 - 110,343,320 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5110,339,812 - 110,343,212 (-)EnsemblGRCm38mm10GRCm38
MGSCv375110,768,831 - 110,772,054 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365110,580,114 - 110,583,514 (-)NCBIMGSCv36mm8
Celera5107,464,481 - 107,467,704 (-)NCBICelera
Cytogenetic Map5FNCBI
P2rx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955482419,213 - 421,583 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955482418,101 - 422,058 (-)NCBIChiLan1.0ChiLan1.0
P2RX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112134,679,826 - 134,694,613 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v012129,969,793 - 129,974,399 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
P2RX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.126480,370 - 485,527 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl26482,425 - 485,502 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha26521,018 - 527,367 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.026537,116 - 543,463 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl26540,383 - 543,463 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.126480,971 - 484,056 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.026565,312 - 571,661 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.026496,140 - 502,489 (-)NCBIUU_Cfam_GSD_1.0
P2rx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118122,147,514 - 122,150,459 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366602,570,625 - 2,573,296 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366602,570,627 - 2,574,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1422,854,828 - 22,858,386 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11422,854,828 - 22,858,574 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21424,390,356 - 24,393,061 (+)NCBISscrofa10.2Sscrofa10.2susScr3
P2RX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111127,961,004 - 127,964,529 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11127,961,079 - 127,964,113 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037116,903,349 - 116,907,655 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2rx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474728,020,652 - 28,023,392 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474728,019,305 - 28,023,558 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in P2rx2
15 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:286
Count of miRNA genes:163
Interacting mature miRNAs:178
Transcripts:ENSRNOT00000056692, ENSRNOT00000056693, ENSRNOT00000056694
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat

Markers in Region
RH137980  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21246,342,722 - 46,342,867 (+)MAPPERmRatBN7.2
Rnor_6.01252,400,837 - 52,400,981NCBIRnor6.0
Rnor_5.01254,136,211 - 54,136,355UniSTSRnor5.0
RGSC_v3.41246,488,151 - 46,488,295UniSTSRGSC3.4
Celera1247,899,166 - 47,899,310UniSTS
RH 3.4 Map12803.3UniSTS
Cytogenetic Map12q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 19 7
Low 2 24 17 6 14 6 2 3 53 19 32 7 2
Below cutoff 16 35 30 5 30 5 7 2 10 2 4 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF013241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF020756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF020757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF020758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF020759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF028603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF028604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF028605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF064549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY749416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L43511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y09910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y10473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y10474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y10475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000056692   ⟹   ENSRNOP00000053531
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1252,397,830 - 52,400,751 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000056693   ⟹   ENSRNOP00000053532
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1246,339,717 - 46,342,637 (+)Ensembl
Rnor_6.0 Ensembl1252,397,830 - 52,400,751 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000056694   ⟹   ENSRNOP00000053533
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1246,339,549 - 46,342,891 (+)Ensembl
Rnor_6.0 Ensembl1252,397,812 - 52,401,005 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081447   ⟹   ENSRNOP00000073541
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1252,397,847 - 52,400,627 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085661   ⟹   ENSRNOP00000074992
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1246,339,549 - 46,342,891 (+)Ensembl
Rnor_6.0 Ensembl1252,397,792 - 52,401,015 (+)Ensembl
RefSeq Acc Id: NM_053656   ⟹   NP_446108
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21246,339,698 - 46,342,891 (+)NCBI
Rnor_6.01252,397,811 - 52,401,005 (+)NCBI
Rnor_5.01254,133,143 - 54,136,379 (+)NCBI
RGSC_v3.41246,485,125 - 46,488,319 (+)RGD
Celera1247,896,140 - 47,899,334 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249515   ⟹   XP_006249577
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21246,339,425 - 46,342,891 (+)NCBI
Rnor_6.01252,397,668 - 52,401,005 (+)NCBI
Rnor_5.01254,133,143 - 54,136,379 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006249516   ⟹   XP_006249578
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21246,339,425 - 46,342,891 (+)NCBI
Rnor_6.01252,397,668 - 52,401,005 (+)NCBI
Rnor_5.01254,133,143 - 54,136,379 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006249517   ⟹   XP_006249579
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21246,339,425 - 46,342,891 (+)NCBI
Rnor_6.01252,397,670 - 52,401,005 (+)NCBI
Rnor_5.01254,133,143 - 54,136,379 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769305   ⟹   XP_008767527
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21246,339,425 - 46,342,891 (+)NCBI
Rnor_6.01252,397,668 - 52,401,005 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769306   ⟹   XP_008767528
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21246,339,728 - 46,342,891 (+)NCBI
Rnor_6.01252,397,915 - 52,401,005 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598234   ⟹   XP_017453723
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21246,339,425 - 46,342,891 (+)NCBI
Rnor_6.01252,397,666 - 52,401,005 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598235   ⟹   XP_017453724
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21246,339,425 - 46,342,891 (+)NCBI
Rnor_6.01252,397,668 - 52,401,005 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598236   ⟹   XP_017453725
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21246,339,425 - 46,342,891 (+)NCBI
Rnor_6.01252,397,666 - 52,401,005 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089005   ⟹   XP_038944933
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21246,339,425 - 46,342,891 (+)NCBI
RefSeq Acc Id: XM_039089007   ⟹   XP_038944935
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21246,339,635 - 46,342,891 (+)NCBI
RefSeq Acc Id: XM_039089008   ⟹   XP_038944936
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21246,339,650 - 46,342,891 (+)NCBI
RefSeq Acc Id: XM_039089009   ⟹   XP_038944937
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21246,338,979 - 46,342,891 (+)NCBI
RefSeq Acc Id: XR_005491585
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21246,339,425 - 46,342,891 (+)NCBI
Protein Sequences
Protein RefSeqs NP_446108 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249577 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249578 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249579 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767527 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767528 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453723 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453724 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453725 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944933 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944935 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944936 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944937 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA50756 (Get FASTA)   NCBI Sequence Viewer  
  AAB94570 (Get FASTA)   NCBI Sequence Viewer  
  AAB94571 (Get FASTA)   NCBI Sequence Viewer  
  AAB94572 (Get FASTA)   NCBI Sequence Viewer  
  AAB94573 (Get FASTA)   NCBI Sequence Viewer  
  AAC15083 (Get FASTA)   NCBI Sequence Viewer  
  AAC16883 (Get FASTA)   NCBI Sequence Viewer  
  AAC42067 (Get FASTA)   NCBI Sequence Viewer  
  AAC72285 (Get FASTA)   NCBI Sequence Viewer  
  AAC72286 (Get FASTA)   NCBI Sequence Viewer  
  AAC72287 (Get FASTA)   NCBI Sequence Viewer  
  CAA71046 (Get FASTA)   NCBI Sequence Viewer  
  CAA71499 (Get FASTA)   NCBI Sequence Viewer  
  CAA71500 (Get FASTA)   NCBI Sequence Viewer  
  CAA71501 (Get FASTA)   NCBI Sequence Viewer  
  EDM14046 (Get FASTA)   NCBI Sequence Viewer  
  EDM14047 (Get FASTA)   NCBI Sequence Viewer  
  EDM14048 (Get FASTA)   NCBI Sequence Viewer  
  EDM14049 (Get FASTA)   NCBI Sequence Viewer  
  EDM14050 (Get FASTA)   NCBI Sequence Viewer  
  EDM14051 (Get FASTA)   NCBI Sequence Viewer  
  EDM14052 (Get FASTA)   NCBI Sequence Viewer  
  EDM14053 (Get FASTA)   NCBI Sequence Viewer  
  P49653 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446108   ⟸   NM_053656
- UniProtKB: O54868 (UniProtKB/Swiss-Prot),   P49653 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006249577   ⟸   XM_006249515
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006249578   ⟸   XM_006249516
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006249579   ⟸   XM_006249517
- Peptide Label: isoform X7
- UniProtKB: A0A0G2K9G8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767527   ⟸   XM_008769305
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008767528   ⟸   XM_008769306
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_017453723   ⟸   XM_017598234
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017453725   ⟸   XM_017598236
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_017453724   ⟸   XM_017598235
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000074992   ⟸   ENSRNOT00000085661
RefSeq Acc Id: ENSRNOP00000053533   ⟸   ENSRNOT00000056694
RefSeq Acc Id: ENSRNOP00000053532   ⟸   ENSRNOT00000056693
RefSeq Acc Id: ENSRNOP00000053531   ⟸   ENSRNOT00000056692
RefSeq Acc Id: ENSRNOP00000073541   ⟸   ENSRNOT00000081447
RefSeq Acc Id: XP_038944937   ⟸   XM_039089009
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038944933   ⟸   XM_039089005
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038944935   ⟸   XM_039089007
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038944936   ⟸   XM_039089008
- Peptide Label: isoform X9

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49653-F1-model_v2 AlphaFold P49653 1-472 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620251 AgrOrtholog
BioCyc Gene G2FUF-18806 BioCyc
Ensembl Genes ENSRNOG00000037456 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000053532 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000053533 ENTREZGENE
  ENSRNOP00000053533.4 UniProtKB/TrEMBL
  ENSRNOP00000074992 ENTREZGENE
  ENSRNOP00000074992.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056693 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000056694 ENTREZGENE
  ENSRNOT00000056694.5 UniProtKB/TrEMBL
  ENSRNOT00000085661 ENTREZGENE
  ENSRNOT00000085661.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.490.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P2X2_purnocptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_extracellular_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_purnocptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114115 UniProtKB/Swiss-Prot
NCBI Gene 114115 ENTREZGENE
PhenoGen P2rx2 PhenoGen
PIRSF P2X_purinoceptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS P2X2RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2XRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE P2X_RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs P2X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K9G8 ENTREZGENE, UniProtKB/TrEMBL
  A0A140TAH4_RAT UniProtKB/TrEMBL
  O54868 ENTREZGENE
  P2RX2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O54868 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 P2rx2  purinergic receptor P2X 2  P2rx2  purinergic receptor P2X, ligand-gated ion channel, 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 P2rx2  purinergic receptor P2X, ligand-gated ion channel, 2      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 P2rx2  purinergic receptor P2X, ligand-gated ion channel, 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in pituitary gland and the secretory epithelial tissue of the cochlea 633339
gene_regulation expression is upregulated by cerebellar lesion in precerebellar nuclei 633341