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Gene: P2rx2 (purinergic receptor P2X 2) Rattus norvegicus
Symbol: P2rx2
Name: purinergic receptor P2X 2
Description: Exhibits several functions, including anion binding activity; extracellularly ATP-gated cation channel activity; and transition metal ion binding activity. Involved in several processes, including neuronal action potential; regulation of presynaptic cytosolic calcium ion concentration; and response to ischemia. Localizes to several cellular components, including glutamatergic synapse; integral component of presynaptic active zone membrane; and postsynaptic density. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 41. Orthologous to human P2RX2 (purinergic receptor P2X 2); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 1,4-dithiothreitol; 6-propyl-2-thiouracil; 9-cis-retinoic acid.
Type: protein-coding
Also known as: ATP receptor; P2X purinoceptor 2; P2X2; purinergic receptor P2X, ligand-gated ion channel, 2
Homo sapiens (human) : P2RX2 (purinergic receptor P2X 2)  HGNC  Alliance
Mus musculus (house mouse) : P2rx2 (purinergic receptor P2X, ligand-gated ion channel, 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P2rx2 (purinergic receptor P2X 2)
Pan paniscus (bonobo/pygmy chimpanzee) : P2RX2 (purinergic receptor P2X 2)
Canis lupus familiaris (dog) : P2RX2 (purinergic receptor P2X 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P2rx2 (purinergic receptor P2X 2)
Sus scrofa (pig) : P2RX2 (purinergic receptor P2X 2)
Chlorocebus sabaeus (African green monkey) : P2RX2 (purinergic receptor P2X 2)
Heterocephalus glaber (naked mole-rat) : P2rx2 (purinergic receptor P2X 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01252,397,666 - 52,401,005 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,397,792 - 52,401,015 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01254,133,143 - 54,136,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,485,125 - 46,488,319 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11246,352,056 - 46,355,251 (+)NCBI
Celera1247,896,140 - 47,899,334 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on P2rx2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620251
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.