Ksr2 (kinase suppressor of ras 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ksr2 (kinase suppressor of ras 2) Rattus norvegicus
Analyze
Symbol: Ksr2
Name: kinase suppressor of ras 2
RGD ID: 1562674
Description: Predicted to enable MAP-kinase scaffold activity; mitogen-activated protein kinase kinase binding activity; and protein kinase activity. Predicted to be involved in Ras protein signal transduction; calcium-mediated signaling; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be active in cytosol and plasma membrane. Orthologous to human KSR2 (kinase suppressor of ras 2); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC288691; RGD1562674; similar to kinase suppressor of ras 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21238,802,796 - 39,187,809 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1238,802,004 - 39,188,375 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01244,531,376 - 44,911,835 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1244,536,293 - 44,911,147 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01246,352,196 - 46,732,484 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41239,998,030 - 40,376,125 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1240,461,342 - 40,832,198 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (IBA,ISO)
plasma membrane  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis. Guo L, etal., Mol Metab. 2016 Dec 18;6(2):194-205. doi: 10.1016/j.molmet.2016.12.004. eCollection 2017 Feb.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19560418   PMID:29433126  


Genomics

Comparative Map Data
Ksr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21238,802,796 - 39,187,809 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1238,802,004 - 39,188,375 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01244,531,376 - 44,911,835 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1244,536,293 - 44,911,147 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01246,352,196 - 46,732,484 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41239,998,030 - 40,376,125 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1240,461,342 - 40,832,198 (-)NCBICelera
Cytogenetic Map12q16NCBI
KSR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812117,453,012 - 117,968,990 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl12117,453,012 - 117,968,990 (-)EnsemblGRCh38hg38GRCh38
GRCh3712117,890,817 - 118,406,795 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612116,375,222 - 116,777,724 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412116,370,185 - 116,756,061NCBI
Celera12117,521,406 - 118,036,368 (-)NCBICelera
Cytogenetic Map12q24.22-q24.23NCBI
HuRef12114,899,825 - 115,416,596 (-)NCBIHuRef
CHM1_112117,858,453 - 118,373,654 (-)NCBICHM1_1
T2T-CHM13v2.012117,440,139 - 117,956,270 (-)NCBIT2T-CHM13v2.0
Ksr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395117,552,067 - 117,906,061 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5117,552,036 - 117,913,068 (+)EnsemblGRCm39 Ensembl
GRCm385117,414,002 - 117,767,996 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5117,414,000 - 117,775,003 (+)EnsemblGRCm38mm10GRCm38
MGSCv375117,864,009 - 118,213,329 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365117,675,030 - 117,816,972 (+)NCBIMGSCv36mm8
MGSCv365115,410,053 - 115,812,068 (+)NCBIMGSCv36mm8
Celera5114,504,419 - 114,853,593 (+)NCBICelera
Cytogenetic Map5FNCBI
Ksr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545513,374,729 - 13,773,392 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545513,375,306 - 13,777,681 (+)NCBIChiLan1.0ChiLan1.0
KSR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112118,416,905 - 118,926,529 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12118,420,483 - 118,925,686 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012115,038,344 - 115,548,452 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
KSR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12613,986,172 - 14,394,236 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2613,987,827 - 14,395,111 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2613,980,199 - 14,427,107 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02614,246,948 - 14,695,831 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2614,248,572 - 14,656,112 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12614,208,068 - 14,660,716 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02614,286,011 - 14,732,741 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02614,321,636 - 14,768,099 (-)NCBIUU_Cfam_GSD_1.0
Ksr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118154,331,733 - 154,693,702 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365584,785,718 - 5,141,609 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365584,786,148 - 5,146,062 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KSR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1434,676,164 - 35,089,997 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11434,675,349 - 35,090,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21437,050,362 - 37,325,101 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KSR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111112,784,275 - 113,307,935 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11112,784,728 - 113,084,697 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037131,800,747 - 132,308,761 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ksr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474715,493,281 - 15,916,052 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474715,492,312 - 15,931,358 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ksr2
2643 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:153
Count of miRNA genes:114
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000046190
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

Markers in Region
D12Rat31  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21239,074,768 - 39,075,003 (+)MAPPERmRatBN7.2
Rnor_6.01244,802,542 - 44,802,776NCBIRnor6.0
Rnor_5.01246,623,208 - 46,623,442UniSTSRnor5.0
RGSC_v3.41240,261,672 - 40,261,906UniSTSRGSC3.4
RGSC_v3.41240,261,671 - 40,261,906RGDRGSC3.4
RGSC_v3.11240,125,060 - 40,125,294RGD
Celera1240,726,011 - 40,726,245UniSTS
RH 3.4 Map12727.31RGD
RH 3.4 Map12727.31UniSTS
RH 2.0 Map12514.4RGD
FHH x ACI Map1237.03RGD
Cytogenetic Map12q16UniSTS
D12Rat87  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,757,340 - 38,757,548 (+)MAPPERmRatBN7.2
Rnor_6.01244,426,506 - 44,426,713NCBIRnor6.0
Rnor_5.01246,255,008 - 46,255,215UniSTSRnor5.0
RGSC_v3.41239,927,729 - 39,927,937RGDRGSC3.4
RGSC_v3.41239,927,730 - 39,927,937UniSTSRGSC3.4
RGSC_v3.11239,791,050 - 39,791,392RGD
Celera1240,412,798 - 40,413,005UniSTS
FHH x ACI Map1237.03UniSTS
FHH x ACI Map1237.03RGD
Cytogenetic Map12q16UniSTS
D12Got93  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21239,107,186 - 39,107,445 (+)MAPPERmRatBN7.2
Rnor_6.01244,832,795 - 44,833,053NCBIRnor6.0
Rnor_5.01246,653,461 - 46,653,719UniSTSRnor5.0
RGSC_v3.41240,294,082 - 40,294,341RGDRGSC3.4
RGSC_v3.41240,294,083 - 40,294,341UniSTSRGSC3.4
RGSC_v3.11240,157,471 - 40,157,729RGD
Celera1240,751,417 - 40,751,675UniSTS
RH 3.4 Map12740.3UniSTS
RH 3.4 Map12740.3RGD
RH 2.0 Map12509.8RGD
Cytogenetic Map12q16UniSTS
RH133186  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,810,147 - 38,810,459 (+)MAPPERmRatBN7.2
Rnor_6.01244,535,289 - 44,535,600NCBIRnor6.0
Rnor_5.01246,359,190 - 46,359,501UniSTSRnor5.0
RGSC_v3.41239,997,235 - 39,997,546UniSTSRGSC3.4
Celera1240,465,255 - 40,465,566UniSTS
RH 3.4 Map12719.8UniSTS
Cytogenetic Map12q16UniSTS
RH144202  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21239,156,929 - 39,157,165 (+)MAPPERmRatBN7.2
Rnor_6.01244,881,674 - 44,881,909NCBIRnor6.0
Rnor_5.01246,702,152 - 46,702,387UniSTSRnor5.0
RGSC_v3.41240,342,525 - 40,342,760UniSTSRGSC3.4
Celera1240,801,014 - 40,801,249UniSTS
RH 3.4 Map12726.5UniSTS
Cytogenetic Map12q16UniSTS
BF403270  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,946,888 - 38,947,078 (+)MAPPERmRatBN7.2
Rnor_6.01244,671,020 - 44,671,209NCBIRnor6.0
Rnor_5.01246,494,016 - 46,494,205UniSTSRnor5.0
RGSC_v3.41240,133,308 - 40,133,497UniSTSRGSC3.4
Celera1240,600,963 - 40,601,152UniSTS
RH 3.4 Map12731.4UniSTS
Cytogenetic Map12q16UniSTS
BE120958  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,803,476 - 38,803,683 (+)MAPPERmRatBN7.2
Rnor_6.01244,528,618 - 44,528,824NCBIRnor6.0
Rnor_5.01246,352,519 - 46,352,725UniSTSRnor5.0
RGSC_v3.41239,990,564 - 39,990,770UniSTSRGSC3.4
Celera1240,458,584 - 40,458,790UniSTS
RH 3.4 Map12726.4UniSTS
Cytogenetic Map12q16UniSTS
BF406370  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21239,148,266 - 39,148,408 (+)MAPPERmRatBN7.2
Rnor_6.01244,873,012 - 44,873,153NCBIRnor6.0
Rnor_5.01246,693,490 - 46,693,631UniSTSRnor5.0
RGSC_v3.41240,333,862 - 40,334,003UniSTSRGSC3.4
Celera1240,792,418 - 40,792,559UniSTS
RH 3.4 Map12730.0UniSTS
Cytogenetic Map12q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 40
Low 21 13 13 34 23 12
Below cutoff 1 18 27 26 3 26 1 1 12 24 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000046190   ⟹   ENSRNOP00000041584
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1238,805,428 - 39,188,375 (-)Ensembl
Rnor_6.0 Ensembl1244,538,476 - 44,911,147 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000071074   ⟹   ENSRNOP00000066865
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1238,805,428 - 39,134,755 (-)Ensembl
Rnor_6.0 Ensembl1244,536,293 - 44,911,147 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103994   ⟹   ENSRNOP00000082149
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1238,802,004 - 39,188,375 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105197   ⟹   ENSRNOP00000077881
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1238,802,004 - 39,188,375 (-)Ensembl
RefSeq Acc Id: XM_006249485   ⟹   XP_006249547
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21238,802,796 - 39,187,809 (-)NCBI
Rnor_6.01244,531,376 - 44,911,835 (-)NCBI
Rnor_5.01246,352,196 - 46,732,484 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598534   ⟹   XP_017454023
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21238,802,796 - 39,187,809 (-)NCBI
Rnor_6.01244,531,376 - 44,911,834 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_006249547 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454023 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_006249547   ⟸   XM_006249485
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y9T2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454023   ⟸   XM_017598534
- Peptide Label: isoform X1
- UniProtKB: M0RBD3 (UniProtKB/TrEMBL),   A0A8I6G920 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066865   ⟸   ENSRNOT00000071074
RefSeq Acc Id: ENSRNOP00000041584   ⟸   ENSRNOT00000046190
RefSeq Acc Id: ENSRNOP00000077881   ⟸   ENSRNOT00000105197
RefSeq Acc Id: ENSRNOP00000082149   ⟸   ENSRNOT00000103994
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LY04-F1-model_v2 AlphaFold F1LY04 1-958 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562674 AgrOrtholog
BioCyc Gene G2FUF-19067 BioCyc
Ensembl Genes ENSRNOG00000028630 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000041584.6 UniProtKB/TrEMBL
  ENSRNOP00000066865.3 UniProtKB/TrEMBL
  ENSRNOP00000077881 ENTREZGENE
  ENSRNOP00000077881.1 UniProtKB/TrEMBL
  ENSRNOP00000082149.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046190.6 UniProtKB/TrEMBL
  ENSRNOT00000071074.3 UniProtKB/TrEMBL
  ENSRNOT00000103994.1 UniProtKB/TrEMBL
  ENSRNOT00000105197 ENTREZGENE
  ENSRNOT00000105197.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  6.10.140.1120 UniProtKB/TrEMBL
InterPro C1-like_sf UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  KSR_SAM-like_dom UniProtKB/TrEMBL
  Prot_Kinase_C-like_PE/DAG-bd UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  SAM_KSR1_N UniProtKB/TrEMBL
  SAM_KSR1_N_sf UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene 288691 ENTREZGENE
Pfam KSR1-SAM UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  SAM_KSR1_N UniProtKB/TrEMBL
PhenoGen Ksr2 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A8I5Y9T2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G920 ENTREZGENE, UniProtKB/TrEMBL
  F1LY04_RAT UniProtKB/TrEMBL
  M0RBD3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-12 Ksr2  kinase suppressor of ras 2  RGD1562674  similar to kinase suppressor of ras 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562674  similar to kinase suppressor of ras 2   RGD1562674_predicted  similar to kinase suppressor of ras 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562674_predicted  similar to kinase suppressor of ras 2 (predicted)  LOC288691  similar to kinase suppressor of ras 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC288691  similar to kinase suppressor of ras 2      Symbol and Name status set to provisional 70820 PROVISIONAL