Myo1h (myosin IH) - Rat Genome Database

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Gene: Myo1h (myosin IH) Rattus norvegicus
Analyze
Symbol: Myo1h
Name: myosin IH
RGD ID: 1596237
Description: Predicted to enable ATP binding activity; actin binding activity; and cytoskeletal motor activity. Predicted to be part of myosin complex. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to human MYO1H (myosin IH); INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog); 2,2',5,5'-tetrachlorobiphenyl (ortholog); 4,4'-sulfonyldiphenol (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07036550.1; LOC108352465; LOC687866; similar to Myosin IB (MIB) (Brush border myosin IB) (BBMIB); unconventional myosin-Ih; unconventional myosin-Ih-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,908,716 - 47,916,668 (-)NCBIGRCr8
mRatBN7.21242,248,942 - 42,300,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,247,138 - 42,323,730 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01248,025,946 - 48,095,967 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,011,100 - 48,048,540 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01249,831,773 - 49,882,416 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01249,800,615 - 49,818,949 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1243,862,046 - 43,943,131 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Myo1h
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,908,716 - 47,916,668 (-)NCBIGRCr8
mRatBN7.21242,248,942 - 42,300,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,247,138 - 42,323,730 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01248,025,946 - 48,095,967 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,011,100 - 48,048,540 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01249,831,773 - 49,882,416 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01249,800,615 - 49,818,949 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1243,862,046 - 43,943,131 (-)NCBICelera
Cytogenetic Map12q16NCBI
MYO1H
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812109,310,468 - 109,448,379 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12109,347,900 - 109,455,523 (+)EnsemblGRCh38hg38GRCh38
GRCh3712109,785,705 - 109,886,184 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612108,310,871 - 108,370,561 (+)NCBINCBI36Build 36hg18NCBI36
Celera12109,450,872 - 109,510,550 (+)NCBICelera
Cytogenetic Map12q24.11NCBI
HuRef12106,844,483 - 106,904,181 (+)NCBIHuRef
CHM1_112109,794,384 - 109,854,027 (+)NCBICHM1_1
T2T-CHM13v2.012109,285,438 - 109,423,273 (+)NCBIT2T-CHM13v2.0
Myo1h
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395114,427,314 - 114,502,637 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5114,427,227 - 114,503,418 (+)EnsemblGRCm39 Ensembl
GRCm385114,289,253 - 114,364,576 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,289,166 - 114,365,357 (+)EnsemblGRCm38mm10GRCm38
MGSCv375114,764,950 - 114,814,585 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365114,575,638 - 114,624,060 (+)NCBIMGSCv36mm8
Celera5111,414,201 - 111,463,749 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.99NCBI
Myo1h
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554559,066,529 - 9,115,806 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554559,064,914 - 9,115,776 (-)NCBIChiLan1.0ChiLan1.0
MYO1H
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210117,420,813 - 117,515,131 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112117,417,213 - 117,512,057 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012106,965,514 - 107,025,380 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112110,359,957 - 110,419,574 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12110,359,936 - 110,419,574 (+)Ensemblpanpan1.1panPan2
MYO1H
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12617,626,161 - 17,669,772 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2617,626,121 - 17,729,757 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2618,131,867 - 18,176,584 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02617,970,245 - 18,012,327 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2617,969,016 - 18,043,999 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12618,340,945 - 18,385,923 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02617,957,882 - 18,002,909 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02617,977,557 - 18,022,809 (-)NCBIUU_Cfam_GSD_1.0
Myo1h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118144,304,432 - 144,366,845 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367691,109,753 - 1,171,040 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367691,134,076 - 1,171,040 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO1H
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1441,470,916 - 41,559,445 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11441,469,191 - 41,588,934 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21443,985,772 - 44,040,480 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYO1H
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111104,575,208 - 104,683,418 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11104,629,619 - 104,683,000 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037140,433,700 - 140,493,127 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo1h
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474710,978,830 - 11,056,618 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474710,978,231 - 11,056,726 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myo1h
458 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000071335   ⟹   ENSRNOP00000065619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,247,138 - 42,323,730 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078807   ⟹   ENSRNOP00000072401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,247,138 - 42,323,730 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104831   ⟹   ENSRNOP00000085304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,249,794 - 42,254,498 (-)Ensembl
RefSeq Acc Id: XM_039090195   ⟹   XP_038946123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,909,540 - 47,914,978 (-)NCBI
mRatBN7.21242,248,942 - 42,300,103 (-)NCBI
RefSeq Acc Id: XM_063271899   ⟹   XP_063127969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,908,716 - 47,916,668 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038946123 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127969 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065619.3
  ENSRNOP00000072401.2
  ENSRNOP00000085304.1
Reference Protein Sequences
RefSeq Acc Id: XP_038946123   ⟸   XM_039090195
RefSeq Acc Id: ENSRNOP00000085304   ⟸   ENSRNOT00000104831
RefSeq Acc Id: ENSRNOP00000072401   ⟸   ENSRNOT00000078807
RefSeq Acc Id: ENSRNOP00000065619   ⟸   ENSRNOT00000071335
RefSeq Acc Id: XP_063127969   ⟸   XM_063271899
Protein Domains
Myosin motor   TH1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R829-F1-model_v2 AlphaFold M0R829 1-754 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596237 AgrOrtholog
BioCyc Gene G2FUF-18943 BioCyc
Ensembl Genes ENSRNOG00000047191 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071335.4 UniProtKB/TrEMBL
  ENSRNOT00000078807.2 UniProtKB/TrEMBL
  ENSRNOT00000104831.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.820 UniProtKB/TrEMBL
  1.20.5.190 UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/TrEMBL
  6.20.240.20 UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/TrEMBL
  Myosin_TH1 UniProtKB/TrEMBL
  MYSc_Myo1 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 687866 ENTREZGENE
PANTHER MYOSIN UniProtKB/TrEMBL
  UNCONVENTIONAL MYOSIN-IH UniProtKB/TrEMBL
Pfam Myosin_head UniProtKB/TrEMBL
  Myosin_TH1 UniProtKB/TrEMBL
PhenoGen Myo1h PhenoGen
PRINTS MYOSINHEAVY UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  TH1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047191 RatGTEx
SMART MYSc UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2K2W3_RAT UniProtKB/TrEMBL
  A0A8I6A1D5_RAT UniProtKB/TrEMBL
  M0R829_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Myo1h  myosin IH  AABR07036550.1    Data merged from RGD:15005197 737654 PROVISIONAL
2021-03-09 Myo1h  myosin IH  LOC108352465  unconventional myosin-Ih-like  Data merged from RGD:11459139 737654 PROVISIONAL
2019-11-08 AABR07036550.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2016-08-02 LOC108352465  unconventional myosin-Ih-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2016-01-11 Myo1h  myosin IH  LOC687866  similar to Myosin IB (MIB) (Brush border myosin IB) (BBMIB)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC687866  similar to Myosin IB (MIB) (Brush border myosin IB) (BBMIB)      Symbol and Name status set to provisional 70820 PROVISIONAL