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Gene: Chek2 (checkpoint kinase 2) Rattus norvegicus
Symbol: Chek2
Name: checkpoint kinase 2
Description: Exhibits protein serine/threonine kinase activity. Involved in several processes, including cellular response to bisphenol A; positive regulation of anoikis; and positive regulation of cell cycle. Localizes to the nucleus. Predicted to colocalize with the chromosome, telomeric region. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Orthologous to human CHEK2 (checkpoint kinase 2); PARTICIPATES IN p53 signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17beta-estradiol; 2,6-dinitrotoluene.
Type: protein-coding
Also known as: Chk2; CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe); protein kinase Chk2; Rad53; serine/threonine-protein kinase Chk2
Homo sapiens (human) : CHEK2 (checkpoint kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Chek2 (checkpoint kinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chek2 (checkpoint kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CHEK2 (checkpoint kinase 2)
Canis lupus familiaris (dog) : CHEK2 (checkpoint kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chek2 (checkpoint kinase 2)
Sus scrofa (pig) : CHEK2 (checkpoint kinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01251,845,574 - 51,878,098 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01253,583,932 - 53,616,450 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41245,933,900 - 45,965,427 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11245,797,764 - 45,829,292 (-)NCBI
Celera1247,348,969 - 47,380,486 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Chek2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621543
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.