(1S)-bornane-2,3-dione increases phosphorylation ISO RGD:732861 6480464 camphorquinone results in increased phosphorylation of CHEK2 protein CTD PMID:26658076 (S)-naringenin multiple interactions ISO RGD:732861 6480464 [naringenin co-treated with bisphenol A] results in increased expression of CHEK2 mRNA, [naringenin metabolite co-treated with bisphenol A] results in increased expression of CHEK2 mRNA CTD PMID:36235125 (S)-nicotine multiple interactions ISO RGD:732861 6480464 Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form] CTD PMID:23907605 1,2-dichloroethane decreases expression ISO RGD:732862 6480464 ethylene dichloride results in decreased expression of CHEK2 mRNA CTD PMID:28960355 1,2-dimethylhydrazine increases expression ISO RGD:732862 6480464 1, 2-Dimethylhydrazine results in increased expression of CHEK2 mRNA CTD PMID:22206623 17beta-estradiol multiple interactions ISO RGD:732862 6480464 ESR1 protein promotes the reaction [Estradiol results in increased expression of CHEK2 mRNA] CTD PMID:25210133 17beta-estradiol multiple interactions EXP 6480464 fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of CHEK2 protein] CTD PMID:23788033 17beta-estradiol increases phosphorylation EXP 6480464 Estradiol results in increased phosphorylation of CHEK2 protein CTD PMID:23788033 17beta-estradiol decreases expression ISO RGD:732861 6480464 Estradiol results in decreased expression of CHEK2 mRNA CTD PMID:23373633 17beta-estradiol increases expression ISO RGD:732862 6480464 Estradiol results in increased expression of CHEK2 mRNA CTD PMID:25210133 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one multiple interactions ISO RGD:732861 6480464 [Curcumin co-treated with Metribolone] results in increased phosphorylation of CHEK2 protein CTD PMID:21134073 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases phosphorylation ISO RGD:732861 6480464 Metribolone results in increased phosphorylation of CHEK2 protein CTD PMID:23272087 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO RGD:732861 6480464 [Curcumin co-treated with Dihydrotestosterone] results in increased phosphorylation of CHEK2 protein, Flutamide inhibits the reaction [[Dihydrotestosterone co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein] CTD PMID:21134073 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:732862 6480464 Tetrachlorodibenzodioxin results in increased expression of CHEK2 mRNA CTD PMID:15310856 , PMID:15667827 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of CHEK2 mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:732862 6480464 Tetrachlorodibenzodioxin affects the expression of CHEK2 mRNA CTD PMID:21570461 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of CHEK2 mRNA CTD PMID:21346803 2-butoxyethanol increases expression ISO RGD:732862 6480464 n-butoxyethanol results in increased expression of CHEK2 mRNA CTD PMID:19812364 4,4'-diaminodiphenylmethane decreases expression ISO RGD:732862 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of CHEK2 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CHEK2 mRNA CTD PMID:36041667 4-amino-1,8-naphthalimide increases phosphorylation ISO RGD:732862 6480464 4-amino-1, 8-naphthalimide results in increased phosphorylation of CHEK2 protein CTD PMID:16556909 4-amino-1,8-naphthalimide multiple interactions ISO RGD:732862 6480464 PARP1 protein affects the reaction [4-amino-1, 8-naphthalimide results in increased phosphorylation of CHEK2 protein] CTD PMID:16556909 4-hydroxyphenyl retinamide increases expression ISO RGD:732862 6480464 Fenretinide results in increased expression of CHEK2 mRNA CTD PMID:28973697 4-methoxy-TEMPO increases phosphorylation ISO RGD:732861 6480464 4-methoxy-2 more ... CTD PMID:28993908 4-nonylphenol increases phosphorylation ISO RGD:732861 6480464 4-nonylphenol results in increased phosphorylation of CHEK2 protein CTD PMID:32466334 4-tert-Octylphenol increases phosphorylation ISO RGD:732861 6480464 4-tert-octylphenol results in increased phosphorylation of CHEK2 protein CTD PMID:32466334 5-fluorouracil multiple interactions ISO RGD:732861 6480464 Fluorouracil results in increased phosphorylation of and results in increased activity of CHEK2 protein CTD PMID:21613406 6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine multiple interactions ISO RGD:732861 6480464 4-cyclohexylmethoxy-5-nitrosopyrimidine-2, 6-diamine inhibits the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased phosphorylation of CHEK2 protein] CTD PMID:26208482 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of CHEK2 mRNA CTD PMID:24780913 acetamide increases expression EXP 6480464 acetamide results in increased expression of CHEK2 mRNA CTD PMID:31881176 acetylsalicylic acid increases expression ISO RGD:732861 6480464 Aspirin results in increased expression of CHEK2 mRNA CTD PMID:20457246 acrolein increases expression ISO RGD:732861 6480464 Acrolein results in increased expression of CHEK2 protein CTD PMID:34958888 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of CHEK2 mRNA CTD PMID:28959563 Aflatoxin B2 alpha decreases methylation ISO RGD:732861 6480464 aflatoxin B2 results in decreased methylation of CHEK2 intron CTD PMID:30157460 Aflatoxin G1 increases expression ISO RGD:732861 6480464 aflatoxin G1 results in increased expression of CHEK2 protein modified form CTD PMID:23907605 Aflatoxin G1 increases activity ISO RGD:732861 6480464 aflatoxin G1 results in increased activity of CHEK2 protein CTD PMID:23907605 Aflatoxin G1 multiple interactions ISO RGD:732861 6480464 Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form], Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form] CTD PMID:23907605 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CHEK2 mRNA CTD PMID:16483693 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of CHEK2 protein CTD PMID:16483693 amphibole asbestos decreases expression ISO RGD:732861 6480464 Asbestos, Amphibole results in decreased expression of CHEK2 protein CTD PMID:20855422 anthocyanin increases phosphorylation ISO RGD:732861 6480464 Anthocyanins results in increased phosphorylation of CHEK2 protein CTD PMID:27444805 antirheumatic drug decreases expression ISO RGD:732861 6480464 Antirheumatic Agents results in decreased expression of CHEK2 mRNA CTD PMID:24449571 aphidicolin multiple interactions ISO RGD:732861 6480464 Caffeine promotes the reaction [Aphidicolin promotes the reaction [PRKDC protein results in increased phosphorylation of and results in increased activity of CHEK2 protein]] CTD PMID:18158334 aphidicolin multiple interactions ISO RGD:732862 6480464 [7-hydroxystaurosporine results in decreased activity of [CHEK1 protein co-treated with BSCL2 protein]] inhibits the reaction [Aphidicolin results in increased expression of CHEK2 mRNA] CTD PMID:22003191 aristolochic acid A decreases expression ISO RGD:732861 6480464 aristolochic acid I results in decreased expression of CHEK2 mRNA CTD PMID:33212167 aristolochic acids increases expression ISO RGD:732861 6480464 Aristolochic Acids results in increased expression of CHEK2 protein modified form CTD PMID:24792323 aristolochic acids multiple interactions ISO RGD:732861 6480464 Acetylcysteine inhibits the reaction [Aristolochic Acids results in increased expression of CHEK2 protein modified form] CTD PMID:24792323 arsane multiple interactions ISO RGD:732861 6480464 [UNG protein affects the susceptibility to Arsenic] which affects the phosphorylation of CHEK2 protein, APOBEC3B protein affects the reaction [[UNG protein affects the susceptibility to Arsenic] which affects the phosphorylation of CHEK2 protein] CTD PMID:34998823 arsenic atom multiple interactions ISO RGD:732861 6480464 [UNG protein affects the susceptibility to Arsenic] which affects the phosphorylation of CHEK2 protein, APOBEC3B protein affects the reaction [[UNG protein affects the susceptibility to Arsenic] which affects the phosphorylation of CHEK2 protein] CTD PMID:34998823 arsenous acid multiple interactions EXP 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of CHEK2 protein] CTD PMID:23337567 arsenous acid increases expression ISO RGD:732861 6480464 Arsenic Trioxide results in increased expression of CHEK2 mRNA CTD PMID:22521957 arsenous acid multiple interactions ISO RGD:732862 6480464 Arsenic Trioxide results in increased phosphorylation of and results in increased activity of CHEK2 protein CTD PMID:16891316 arsenous acid increases phosphorylation EXP 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK2 protein CTD PMID:23337567 arsenous acid multiple interactions ISO RGD:732861 6480464 [ruxolitinib co-treated with Arsenic Trioxide] results in increased phosphorylation of CHEK2 protein more ... CTD PMID:16891316 more ... artesunate multiple interactions ISO RGD:732861 6480464 APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein] CTD PMID:31664825 artesunate increases phosphorylation ISO RGD:732861 6480464 Artesunate results in increased phosphorylation of CHEK2 protein CTD PMID:31664825 atrazine increases expression ISO RGD:732862 6480464 Atrazine results in increased expression of CHEK2 mRNA CTD PMID:22515965 auraptene affects expression ISO RGD:732861 6480464 aurapten affects the expression of CHEK2 mRNA CTD PMID:23320178 azoxystrobin multiple interactions EXP 6480464 [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CHEK2 mRNA CTD PMID:33854195 benzo[a]pyrene decreases expression ISO RGD:732861 6480464 Benzo(a)pyrene results in decreased expression of CHEK2 mRNA CTD PMID:20064835 , PMID:21802500 benzo[a]pyrene increases expression ISO RGD:732862 6480464 Benzo(a)pyrene results in increased expression of CHEK2 mRNA CTD PMID:22641617 berberine increases expression ISO RGD:732861 6480464 Berberine results in increased expression of CHEK2 protein modified form CTD PMID:23747414 bis(2-chloroethyl) sulfide increases expression ISO RGD:732862 6480464 Mustard Gas results in increased expression of CHEK2 mRNA CTD PMID:18955075 bis(2-chloroethyl) sulfide increases phosphorylation ISO RGD:732861 6480464 Mustard Gas results in increased phosphorylation of CHEK2 protein CTD PMID:22119920 bis(2-chloroethyl) sulfide multiple interactions ISO RGD:732861 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK2 protein], wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK2 protein] CTD PMID:22119920 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:732861 6480464 Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK2 protein modified form] CTD PMID:30720231 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CHEK2 mRNA, Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of CHEK2 protein] CTD PMID:23788033 , PMID:36041667 bisphenol A multiple interactions ISO RGD:732861 6480464 [naringenin co-treated with bisphenol A] results in increased expression of CHEK2 mRNA, [naringenin metabolite co-treated with bisphenol A] results in increased expression of CHEK2 mRNA CTD PMID:36235125 bisphenol A increases phosphorylation ISO RGD:732861 6480464 bisphenol A results in increased phosphorylation of CHEK2 protein CTD PMID:32466334 bisphenol A decreases methylation ISO RGD:732861 6480464 bisphenol A results in decreased methylation of CHEK2 gene CTD PMID:31601247 bisphenol A increases phosphorylation EXP 6480464 bisphenol A results in increased phosphorylation of CHEK2 protein CTD PMID:23788033 , PMID:25344109 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CHEK2 mRNA CTD PMID:25181051 , PMID:34947998 bisphenol F multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CHEK2 mRNA CTD PMID:36041667 bleomycin A2 increases phosphorylation ISO RGD:732861 6480464 Bleomycin results in increased phosphorylation of CHEK2 protein CTD PMID:24933654 bleomycin A2 multiple interactions ISO RGD:732861 6480464 resveratrol promotes the reaction [Bleomycin results in increased phosphorylation of CHEK2 protein] CTD PMID:24933654 Brevetoxin B increases expression ISO RGD:732861 6480464 brevetoxin 2 results in increased expression of CHEK2 mRNA CTD PMID:20498034 busulfan multiple interactions ISO RGD:732861 6480464 [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK2 protein CTD PMID:20933509 caffeine multiple interactions ISO RGD:732861 6480464 Caffeine inhibits the reaction [[Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]] more ... CTD PMID:15975956 more ... caffeine decreases activity ISO RGD:732861 6480464 Caffeine results in decreased activity of CHEK2 protein CTD PMID:10531013 calcitriol decreases expression ISO RGD:732861 6480464 Calcitriol results in decreased expression of CHEK2 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:732861 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of CHEK2 mRNA CTD PMID:21592394 camptothecin increases expression ISO RGD:732861 6480464 Camptothecin results in increased expression of CHEK2 protein modified form CTD PMID:25269479 more ... camptothecin multiple interactions ISO RGD:732861 6480464 Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK2 protein modified form] CTD PMID:30720231 camptothecin increases phosphorylation ISO RGD:732861 6480464 Camptothecin results in increased phosphorylation of CHEK2 protein CTD PMID:21646468 cannabidiol decreases expression ISO RGD:732861 6480464 Cannabidiol results in decreased expression of CHEK2 mRNA CTD PMID:36519830 cannabidiol multiple interactions ISO RGD:732861 6480464 [Cannabidiol co-treated with moringin] results in decreased expression of CHEK2 mRNA CTD PMID:30096889 capsaicin increases expression ISO RGD:732861 6480464 Capsaicin results in increased expression of CHEK2 mRNA CTD PMID:19502594 casticin increases expression ISO RGD:732861 6480464 casticin results in increased expression of CHEK2 protein CTD PMID:29098808 CGP 52608 multiple interactions ISO RGD:732861 6480464 CGP 52608 promotes the reaction [RORA protein binds to CHEK2 gene] CTD PMID:28238834 chlorpyrifos multiple interactions EXP 6480464 [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CHEK2 mRNA CTD PMID:33854195 choline multiple interactions ISO RGD:732862 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CHEK2 gene CTD PMID:20938992 chromium(6+) multiple interactions ISO RGD:732861 6480464 Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of CHEK2 protein] CTD PMID:31388677 chromium(6+) increases phosphorylation ISO RGD:732861 6480464 chromium hexavalent ion results in increased phosphorylation of CHEK2 protein CTD PMID:31388677 cisplatin multiple interactions ISO RGD:732861 6480464 [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of CHEK2 mRNA more ... CTD PMID:21107699 more ... cisplatin increases expression ISO RGD:732861 6480464 Cisplatin results in increased expression of CHEK2 mRNA CTD PMID:25450742 cisplatin multiple interactions EXP 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK2 protein modified form] CTD PMID:26739623 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of CHEK2 protein modified form CTD PMID:26739623 cisplatin increases phosphorylation ISO RGD:732861 6480464 Cisplatin results in increased phosphorylation of CHEK2 protein CTD PMID:21285353 more ... cisplatin increases activity ISO RGD:732861 6480464 Cisplatin results in increased activity of CHEK2 protein CTD PMID:21324906 , PMID:21592546 cisplatin multiple interactions ISO RGD:732862 6480464 [7-hydroxystaurosporine results in decreased activity of [CHEK1 protein co-treated with BSCL2 protein]] inhibits the reaction [Cisplatin results in increased expression of CHEK2 mRNA], MSH2 protein promotes the reaction [Cisplatin results in increased phosphorylation of CHEK2 protein] CTD PMID:21285353 , PMID:22003191 cisplatin increases phosphorylation ISO RGD:732862 6480464 Cisplatin results in increased phosphorylation of CHEK2 protein CTD PMID:21285353 clofarabine multiple interactions ISO RGD:732861 6480464 [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK2 protein, [clofarabine co-treated with fludarabine] results in increased phosphorylation of CHEK2 protein CTD PMID:20933509 cobalt atom increases expression ISO RGD:732862 6480464 Cobalt results in increased expression of CHEK2 mRNA CTD PMID:22147119 cobalt atom multiple interactions ISO RGD:732862 6480464 [Organometallic Compounds co-treated with Cobalt] results in increased expression of CHEK2 mRNA CTD PMID:22147119 copper atom multiple interactions ISO RGD:732861 6480464 [Chelating Agents binds to Copper] which results in decreased expression of CHEK2 mRNA, [Thiosemicarbazones binds to Copper] which results in increased phosphorylation of CHEK2 protein CTD PMID:20931265 , PMID:30911355 copper(0) multiple interactions ISO RGD:732861 6480464 [Chelating Agents binds to Copper] which results in decreased expression of CHEK2 mRNA, [Thiosemicarbazones binds to Copper] which results in increased phosphorylation of CHEK2 protein CTD PMID:20931265 , PMID:30911355 copper(II) sulfate decreases expression ISO RGD:732861 6480464 Copper Sulfate results in decreased expression of CHEK2 mRNA CTD PMID:19549813 coumestrol multiple interactions ISO RGD:732861 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 Cuprizon increases expression EXP 6480464 Cuprizone results in increased expression of CHEK2 mRNA CTD PMID:26577399 curcumin multiple interactions ISO RGD:732861 6480464 [Curcumin co-treated with Dihydrotestosterone] results in increased phosphorylation of CHEK2 protein more ... CTD PMID:21134073 curcumin increases phosphorylation ISO RGD:732861 6480464 Curcumin results in increased phosphorylation of CHEK2 protein CTD PMID:21134073 decabromodiphenyl ether affects expression ISO RGD:732861 6480464 decabromobiphenyl ether affects the expression of CHEK2 mRNA CTD PMID:24834073 Decamethylcyclopentasiloxane decreases expression ISO RGD:732861 6480464 decamethylcyclopentasiloxane results in decreased expression of CHEK2 mRNA CTD PMID:27601420 diarsenic trioxide multiple interactions ISO RGD:732861 6480464 [ruxolitinib co-treated with Arsenic Trioxide] results in increased phosphorylation of CHEK2 protein more ... CTD PMID:16891316 more ... diarsenic trioxide multiple interactions ISO RGD:732862 6480464 Arsenic Trioxide results in increased phosphorylation of and results in increased activity of CHEK2 protein CTD PMID:16891316 diarsenic trioxide multiple interactions EXP 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of CHEK2 protein] CTD PMID:23337567 diarsenic trioxide increases expression ISO RGD:732861 6480464 Arsenic Trioxide results in increased expression of CHEK2 mRNA CTD PMID:22521957 diarsenic trioxide increases phosphorylation EXP 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK2 protein CTD PMID:23337567 dibutyl phthalate decreases expression ISO RGD:732862 6480464 Dibutyl Phthalate results in decreased expression of CHEK2 mRNA CTD PMID:21266533 dichlorvos multiple interactions EXP 6480464 TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CHEK2 mRNA], TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CHEK2 protein] CTD PMID:24369695 dichlorvos increases expression EXP 6480464 Dichlorvos results in increased expression of CHEK2 mRNA, Dichlorvos results in increased expression of CHEK2 protein CTD PMID:24369695 dieldrin affects expression EXP 6480464 Dieldrin affects the expression of CHEK2 mRNA CTD PMID:22546817 diethyl sulfate decreases expression ISO RGD:732861 6480464 diethyl sulfate results in decreased expression of CHEK2 protein modified form CTD PMID:23830811 diethyl sulfate increases expression ISO RGD:732861 6480464 diethyl sulfate results in increased expression of CHEK2 protein modified form CTD PMID:23830811 digitoxin decreases expression ISO RGD:732861 6480464 Digitoxin analog results in decreased expression of CHEK2 protein, Digitoxin results in decreased expression of CHEK2 protein CTD PMID:22037315 dihydroxyacetone decreases expression ISO RGD:732861 6480464 Dihydroxyacetone results in decreased expression of CHEK2 mRNA CTD PMID:32506039 dimethyl sulfoxide affects expression ISO RGD:732861 6480464 Dimethyl Sulfoxide affects the expression of CHEK2 mRNA CTD PMID:24834073 dimethylarsinic acid increases expression EXP 6480464 Cacodylic Acid results in increased expression of CHEK2 mRNA CTD PMID:17720352 dioscin decreases expression ISO RGD:732861 6480464 dioscin results in decreased expression of CHEK2 mRNA, dioscin results in decreased expression of CHEK2 protein CTD PMID:29990575 diuron increases expression EXP 6480464 Diuron results in increased expression of CHEK2 mRNA CTD PMID:21551480 dorsomorphin increases phosphorylation ISO RGD:732861 6480464 dorsomorphin results in increased phosphorylation of CHEK2 protein CTD PMID:23274516 dorsomorphin multiple interactions ISO RGD:732861 6480464 Acetylcysteine inhibits the reaction [dorsomorphin results in increased phosphorylation of CHEK2 protein], Caffeine inhibits the reaction [dorsomorphin results in increased phosphorylation of CHEK2 protein] CTD PMID:23274516 doxorubicin multiple interactions ISO RGD:732861 6480464 [3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide affects the susceptibility to Doxorubicin] which results in decreased expression of CHEK2 mRNA more ... CTD PMID:15489221 more ... doxorubicin decreases expression ISO RGD:732862 6480464 Doxorubicin results in decreased expression of CHEK2 mRNA CTD PMID:29653124 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of CHEK2 mRNA CTD PMID:19801496 , PMID:27181935 doxorubicin multiple interactions EXP 6480464 Fungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of CHEK2 mRNA] CTD PMID:27181935 doxorubicin increases phosphorylation ISO RGD:732861 6480464 Doxorubicin results in increased phosphorylation of CHEK2 protein CTD PMID:17085670 , PMID:21646468 doxorubicin increases phosphorylation ISO RGD:732862 6480464 Doxorubicin results in increased phosphorylation of CHEK2 protein CTD PMID:22242153 endosulfan increases expression ISO RGD:732862 6480464 Endosulfan results in increased expression of CHEK2 mRNA CTD PMID:22515965 Enterolactone multiple interactions ISO RGD:732861 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CHEK2 mRNA CTD PMID:19167446 etoposide increases phosphorylation ISO RGD:732862 6480464 Etoposide results in increased phosphorylation of CHEK2 protein CTD PMID:22242153 etoposide increases phosphorylation ISO RGD:732861 6480464 Etoposide results in increased phosphorylation of CHEK2 protein CTD PMID:21186793 , PMID:26259609 etoposide multiple interactions ISO RGD:732861 6480464 4-fluoro-2-(4-(4-(2-hydroxypropan-2-yl)pyrrolidin-3-ylamino)-6 more ... CTD PMID:21186793 , PMID:26259609 fenofibrate multiple interactions EXP 6480464 [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CHEK2 mRNA CTD PMID:18253720 fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of CHEK2 mRNA CTD PMID:30307764 fisetin increases expression ISO RGD:732861 6480464 fisetin results in increased expression of CHEK2 protein CTD PMID:28181380 flavanones increases phosphorylation ISO RGD:732861 6480464 Flavanones results in increased phosphorylation of CHEK2 protein CTD PMID:21616090 floxuridine multiple interactions ISO RGD:732861 6480464 Floxuridine results in increased phosphorylation of and results in increased activity of CHEK2 protein CTD PMID:21613406 floxuridine increases activity ISO RGD:732861 6480464 Floxuridine results in increased activity of CHEK2 protein CTD PMID:22194930 fluoranthene increases expression ISO RGD:732862 6480464 fluoranthene results in increased expression of CHEK2 mRNA CTD PMID:28329830 fluoranthene multiple interactions ISO RGD:732862 6480464 [1-methylanthracene co-treated with fluoranthene] results in increased expression of CHEK2 mRNA CTD PMID:28329830 flutamide multiple interactions ISO RGD:732861 6480464 Flutamide inhibits the reaction [[Dihydrotestosterone co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein] CTD PMID:21134073 folic acid multiple interactions ISO RGD:732862 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CHEK2 gene CTD PMID:20938992 formaldehyde decreases expression ISO RGD:732861 6480464 Formaldehyde results in decreased expression of CHEK2 mRNA CTD PMID:23649840 fulvestrant multiple interactions EXP 6480464 fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of CHEK2 protein], fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of CHEK2 protein] CTD PMID:23788033 furan increases expression ISO RGD:732862 6480464 furan results in increased expression of CHEK2 mRNA CTD PMID:20194422 furan increases expression EXP 6480464 furan results in increased expression of CHEK2 mRNA CTD PMID:25539665 furosemide affects expression EXP 6480464 Furosemide affects the expression of CHEK2 mRNA CTD PMID:17497460 genistein multiple interactions ISO RGD:732861 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of CHEK2 protein] more ... CTD PMID:19038232 genistein increases phosphorylation ISO RGD:732861 6480464 Genistein results in increased phosphorylation of CHEK2 protein CTD PMID:19038232 gingerol multiple interactions ISO RGD:732861 6480464 gingerol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CHEK2 protein] CTD PMID:28988496 glyphosate multiple interactions EXP 6480464 [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CHEK2 mRNA CTD PMID:33854195 Goe 6976 multiple interactions ISO RGD:732861 6480464 Go 6976 inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of CHEK2 protein] CTD PMID:17320279 gold atom decreases expression ISO RGD:732861 6480464 Gold analog results in decreased expression of CHEK2 mRNA CTD PMID:36057382 gold(0) decreases expression ISO RGD:732861 6480464 Gold analog results in decreased expression of CHEK2 mRNA CTD PMID:36057382 GW 4064 increases expression ISO RGD:732861 6480464 GW 4064 results in increased expression of CHEK2 mRNA CTD PMID:31437187 hellebrigenin increases phosphorylation ISO RGD:732861 6480464 hellebrigenin results in increased phosphorylation of CHEK2 protein CTD PMID:24954031 hexamethylcyclotrisiloxane decreases expression ISO RGD:732861 6480464 hexamethylcyclotrisiloxane results in decreased expression of CHEK2 mRNA CTD PMID:27601420 hydrogen peroxide multiple interactions ISO RGD:732861 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CHEK2 protein] more ... CTD PMID:24933654 hydrogen peroxide increases phosphorylation ISO RGD:732861 6480464 Hydrogen Peroxide results in increased phosphorylation of CHEK2 protein CTD PMID:24933654 , PMID:26208482 hydroxyurea increases expression ISO RGD:732861 6480464 Hydroxyurea results in increased expression of CHK2 protein modified form CTD PMID:21840268 hydroxyurea increases phosphorylation ISO RGD:732861 6480464 Hydroxyurea results in increased phosphorylation of CHEK2 protein CTD PMID:32466334 imidacloprid multiple interactions EXP 6480464 [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CHEK2 mRNA CTD PMID:33854195 indole-3-methanol multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CHEK2 mRNA CTD PMID:22129741 irinotecan increases phosphorylation ISO RGD:732861 6480464 Irinotecan results in increased phosphorylation of CHEK2 protein CTD PMID:22898888 iron atom multiple interactions EXP 6480464 [Nickel co-treated with Iron co-treated with Tungsten] results in decreased expression of CHEK2 mRNA CTD PMID:22198552 iron(0) multiple interactions EXP 6480464 [Nickel co-treated with Iron co-treated with Tungsten] results in decreased expression of CHEK2 mRNA CTD PMID:22198552 isoflavones multiple interactions ISO RGD:732861 6480464 [Isoflavones co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein CTD PMID:21134073 isoflurane increases expression EXP 6480464 Isoflurane results in increased expression of CHEK2 mRNA CTD PMID:16978161 kaempferol increases phosphorylation ISO RGD:732862 6480464 kaempferol results in increased phosphorylation of CHEK2 protein CTD PMID:24595819 kojic acid multiple interactions EXP 6480464 [kojic acid co-treated with Diethylnitrosamine] results in increased expression of CHEK2 mRNA, Ascorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of CHEK2 mRNA] CTD PMID:18544905 L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of CHEK2 mRNA] CTD PMID:18544905 L-ascorbic acid multiple interactions ISO RGD:732861 6480464 Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of CHEK2 protein] more ... CTD PMID:25977998 , PMID:31388677 L-methionine multiple interactions ISO RGD:732862 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CHEK2 gene CTD PMID:20938992 lead(0) affects expression ISO RGD:732861 6480464 Lead affects the expression of CHEK2 mRNA CTD PMID:22313790 lead(2+) affects expression ISO RGD:732861 6480464 Lead affects the expression of CHEK2 mRNA CTD PMID:22313790 leptomycin B multiple interactions ISO RGD:732861 6480464 [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of CHEK2 mRNA CTD PMID:20803015 levonorgestrel multiple interactions ISO RGD:732861 6480464 [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of CHEK2 mRNA CTD PMID:19074003 Licochalcone B increases phosphorylation ISO RGD:732861 6480464 licochalcone B results in increased phosphorylation of CHEK2 protein CTD PMID:35948134 lovastatin multiple interactions EXP 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK2 protein modified form] CTD PMID:26739623 melphalan increases phosphorylation ISO RGD:732861 6480464 Melphalan results in increased phosphorylation of CHEK2 protein CTD PMID:26208482 metformin multiple interactions ISO RGD:732861 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of CHEK2 mRNA CTD PMID:29309887 methoxsalen multiple interactions ISO RGD:732861 6480464 Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form] CTD PMID:23907605 methoxychlor increases phosphorylation ISO RGD:732861 6480464 Methoxychlor results in increased phosphorylation of CHEK2 protein CTD PMID:32466334 methyl isocyanate decreases expression ISO RGD:732862 6480464 methyl isocyanate results in decreased expression of CHEK2 mRNA CTD PMID:22223508 methylmercury chloride affects expression EXP 6480464 methylmercuric chloride affects the expression of CHEK2 mRNA CTD PMID:20864626 methylseleninic acid increases expression ISO RGD:732861 6480464 methylselenic acid results in increased expression of CHEK2 mRNA CTD PMID:12517777 mitomycin C increases phosphorylation ISO RGD:732861 6480464 Mitomycin results in increased phosphorylation of CHEK2 protein CTD PMID:26208482 mono(2-ethylhexyl) phthalate multiple interactions ISO RGD:732861 6480464 gingerol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CHEK2 protein] CTD PMID:28988496 mono(2-ethylhexyl) phthalate increases phosphorylation ISO RGD:732861 6480464 mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CHEK2 protein CTD PMID:28988496 monocrotaline multiple interactions ISO RGD:732862 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA CTD PMID:21224054 morin decreases expression ISO RGD:732861 6480464 morin results in decreased expression of CHEK2 mRNA CTD PMID:28689916 myristicin decreases expression ISO RGD:732861 6480464 myristicin results in decreased expression of CHEK2 mRNA CTD PMID:24792648 N-acetyl-L-cysteine multiple interactions ISO RGD:732861 6480464 Acetylcysteine inhibits the reaction [Aristolochic Acids results in increased expression of CHEK2 protein modified form] more ... CTD PMID:15489221 more ... N-acetyl-L-cysteine increases expression ISO RGD:732861 6480464 Acetylcysteine results in increased expression of CHEK2 protein CTD PMID:31715134 N-ethyl-N-nitrosourea decreases expression ISO RGD:732862 6480464 Ethylnitrosourea results in decreased expression of CHEK2 protein CTD PMID:28549617 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO RGD:732861 6480464 CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F1 protein] more ... CTD PMID:26921499 N-methyl-N-nitrosourea increases phosphorylation ISO RGD:732862 6480464 Methylnitrosourea results in increased phosphorylation of CHEK2 protein CTD PMID:21285353 N-methyl-N-nitrosourea multiple interactions ISO RGD:732862 6480464 MSH2 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of CHEK2 protein] CTD PMID:21285353 N-nitrosodiethylamine multiple interactions EXP 6480464 [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CHEK2 mRNA more ... CTD PMID:18253720 more ... nickel atom multiple interactions EXP 6480464 [Nickel co-treated with Iron co-treated with Tungsten] results in decreased expression of CHEK2 mRNA CTD PMID:22198552 nicotine multiple interactions ISO RGD:732861 6480464 Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form] CTD PMID:23907605 Nonidet P-40 increases expression ISO RGD:732861 6480464 Nonidet P-40 results in increased expression of CHEK2 mRNA CTD PMID:26552463 O-methyleugenol decreases expression EXP 6480464 methyleugenol results in decreased expression of CHEK2 mRNA CTD PMID:26011634 octamethylcyclotetrasiloxane decreases expression ISO RGD:732861 6480464 octamethylcyclotetrasiloxane results in decreased expression of CHEK2 mRNA CTD PMID:27601420 oroxylin A multiple interactions ISO RGD:732861 6480464 diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5, 7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of CHEK2 protein modified form] CTD PMID:23470866 oroxylin A increases expression ISO RGD:732861 6480464 5, 7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of CHEK2 protein modified form CTD PMID:23470866 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CHEK2 mRNA CTD PMID:25729387 oxaliplatin increases phosphorylation ISO RGD:732861 6480464 oxaliplatin results in increased phosphorylation of CHEK2 protein CTD PMID:21750216 p-tert-Amylphenol increases phosphorylation ISO RGD:732861 6480464 4-tert-octylphenol results in increased phosphorylation of CHEK2 protein CTD PMID:32466334 paclitaxel multiple interactions ISO RGD:732861 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of CHEK2 mRNA CTD PMID:29309887 paracetamol increases expression ISO RGD:732861 6480464 Acetaminophen results in increased expression of CHEK2 mRNA CTD PMID:22230336 pentobarbital increases expression EXP 6480464 Pentobarbital results in increased expression of CHEK2 mRNA CTD PMID:16978161 phenytoin multiple interactions ISO RGD:732862 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA CTD PMID:21224054 PhIP increases phosphorylation ISO RGD:732861 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased phosphorylation of CHEK2 protein CTD PMID:32466334 platinum multiple interactions ISO RGD:732861 6480464 Platinum analog results in increased phosphorylation of and results in increased activity of CHEK2 protein CTD PMID:21107699 platinum(0) multiple interactions ISO RGD:732861 6480464 Platinum analog results in increased phosphorylation of and results in increased activity of CHEK2 protein CTD PMID:21107699 potassium chromate multiple interactions ISO RGD:732861 6480464 2-(2 more ... CTD PMID:25977998 potassium chromate increases phosphorylation ISO RGD:732861 6480464 potassium chromate(VI) results in increased phosphorylation of CHEK2 protein CTD PMID:25977998 potassium chromate increases expression ISO RGD:732861 6480464 potassium chromate(VI) results in increased expression of CHEK2 protein modified form CTD PMID:25977998 promethazine decreases expression EXP 6480464 Promethazine results in decreased expression of CHEK2 mRNA CTD PMID:26011634 quercetin multiple interactions ISO RGD:732861 6480464 Quercetin results in increased phosphorylation of and results in increased activity of CHEK2 protein CTD PMID:19009557 quercetin increases phosphorylation ISO RGD:732862 6480464 Quercetin results in increased phosphorylation of CHEK2 protein CTD PMID:24595819 resveratrol multiple interactions ISO RGD:732861 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [resveratrol promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of CHEK2 protein]] more ... CTD PMID:15975956 more ... resveratrol increases phosphorylation ISO RGD:732861 6480464 resveratrol results in increased phosphorylation of CHEK2 protein CTD PMID:20080969 more ... rifampicin multiple interactions ISO RGD:732862 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA CTD PMID:21224054 ruxolitinib multiple interactions ISO RGD:732861 6480464 [ruxolitinib co-treated with Arsenic Trioxide] results in increased phosphorylation of CHEK2 protein CTD PMID:30012499 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO RGD:732861 6480464 Buthionine Sulfoximine promotes the reaction [potassium chromate(VI) results in increased expression of CHEK2 protein modified form] CTD PMID:25977998 silibinin multiple interactions ISO RGD:732861 6480464 Caffeine inhibits the reaction [Silybin results in increased phosphorylation of CHEK2 protein] CTD PMID:16777994 silibinin increases phosphorylation ISO RGD:732861 6480464 Silybin results in increased phosphorylation of CHEK2 protein CTD PMID:16777994 silicon dioxide decreases expression ISO RGD:732861 6480464 Silicon Dioxide analog results in decreased expression of CHEK2 mRNA CTD PMID:25895662 silver(1+) nitrate increases expression ISO RGD:732861 6480464 Silver Nitrate analog results in increased expression of CHEK2 mRNA CTD PMID:22831968 sodium arsenite multiple interactions ISO RGD:732861 6480464 [sodium arsenite promotes the reaction [CHEK2 protein results in increased phosphorylation of ELAVL1 protein]] promotes the reaction [[ELAVL1 protein binds to TRA2B exon] which results in increased expression of TRA2B mRNA modified form] more ... CTD PMID:24865968 sodium arsenite increases phosphorylation ISO RGD:732862 6480464 sodium arsenite results in increased phosphorylation of CHEK2 protein CTD PMID:18996350 sodium arsenite increases phosphorylation ISO RGD:732861 6480464 sodium arsenite results in increased phosphorylation of CHEK2 protein CTD PMID:24865968 , PMID:29039521 sodium arsenite multiple interactions ISO RGD:732862 6480464 CHEK2 protein affects the reaction [sodium arsenite results in decreased expression of HSP90AB1 mRNA], CHEK2 protein affects the reaction [sodium arsenite results in increased phosphorylation of TRP53 protein] CTD PMID:18996350 sterigmatocystin multiple interactions ISO RGD:732861 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Sterigmatocystin results in increased expression of CHEK2 protein modified form] CTD PMID:26914363 sterigmatocystin increases expression ISO RGD:732861 6480464 Sterigmatocystin results in increased expression of CHEK2 protein modified form CTD PMID:26914363 sunitinib decreases expression ISO RGD:732861 6480464 Sunitinib results in decreased expression of CHEK2 mRNA CTD PMID:31533062 T-2 toxin multiple interactions ISO RGD:732861 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [T-2 Toxin results in increased activity of CHEK2 protein] CTD PMID:20150440 T-2 toxin increases activity ISO RGD:732861 6480464 T-2 Toxin results in increased activity of CHEK2 protein CTD PMID:20150440 temozolomide multiple interactions ISO RGD:732861 6480464 [temozolomide co-treated with resveratrol] results in increased phosphorylation of CHEK2 protein, AKT1 protein inhibits the reaction [temozolomide results in increased phosphorylation of CHEK2 protein] CTD PMID:15930307 , PMID:23522185 temozolomide increases phosphorylation ISO RGD:732861 6480464 temozolomide results in increased phosphorylation of CHEK2 protein CTD PMID:15930307 , PMID:23522185 testosterone decreases expression ISO RGD:732861 6480464 Testosterone results in decreased expression of CHEK2 mRNA CTD PMID:21592394 testosterone multiple interactions ISO RGD:732861 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of CHEK2 mRNA CTD PMID:21592394 testosterone undecanoate multiple interactions ISO RGD:732861 6480464 [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of CHEK2 mRNA CTD PMID:19074003 testosterone undecanoate decreases expression ISO RGD:732861 6480464 testosterone undecanoate results in decreased expression of CHEK2 mRNA CTD PMID:19074003 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of CHEK2 mRNA CTD PMID:16644059 tetrachloromethane increases phosphorylation ISO RGD:732862 6480464 Carbon Tetrachloride results in increased phosphorylation of CHK2 protein CTD PMID:36526012 tetrachloromethane multiple interactions ISO RGD:732862 6480464 ATM protein promotes the reaction [Carbon Tetrachloride results in increased phosphorylation of CHK2 protein] CTD PMID:36526012 tetrachloromethane increases expression ISO RGD:732862 6480464 Carbon Tetrachloride results in increased expression of CHEK2 mRNA CTD PMID:31919559 thiabendazole multiple interactions EXP 6480464 [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CHEK2 mRNA CTD PMID:33854195 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of CHEK2 mRNA CTD PMID:26011634 , PMID:34492290 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of CHEK2 mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CHEK2 mRNA CTD PMID:25729387 trichostatin A decreases expression ISO RGD:732861 6480464 trichostatin A results in decreased expression of CHEK2 mRNA CTD PMID:23770000 trimellitic anhydride increases expression ISO RGD:732862 6480464 trimellitic anhydride results in increased expression of CHEK2 mRNA CTD PMID:19042947 triptonide affects expression ISO RGD:732862 6480464 triptonide affects the expression of CHEK2 mRNA CTD PMID:33045310 tungsten multiple interactions EXP 6480464 [Nickel co-treated with Iron co-treated with Tungsten] results in decreased expression of CHEK2 mRNA CTD PMID:22198552 urethane increases expression ISO RGD:732861 6480464 Urethane results in increased expression of CHEK2 mRNA CTD PMID:28818685 usnic acid increases expression ISO RGD:732861 6480464 usnic acid results in increased expression of CHEK2 protein, usnic acid results in increased expression of CHEK2 protein modified form CTD PMID:27369375 , PMID:31715134 usnic acid multiple interactions ISO RGD:732861 6480464 Acetylcysteine inhibits the reaction [usnic acid results in increased expression of CHEK2 protein] CTD PMID:31715134 valproic acid decreases methylation ISO RGD:732861 6480464 Valproic Acid results in decreased methylation of CHEK2 gene CTD PMID:29154799 vincristine decreases expression ISO RGD:732861 6480464 Vincristine results in decreased expression of CHEK2 mRNA CTD PMID:23649840 wortmannin multiple interactions ISO RGD:732861 6480464 wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of CHEK2 protein], wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK2 protein] CTD PMID:19111594 , PMID:22119920 wortmannin decreases phosphorylation ISO RGD:732861 6480464 wortmannin results in decreased phosphorylation of CHEK2 protein CTD PMID:22119920 yttrium chloride decreases phosphorylation EXP 6480464 yttrium chloride results in decreased phosphorylation of CHEK2 protein CTD PMID:35088107 zearalenone decreases expression ISO RGD:732862 6480464 Zearalenone results in decreased expression of CHEK2 protein CTD PMID:35504548 zidovudine decreases expression ISO RGD:732861 6480464 Zidovudine results in decreased expression of CHEK2 protein CTD PMID:19541796 zidovudine increases phosphorylation ISO RGD:732861 6480464 Zidovudine results in increased phosphorylation of CHEK2 protein CTD PMID:19541796 zinc pyrithione increases expression ISO RGD:732861 6480464 pyrithione zinc results in increased expression of CHEK2 mRNA CTD PMID:21424779
