Acads (acyl-CoA dehydrogenase short chain) - Rat Genome Database

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Gene: Acads (acyl-CoA dehydrogenase short chain) Rattus norvegicus
Analyze
Symbol: Acads
Name: acyl-CoA dehydrogenase short chain
RGD ID: 620514
Description: Enables FAD binding activity; acyl-CoA dehydrogenase activity; and protein homodimerization activity. Involved in fatty acid catabolic process; response to glucocorticoid; and response to starvation. Located in mitochondrial matrix and mitochondrial membrane. Human ortholog(s) of this gene implicated in alcohol use disorder and short chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADS (acyl-CoA dehydrogenase short chain); PARTICIPATES IN fatty acid beta degradation pathway; 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acetyl-Coenzyme A dehydrogenase, short chain; acyl-CoA dehydrogenase, C-2 to C-3 short chain; acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain; acyl-Coenzyme A dehydrogenase, short chain; butyryl-CoA dehydrogenase; Scad; short chain acyl-coenzyme A dehydrogenase; short-chain acyl-CoA dehydrogenase; short-chain specific acyl-CoA dehydrogenase, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bw128 Foco6 Foco10
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,154,259 - 47,163,580 (+)NCBIGRCr8
mRatBN7.21241,493,650 - 41,502,897 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,493,626 - 41,502,898 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,661,140 - 42,670,447 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,274,797 - 43,284,104 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,335,363 - 42,344,671 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,254,503 - 47,263,747 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,254,484 - 47,263,747 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,049,549 - 49,059,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,765,284 - 42,774,528 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,628,671 - 42,637,916 (+)NCBI
Celera1243,112,383 - 43,121,613 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
acadesine  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
aspartame  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
choline  (ISO)
clofibrate  (EXP,ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyproconazole  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dioscin  (EXP,ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (EXP,ISO)
farnesol  (ISO)
fenamidone  (ISO)
fenofibrate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
glafenine  (EXP)
glycidol  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
hypochlorous acid  (ISO)
indometacin  (EXP)
isoprenaline  (EXP)
ketoconazole  (EXP)
L-methionine  (ISO)
maneb  (ISO)
melatonin  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (ISO)
N-nitrosomorpholine  (EXP)
okadaic acid  (ISO)
oleic acid  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP)
propiconazole  (ISO)
resveratrol  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
troglitazone  (EXP)
urethane  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Functional role of the active site glutamate-368 in rat short chain acyl-CoA dehydrogenase. Battaile KP, etal., Biochemistry. 1996 Dec 3;35(48):15356-63.
2. Crystal structure of rat short chain acyl-CoA dehydrogenase complexed with acetoacetyl-CoA: comparison with other acyl-CoA dehydrogenases. Battaile KP, etal., J Biol Chem 2002 Apr 5;277(14):12200-7.
3. The influence of chylomicron remnants on cholesteryl ester metabolism in cultured rat hepatocytes: comparison of the effects of particles enriched in n-3 or n-6 polyunsaturated fatty acids. Botham KM, etal., Biochim Biophys Acta. 2001 Dec 30;1534(2-3):96-109.
4. Treatment of metritis in cattle with prostaglandin F2 alpha. Coulson A Vet Rec 1978 Oct 14;103(16):359.
5. [Effect of truncal vagotomy on the exocrine function of the pancreas in the dog] Dabrowski Z, etal., Pol Tyg Lek 1978 Jul 10;33(28):1093-5.
6. Redesigning the active-site of an acyl-CoA dehydrogenase: new evidence supporting a one-base mechanism. Dakoji S, etal., Bioorg Med Chem. 1997 Dec;5(12):2157-64.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Acyl-CoA dehydrogenases. A mechanistic overview. Ghisla S and Thorpe C, Eur J Biochem. 2004 Feb;271(3):494-508.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Biosynthesis of four rat liver mitochondrial acyl-CoA dehydrogenases: in vitro synthesis, import into mitochondria, and processing of their precursors in a cell-free system and in cultured cells. Ikeda Y, etal., Arch Biochem Biophys. 1987 Feb 1;252(2):662-74.
11. Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme. Ikeda Y, etal., J Biol Chem. 1985 Jan 25;260(2):1311-25.
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. Importance of acyl-coenzyme A:cholesterol acyltransferase 1/2 dual inhibition for anti-atherosclerotic potency of pactimibe. Kitayama K, etal., Eur J Pharmacol. 2006 Jul 1;540(1-3):121-30. Epub 2006 Apr 29.
14. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. Kovanen L, etal., Alcohol Alcohol. 2010 Jul-Aug;45(4):303-11. doi: 10.1093/alcalc/agq035. Epub 2010 Jun 16.
15. Molecular cloning and nucleotide sequence of cDNAs encoding the precursors of rat long chain acyl-coenzyme A, short chain acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence homology of four enzymes of the acyl-CoA dehydrogenase family. Matsubara Y, etal., J Biol Chem 1989 Sep 25;264(27):16321-31.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Developmental, nutritional, and hormonal regulation of tissue-specific expression of the genes encoding various acyl-CoA dehydrogenases and alpha-subunit of electron transfer flavoprotein in rat. Nagao M, etal., J Biol Chem. 1993 Nov 15;268(32):24114-24.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. A novel short-chain alcohol dehydrogenase from rats with retinol dehydrogenase activity, cyclically expressed in uterine epithelium. Rexer BN and Ong DE, Biol Reprod 2002 Nov;67(5):1555-64.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:3597357   PMID:11134486   PMID:14651853   PMID:16729965   PMID:18614015   PMID:21630459   PMID:25636810   PMID:25753319   PMID:26316108   PMID:26989860   PMID:29867124   PMID:31505169  
PMID:36883465  


Genomics

Comparative Map Data
Acads
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,154,259 - 47,163,580 (+)NCBIGRCr8
mRatBN7.21241,493,650 - 41,502,897 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,493,626 - 41,502,898 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,661,140 - 42,670,447 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,274,797 - 43,284,104 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,335,363 - 42,344,671 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,254,503 - 47,263,747 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,254,484 - 47,263,747 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,049,549 - 49,059,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,765,284 - 42,774,528 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,628,671 - 42,637,916 (+)NCBI
Celera1243,112,383 - 43,121,613 (+)NCBICelera
Cytogenetic Map12q16NCBI
ACADS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812120,725,826 - 120,740,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12120,725,774 - 120,740,008 (+)EnsemblGRCh38hg38GRCh38
GRCh3712121,163,629 - 121,177,811 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612119,648,050 - 119,662,193 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412119,626,385 - 119,640,530NCBI
Celera12120,797,834 - 120,812,046 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12118,172,924 - 118,187,098 (+)NCBIHuRef
CHM1_112121,132,346 - 121,146,588 (+)NCBICHM1_1
T2T-CHM13v2.012120,714,964 - 120,729,131 (+)NCBIT2T-CHM13v2.0
Acads
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395115,248,358 - 115,257,405 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5115,248,358 - 115,257,405 (-)EnsemblGRCm39 Ensembl
GRCm385115,110,299 - 115,119,346 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5115,110,299 - 115,119,346 (-)EnsemblGRCm38mm10GRCm38
MGSCv375115,560,308 - 115,569,322 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365115,371,298 - 115,380,312 (-)NCBIMGSCv36mm8
Celera5112,206,409 - 112,215,487 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.99NCBI
Acads
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545510,928,560 - 10,942,926 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545510,928,560 - 10,942,748 (-)NCBIChiLan1.0ChiLan1.0
ACADS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210128,794,025 - 128,810,226 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112128,790,398 - 128,806,613 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012118,309,303 - 118,323,489 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112121,682,113 - 121,696,376 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12121,682,113 - 121,696,376 (+)Ensemblpanpan1.1panPan2
ACADS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12616,572,936 - 16,584,760 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2616,572,947 - 16,584,194 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2616,574,053 - 16,587,252 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02616,837,490 - 16,850,715 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2616,837,499 - 16,850,713 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12616,798,031 - 16,811,155 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02616,873,738 - 16,886,985 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02616,916,088 - 16,929,300 (+)NCBIUU_Cfam_GSD_1.0
Acads
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118145,758,321 - 145,773,223 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936668254,595 - 272,118 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936668257,214 - 272,089 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACADS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1440,642,881 - 40,659,081 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11440,642,810 - 40,656,922 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21443,110,578 - 43,124,662 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q16.2-q23.2NCBI
ACADS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111116,083,156 - 116,096,554 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11116,083,276 - 116,096,607 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037129,000,614 - 129,013,678 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acads
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474712,955,118 - 12,966,242 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474712,954,635 - 12,966,320 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acads
37 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:186
Count of miRNA genes:128
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000001556
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134043551788Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat

Markers in Region
RH134326  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21241,502,526 - 41,502,724 (+)MAPPERmRatBN7.2
Rnor_6.01247,263,377 - 47,263,574NCBIRnor6.0
Rnor_5.01249,058,793 - 49,058,990UniSTSRnor5.0
RGSC_v3.41242,774,158 - 42,774,355UniSTSRGSC3.4
Celera1243,121,243 - 43,121,440UniSTS
RH 3.4 Map12777.83UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000001556   ⟹   ENSRNOP00000001556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,493,626 - 41,502,898 (+)Ensembl
Rnor_6.0 Ensembl1247,254,484 - 47,263,747 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098620   ⟹   ENSRNOP00000093188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,494,674 - 41,502,898 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102388   ⟹   ENSRNOP00000084893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,493,631 - 41,502,897 (+)Ensembl
RefSeq Acc Id: NM_022512   ⟹   NP_071957
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,154,333 - 47,163,579 (+)NCBI
mRatBN7.21241,493,650 - 41,502,897 (+)NCBI
Rnor_6.01247,254,503 - 47,263,747 (+)NCBI
Rnor_5.01249,049,549 - 49,059,164 (+)NCBI
RGSC_v3.41242,765,284 - 42,774,528 (+)RGD
Celera1243,112,383 - 43,121,613 (+)RGD
Sequence:
RefSeq Acc Id: XM_063271614   ⟹   XP_063127684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,154,259 - 47,163,580 (+)NCBI
Protein Sequences
Protein RefSeqs NP_071957 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127684 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40669 (Get FASTA)   NCBI Sequence Viewer  
  AAH72545 (Get FASTA)   NCBI Sequence Viewer  
  EDM13909 (Get FASTA)   NCBI Sequence Viewer  
  EDM13910 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001556
GenBank Protein P15651 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071957   ⟸   NM_022512
- Peptide Label: precursor
- UniProtKB: P15651 (UniProtKB/Swiss-Prot),   Q6IMX3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001556   ⟸   ENSRNOT00000001556
Ensembl Acc Id: ENSRNOP00000093188   ⟸   ENSRNOT00000098620
Ensembl Acc Id: ENSRNOP00000084893   ⟸   ENSRNOT00000102388
RefSeq Acc Id: XP_063127684   ⟸   XM_063271614
- Peptide Label: isoform X1
- UniProtKB: P15651 (UniProtKB/Swiss-Prot),   F7F6Q6 (UniProtKB/TrEMBL)
Protein Domains
Acyl-CoA dehydrogenase/oxidase C-terminal   Acyl-CoA dehydrogenase/oxidase N-terminal   Acyl-CoA oxidase/dehydrogenase middle

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15651-F1-model_v2 AlphaFold P15651 1-412 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698702
Promoter ID:EPDNEW_R9226
Type:initiation region
Name:Acads_1
Description:acyl-CoA dehydrogenase short chain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01247,254,466 - 47,254,526EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620514 AgrOrtholog
BioCyc Gene G2FUF-18972 BioCyc
Ensembl Genes ENSRNOG00000001177 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000001556 ENTREZGENE
Gene3D-CATH 1.10.540.10 UniProtKB/Swiss-Prot
  2.40.110.10 UniProtKB/Swiss-Prot
  Butyryl-CoA Dehydrogenase, subunit A, domain 3 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7105799 IMAGE-MGC_LOAD
InterPro Acyl-CoA_DH_CS UniProtKB/Swiss-Prot
  Acyl-CoA_Oxase/DH_cen-dom UniProtKB/Swiss-Prot
  Acyl-CoA_Oxase/DH_mid-dom_sf UniProtKB/Swiss-Prot
  AcylCo_DH-like_C UniProtKB/Swiss-Prot
  AcylCo_DH/oxidase_C UniProtKB/Swiss-Prot
  AcylCoA_DH/ox_N UniProtKB/Swiss-Prot
  AcylCoA_DH/ox_N_sf UniProtKB/Swiss-Prot
  AcylCoA_DH/oxidase_NM_dom UniProtKB/Swiss-Prot
KEGG Report rno:64304 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91690 IMAGE-MGC_LOAD
NCBI Gene 64304 ENTREZGENE
PANTHER ACYL-COA DEHYDROGENASE UniProtKB/Swiss-Prot
  ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot
Pfam Acyl-CoA_dh_1 UniProtKB/Swiss-Prot
  Acyl-CoA_dh_M UniProtKB/Swiss-Prot
  Acyl-CoA_dh_N UniProtKB/Swiss-Prot
PhenoGen Acads PhenoGen
PIRSF HsaA UniProtKB/Swiss-Prot
PROSITE ACYL_COA_DH_1 UniProtKB/Swiss-Prot
  ACYL_COA_DH_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001177 RatGTEx
Superfamily-SCOP SSF47203 UniProtKB/Swiss-Prot
  SSF56645 UniProtKB/Swiss-Prot
UniProt A0A8I6AJ45_RAT UniProtKB/TrEMBL
  A0A8I6GC92_RAT UniProtKB/TrEMBL
  A6J1X1_RAT UniProtKB/TrEMBL
  ACADS_RAT UniProtKB/Swiss-Prot
  F7F6Q6 ENTREZGENE, UniProtKB/TrEMBL
  P15651 ENTREZGENE
  Q6IMX3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-09 Acads  acyl-CoA dehydrogenase short chain  Acads  acyl-CoA dehydrogenase, C-2 to C-3 short chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-28 Acads  acyl-CoA dehydrogenase, C-2 to C-3 short chain  Acads  acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Acads  acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain  Acads  acyl-Coenzyme A dehydrogenase, short chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Acads  acyl-Coenzyme A dehydrogenase, short chain  Acads  acetyl-Coenzyme A dehydrogenase, short chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Acads  acetyl-Coenzyme A dehydrogenase, short chain    acyl-coenzyme A dehydrogenase, short chain  Name updated 1299863 APPROVED
2005-01-20 Acads  acyl-coenzyme A dehydrogenase, short chain    short chain acyl-coenzyme A dehydrogenase  Name updated 1299863 APPROVED
2002-08-07 Acads  short chain acyl-coenzyme A dehydrogenase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the acyl CoA dehydrogenase family 631718