Oas3 (2'-5'-oligoadenylate synthetase 3) - Rat Genome Database

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Gene: Oas3 (2'-5'-oligoadenylate synthetase 3) Rattus norvegicus
Analyze
Symbol: Oas3
Name: 2'-5'-oligoadenylate synthetase 3
RGD ID: 1359319
Description: Predicted to enable 2'-5'-oligoadenylate synthetase activity; ATP binding activity; and double-stranded RNA binding activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of type I interferon-mediated signaling pathway; and regulation of cytokine production. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol; membrane; and nucleoplasm. Orthologous to human OAS3 (2'-5'-oligoadenylate synthetase 3); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; acetamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: (2-5')oligo(A) synthase 3; 2 ' -5 ' -oligoadenylate synthetase 3; 2'-5'-oligoadenylate synthase 3; 2-5A synthase 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21235,779,028 - 35,802,781 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1235,779,022 - 35,802,781 (+)Ensembl
Rnor_6.01241,313,081 - 41,368,217 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,316,764 - 41,336,562 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,148,698 - 43,225,332 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11236,788,800 - 36,789,002 (+)NCBI
Celera1237,441,178 - 37,464,363 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4-hydroxynon-2-enal  (ISO)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amosite asbestos  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cholesterol  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
folic acid  (ISO)
fucoxanthin  (ISO)
glucose  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrates  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9880533   PMID:12396720   PMID:17024523   PMID:19056102   PMID:19923450   PMID:23580065  


Genomics

Comparative Map Data
Oas3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21235,779,028 - 35,802,781 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1235,779,022 - 35,802,781 (+)Ensembl
Rnor_6.01241,313,081 - 41,368,217 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,316,764 - 41,336,562 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,148,698 - 43,225,332 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11236,788,800 - 36,789,002 (+)NCBI
Celera1237,441,178 - 37,464,363 (+)NCBICelera
Cytogenetic Map12q16NCBI
OAS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812112,938,474 - 112,973,251 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl12112,938,051 - 112,976,460 (+)EnsemblGRCh38hg38GRCh38
GRCh3712113,376,279 - 113,411,056 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612111,860,632 - 111,895,437 (+)NCBINCBI36hg18NCBI36
Build 3412111,838,968 - 111,873,772NCBI
Celera12113,003,302 - 113,038,091 (+)NCBI
Cytogenetic Map12q24.13NCBI
HuRef12110,388,815 - 110,423,598 (+)NCBIHuRef
CHM1_112113,344,610 - 113,379,413 (+)NCBICHM1_1
T2T-CHM13v2.012112,915,123 - 112,949,876 (+)NCBI
Oas3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395120,891,163 - 120,915,755 (-)NCBIGRCm39mm39
GRCm39 Ensembl5120,891,163 - 120,915,726 (-)Ensembl
GRCm385120,753,098 - 120,777,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5120,753,098 - 120,777,661 (-)EnsemblGRCm38mm10GRCm38
MGSCv375121,203,107 - 121,227,668 (-)NCBIGRCm37mm9NCBIm37
MGSCv365121,013,715 - 121,038,276 (-)NCBImm8
Celera5117,839,359 - 117,863,925 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map560.64NCBI
Oas3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554829,339,174 - 9,359,266 (+)NCBIChiLan1.0ChiLan1.0
OAS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112113,928,010 - 113,962,931 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12113,928,202 - 113,959,654 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012110,543,522 - 110,578,463 (+)NCBIMhudiblu_PPA_v0panPan3
OAS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12610,404,548 - 10,423,039 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2610,404,414 - 10,423,039 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2610,522,153 - 10,540,643 (+)NCBI
ROS_Cfam_1.02610,643,960 - 10,662,689 (+)NCBI
ROS_Cfam_1.0 Ensembl2610,643,826 - 10,665,762 (+)Ensembl
UMICH_Zoey_3.12610,617,704 - 10,636,208 (+)NCBI
UNSW_CanFamBas_1.02610,680,918 - 10,699,398 (+)NCBI
UU_Cfam_GSD_1.02610,729,355 - 10,747,851 (+)NCBI
Oas3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118148,435,253 - 148,466,985 (+)NCBI
SpeTri2.0NW_0049366682,917,978 - 2,965,336 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OAS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111108,192,595 - 108,210,332 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl11108,192,509 - 108,213,333 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037136,873,129 - 136,893,457 (-)NCBIVero_WHO_p1.0

Position Markers
D12Rat54  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,797,021 - 35,797,136 (+)MAPPERmRatBN7.2
Rnor_6.01241,331,323 - 41,331,437NCBIRnor6.0
Rnor_5.01243,189,384 - 43,189,498UniSTSRnor5.0
Celera1237,458,600 - 37,458,708UniSTS
RH 3.4 Map12632.9UniSTS
RH 3.4 Map12632.9RGD
RH 2.0 Map12525.5RGD
FHH x ACI Map1234.67RGD
D12Arb6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,682,559 - 35,682,913 (+)MAPPERmRatBN7.2
mRatBN7.21235,682,559 - 35,682,913 (-)MAPPERmRatBN7.2
Rnor_6.01241,291,378 - 41,291,738NCBIRnor6.0
Rnor_6.01241,213,448 - 41,213,801NCBIRnor6.0
Rnor_5.01243,150,549 - 43,150,909UniSTSRnor5.0
RGSC_v3.41236,818,780 - 36,819,134RGDRGSC3.4
RGSC_v3.41236,894,446 - 36,894,750RGDRGSC3.4
RGSC_v3.41236,818,781 - 36,819,134UniSTSRGSC3.4
RGSC_v3.41236,894,447 - 36,894,750UniSTSRGSC3.4
RGSC_v3.11236,757,835 - 36,758,138RGD
Celera1237,422,909 - 37,423,212UniSTS
Celera1237,346,026 - 37,346,376UniSTS
RH 3.4 Map12618.9UniSTS
RH 3.4 Map12618.9RGD
RH 2.0 Map12466.8RGD
SHRSP x BN Map1244.35RGD
Cytogenetic Map12 RGD
D12Got219  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,761,582 - 35,761,721 (+)MAPPERmRatBN7.2
Rnor_6.01241,292,902 - 41,293,040NCBIRnor6.0
Rnor_5.01243,152,073 - 43,152,211UniSTSRnor5.0
RGSC_v3.41236,895,919 - 36,896,057UniSTSRGSC3.4
Celera1237,424,381 - 37,424,519UniSTS
Cytogenetic Map12 RGD
RH129983  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,680,351 - 35,680,501 (+)MAPPERmRatBN7.2
mRatBN7.21235,680,351 - 35,680,501 (-)MAPPERmRatBN7.2
Rnor_6.01241,293,807 - 41,293,956NCBIRnor6.0
Rnor_6.01241,211,240 - 41,211,389NCBIRnor6.0
Rnor_5.01243,152,978 - 43,153,127UniSTSRnor5.0
Rnor_5.01243,075,247 - 43,075,396UniSTSRnor5.0
RGSC_v3.41236,896,820 - 36,896,969UniSTSRGSC3.4
RGSC_v3.41236,816,573 - 36,816,722UniSTSRGSC3.4
Celera1237,343,818 - 37,343,967UniSTS
Celera1237,425,280 - 37,425,429UniSTS
RH 3.4 Map12621.5UniSTS
Cytogenetic Map12q16UniSTS
AI454805  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,759,079 - 35,759,267 (+)MAPPERmRatBN7.2
Rnor_6.01241,290,276 - 41,290,463NCBIRnor6.0
Rnor_5.01243,149,447 - 43,149,634UniSTSRnor5.0
RGSC_v3.41236,893,416 - 36,893,603UniSTSRGSC3.4
Celera1237,421,878 - 37,422,065UniSTS
RH 3.4 Map12633.5UniSTS
Cytogenetic Map12q16UniSTS
AU046598  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,771,818 - 35,772,000 (+)MAPPERmRatBN7.2
Rnor_6.01241,307,461 - 41,307,640NCBIRnor6.0
Rnor_5.01243,165,833 - 43,166,012UniSTSRnor5.0
RGSC_v3.41236,906,437 - 36,906,616UniSTSRGSC3.4
Celera1237,434,147 - 37,434,327UniSTS
Cytogenetic Map12q16UniSTS
AU049134  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,682,743 - 35,682,895 (+)MAPPERmRatBN7.2
mRatBN7.21235,682,743 - 35,682,895 (-)MAPPERmRatBN7.2
Rnor_6.01241,291,396 - 41,291,554NCBIRnor6.0
Rnor_6.01241,213,632 - 41,213,783NCBIRnor6.0
Rnor_5.01243,150,567 - 43,150,725UniSTSRnor5.0
RGSC_v3.41236,894,465 - 36,894,566UniSTSRGSC3.4
RGSC_v3.41236,818,965 - 36,819,116UniSTSRGSC3.4
Celera1237,346,210 - 37,346,358UniSTS
Celera1237,422,927 - 37,423,028UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122860752637691617Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:30
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000072139
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 19 9 19 9 2 14 10
Below cutoff 14 32 26 26 7 9 19 19 21 1 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000090867   ⟹   ENSRNOP00000073069
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1235,779,022 - 35,802,781 (+)Ensembl
Rnor_6.0 Ensembl1241,316,764 - 41,336,562 (+)Ensembl
RefSeq Acc Id: NM_001009493   ⟹   NP_001009493
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21235,779,118 - 35,802,781 (+)NCBI
Rnor_6.01241,313,081 - 41,368,217 (+)NCBI
Rnor_5.01243,148,698 - 43,225,332 (+)NCBI
Celera1237,441,178 - 37,464,363 (+)RGD
Sequence:
RefSeq Acc Id: XM_039089662   ⟹   XP_038945590
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21235,779,028 - 35,797,523 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001009493 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945590 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP76224 (Get FASTA)   NCBI Sequence Viewer  
  EDM13765 (Get FASTA)   NCBI Sequence Viewer  
  Q5MYT7 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001009493   ⟸   NM_001009493
- UniProtKB: Q5MYT7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073069   ⟸   ENSRNOT00000090867
RefSeq Acc Id: XP_038945590   ⟸   XM_039089662
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5MYT7-F1-model_v2 AlphaFold Q5MYT7 1-1137 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
12 43158409 43158410 C T snv COP/CrCrl (MCW & UW), GH/OmrMcwi (MCW), BUF/MNa (KyushuU), ZFDM (KyushuU), KFRS3B/Kyo (KyushuU), ZF (KyushuU), NIG-III/Hok (KyushuU)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359319 AgrOrtholog
BioCyc Gene G2FUF-19190 BioCyc
Ensembl Genes ENSRNOG00000059207 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000073069 ENTREZGENE
  ENSRNOP00000073069.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090867 ENTREZGENE
  ENSRNOT00000090867.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.460.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 2-5-oligoadenylate_synth_CS UniProtKB/Swiss-Prot
  2-5-oligoadenylate_synth_N UniProtKB/Swiss-Prot
  2-5-oligoAdlate_synth_1_dom2/C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2-5A_synthase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2-5OAS_C_CS UniProtKB/TrEMBL
  2-5OAS_N_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NT_2-5OAS_ClassI-CCAase UniProtKB/TrEMBL
  NT_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Polymerase_NTP_transf_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:494202 UniProtKB/Swiss-Prot
NCBI Gene 494202 ENTREZGENE
PANTHER PTHR11258 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NTP_transf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAS1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Oas3 PhenoGen
PROSITE 25A_SYNTH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  25A_SYNTH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  25A_SYNTH_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81301 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K4J7_RAT UniProtKB/TrEMBL
  OAS3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-29 Oas3  2'-5'-oligoadenylate synthetase 3  Oas3  2 ' -5 ' -oligoadenylate synthetase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 Oas3  2 ' -5 ' -oligoadenylate synthetase 3      Symbol and Name status set to provisional 70820 PROVISIONAL