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Gene: Pdgfa (platelet derived growth factor subunit A) Rattus norvegicus
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Symbol: Pdgfa
Name: platelet derived growth factor subunit A
Description: Predicted to have several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in several processes, including animal organ development; response to estradiol; and response to retinoic acid. Predicted to localize to the cell surface; extracellular space; and microvillus. Biomarker of chronic ulcer of skin; oligohydramnios; pancreatitis; pulmonary hypertension; and renovascular hypertension. Human ortholog(s) of this gene implicated in malignant glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A); PARTICIPATES IN ceramide signaling pathway; platelet-derived growth factor signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-nicotine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: PDGF subunit A; PDGF-1; PDGFACP; platelet derived growth factor, alpha; Platelet-derived growth factor A chain; platelet-derived growth factor alpha polypeptide; platelet-derived growth factor subunit A
Orthologs:
Homo sapiens (human) : PDGFA (platelet derived growth factor subunit A)  HGNC  Alliance
Mus musculus (house mouse) : Pdgfa (platelet derived growth factor, alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdgfa (platelet derived growth factor subunit A)
Pan paniscus (bonobo/pygmy chimpanzee) : PDGFA (platelet derived growth factor subunit A)
Canis lupus familiaris (dog) : PDGFA (platelet derived growth factor subunit A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdgfa (platelet derived growth factor subunit A)
Sus scrofa (pig) : PDGFA (platelet derived growth factor subunit A)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01217,734,141 - 17,756,186 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01219,727,672 - 19,749,009 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41216,151,045 - 16,172,412 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11216,180,972 - 16,202,334 (+)NCBI
Celera1217,398,134 - 17,419,591 (+)NCBICelera
Cytogenetic Map12q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pdgfa
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3282
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.