Dynll1 (dynein light chain LC8-type 1) - Rat Genome Database

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Gene: Dynll1 (dynein light chain LC8-type 1) Rattus norvegicus
Analyze
Symbol: Dynll1
Name: dynein light chain LC8-type 1
RGD ID: 619866
Description: Enables several functions, including identical protein binding activity; nitric-oxide synthase inhibitor activity; and scaffold protein binding activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus and spermatid development. Acts upstream of or within negative regulation of nitric oxide biosynthetic process. Located in axon cytoplasm and secretory granule. Part of cytoplasmic dynein complex. Used to study hypertension and impotence. Biomarker of cardiac arrest; congestive heart failure; and middle cerebral artery infarction. Orthologous to human DYNLL1 (dynein light chain LC8-type 1); PARTICIPATES IN mitochondria transport pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 8 kDa dynein light chain; 8kD LC; 8kDLC; Dlc8; Dnclc1; dynein LC8; dynein light chain 1, cytoplasmic; dynein, cytoplasmic, light chain 1; MGC72986; Pin; protein inhibitor of neuronal nitric oxide synthase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Dynll1-ps3   Dynll1l1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,945,291 - 46,976,867 (+)NCBIGRCr8
mRatBN7.21241,312,365 - 41,316,157 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,312,367 - 41,314,741 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,479,075 - 42,481,446 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,092,738 - 43,095,109 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,153,290 - 42,155,661 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,074,200 - 47,076,573 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,074,200 - 47,076,572 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01248,867,516 - 48,869,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,580,542 - 42,582,915 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,443,929 - 42,446,302 (+)NCBI
Celera1242,933,102 - 42,935,475 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aconitine  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benidipine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buspirone  (EXP)
cadmium dichloride  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
clofibric acid  (EXP)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diethylstilbestrol  (EXP)
diuron  (EXP,ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
Mesaconitine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
N(4)-hydroxycytidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
ozone  (EXP)
p-tert-Amylphenol  (EXP)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
sarin  (ISO)
sevoflurane  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sulfadimethoxine  (EXP)
sulindac  (EXP)
sulindac sulfide  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
tolcapone  (EXP)
trichloroethene  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cytoplasmic dynein. Allan VJ, Biochem Soc Trans. 2011 Oct;39(5):1169-78. doi: 10.1042/BST0391169.
2. Dynein light chain LC8 regulates syntaphilin-mediated mitochondrial docking in axons. Chen YM, etal., J Neurosci. 2009 Jul 29;29(30):9429-38. doi: 10.1523/JNEUROSCI.1472-09.2009.
3. Myotonia congenita with strabismus in a large family with a mutation in the SCN4A gene. Du H, etal., Eye (Lond). 2012 Aug;26(8):1039-43. doi: 10.1038/eye.2012.80. Epub 2012 Jun 1.
4. Backbone dynamics of the 8 kDa dynein light chain dimer reveals molecular basis of the protein's functional diversity. Fan JS, etal., J Biomol NMR 2002 Jun;23(2):103-14.
5. Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon. Fejtova A, etal., J Cell Biol. 2009 Apr 20;185(2):341-55. doi: 10.1083/jcb.200807155.
6. Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes. Fuhrmann JC, etal., J Neurosci 2002 Jul 1;22(13):5393-402.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Induction of protein inhibitor of neuronal nitric oxide synthase/cytoplasmic dynein light chain following cerebral ischemia. Gillardon F, etal., Neuroscience. 1998 May;84(1):81-8.
9. PIN: an associated protein inhibitor of neuronal nitric oxide synthase. Jaffrey SR and Snyder SH, Science 1996 Nov 1;274(5288):774-7.
10. Brain cytoplasmic and flagellar outer arm dyneins share a highly conserved Mr 8,000 light chain. King SM, etal., J Biol Chem. 1996 Aug 9;271(32):19358-66.
11. Protein inhibitor of neuronal nitric oxide synthase (PIN) is a new regulator of glucose-induced insulin secretion. Lajoix AD, etal., Diabetes. 2006 Dec;55(12):3279-88.
12. Cellulose membrane supported peptide arrays for deciphering protein-protein interaction sites: the case of PIN, a protein with multiple natural partners. Lajoix AD, etal., Mol Divers. 2004;8(3):281-90.
13. Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex. Lo KW, etal., J Biol Chem. 2007 Dec 21;282(51):36871-8. Epub 2007 Oct 27.
14. Antisense and short hairpin RNA (shRNA) constructs targeting PIN (Protein Inhibitor of NOS) ameliorate aging-related erectile dysfunction in the rat. Magee TR, etal., J Sex Med. 2007 May;4(3):633-43. Epub 2007 Apr 13.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Proteomic identification of brain proteins that interact with dynein light chain LC8. Navarro-Lerida I, etal., Proteomics. 2004 Feb;4(2):339-46.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Subcellular localization of PMES-2 proteins regulated by their two cytoskeleton-associated domains. Ninomiya K, etal., Cell Mol Neurobiol. 2005 Aug;25(5):899-911. doi: 10.1007/s10571-005-4955-5.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Angiotensin II-mediated post-translational modification of nNOS in the PVN of rats with CHF: Role for PIN. Sharma NM, etal., Am J Physiol Heart Circ Physiol. 2013 Jul 5.
23. Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. Thompson S, etal., J Biol Chem. 2011 Jun 3;286(22):19331-9. doi: 10.1074/jbc.M110.197707. Epub 2011 Apr 8.
24. Stage-specific expression of dynein light chain-1 and its interacting kinase, p21-activated kinase-1, in rodent testes: implications in spermiogenesis. Wang RA, etal., J Histochem Cytochem. 2005 Oct;53(10):1235-43. Epub 2005 Jun 27.
25. RNA silencing targeting PIN (protein inhibitor of neuronal nitric oxide synthase) attenuates the development of hypertension in young spontaneously hypertensive rats. Wang SC, etal., J Am Soc Hypertens. 2014 Jan;8(1):5-13. doi: 10.1016/j.jash.2013.07.010. Epub 2013 Sep 12.
26. Structure of the monomeric 8-kDa dynein light chain and mechanism of the domain-swapped dimer assembly. Wang W, etal., J Biol Chem 2003 Oct 17;278(42):41491-9.
Additional References at PubMed
PMID:8628263   PMID:9299562   PMID:11148209   PMID:11148215   PMID:11178896   PMID:12477932   PMID:14561217   PMID:14713293   PMID:15136728   PMID:15489334   PMID:15891768   PMID:16098226  
PMID:16176937   PMID:18579519   PMID:18850735   PMID:19946888   PMID:20133940   PMID:21145319   PMID:21399614   PMID:22871113   PMID:22926577   PMID:23376485   PMID:24958506   PMID:25002582  
PMID:25294941   PMID:25830415   PMID:26459761   PMID:30018294   PMID:31904090  


Genomics

Comparative Map Data
Dynll1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,945,291 - 46,976,867 (+)NCBIGRCr8
mRatBN7.21241,312,365 - 41,316,157 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,312,367 - 41,314,741 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,479,075 - 42,481,446 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,092,738 - 43,095,109 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,153,290 - 42,155,661 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,074,200 - 47,076,573 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,074,200 - 47,076,572 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01248,867,516 - 48,869,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,580,542 - 42,582,915 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,443,929 - 42,446,302 (+)NCBI
Celera1242,933,102 - 42,935,475 (+)NCBICelera
Cytogenetic Map12q16NCBI
DYNLL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812120,469,842 - 120,498,493 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12120,469,850 - 120,498,493 (+)EnsemblGRCh38hg38GRCh38
GRCh3712120,907,645 - 120,936,296 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612119,392,043 - 119,420,681 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412119,396,652 - 119,399,010NCBI
Celera12120,542,375 - 120,570,391 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12117,917,550 - 117,946,088 (+)NCBIHuRef
CHM1_112120,876,465 - 120,905,100 (+)NCBICHM1_1
T2T-CHM13v2.012120,459,024 - 120,487,665 (+)NCBIT2T-CHM13v2.0
Dynll1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395115,435,129 - 115,438,995 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5115,435,169 - 115,439,058 (-)EnsemblGRCm39 Ensembl
GRCm385115,297,110 - 115,300,990 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5115,297,110 - 115,300,999 (-)EnsemblGRCm38mm10GRCm38
MGSCv375115,747,119 - 115,750,999 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365115,559,422 - 115,561,933 (-)NCBIMGSCv36mm8
Celera5112,394,410 - 112,398,301 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map556.04NCBI
Dynll1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545511,148,047 - 11,150,859 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545511,148,041 - 11,150,860 (-)NCBIChiLan1.0ChiLan1.0
DYNLL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210128,539,098 - 128,567,509 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112128,535,475 - 128,563,886 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012118,078,401 - 118,080,822 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112121,452,118 - 121,454,550 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12121,452,118 - 121,454,550 (+)Ensemblpanpan1.1panPan2
DYNLL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12616,369,878 - 16,402,302 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2616,398,886 - 16,402,021 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2616,399,889 - 16,402,458 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2616,373,479 - 16,405,461 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02616,637,042 - 16,669,452 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2616,667,035 - 16,670,006 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12616,597,102 - 16,629,472 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02616,673,811 - 16,705,772 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02616,715,648 - 16,747,621 (+)NCBIUU_Cfam_GSD_1.0
Dynll1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118145,952,956 - 145,985,917 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936668448,489 - 500,800 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936668451,846 - 484,841 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYNLL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1440,455,985 - 40,459,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11440,455,954 - 40,458,352 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21442,956,562 - 42,958,960 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DYNLL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111115,851,020 - 115,855,526 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11115,851,381 - 115,851,647 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037129,247,006 - 129,249,444 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dynll1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474713,169,865 - 13,172,525 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474713,169,865 - 13,172,592 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dynll1
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:181
Count of miRNA genes:136
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000014910
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

Markers in Region
RH128914  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q16UniSTS
BF418128  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21241,306,773 - 41,307,220 (+)MAPPERmRatBN7.2
mRatBN7.21241,307,011 - 41,307,220 (+)MAPPERmRatBN7.2
Rnor_6.01247,068,845 - 47,069,053NCBIRnor6.0
Rnor_6.01247,068,457 - 47,069,053NCBIRnor6.0
Rnor_5.01248,861,773 - 48,862,369UniSTSRnor5.0
Rnor_5.01248,862,161 - 48,862,369UniSTSRnor5.0
RGSC_v3.41242,575,187 - 42,575,395UniSTSRGSC3.4
Celera1242,927,740 - 42,927,948UniSTS
RH 3.4 Map12774.62UniSTS
Cytogenetic Map12q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 3 43 57 41 19 41 8 11 74 35 40 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000014910   ⟹   ENSRNOP00000061342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,312,367 - 41,314,741 (+)Ensembl
Rnor_6.0 Ensembl1247,074,200 - 47,076,572 (+)Ensembl
RefSeq Acc Id: NM_053319   ⟹   NP_445771
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,973,077 - 46,976,867 (+)NCBI
mRatBN7.21241,312,365 - 41,316,157 (+)NCBI
Rnor_6.01247,074,200 - 47,076,573 (+)NCBI
Rnor_5.01248,867,516 - 48,869,889 (+)NCBI
RGSC_v3.41242,580,542 - 42,582,915 (+)RGD
Celera1242,933,102 - 42,935,475 (+)RGD
Sequence:
RefSeq Acc Id: XM_063271606   ⟹   XP_063127676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,945,291 - 46,975,452 (+)NCBI
RefSeq Acc Id: NP_445771   ⟸   NM_053319
- UniProtKB: P63170 (UniProtKB/Swiss-Prot),   A6J1V5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061342   ⟸   ENSRNOT00000014910
RefSeq Acc Id: XP_063127676   ⟸   XM_063271606
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63170-F1-model_v2 AlphaFold P63170 1-89 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698695
Promoter ID:EPDNEW_R9220
Type:multiple initiation site
Name:Dynll1_1
Description:dynein light chain LC8-type 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01247,074,200 - 47,074,260EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619866 AgrOrtholog
BIND 134400
BioCyc Gene G2FUF-18983 BioCyc
Ensembl Genes ENSRNOG00000011222 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055001858 UniProtKB/Swiss-Prot
  ENSRNOG00060006482 UniProtKB/Swiss-Prot
  ENSRNOG00065006260 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014910 ENTREZGENE
  ENSRNOT00000014910.6 UniProtKB/Swiss-Prot
  ENSRNOT00055003006 UniProtKB/Swiss-Prot
  ENSRNOT00060010625 UniProtKB/Swiss-Prot
  ENSRNOT00065009572 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.740.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6887897 IMAGE-MGC_LOAD
InterPro DLC_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_light_1/2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynein_light_chain_typ-1/2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72986 IMAGE-MGC_LOAD
NCBI Gene 58945 ENTREZGENE
PANTHER DYNEIN LIGHT CHAIN UniProtKB/TrEMBL
  DYNEIN LIGHT CHAIN 1, CYTOPLASMIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11886 UniProtKB/Swiss-Prot
Pfam Dynein_light UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dynll1 PhenoGen
PROSITE DYNEIN_LIGHT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011222 RatGTEx
  ENSRNOG00055001858 RatGTEx
  ENSRNOG00060006482 RatGTEx
  ENSRNOG00065006260 RatGTEx
SMART Dynein_light UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP DLC UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6J1V5 ENTREZGENE, UniProtKB/TrEMBL
  DYL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q15701 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Dynll1  dynein light chain LC8-type 1  Dnclc1  dynein, cytoplasmic, light chain 1  Symbol and Name updated 1299863 APPROVED
2004-12-14 Dnclc1  dynein, cytoplasmic, light chain 1  Pin    Symbol updated 1299863 APPROVED
2002-08-07 Pin  dynein, cytoplasmic, light chain 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization cytoplasmic and synaptic localization in hippocampal cells 628355
gene_function destabilizes the nNOS dimer 633683
gene_function light chain of cytoplasmic dynein 628355
gene_function binds to gephyrin, a tubulin-binding protein 628355
gene_physical_interaction directily interacts with synaptic scaffolding protein gephyrin 628355
gene_process plays a role in postsynaptic targeting of neurotransmitter receptors or scaffolding proteins 628355
gene_protein 89 amino acids 633683