Azgp1 (alpha-2-glycoprotein 1, zinc-binding) - Rat Genome Database

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Gene: Azgp1 (alpha-2-glycoprotein 1, zinc-binding) Rattus norvegicus
Analyze
Symbol: Azgp1
Name: alpha-2-glycoprotein 1, zinc-binding
RGD ID: 2187
Description: Involved in cellular response to insulin stimulus and cellular response to magnesium ion. Predicted to be active in external side of plasma membrane and extracellular space. Biomarker of chronic kidney disease; epilepsy; liver disease (multiple); obesity; and rheumatoid arthritis. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human AZGP1 (alpha-2-glycoprotein 1, zinc-binding); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-2 - glycoprotein 1 zinc; alpha-2 - glycoprotein 1, zinc; alpha-2-glycoprotein 1, zinc; MGC124966; ZA2GA; zinc-alpha-2-glycoprotein; Zn - alpha2 - glycoprotein; zn-alpha-2-glycoprotein; zn-alpha-2-GP; Zna2gp
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81222,044,685 - 22,051,248 (+)NCBIGRCr8
mRatBN7.21216,930,990 - 16,939,333 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1216,931,024 - 16,939,091 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1217,761,589 - 17,767,981 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,385,332 - 18,391,726 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,438,735 - 17,445,127 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,196,565 - 19,203,094 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,196,611 - 19,202,647 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,255,645 - 21,262,122 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41217,492,913 - 17,498,949 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11217,482,434 - 17,488,471 (+)NCBI
Celera1218,867,978 - 18,873,945 (+)NCBICelera
RH 3.4 Map12256.8RGD
Cytogenetic Map12q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
aconitine  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
antimony(0)  (ISO)
aristolochic acid A  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
chromium atom  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
doxorubicin  (ISO)
enzalutamide  (ISO)
ethanol  (EXP)
fipronil  (EXP)
flavonoids  (EXP)
fructose  (EXP)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
lead(0)  (ISO)
levonorgestrel  (ISO)
medroxyprogesterone acetate  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
phenobarbital  (EXP)
potassium dichromate  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
testosterone  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Plasma proteome analysis in diet-induced obesity-prone and obesity-resistant rats. Choi JW, etal., Proteomics. 2010 Dec;10(24):4386-400. doi: 10.1002/pmic.201000391. Epub 2010 Nov 17.
2. AZGP1 mRNA levels in normal human lung tissue correlate with lung cancer disease status. Falvella FS, etal., Oncogene. 2008 Mar 6;27(11):1650-6. doi: 10.1038/sj.onc.1210775. Epub 2007 Aug 27.
3. Cloning and expression analysis of the cDNA encoding rat Zn-alpha 2-glycoprotein. Fueyo A, etal., Gene 1994 Aug 5;145(2):245-9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer. Hale LP, etal., Clin Cancer Res. 2001 Apr;7(4):846-53.
6. Peroxiredoxin-2 and zinc-alpha-2-glycoprotein as potentially combined novel salivary biomarkers for early detection of oral squamous cell carcinoma using proteomic approaches. Heawchaiyaphum C, etal., J Proteomics. 2018 Feb 20;173:52-61. doi: 10.1016/j.jprot.2017.11.022. Epub 2017 Dec 1.
7. Decreased expression of AZGP1 is associated with poor prognosis in primary gastric cancer. Huang CY, etal., PLoS One. 2013 Jul 23;8(7):e69155. doi: 10.1371/journal.pone.0069155. Print 2013.
8. Decreased expression of zinc-alpha2-glycoprotein in hepatocellular carcinoma associates with poor prognosis. Huang Y, etal., J Transl Med. 2012 May 24;10:106. doi: 10.1186/1479-5876-10-106.
9. Identification of potential salivary biomarker panels for oral squamous cell carcinoma. Jain A, etal., Sci Rep. 2021 Feb 9;11(1):3365. doi: 10.1038/s41598-021-82635-0.
10. Prognostic role of serum AZGP1, PEDF and PRDX2 in colorectal cancer patients. Ji D, etal., Carcinogenesis. 2013 Jun;34(6):1265-72. doi: 10.1093/carcin/bgt056. Epub 2013 Feb 7.
11. Canagliflozin protects against non-alcoholic steatohepatitis in type-2 diabetic rats through zinc alpha-2 glycoprotein up-regulation. Kabil SL and Mahmoud NM, Eur J Pharmacol. 2018 Jun 5;828:135-145. doi: 10.1016/j.ejphar.2018.03.043. Epub 2018 Mar 30.
12. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
13. Effect of curcumin on visfatin and zinc-α2-glycoprotein in a rat model of non-alcoholic fatty liver disease. Li C, etal., Acta Cir Bras. 2016 Nov;31(11):706-713. doi: 10.1590/S0102-865020160110000001.
14. The Chinese herbal formula Zhibai Dihuang Granule treat Yin-deficiency-heat syndrome rats by regulating the immune responses. Liu CM, etal., J Ethnopharmacol. 2018 Oct 28;225:271-278. doi: 10.1016/j.jep.2018.05.001. Epub 2018 May 2.
15. Neuronal zinc-α2-glycoprotein is decreased in temporal lobe epilepsy in patients and rats. Liu Y, etal., Neuroscience. 2017 Aug 15;357:56-66. doi: 10.1016/j.neuroscience.2017.05.043. Epub 2017 May 31.
16. Adipose tissue loss in adjuvant arthritis is associated with a decrease in lipogenesis, but not with an increase in lipolysis. Martín AI, etal., J Endocrinol. 2008 Apr;197(1):111-9. doi: 10.1677/JOE-07-0491.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Enhanced ZAG production by subcutaneous adipose tissue is linked to weight loss in gastrointestinal cancer patients. Mracek T, etal., Br J Cancer. 2011 Feb 1;104(3):441-7. doi: 10.1038/sj.bjc.6606083. Epub 2011 Jan 18.
19. Downregulation of zinc-{alpha}2-glycoprotein in adipose tissue and liver of obese ob/ob mice and by tumour necrosis factor-alpha in adipocytes. Mracek T, etal., J Endocrinol. 2010 Feb;204(2):165-72. doi: 10.1677/JOE-09-0299. Epub 2009 Nov 24.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. White adipose tissue overproduces the lipid-mobilizing factor zinc α2-glycoprotein in chronic kidney disease. Pelletier CC, etal., Kidney Int. 2013 May;83(5):878-86. doi: 10.1038/ki.2013.9. Epub 2013 Feb 20.
22. GOA pipeline RGD automated data pipeline
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Zinc-alpha2-glycoprotein in patients with acute and chronic kidney disease. Sörensen-Zender I, etal., BMC Nephrol. 2013 Jul 12;14:145. doi: 10.1186/1471-2369-14-145.
25. Zinc-α2-Glycoprotein Exerts Antifibrotic Effects in Kidney and Heart. Sörensen-Zender I, etal., J Am Soc Nephrol. 2015 Nov;26(11):2659-68. doi: 10.1681/ASN.2014050485. Epub 2015 Mar 18.
26. Seizure-induced impairment in neuronal ketogenesis: Role of zinc-α2-glycoprotein in mitochondria. Tan C, etal., J Cell Mol Med. 2020 Jun;24(12):6833-6845. doi: 10.1111/jcmm.15337. Epub 2020 Apr 27.
27. Reduction of AZGP1 predicts poor prognosis in esophageal squamous cell carcinoma patients in Northern China. Tang H, etal., Onco Targets Ther. 2016 Dec 20;10:85-94. doi: 10.2147/OTT.S113932. eCollection 2017.
28. Downregulation of AZGP1 by Ikaros and histone deacetylase promotes tumor progression through the PTEN/Akt and CD44s pathways in hepatocellular carcinoma. Tian H, etal., Carcinogenesis. 2017 Feb 1;38(2):207-217. doi: 10.1093/carcin/bgw125.
29. Structure and expression of rat and mouse mRNAs for Zn-alpha 2-glycoprotein. Ueyama H, etal., J Biochem (Tokyo) 1994 Sep;116(3):677-81.
30. Insulin attenuates epileptiform discharge-induced oxidative stress by increasing zinc-α2-glycoprotein in primary cultured cortical neurons. Wei X, etal., Neuroreport. 2019 May 22;30(8):580-585. doi: 10.1097/WNR.0000000000001250.
31. AZGP1 suppresses epithelial-to-mesenchymal transition and hepatic carcinogenesis by blocking TGFβ1-ERK2 pathways. Xu MY, etal., Cancer Lett. 2016 May 1;374(2):241-9. doi: 10.1016/j.canlet.2016.02.025. Epub 2016 Feb 20.
32. Zinc-α-2-glycoprotein: a candidate biomarker for colon cancer diagnosis in Chinese population. Xue Y, etal., Int J Mol Sci. 2014 Dec 30;16(1):691-703. doi: 10.3390/ijms16010691.
33. AZGP1 suppresses the process of colorectal cancer after upregulating FASN expression via mTOR signal pathway. Yu W, etal., Gen Physiol Biophys. 2020 May;39(3):239-248. doi: 10.4149/gpb_2019061.
34. Circulating and Adipose Tissue mRNA Levels of Zinc-α2-Glycoprotein, Leptin, High-Molecular-Weight Adiponectin, and Tumor Necrosis Factor-Alpha in Colorectal Cancer Patients With or Without Obesity. Zhu H, etal., Front Endocrinol (Lausanne). 2018 Apr 26;9:190. doi: 10.3389/fendo.2018.00190. eCollection 2018.
Additional References at PubMed
PMID:8647453   PMID:9813179   PMID:12477932   PMID:16502470   PMID:19199708   PMID:21630459   PMID:22664934   PMID:23376485   PMID:23533145   PMID:23580065   PMID:24248522   PMID:27068509  
PMID:27559042   PMID:29566716  


Genomics

Comparative Map Data
Azgp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81222,044,685 - 22,051,248 (+)NCBIGRCr8
mRatBN7.21216,930,990 - 16,939,333 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1216,931,024 - 16,939,091 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1217,761,589 - 17,767,981 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,385,332 - 18,391,726 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,438,735 - 17,445,127 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,196,565 - 19,203,094 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,196,611 - 19,202,647 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,255,645 - 21,262,122 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41217,492,913 - 17,498,949 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11217,482,434 - 17,488,471 (+)NCBI
Celera1218,867,978 - 18,873,945 (+)NCBICelera
RH 3.4 Map12256.8RGD
Cytogenetic Map12q11NCBI
AZGP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,966,730 - 99,976,031 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl799,966,720 - 99,976,042 (-)EnsemblGRCh38hg38GRCh38
GRCh37799,564,353 - 99,573,654 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,402,286 - 99,411,623 (-)NCBINCBI36Build 36hg18NCBI36
Build 34799,209,002 - 99,218,338NCBI
Celera794,298,908 - 94,308,290 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,200,047 - 94,209,434 (-)NCBIHuRef
CHM1_1799,494,515 - 99,503,901 (-)NCBICHM1_1
T2T-CHM13v2.07101,206,237 - 101,220,128 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2798,924,486 - 98,933,868 (-)NCBI
Azgp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,979,783 - 137,988,495 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,979,782 - 137,988,495 (+)EnsemblGRCm39 Ensembl
GRCm385137,981,521 - 137,990,233 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,981,520 - 137,990,233 (+)EnsemblGRCm38mm10GRCm38
MGSCv375138,422,749 - 138,431,461 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365138,211,348 - 138,220,018 (+)NCBIMGSCv36mm8
Celera5134,967,149 - 134,978,633 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.92NCBI
Azgp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573899,798 - 912,272 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955573902,153 - 910,481 (-)NCBIChiLan1.0ChiLan1.0
LOC100980965
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26117,883,884 - 117,897,021 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,148,518 - 166,161,655 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0791,999,717 - 92,009,066 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17105,432,782 - 105,442,219 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,432,782 - 105,442,219 (-)Ensemblpanpan1.1panPan2
AZGP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,622,991 - 9,629,154 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,622,992 - 9,629,154 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha611,261,385 - 11,267,549 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.069,560,452 - 9,566,604 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl69,560,452 - 9,566,605 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.169,409,423 - 9,415,561 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.069,389,742 - 9,395,878 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,568,881 - 9,575,021 (-)NCBIUU_Cfam_GSD_1.0
Azgp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,922,347 - 133,930,595 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543105,956 - 114,190 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936543105,983 - 113,475 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AZGP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.137,867,521 - 7,874,857 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.237,121,544 - 7,129,596 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AZGP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12813,104,262 - 13,120,329 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2813,104,323 - 13,120,363 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,149,715 - 3,159,344 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Azgp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474017,054,221 - 17,063,226 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474017,054,221 - 17,062,420 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Azgp1
108 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:273
Count of miRNA genes:178
Interacting mature miRNAs:224
Transcripts:ENSRNOT00000001801
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121300829619212979Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat

Markers in Region
D12Hmgc1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21216,932,935 - 16,933,106 (+)MAPPERmRatBN7.2
Rnor_6.01219,198,497 - 19,198,667NCBIRnor6.0
Rnor_5.01221,257,572 - 21,257,742UniSTSRnor5.0
RGSC_v3.41217,494,799 - 17,494,969UniSTSRGSC3.4
Celera1218,869,861 - 18,870,031UniSTS
RH 3.4 Map12254.4UniSTS
RH 3.4 Map12254.4RGD
Cytogenetic Map12q11UniSTS
RH94525  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21216,936,912 - 16,937,085 (+)MAPPERmRatBN7.2
Rnor_6.01219,202,474 - 19,202,646NCBIRnor6.0
Rnor_5.01221,261,549 - 21,261,721UniSTSRnor5.0
RGSC_v3.41217,498,776 - 17,498,948UniSTSRGSC3.4
Celera1218,873,838 - 18,874,010UniSTS
RH 3.4 Map12256.8UniSTS
Cytogenetic Map12q11UniSTS
RH138481  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21216,937,303 - 16,937,471 (+)MAPPERmRatBN7.2
Rnor_6.01219,202,865 - 19,203,032NCBIRnor6.0
Rnor_5.01221,261,940 - 21,262,107UniSTSRnor5.0
RGSC_v3.41217,499,167 - 17,499,334UniSTSRGSC3.4
Celera1218,874,229 - 18,874,396UniSTS
RH 3.4 Map12254.4UniSTS
Cytogenetic Map12q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 9 9 9
Medium 18 18 18 10 1 2
Low 3 2 18 6 14 6 4 4 13 11 11 9 4
Below cutoff 9 8 4 5 4 4 5 12 4 11 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001801   ⟹   ENSRNOP00000001801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1216,931,053 - 16,937,090 (+)Ensembl
Rnor_6.0 Ensembl1219,196,611 - 19,202,647 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096300   ⟹   ENSRNOP00000082549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1216,931,745 - 16,939,091 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102149   ⟹   ENSRNOP00000088478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1216,931,024 - 16,939,091 (+)Ensembl
RefSeq Acc Id: NM_012826   ⟹   NP_036958
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,044,757 - 22,050,732 (+)NCBI
mRatBN7.21216,931,043 - 16,937,020 (+)NCBI
Rnor_6.01219,196,606 - 19,202,581 (+)NCBI
Rnor_5.01221,255,645 - 21,262,122 (+)NCBI
RGSC_v3.41217,492,913 - 17,498,949 (+)RGD
Celera1218,867,978 - 18,873,945 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006249003   ⟹   XP_006249065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,044,685 - 22,051,248 (+)NCBI
mRatBN7.21216,930,990 - 16,939,333 (+)NCBI
Rnor_6.01219,196,565 - 19,203,094 (+)NCBI
Rnor_5.01221,255,645 - 21,262,122 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006249004   ⟹   XP_006249066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,044,685 - 22,051,248 (+)NCBI
mRatBN7.21216,930,990 - 16,939,333 (+)NCBI
Rnor_6.01219,196,565 - 19,203,094 (+)NCBI
Rnor_5.01221,255,645 - 21,262,122 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036958   ⟸   NM_012826
- Peptide Label: precursor
- UniProtKB: Q63678 (UniProtKB/Swiss-Prot),   Q63523 (UniProtKB/Swiss-Prot),   Q3B8R6 (UniProtKB/TrEMBL),   A6KSS1 (UniProtKB/TrEMBL),   A0A8I6A9I2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249065   ⟸   XM_006249003
- Peptide Label: isoform X1
- UniProtKB: Q63678 (UniProtKB/Swiss-Prot),   Q63523 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006249066   ⟸   XM_006249004
- Peptide Label: isoform X2
- UniProtKB: Q63678 (UniProtKB/Swiss-Prot),   Q63523 (UniProtKB/Swiss-Prot),   F7F110 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001801   ⟸   ENSRNOT00000001801
RefSeq Acc Id: ENSRNOP00000088478   ⟸   ENSRNOT00000102149
RefSeq Acc Id: ENSRNOP00000082549   ⟸   ENSRNOT00000096300
Protein Domains
Ig-like   Ig-like C1-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63678-F1-model_v2 AlphaFold Q63678 1-296 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698489
Promoter ID:EPDNEW_R9014
Type:initiation region
Name:Azgp1_1
Description:alpha-2-glycoprotein 1, zinc-binding
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01219,196,605 - 19,196,665EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2187 AgrOrtholog
BioCyc Gene G2FUF-19829 BioCyc
Ensembl Genes ENSRNOG00000001333 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055011286 UniProtKB/Swiss-Prot
  ENSRNOG00060024999 UniProtKB/Swiss-Prot
  ENSRNOG00065000046 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001801.7 UniProtKB/TrEMBL
  ENSRNOT00000096300.1 UniProtKB/TrEMBL
  ENSRNOT00000102149 ENTREZGENE
  ENSRNOT00000102149.1 UniProtKB/TrEMBL
  ENSRNOT00055019154 UniProtKB/Swiss-Prot
  ENSRNOT00060043414 UniProtKB/Swiss-Prot
  ENSRNOT00065000074 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.500.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7371444 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_I-like_Ag-recog UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_I-like_Ag-recog_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_I/II-like_Ag-recog UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_I_a_a1/a2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25294 UniProtKB/TrEMBL
MGC_CLONE MGC:124966 IMAGE-MGC_LOAD
NCBI Gene 25294 ENTREZGENE
PANTHER MHC CLASS I-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC-ALPHA-2-GLYCOPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Azgp1 PhenoGen
PRINTS MHCCLASSI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001333 RatGTEx
  ENSRNOG00055011286 RatGTEx
  ENSRNOG00060024999 RatGTEx
  ENSRNOG00065000046 RatGTEx
SMART IGc1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZXF5_RAT UniProtKB/TrEMBL
  A0A8I6A9I2 ENTREZGENE, UniProtKB/TrEMBL
  A6KSS1 ENTREZGENE, UniProtKB/TrEMBL
  F7F110 ENTREZGENE, UniProtKB/TrEMBL
  Q3B8R6 ENTREZGENE
  Q63523 ENTREZGENE
  Q63678 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3B8R6 UniProtKB/TrEMBL
  Q63523 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Azgp1  alpha-2-glycoprotein 1, zinc-binding  Azgp1  alpha-2-glycoprotein 1, zinc  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Azgp1  alpha-2-glycoprotein 1, zinc    alpha-2 - glycoprotein 1, zinc  Name updated 625702 APPROVED
2001-07-23 Azgp1  Zn - alpha2 - glycoprotein      Name withdrawn 67952 WITHDRAWN
2001-07-23 Azgp1  alpha-2 - glycoprotein 1, zinc      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to plasma 631730
gene_expression expressed at high level in liver, expressed at low level in submandibular gland, lung, kidney, and stomach 631730
gene_expression not expressed in prostate, mammary gland, intestine, pancreas, ovary, uterus, thyroid, placenta, spleen, brain and heart 631786
gene_homology has 60% identity with human protein 631730
gene_protein 293 amino acids 631730