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Gene: Grk3 (G protein-coupled receptor kinase 3) Rattus norvegicus
Symbol: Grk3
Name: G protein-coupled receptor kinase 3
RGD ID: 2063
Description: Exhibits D1 dopamine receptor binding activity; G protein-coupled receptor kinase activity; and beta-adrenergic receptor kinase activity. Involved in several processes, including cellular protein metabolic process; desensitization of G protein-coupled receptor signaling pathway; and response to morphine. Localizes to several cellular components, including Z disc; dendrite; and sperm midpiece. Biomarker of Parkinson's disease; hypertension; and hypothyroidism. Orthologous to human GRK3 (G protein-coupled receptor kinase 3); PARTICIPATES IN G protein mediated signaling pathway; angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: Adrbk2; Adrenergic receptor kinase beta 2 (G-protein-linked receptor kinase); adrenergic receptor kinase, beta 2; Adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase); adrenergic, beta, receptor kinase 2; beta ARK2; beta-adrenergic receptor kinase 2; beta-ARK-2; G-protein-coupled receptor kinase 3
Homo sapiens (human) : GRK3 (G protein-coupled receptor kinase 3)  HGNC  Alliance
Mus musculus (house mouse) : Grk3 (G protein-coupled receptor kinase 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk3 (G protein-coupled receptor kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK3 (G protein-coupled receptor kinase 3)
Canis lupus familiaris (dog) : GRK3 (G protein-coupled receptor kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk3 (G protein-coupled receptor kinase 3)
Sus scrofa (pig) : GRK3 (G protein-coupled receptor kinase 3)
Chlorocebus sabaeus (African green monkey) : GRK3 (G protein-coupled receptor kinase 3)
Heterocephalus glaber (naked mole-rat) : Grk3 (G protein-coupled receptor kinase 3)
more info ...
Is Marker For: Strains:   SHHF  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01249,626,871 - 49,750,389 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1249,626,871 - 49,746,272 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01251,433,367 - 51,510,797 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1245,261,279 - 45,319,394 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Grk3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2063
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.