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Gene: Grk3 (G protein-coupled receptor kinase 3) Rattus norvegicus
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Symbol: Grk3
Name: G protein-coupled receptor kinase 3
Description: Exhibits D1 dopamine receptor binding activity; G protein-coupled receptor kinase activity; and beta-adrenergic receptor kinase activity. Involved in several processes, including cellular protein metabolic process; desensitization of G protein-coupled receptor signaling pathway; and response to morphine. Localizes to several cellular components, including the cytoplasm; neuron projection; and sperm midpiece. Biomarker of Parkinson's disease; hypertension; and hypothyroidism. Orthologous to human GRK3 (G protein-coupled receptor kinase 3); PARTICIPATES IN G protein mediated signaling pathway; angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; INTERACTS WITH 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Adrbk2; Adrenergic receptor kinase beta 2 (G-protein-linked receptor kinase); adrenergic receptor kinase, beta 2; Adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase); adrenergic, beta, receptor kinase 2; beta ARK2; beta-adrenergic receptor kinase 2; beta-ARK-2; G-protein-coupled receptor kinase 3
Orthologs:
Homo sapiens (human) : GRK3 (G protein-coupled receptor kinase 3)  HGNC  Alliance
Mus musculus (house mouse) : Grk3 (G protein-coupled receptor kinase 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk3 (G protein-coupled receptor kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK3 (G protein-coupled receptor kinase 3)
Canis lupus familiaris (dog) : GRK3 (G protein-coupled receptor kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk3 (G protein-coupled receptor kinase 3)
Sus scrofa (pig) : GRK3 (G protein-coupled receptor kinase 3)
more info ...
Is Marker For: Strains:   SHHF  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01249,626,871 - 49,750,389 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01251,433,367 - 51,510,797 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1245,261,279 - 45,319,394 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Grk3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2063
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.