Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Grk3 | Rat | bipolar disorder | | ISO | GRK3 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:12808434 | |
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Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Grk3 | Rat | bipolar disorder | | ISO | GRK3 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:12808434 | |
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# | Reference Title | Reference Citation |
1. | Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment. | Ahmed MR, etal., J Neurochem. 2008 Mar;104(6):1622-36. Epub 2007 Nov 7. |
2. | The changes in beta-adrenoceptor-mediated cardiac function in experimental hypothyroidism: the possible contribution of cardiac beta3-adrenoceptors. | Arioglu E, etal., Mol Cell Biochem. 2010 Feb;335(1-2):59-66. Epub 2009 Sep 1. |
3. | The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. | Arriza JL, etal., J Neurosci 1992 Oct;12(10):4045-55. |
4. | The physiology, signaling, and pharmacology of dopamine receptors. | Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8. |
5. | Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins. | Boekhoff I, etal., J Biol Chem. 1994 Jan 7;269(1):37-40. |
6. | Gender differences in beta-adrenoceptor system in cardiac hypertrophy due to arteriovenous fistula. | Dent MR, etal., J Cell Physiol. 2011 Jan;226(1):181-6. |
7. | Chronic treatment with mood stabilizers increases membrane GRK3 in rat frontal cortex. | Ertley RN, etal., Biol Psychiatry. 2007 Jan 15;61(2):246-9. Epub 2006 May 12. |
8. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
9. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
10. | Prolonged Morphine Treatment Alters Expression and Plasma Membrane Distribution of ß-Adrenergic Receptors and Some Other Components of Their Signaling System in Rat Cerebral Cortex. | Hejnova L, etal., J Mol Neurosci. 2017 Dec;63(3-4):364-376. doi: 10.1007/s12031-017-0987-9. Epub 2017 Oct 28. |
11. | The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. | Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16. |
12. | G protein-coupled receptor kinases and beta arrestins are relocalized and attenuate cyclic 3',5'-adenosine monophosphate response to follicle-stimulating hormone in rat primary Sertoli cells. | Marion S, etal., Biol Reprod. 2002 Jan;66(1):70-6. |
13. | The fine-structural distribution of G-protein receptor kinase 3, beta-arrestin-2, Ca2+/calmodulin-dependent protein kinase II and phosphodiesterase PDE1C2, and a Cl(-)-cotransporter in rodent olfactory epithelia. | Menco BP J Neurocytol. 2005 Mar;34(1-2):11-36. |
14. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
15. | beta2- and beta1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases. | Monto F, etal., J Cardiovasc Pharmacol. 2015 Nov;66(5):478-86. doi: 10.1097/FJC.0000000000000299. |
16. | Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables. | Montó F, etal., Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H368-76. doi: 10.1152/ajpheart.01061.2011. Epub 2012 Jun 8. |
17. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
18. | Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. | Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6. |
19. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
20. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
21. | Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients. | Rao JS, etal., Int J Neuropsychopharmacol. 2009 Jul;12(6):851-60. Epub 2009 Apr 29. |
22. | GOA pipeline | RGD automated data pipeline |
23. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
24. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
25. | A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. | Schleicher S, etal., Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1420-4. |
26. | Upregulation of G protein-linked receptor kinases with advancing age in rat aorta. | Schutzer WE, etal., Am J Physiol Regul Integr Comp Physiol. 2001 Mar;280(3):R897-903. |
27. | Cytoplasmic tail of D1 dopaminergic receptor differentially regulates desensitization and phosphorylation by G protein-coupled receptor kinase 2 and 3. | Sedaghat K and Tiberi M, Cell Signal. 2011 Jan;23(1):180-92. Epub 2010 Sep 17. |
28. | Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. | Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38. |
29. | Angiotensin II-stimulated signaling through G proteins and beta-arrestin. | Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14. |
30. | Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts. | Spurney RF, etal., J Clin Invest 2002 May;109(10):1361-71. |
31. | Myocardial distribution and regulation of GRK and beta-arrestin isoforms in congestive heart failure in rats. | Vinge LE, etal., Am J Physiol Heart Circ Physiol 2001 Dec;281(6):H2490-9. |
32. | Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function. | Vinge LE, etal., Mol Pharmacol. 2007 Sep;72(3):582-91. Epub 2007 Jun 15. |
33. | Odorant receptors and desensitization proteins colocalize in mammalian sperm. | Walensky LD, etal., Mol Med. 1995 Jan;1(2):130-41. |
34. | Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats. | Wang FL, etal., Mol Biol Rep. 2013 Mar;40(3):2405-18. doi: 10.1007/s11033-012-2321-5. Epub 2012 Nov 30. |
35. | Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failure. | Yi XP, etal., Anat Rec A Discov Mol Cell Evol Biol. 2005 Jan;282(1):13-23. |
36. | Myocyte redistribution of GRK2 and GRK5 in hypertensive, heart-failure-prone rats. | Yi XP, etal., Hypertension 2002 Jun;39(6):1058-63. |
37. | Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents. | Álvaro-Bartolomé M and García-Sevilla JA, Neuroscience. 2013 Sep 5;247:294-308. doi: 10.1016/j.neuroscience.2013.05.035. Epub 2013 May 29. |
PMID:1869533 | PMID:12600992 | PMID:15297467 | PMID:17583697 | PMID:20074556 | PMID:21333691 | PMID:23935208 | PMID:26043205 |
Grk3 (Rattus norvegicus - Norway rat) |
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GRK3 (Homo sapiens - human) |
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Grk3 (Mus musculus - house mouse) |
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Grk3 (Chinchilla lanigera - long-tailed chinchilla) |
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GRK3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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GRK3 (Canis lupus familiaris - dog) |
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Grk3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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GRK3 (Sus scrofa - pig) |
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GRK3 (Chlorocebus sabaeus - green monkey) |
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Grk3 (Heterocephalus glaber - naked mole-rat) |
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Variants in Grk3
851 total Variants |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
AU046882 |
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AU046729 |
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BE119364 |
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UniSTS:235264 |
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alimentary part of gastrointestinal system
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appendage
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circulatory system
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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integumental system
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mesenchyme
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mesoderm
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nervous system
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renal system
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reproductive system
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respiratory system
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9 | 11 | 49 | 113 | 91 | 90 | 59 | 25 | 59 | 6 | 218 | 97 | 93 | 45 | 60 | 31 |
RefSeq Transcripts | NM_012897 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_017598272 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039089109 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | CH473973 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
JAXUCZ010000012 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Ensembl Acc Id: | ENSRNOT00000082322 ⟹ ENSRNOP00000071696 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Ensembl Acc Id: | ENSRNOT00000082593 ⟹ ENSRNOP00000075107 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Ensembl Acc Id: | ENSRNOT00000086397 ⟹ ENSRNOP00000070946 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_012897 ⟹ NP_037029 | ||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039089109 ⟹ XP_038945037 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Protein RefSeqs | NP_037029 | (Get FASTA) | NCBI Sequence Viewer |
XP_038945037 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | EDM13986 | (Get FASTA) | NCBI Sequence Viewer |
Ensembl Protein | ENSRNOP00000071696.2 | ||
ENSRNOP00000075107.2 | |||
GenBank Protein | P26819 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_037029 ⟸ NM_012897 |
- UniProtKB: | P26819 (UniProtKB/Swiss-Prot), A0A0G2K145 (UniProtKB/TrEMBL) |
- Sequence: |
Ensembl Acc Id: | ENSRNOP00000075107 ⟸ ENSRNOT00000082593 |
Ensembl Acc Id: | ENSRNOP00000071696 ⟸ ENSRNOT00000082322 |
Ensembl Acc Id: | ENSRNOP00000070946 ⟸ ENSRNOT00000086397 |
RefSeq Acc Id: | XP_038945037 ⟸ XM_039089109 |
- Peptide Label: | isoform X1 |
- UniProtKB: | P26819 (UniProtKB/Swiss-Prot) |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P26819-F1-model_v2 | AlphaFold | P26819 | 1-688 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13698723 | ||||||||
Promoter ID: | EPDNEW_R9248 | ||||||||
Type: | single initiation site | ||||||||
Name: | Grk3_1 | ||||||||
Description: | G protein-coupled receptor kinase 3 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:2063 | AgrOrtholog |
BioCyc Gene | G2FUF-18879 | BioCyc |
Ensembl Genes | ENSRNOG00000059456 | Ensembl, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000082322.2 | UniProtKB/TrEMBL |
ENSRNOT00000082593.2 | UniProtKB/TrEMBL | |
Gene3D-CATH | 1.10.167.10 | UniProtKB/TrEMBL |
1.10.287.1270 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
2.30.29.30 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Transferase(Phosphotransferase) domain 1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
InterPro | AGC-kinase_C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
GPCR_kinase | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Kinase-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PH-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PH_domain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Prot_kinase_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RGS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RGS_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RGS_subdomain_2 | UniProtKB/TrEMBL | |
Ser/Thr_kinase_AS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:25372 | UniProtKB/Swiss-Prot |
NCBI Gene | 25372 | ENTREZGENE |
PANTHER | BETA-ADRENERGIC RECEPTOR KINASE 2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | PF00169 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Pkinase | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RGS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Grk3 | PhenoGen |
PRINTS | GPCRKINASE | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PROSITE | AGC_KINASE_CTER | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PH_DOMAIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RGS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000059456 | RatGTEx |
SMART | RGS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
S_TK_X | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
S_TKc | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SM00233 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | PH domain-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SSF48097 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SSF56112 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UniProt | A0A0G2K145 | ENTREZGENE, UniProtKB/TrEMBL |
A0A0G2K9S3_RAT | UniProtKB/TrEMBL | |
A6J244_RAT | UniProtKB/TrEMBL | |
A6J245_RAT | UniProtKB/TrEMBL | |
ARBK2_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2016-05-20 | Grk3 | G protein-coupled receptor kinase 3 | Adrbk2 | adrenergic, beta, receptor kinase 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-09-25 | Adrbk2 | adrenergic, beta, receptor kinase 2 | Adrbk2 | adrenergic receptor kinase, beta 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2002-11-06 | Adrbk2 | adrenergic receptor kinase, beta 2 | Adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase) | Name updated | 625702 | APPROVED | |
2002-06-10 | Adrbk2 | Adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase) | Symbol and Name status set to approved | 70586 | APPROVED |
Note Type | Note | Reference |
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gene_cellular_localization | distributed diffusely in the cytoplasm | 70720 |
gene_disease | associated with the development of cardiac hypertrophy | 70720 |
gene_expression | expressed in endothelial cells | 70720 |
gene_expression | expressed in brain | 632163 |
gene_expression | expressed in cardiac myocytes | 70720 |
gene_function | catalyzes the phosphorylation of agonist-bound beta-adrenergic receptors | 632163 |
gene_function | kinase | 70720 |
gene_physical_interaction | co-localized with coilin, a major component of nuclear substructure of myocytes | 70720 |
gene_process | mediates a reduction in adenylate cyclase activity | 632163 |
gene_process | involved in RNA synthesis and processing, might regulate hypertrophic gene expression | 70720 |
gene_process | involved in G protein-coupled receptor phosphorylation and desensitization | 70720 |
gene_process | mediates desensitization and downregulation of G protein-coupled receptors (GPCRs) | 628504 |
gene_process | plays a role in regulating GPCRs (G-protein-coupled receptors) in bone; mediates bone formation | 625698 |
gene_process | may play a role in desensitization of synaptic receptors | 632163 |
gene_product | member of serine/ threonine kinase family | 70720 |
gene_regulation | mRNA level increases in postinfarction (heart) failure | 70720 |