Grk3 (G protein-coupled receptor kinase 3) - Rat Genome Database

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Gene: Grk3 (G protein-coupled receptor kinase 3) Rattus norvegicus
Symbol: Grk3
Name: G protein-coupled receptor kinase 3
RGD ID: 2063
Description: Enables D1 dopamine receptor binding activity; G protein-coupled receptor kinase activity; and beta-adrenergic receptor kinase activity. Involved in several processes, including multicellular organism aging; response to morphine; and rhodopsin metabolic process. Located in several cellular components, including Z disc; dendrite; and sperm midpiece. Is active in glutamatergic synapse; postsynaptic density; and presynapse. Biomarker of Parkinson's disease; hypertension; and hypothyroidism. Orthologous to human GRK3 (G protein-coupled receptor kinase 3); PARTICIPATES IN G protein mediated signaling pathway; angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
Previously known as: Adrbk2; Adrenergic receptor kinase beta 2 (G-protein-linked receptor kinase); adrenergic receptor kinase, beta 2; Adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase); adrenergic, beta, receptor kinase 2; beta ARK2; beta-adrenergic receptor kinase 2; beta-ARK-2; G-protein-coupled receptor kinase 3
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SHHF  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21243,624,778 - 43,735,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,624,897 - 43,731,262 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1244,792,406 - 44,899,008 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01245,404,111 - 45,510,489 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01244,464,630 - 44,571,012 (+)NCBIRnor_WKY
Rnor_6.01249,626,871 - 49,750,389 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1249,626,871 - 49,746,272 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01251,433,367 - 51,510,797 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1245,261,279 - 45,319,394 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
desipramine  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP)
dichlorine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
glyphosate  (ISO)
Heliotrine  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methacholine chloride  (ISO)
methimazole  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nitrofen  (EXP)
nitroprusside  (ISO)
ozone  (EXP)
paracetamol  (ISO)
parathion  (ISO)
PCB138  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
Senkirkine  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
tetraphene  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)


References - curated
# Reference Title Reference Citation
1. Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment. Ahmed MR, etal., J Neurochem. 2008 Mar;104(6):1622-36. Epub 2007 Nov 7.
2. The changes in beta-adrenoceptor-mediated cardiac function in experimental hypothyroidism: the possible contribution of cardiac beta3-adrenoceptors. Arioglu E, etal., Mol Cell Biochem. 2010 Feb;335(1-2):59-66. Epub 2009 Sep 1.
3. The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. Arriza JL, etal., J Neurosci 1992 Oct;12(10):4045-55.
4. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
5. Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins. Boekhoff I, etal., J Biol Chem. 1994 Jan 7;269(1):37-40.
6. Gender differences in beta-adrenoceptor system in cardiac hypertrophy due to arteriovenous fistula. Dent MR, etal., J Cell Physiol. 2011 Jan;226(1):181-6.
7. Chronic treatment with mood stabilizers increases membrane GRK3 in rat frontal cortex. Ertley RN, etal., Biol Psychiatry. 2007 Jan 15;61(2):246-9. Epub 2006 May 12.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Prolonged Morphine Treatment Alters Expression and Plasma Membrane Distribution of ß-Adrenergic Receptors and Some Other Components of Their Signaling System in Rat Cerebral Cortex. Hejnova L, etal., J Mol Neurosci. 2017 Dec;63(3-4):364-376. doi: 10.1007/s12031-017-0987-9. Epub 2017 Oct 28.
11. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
12. G protein-coupled receptor kinases and beta arrestins are relocalized and attenuate cyclic 3',5'-adenosine monophosphate response to follicle-stimulating hormone in rat primary Sertoli cells. Marion S, etal., Biol Reprod. 2002 Jan;66(1):70-6.
13. The fine-structural distribution of G-protein receptor kinase 3, beta-arrestin-2, Ca2+/calmodulin-dependent protein kinase II and phosphodiesterase PDE1C2, and a Cl(-)-cotransporter in rodent olfactory epithelia. Menco BP J Neurocytol. 2005 Mar;34(1-2):11-36.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. beta2- and beta1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases. Monto F, etal., J Cardiovasc Pharmacol. 2015 Nov;66(5):478-86. doi: 10.1097/FJC.0000000000000299.
16. Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables. Montó F, etal., Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H368-76. doi: 10.1152/ajpheart.01061.2011. Epub 2012 Jun 8.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients. Rao JS, etal., Int J Neuropsychopharmacol. 2009 Jul;12(6):851-60. Epub 2009 Apr 29.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. Schleicher S, etal., Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1420-4.
26. Upregulation of G protein-linked receptor kinases with advancing age in rat aorta. Schutzer WE, etal., Am J Physiol Regul Integr Comp Physiol. 2001 Mar;280(3):R897-903.
27. Cytoplasmic tail of D1 dopaminergic receptor differentially regulates desensitization and phosphorylation by G protein-coupled receptor kinase 2 and 3. Sedaghat K and Tiberi M, Cell Signal. 2011 Jan;23(1):180-92. Epub 2010 Sep 17.
28. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
29. Angiotensin II-stimulated signaling through G proteins and beta-arrestin. Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14.
30. Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts. Spurney RF, etal., J Clin Invest 2002 May;109(10):1361-71.
31. Myocardial distribution and regulation of GRK and beta-arrestin isoforms in congestive heart failure in rats. Vinge LE, etal., Am J Physiol Heart Circ Physiol 2001 Dec;281(6):H2490-9.
32. Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function. Vinge LE, etal., Mol Pharmacol. 2007 Sep;72(3):582-91. Epub 2007 Jun 15.
33. Odorant receptors and desensitization proteins colocalize in mammalian sperm. Walensky LD, etal., Mol Med. 1995 Jan;1(2):130-41.
34. Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats. Wang FL, etal., Mol Biol Rep. 2013 Mar;40(3):2405-18. doi: 10.1007/s11033-012-2321-5. Epub 2012 Nov 30.
35. Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failure. Yi XP, etal., Anat Rec A Discov Mol Cell Evol Biol. 2005 Jan;282(1):13-23.
36. Myocyte redistribution of GRK2 and GRK5 in hypertensive, heart-failure-prone rats. Yi XP, etal., Hypertension 2002 Jun;39(6):1058-63.
37. Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents. Álvaro-Bartolomé M and García-Sevilla JA, Neuroscience. 2013 Sep 5;247:294-308. doi: 10.1016/j.neuroscience.2013.05.035. Epub 2013 May 29.
Additional References at PubMed
PMID:1869533   PMID:12600992   PMID:15297467   PMID:17583697   PMID:20074556   PMID:21333691   PMID:23935208   PMID:26043205  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21243,624,778 - 43,735,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,624,897 - 43,731,262 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1244,792,406 - 44,899,008 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01245,404,111 - 45,510,489 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01244,464,630 - 44,571,012 (+)NCBIRnor_WKY
Rnor_6.01249,626,871 - 49,750,389 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1249,626,871 - 49,746,272 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01251,433,367 - 51,510,797 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1245,261,279 - 45,319,394 (+)NCBICelera
Cytogenetic Map12q16NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382225,564,675 - 25,729,294 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2225,564,675 - 25,729,294 (+)EnsemblGRCh38hg38GRCh38
GRCh372225,960,642 - 26,125,261 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362224,290,861 - 24,455,259 (+)NCBINCBI36Build 36hg18NCBI36
Build 342224,285,499 - 24,444,470NCBI
Celera229,765,035 - 9,929,436 (+)NCBICelera
Cytogenetic Map22q12.1ENTREZGENE
HuRef228,948,071 - 9,073,051 (+)NCBIHuRef
CHM1_12225,919,893 - 26,084,649 (+)NCBICHM1_1
T2T-CHM13v2.02226,025,826 - 26,190,440 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm395113,058,344 - 113,163,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5113,058,348 - 113,163,657 (-)EnsemblGRCm39 Ensembl
GRCm385112,910,478 - 113,015,660 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5112,910,482 - 113,015,791 (-)EnsemblGRCm38mm10GRCm38
MGSCv375113,339,498 - 113,444,534 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365113,150,781 - 113,255,817 (-)NCBIMGSCv36mm8
Celera5110,031,311 - 110,133,492 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.29NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495544219,640,145 - 19,785,803 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544219,640,145 - 19,785,803 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.12224,353,530 - 24,516,416 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2224,353,533 - 24,509,560 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0226,579,664 - 6,789,846 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12619,385,059 - 19,512,528 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2619,385,058 - 19,516,077 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2619,249,805 - 19,382,153 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02619,749,680 - 19,882,193 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2619,749,732 - 19,878,611 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12619,454,629 - 19,586,996 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02619,720,438 - 19,852,665 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02619,789,809 - 19,922,140 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118115,345,722 - 115,443,919 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936657426,787 - 521,198 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936657425,902 - 522,331 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1443,224,930 - 43,442,965 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11443,305,255 - 43,445,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21446,128,694 - 46,270,654 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1198,438,543 - 8,601,652 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl198,438,380 - 8,600,359 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045117,529,573 - 117,694,607 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247471,576,681 - 1,758,201 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247471,567,540 - 1,758,251 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Grk3
721 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21243,730,291 - 43,730,458 (+)MAPPERmRatBN7.2
Rnor_6.01249,745,303 - 49,745,469NCBIRnor6.0
Rnor_5.01251,509,831 - 51,509,997UniSTSRnor5.0
Celera1245,318,428 - 45,318,594UniSTS
Cytogenetic Map12q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21243,730,281 - 43,730,465 (+)MAPPERmRatBN7.2
Rnor_6.01249,745,293 - 49,745,476NCBIRnor6.0
Rnor_5.01251,509,821 - 51,510,004UniSTSRnor5.0
Celera1245,318,418 - 45,318,601UniSTS
Cytogenetic Map12q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21243,678,878 - 43,679,047 (+)MAPPERmRatBN7.2
Rnor_6.01249,694,073 - 49,694,241NCBIRnor6.0
Rnor_5.01251,458,723 - 51,458,891UniSTSRnor5.0
Cytogenetic Map12q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21243,731,209 - 43,731,553 (+)MAPPERmRatBN7.2
Rnor_6.01249,746,220 - 49,746,563NCBIRnor6.0
Rnor_5.01251,510,748 - 51,511,091UniSTSRnor5.0
Celera1245,319,345 - 45,319,688UniSTS
Cytogenetic Map12q16UniSTS

Related Rat Strains
The following Strains have been annotated to Grk3


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 9 39 3
Low 3 41 35 19 10 19 8 8 35 35 38 11 8
Below cutoff 2 22 22 22 3


Reference Sequences
RefSeq Acc Id: ENSRNOT00000082322   ⟹   ENSRNOP00000071696
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1243,624,897 - 43,731,262 (+)Ensembl
Rnor_6.0 Ensembl1249,665,794 - 49,745,966 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082593   ⟹   ENSRNOP00000075107
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1243,624,897 - 43,684,433 (+)Ensembl
Rnor_6.0 Ensembl1249,626,871 - 49,746,272 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086397   ⟹   ENSRNOP00000070946
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1249,665,282 - 49,746,162 (+)Ensembl
RefSeq Acc Id: NM_012897   ⟹   NP_037029
Rat AssemblyChrPosition (strand)Source
mRatBN7.21243,624,897 - 43,731,259 (+)NCBI
Rnor_6.01249,626,871 - 49,746,269 (+)NCBI
Rnor_5.01251,433,367 - 51,510,797 (+)NCBI
Celera1245,261,279 - 45,319,394 (+)RGD
RefSeq Acc Id: XM_039089109   ⟹   XP_038945037
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21243,624,778 - 43,730,832 (+)NCBI
RefSeq Acc Id: XM_039089110   ⟹   XP_038945038
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21243,671,886 - 43,735,375 (+)NCBI
Protein Sequences
Protein RefSeqs NP_037029 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945037 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945038 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM13986 (Get FASTA)   NCBI Sequence Viewer  
  P26819 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037029   ⟸   NM_012897
- UniProtKB: A0A0G2K145 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075107   ⟸   ENSRNOT00000082593
RefSeq Acc Id: ENSRNOP00000071696   ⟸   ENSRNOT00000082322
RefSeq Acc Id: ENSRNOP00000070946   ⟸   ENSRNOT00000086397
RefSeq Acc Id: XP_038945037   ⟸   XM_039089109
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038945038   ⟸   XM_039089110
- Peptide Label: isoform X2
Protein Domains
AGC-kinase C-terminal   PH   Protein kinase   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26819-F1-model_v2 AlphaFold P26819 1-688 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698723
Promoter ID:EPDNEW_R9248
Type:single initiation site
Description:G protein-coupled receptor kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01249,626,892 - 49,626,952EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2063 AgrOrtholog
BioCyc Gene G2FUF-18879 BioCyc
Ensembl Genes ENSRNOG00000059456 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000071696 ENTREZGENE
  ENSRNOP00000071696.2 UniProtKB/TrEMBL
  ENSRNOP00000075107.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082322 ENTREZGENE
  ENSRNOT00000082322.2 UniProtKB/TrEMBL
  ENSRNOT00000082593.2 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25372 UniProtKB/Swiss-Prot
Pfam PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grk3 PhenoGen
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-20 Grk3  G protein-coupled receptor kinase 3  Adrbk2  adrenergic, beta, receptor kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Adrbk2  adrenergic, beta, receptor kinase 2  Adrbk2  adrenergic receptor kinase, beta 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Adrbk2  adrenergic receptor kinase, beta 2    Adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase)  Name updated 625702 APPROVED
2002-06-10 Adrbk2  Adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization distributed diffusely in the cytoplasm 70720
gene_disease associated with the development of cardiac hypertrophy 70720
gene_expression expressed in endothelial cells 70720
gene_expression expressed in brain 632163
gene_expression expressed in cardiac myocytes 70720
gene_function catalyzes the phosphorylation of agonist-bound beta-adrenergic receptors 632163
gene_function kinase 70720
gene_physical_interaction co-localized with coilin, a major component of nuclear substructure of myocytes 70720
gene_process mediates a reduction in adenylate cyclase activity 632163
gene_process involved in RNA synthesis and processing, might regulate hypertrophic gene expression 70720
gene_process involved in G protein-coupled receptor phosphorylation and desensitization 70720
gene_process mediates desensitization and downregulation of G protein-coupled receptors (GPCRs) 628504
gene_process plays a role in regulating GPCRs (G-protein-coupled receptors) in bone; mediates bone formation 625698
gene_process may play a role in desensitization of synaptic receptors 632163
gene_product member of serine/ threonine kinase family 70720
gene_regulation mRNA level increases in postinfarction (heart) failure 70720