Plod3 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3) - Rat Genome Database

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Gene: Plod3 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3) Rattus norvegicus
Analyze
Symbol: Plod3
Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
RGD ID: 631339
Description: Predicted to enable hexosyltransferase activity; iron ion binding activity; and procollagen-lysine 5-dioxygenase activity. Involved in cellular response to hormone stimulus. Predicted to be located in trans-Golgi network. Predicted to be active in several cellular components, including Golgi apparatus; collagen-containing extracellular matrix; and endoplasmic reticulum. Biomarker of hypothyroidism. Orthologous to human PLOD3 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 3); PARTICIPATES IN lysine degradation pathway; O-linked glycan biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; aconitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bone protein I (BP-I); LH3; lysyl hydroxylase 3; MGC93055; multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3; procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,313,070 - 25,323,631 (-)NCBIGRCr8
mRatBN7.21219,676,384 - 19,686,945 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,676,386 - 19,686,960 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,814,848 - 20,825,421 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,427,553 - 21,438,126 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,492,753 - 20,503,314 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,716,421 - 22,726,982 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,716,423 - 22,726,982 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,728,205 - 24,738,766 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,856,527 - 20,867,088 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11220,846,399 - 20,856,690 (+)NCBI
Celera1221,452,299 - 21,462,860 (-)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Plod3Rathepatocellular carcinoma treatmentISOPlod3 (Mus musculus)155791679 RGD 
Plod3Rathepatocellular carcinoma  ISOPLOD3 (Homo sapiens)155791679mRNA and protein:increased expression:liver (human)RGD 
Plod3Rathypothyroidism  IEP 2314536mRNA:decreased expression:multiple organsRGD 
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Original Reference(s)
Plod3RatBone Fragility with Contractures, Arterial Rupture, and Deafness  ISOPLOD3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
Plod3RatCerebral Hemorrhage  ISOPLOD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Hemorrhage more ...ClinVarPMID:25741868 and PMID:28492532
Plod3Ratgenetic disease  ISOPLOD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:17576681 more ...
Plod3RatPlasminogen Activator Inhibitor-1 Deficiency  ISOPLOD3 (Homo sapiens)8554872ClinVar Annotator: match by term: HYPERFIBRINOLYSIS DUE TO PAI1 DEFICIENCYClinVarPMID:21681106
Plod3Ratpleomorphic xanthoastrocytoma  ISOPLOD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
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Plod3RatBone Fragility with Contractures, Arterial Rupture, and Deafness  ISOPLOD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
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Original Reference(s)
Plod3RatBone Fragility with Contractures, Arterial Rupture, and Deafness  ISOPLOD3 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Plod3Rat(-)-epigallocatechin 3-gallate multiple interactionsISOPLOD3 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PLOD3 mRNACTDPMID:22079256
Plod3Rat(-)-epigallocatechin 3-gallate increases expressionISOPLOD3 (Homo sapiens)6480464epigallocatechin gallate results in increased expression of PLOD3 mRNACTDPMID:20706672
Plod3Rat(S)-nicotine decreases expressionISOPlod3 (Mus musculus)6480464Nicotine results in decreased expression of PLOD3 mRNACTDPMID:17997037
Plod3Rat1,10-phenanthroline increases expressionISOPLOD3 (Homo sapiens)64804641 and 10-phenanthroline results in increased expression of PLOD3 mRNACTDPMID:19502547
Plod3Rat1,2-dichloroethane decreases expressionISOPlod3 (Mus musculus)6480464ethylene dichloride results in decreased expression of PLOD3 mRNACTDPMID:28960355
Plod3Rat1,2-dimethylhydrazine increases expressionISOPlod3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of PLOD3 mRNACTDPMID:22206623
Plod3Rat1,4-dithiothreitol increases expressionISOPLOD3 (Homo sapiens)6480464Dithiothreitol results in increased expression of PLOD3 proteinCTDPMID:21692457
Plod3Rat17alpha-ethynylestradiol multiple interactionsISOPlod3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLOD3 mRNACTDPMID:17942748
Plod3Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOPLOD3 (Homo sapiens)64804642 more ...CTDPMID:31675489
Plod3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPlod3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLOD3 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PLOD3 promoter]CTDPMID:17942748 and PMID:19654925
Plod3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PLOD3 mRNACTDPMID:33387578
Plod3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PLOD3 mRNACTDPMID:34747641
Plod3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPlod3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PLOD3 mRNACTDPMID:21570461
Plod3Rat2,4,6-tribromophenol increases expressionISOPLOD3 (Homo sapiens)64804642 more ...CTDPMID:31675489
Plod3Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of PLOD3 mRNACTDPMID:21346803
Plod3Rat3,3',5,5'-tetrabromobisphenol A increases expressionISOPLOD3 (Homo sapiens)6480464tetrabromobisphenol A results in increased expression of PLOD3 proteinCTDPMID:31675489
Plod3Rat3,4-methylenedioxymethamphetamine increases expressionISOPlod3 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PLOD3 mRNACTDPMID:20188158
Plod3Rat4,4'-diaminodiphenylmethane increases expressionISOPlod3 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in increased expression of PLOD3 mRNACTDPMID:18648102
Plod3Rat4,4'-sulfonyldiphenol decreases expressionISOPlod3 (Mus musculus)6480464bisphenol S results in decreased expression of PLOD3 mRNACTDPMID:39298647
Plod3Rat4,4'-sulfonyldiphenol increases expressionISOPLOD3 (Homo sapiens)6480464bisphenol S results in increased expression of PLOD3 proteinCTDPMID:34186270

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Biological Process
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Plod3Ratbasement membrane assembly acts_upstream_of_or_withinISOPlod3 (Mus musculus)1624291MGI:3620600 more ...RGDPMID:16467571
Plod3Ratbasement membrane assembly acts_upstream_of_or_withinIEAUniProtKB:Q9R0E1 and ensembl:ENSMUSP000000049681600115GO_REF:0000107EnsemblGO_REF:0000107
Plod3Ratcellular response to hormone stimulus  IEP 2314536 RGD 
Plod3Ratcollagen fibril organization involved_inIBAMGI:1347008 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Plod3Ratcollagen fibril organization acts_upstream_of_or_withinIEAUniProtKB:Q9R0E1 and ensembl:ENSMUSP000000049681600115GO_REF:0000107EnsemblGO_REF:0000107
Plod3Ratcollagen fibril organization acts_upstream_of_or_withinISOPlod3 (Mus musculus)1624291MGI:3620600 more ...RGDPMID:16467571
Plod3Ratcollagen metabolic process acts_upstream_of_or_withinISOPlod3 (Mus musculus)1624291 PMID:27435297RGDPMID:27435297
Plod3Ratcollagen metabolic process acts_upstream_of_or_withinIEAUniProtKB:Q9R0E1 and ensembl:ENSMUSP000000049681600115GO_REF:0000107EnsemblGO_REF:0000107
Plod3Ratendothelial cell morphogenesis acts_upstream_of_or_withinISOPlod3 (Mus musculus)1624291MGI:3620600 more ...RGDPMID:16467571
Plod3Ratendothelial cell morphogenesis acts_upstream_of_or_withinIEAUniProtKB:Q9R0E1 and ensembl:ENSMUSP000000049681600115GO_REF:0000107EnsemblGO_REF:0000107
Plod3Ratepidermis morphogenesis acts_upstream_of_or_withinIEAUniProtKB:Q9R0E1 and ensembl:ENSMUSP000000049681600115GO_REF:0000107EnsemblGO_REF:0000107
Plod3Ratepidermis morphogenesis acts_upstream_of_or_withinISOPlod3 (Mus musculus)1624291MGI:3620603 PMID:16467571RGDPMID:16467571
Plod3Rathydroxylysine biosynthetic process involved_inISOPlod3 (Mus musculus)1624291 PMID:16447251RGDPMID:16447251
Plod3Rathydroxylysine biosynthetic process involved_inIEAUniProtKB:Q9R0E1 and ensembl:ENSMUSP000000049681600115GO_REF:0000107EnsemblGO_REF:0000107
Plod3Ratin utero embryonic development acts_upstream_of_or_withinISOPlod3 (Mus musculus)1624291MGI:3620600 more ...RGDPMID:16467571
Plod3Ratin utero embryonic development acts_upstream_of_or_withinIEAUniProtKB:Q9R0E1 and ensembl:ENSMUSP000000049681600115GO_REF:0000107EnsemblGO_REF:0000107
Plod3Ratlung morphogenesis acts_upstream_of_or_withinISOPlod3 (Mus musculus)1624291MGI:3620603 PMID:16467571RGDPMID:16467571
Plod3Ratlung morphogenesis acts_upstream_of_or_withinIEAUniProtKB:Q9R0E1 and ensembl:ENSMUSP000000049681600115GO_REF:0000107EnsemblGO_REF:0000107
Plod3Ratneural tube development acts_upstream_of_or_withinIEAUniProtKB:Q9R0E1 and ensembl:ENSMUSP000000049681600115GO_REF:0000107EnsemblGO_REF:0000107
Plod3Ratneural tube development acts_upstream_of_or_withinISOPlod3 (Mus musculus)1624291MGI:3620600 more ...RGDPMID:16467571
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Cellular Component
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Original Reference(s)
Plod3Ratcollagen-containing extracellular matrix is_active_inIBAMGI:1347008 and PANTHER:PTN0008429621600115GO_REF:0000033GO_CentralGO_REF:0000033
Plod3Ratcollagen-containing extracellular matrix located_inISOPlod3 (Mus musculus)1624291 PMID:27435297RGDPMID:27435297
Plod3Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Plod3Ratendoplasmic reticulum located_inIEAUniProtKB:Q9R0E1 and ensembl:ENSMUSP000000049681600115GO_REF:0000107EnsemblGO_REF:0000107
Plod3Ratendoplasmic reticulum is_active_inIBAFB:FBgn0036147 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Plod3Ratendoplasmic reticulum located_inISOPLOD3 (Homo sapiens)1624291 PMID:10934207RGDPMID:10934207
Plod3Ratendoplasmic reticulum located_inISSUniProtKB:Q9R0E11600115GO_REF:0000024UniProtGO_REF:0000024
Plod3Ratendoplasmic reticulum located_inISOPlod3 (Mus musculus)1624291 PMID:16447251RGDPMID:16447251
Plod3Ratendoplasmic reticulum located_inIEAUniProtKB:O60568 and ensembl:ENSP000002231271600115GO_REF:0000107EnsemblGO_REF:0000107
Plod3Ratendoplasmic reticulum lumen located_inIEAUniProtKB-SubCell:SL-00961600115GO_REF:0000044UniProtGO_REF:0000044
Plod3Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Plod3Ratextracellular region located_inIEAUniProtKB-SubCell:SL-0112 and UniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Plod3Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Plod3Ratextracellular space located_inISSUniProtKB:Q9R0E11600115GO_REF:0000024UniProtGO_REF:0000024
Plod3Ratextracellular space located_inISOPlod3 (Mus musculus)1624291 PMID:16447251RGDPMID:16447251
Plod3Ratextracellular space is_active_inIBAFB:FBgn0036147 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Plod3Ratextracellular space located_inIEAUniProtKB:Q9R0E1 and ensembl:ENSMUSP000000049681600115GO_REF:0000107EnsemblGO_REF:0000107
Plod3RatGolgi apparatus located_inISOPLOD3 (Homo sapiens)1624291 PMID:10934207 and PMID:27435297RGDPMID:10934207 and PMID:27435297
Plod3RatGolgi apparatus located_inIEAUniProtKB:O60568 and ensembl:ENSP000002231271600115GO_REF:0000107EnsemblGO_REF:0000107
Plod3RatGolgi apparatus is_active_inIBAMGI:1347008 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Molecular Function
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Plod3Ratcatalytic activity enablesIEAUniProtKB-KW:KW-05111600115GO_REF:0000043UniProtGO_REF:0000043
Plod3Ratdioxygenase activity enablesIEAUniProtKB-KW:KW-02231600115GO_REF:0000043UniProtGO_REF:0000043
Plod3Ratglycosyltransferase activity enablesIEAUniProtKB-KW:KW-03281600115GO_REF:0000043UniProtGO_REF:0000043
Plod3Ratiron ion binding enablesIEAInterPro:IPR0066201600115GO_REF:0000002InterProGO_REF:0000002
Plod3Ratiron ion binding enablesISOPLOD3 (Homo sapiens)1624291 PMID:30089812RGDPMID:30089812
Plod3RatL-ascorbic acid binding enablesIEAUniProtKB-KW:KW-08471600115GO_REF:0000043UniProtGO_REF:0000043
Plod3RatL-ascorbic acid binding enablesIEAInterPro:IPR0066201600115GO_REF:0000002InterProGO_REF:0000002
Plod3Ratmetal ion binding enablesISOPLOD3 (Homo sapiens)1624291 PMID:30089812RGDPMID:30089812
Plod3Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Plod3Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Plod3Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen enablesIEAInterPro:IPR0066201600115GO_REF:0000002InterProGO_REF:0000002
Plod3Ratprocollagen galactosyltransferase activity enablesISSUniProtKB:O605681600115GO_REF:0000024UniProtGO_REF:0000024
Plod3Ratprocollagen galactosyltransferase activity enablesIEAEC:2.4.1.501600115GO_REF:0000003UniProtGO_REF:0000003
Plod3Ratprocollagen galactosyltransferase activity enablesIEARHEA:126371600115GO_REF:0000116RHEAGO_REF:0000116
Plod3Ratprocollagen galactosyltransferase activity enablesISOPLOD3 (Homo sapiens)1624291 PMID:18298658RGDPMID:18298658
Plod3Ratprocollagen galactosyltransferase activity enablesIEAUniProtKB:O60568 and ensembl:ENSP000002231271600115GO_REF:0000107EnsemblGO_REF:0000107
Plod3Ratprocollagen glucosyltransferase activity enablesISOPLOD3 (Homo sapiens)1624291 PMID:10934207 and PMID:18298658RGDPMID:10934207 and PMID:18298658
Plod3Ratprocollagen glucosyltransferase activity enablesIEARHEA:125761600115GO_REF:0000116RHEAGO_REF:0000116
Plod3Ratprocollagen glucosyltransferase activity enablesIEAEC:2.4.1.661600115GO_REF:0000003UniProtGO_REF:0000003
Plod3Ratprocollagen glucosyltransferase activity enablesISOPlod3 (Mus musculus)1624291 PMID:16447251 more ...RGDPMID:16447251 more ...
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Imported Annotations - KEGG (archival)

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Original Reference(s)
Plod3Ratlysine degradation pathway  IEA 6907045 KEGGrno:00310
Plod3RatO-linked glycan biosynthetic pathway  IEA 6907045 KEGGrno:00514

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Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Identification, expression, and tissue distribution of the three rat lysyl hydroxylase isoforms. Mercer DK, etal., Biochem Biophys Res Commun 2003 Aug 8;307(4):803-9.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Differential expression of procollagen lysine 2-oxoglutarate 5-deoxygenase and matrix metalloproteinase isoforms in hypothyroid rat ovary and disintegration of extracellular matrix. Saha SK, etal., Endocrinology. 2005 Jul;146(7):2963-75. Epub 2005 Apr 7.
11. Barrier to autointegration factor 1, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3, and splicing factor 3b subunit 4 as early-stage cancer decision markers and drivers of hepatocellular carcinoma. Shen Q, etal., Hepatology. 2018 Apr;67(4):1360-1377. doi: 10.1002/hep.29606. Epub 2018 Feb 20.
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PMID:3162363   PMID:9582318   PMID:9724729   PMID:10934207   PMID:12477932   PMID:15489334   PMID:16447251   PMID:16467571   PMID:18298658   PMID:19056867   PMID:19199708   PMID:27435297  



Plod3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,313,070 - 25,323,631 (-)NCBIGRCr8
mRatBN7.21219,676,384 - 19,686,945 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,676,386 - 19,686,960 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,814,848 - 20,825,421 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,427,553 - 21,438,126 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,492,753 - 20,503,314 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,716,421 - 22,726,982 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,716,423 - 22,726,982 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,728,205 - 24,738,766 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,856,527 - 20,867,088 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11220,846,399 - 20,856,690 (+)NCBI
Celera1221,452,299 - 21,462,860 (-)NCBICelera
Cytogenetic Map12q12NCBI
PLOD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387101,205,984 - 101,217,581 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7101,205,977 - 101,218,420 (-)EnsemblGRCh38hg38GRCh38
GRCh377100,849,265 - 100,860,862 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,635,978 - 100,647,731 (-)NCBINCBI36Build 36hg18NCBI36
Build 347100,442,700 - 100,454,303NCBI
Celera795,858,417 - 95,870,169 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef795,442,117 - 95,454,228 (-)NCBIHuRef
CHM1_17100,779,662 - 100,791,414 (-)NCBICHM1_1
T2T-CHM13v2.07102,529,447 - 102,541,882 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27100,207,645 - 100,219,398 (-)NCBI
Plod3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,015,873 - 137,025,500 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,015,873 - 137,025,502 (+)EnsemblGRCm39 Ensembl
GRCm385136,987,019 - 136,996,646 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5136,987,019 - 136,996,648 (+)EnsemblGRCm38mm10GRCm38
MGSCv375137,462,889 - 137,472,516 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365137,271,649 - 137,281,166 (+)NCBIMGSCv36mm8
Celera5134,003,006 - 134,012,645 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.09NCBI
Plod3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545616,082,437 - 16,093,389 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545616,082,424 - 16,090,773 (+)NCBIChiLan1.0ChiLan1.0
PLOD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26119,219,216 - 119,230,857 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17167,483,838 - 167,495,393 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0793,347,335 - 93,358,921 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,587,858 - 106,599,605 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,587,858 - 106,599,605 (-)Ensemblpanpan1.1panPan2
PLOD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,664,135 - 8,671,637 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,664,358 - 8,671,620 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,361,502 - 10,368,957 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.068,483,656 - 8,491,120 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,483,333 - 8,491,117 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,443,884 - 8,451,311 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,414,481 - 8,421,939 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.068,579,093 - 8,586,540 (+)NCBIUU_Cfam_GSD_1.0
Plod3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344132,939,235 - 132,946,261 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365431,090,253 - 1,097,301 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365431,090,268 - 1,097,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLOD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,911,791 - 8,919,516 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,911,787 - 8,919,525 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PLOD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12811,962,394 - 11,974,206 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2811,962,286 - 11,975,228 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660704,378,287 - 4,390,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plod3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,074,141 - 16,082,223 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,074,027 - 16,082,139 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Plod3
181 total Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
12 22718351 22718352 T C snv Buf/N (MCW), WN/N (MCW) View more Information
12 22719456 22719457 C T snv WN/N (MCW), Buf/N (MCW) View more Information
12 22721545 22721546 A G snv Buf/N (MCW), WN/N (MCW) View more Information
12 22723102 22723103 A G snv WN/N (MCW), Buf/N (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:40
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000001921
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 52 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat

1 to 10 of 52 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000001921   ⟹   ENSRNOP00000001921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,676,386 - 19,686,960 (-)Ensembl
Rnor_6.0 Ensembl1222,716,423 - 22,726,982 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111361   ⟹   ENSRNOP00000088013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,676,386 - 19,686,960 (-)Ensembl
RefSeq Acc Id: NM_178101   ⟹   NP_835202
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,313,070 - 25,323,631 (-)NCBI
mRatBN7.21219,676,384 - 19,686,945 (-)NCBI
Rnor_6.01222,716,421 - 22,726,982 (-)NCBI
Rnor_5.01224,728,205 - 24,738,766 (-)NCBI
RGSC_v3.41220,856,527 - 20,867,088 (+)RGD
Celera1221,452,299 - 21,462,860 (-)RGD
Sequence:
RefSeq Acc Id: XM_063271149   ⟹   XP_063127219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,318,656 - 25,323,363 (-)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_835202 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127219 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40820 (Get FASTA)   NCBI Sequence Viewer  
  AAH85683 (Get FASTA)   NCBI Sequence Viewer  
  CAD23628 (Get FASTA)   NCBI Sequence Viewer  
  EDM13298 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001921
  ENSRNOP00000001921.3
GenBank Protein Q5U367 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_835202   ⟸   NM_178101
- Peptide Label: precursor
- UniProtKB: Q811A5 (UniProtKB/Swiss-Prot),   Q5U367 (UniProtKB/Swiss-Prot),   A6J056 (UniProtKB/TrEMBL),   A0A8I6A8W8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001921   ⟸   ENSRNOT00000001921
Ensembl Acc Id: ENSRNOP00000088013   ⟸   ENSRNOT00000111361
RefSeq Acc Id: XP_063127219   ⟸   XM_063271149
- Peptide Label: isoform X1
Fe2OG dioxygenase

Name Modeler Protein Id AA Range Protein Structure
AF-Q5U367-F1-model_v2 AlphaFold Q5U367 1-741 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698528
Promoter ID:EPDNEW_R9052
Type:initiation region
Name:Plod3_1
Description:procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9053  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,726,780 - 22,726,840EPDNEW
RGD ID:13698529
Promoter ID:EPDNEW_R9053
Type:initiation region
Name:Plod3_2
Description:procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9052  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,726,985 - 22,727,045EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-19674 BioCyc
Ensembl Genes ENSRNOG00000001417 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001921 ENTREZGENE
  ENSRNOT00000001921.5 UniProtKB/Swiss-Prot
Gene3D-CATH q2cbj1_9rhob like domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110561 IMAGE-MGC_LOAD
InterPro Collagen_mod_GT25 UniProtKB/Swiss-Prot
  IPNS-like_FE2OG_OXY UniProtKB/Swiss-Prot
  Nucleotide-diphossugar_trans UniProtKB/Swiss-Prot
  Oxoglu/Fe-dep_dioxygenase UniProtKB/Swiss-Prot
  Pro_4_hyd_alph UniProtKB/Swiss-Prot
  Procol_lys_dOase UniProtKB/Swiss-Prot
KEGG Report rno:288583 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93055 IMAGE-MGC_LOAD
NCBI Gene 288583 ENTREZGENE
PANTHER MULTIFUNCTIONAL PROCOLLAGEN LYSINE HYDROXYLASE AND GLYCOSYLTRANSFERASE LH3 UniProtKB/Swiss-Prot
  PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER UniProtKB/Swiss-Prot
Pfam 2OG-FeII_Oxy UniProtKB/Swiss-Prot
PhenoGen Plod3 PhenoGen
PROSITE FE2OG_OXY UniProtKB/Swiss-Prot
  LYS_HYDROXYLASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001417 RatGTEx
SMART P4Hc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53448 UniProtKB/Swiss-Prot
UniProt A0A8I6A8W8 ENTREZGENE, UniProtKB/TrEMBL
  A6J056 ENTREZGENE, UniProtKB/TrEMBL
  PLOD3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q811A5 ENTREZGENE
UniProt Secondary Q811A5 UniProtKB/Swiss-Prot
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Plod3  procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3      Symbol and Name status set to approved 625702 APPROVED

Note Type Note Reference
gene_expression ubiquitously expressed 633907