Scarb1 (scavenger receptor class B, member 1) - Rat Genome Database

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Gene: Scarb1 (scavenger receptor class B, member 1) Rattus norvegicus
Analyze
Symbol: Scarb1
Name: scavenger receptor class B, member 1
RGD ID: 2302
Description: Enables identical protein binding activity and phosphatidylserine binding activity. Involved in several processes, including androgen biosynthetic process; recognition of apoptotic cell; and response to vitamin B3. Located in cell surface and microvillus membrane. Biomarker of end stage renal disease. Orthologous to human SCARB1 (scavenger receptor class B member 1); PARTICIPATES IN retinol metabolic pathway; reverse cholesterol transport pathway; bile acid transport pathway; INTERACTS WITH (+)-schisandrin B; (+)-taxifolin; (E)-thiamethoxam.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1; CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; Cd36l1; scavanger receptor class B type 1; scavenger receptor class B member 1; scavenger receptor class B type I; SR-B1; SR-BI; Srb1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21231,296,143 - 31,362,649 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,296,156 - 31,362,647 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1232,468,363 - 32,534,776 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,079,673 - 33,146,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,131,509 - 32,197,925 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,694,952 - 36,761,445 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,694,960 - 36,761,455 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01238,572,152 - 38,638,465 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,390,183 - 32,457,661 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11232,253,570 - 32,321,047 (+)NCBI
Celera1232,988,597 - 33,054,666 (+)NCBICelera
Cytogenetic Map12q15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (EXP)
(1->4)-beta-D-glucan  (ISO)
(E)-thiamethoxam  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-methylimidazole  (EXP)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinyl palmitate  (EXP)
allethrin  (EXP)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
Aroclor 1254  (EXP)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP,ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bromocriptine  (EXP)
bucladesine  (EXP,ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP)
caffeine  (EXP)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chlordecone  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
cholic acid  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (ISO)
DDE  (EXP)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
Di-n-hexyl phthalate  (EXP)
diazinon  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dicyclohexyl phthalate  (EXP)
diethyl hydrogen phosphate  (EXP)
diethyl maleate  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
diheptyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
Dimethyl phthalate  (EXP)
diosgenin  (EXP)
dipentyl phthalate  (EXP)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ezetimibe  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fructose  (EXP)
genistein  (ISO)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
hexaconazole  (ISO)
high-density lipoprotein cholesterol  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
inulin  (ISO)
iron trichloride  (ISO)
ketoconazole  (EXP,ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
losartan  (ISO)
lovastatin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methyltestosterone  (ISO)
Mezerein  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (EXP,ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorododecanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
phencyclidine  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
PhIP  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propamocarb  (ISO)
propiconazole  (ISO)
pyrethrins  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
ritonavir  (ISO)
Ro 31-8220  (ISO)
rotenone  (EXP,ISO)
saccharin  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenomethionine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Sodium salicylate  (ISO)
sucrose  (EXP)
sulfadimethoxine  (ISO)
sulpiride  (EXP)
temozolomide  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP)
thiamethoxam  (EXP)
thioacetamide  (EXP)
tin(II) chloride (anhydrous)  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vecuronium bromide  (ISO)
vinclozolin  (EXP)
XAV939  (ISO)
zinc dichloride  (ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hormonal regulation of adrenal microvillar channel formation. Azhar S, etal., J Lipid Res. 2002 Jun;43(6):861-71.
2. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Harrison EH Biochim Biophys Acta. 2012 Jan;1821(1):70-7. Epub 2011 Jun 12.
5. Characterization and chromosomal localization of rat scavenger receptor class B type I, a high density lipoprotein receptor with a putative leucine zipper domain and peroxisomal targeting sequence. Johnson MS, etal., Endocrinology 1998 Jan;139(1):72-80.
6. Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular sertoli cells. Kawasaki Y, etal., J Biol Chem 2002 Jul 26;277(30):27559-66. Epub 2002 May 16.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Cloning, characterization, and cellular distribution of rat scavenger receptor class B type I (SRBI) in the ovary. Mizutani T, etal., Biochem Biophys Res Commun 1997 May 19;234(2):499-505.
9. Comparative effect of fish oil feeding and other dietary fatty acids on plasma lipoproteins, biliary lipids, and hepatic expression of proteins involved in reverse cholesterol transport in the rat. Morgado N, etal., Ann Nutr Metab. 2005 Nov-Dec;49(6):397-406. Epub 2005 Oct 14.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Reverse cholesterol transport and cholesterol efflux in atherosclerosis. Ohashi R, etal., QJM. 2005 Dec;98(12):845-56. Epub 2005 Oct 28.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Dimerization of the scavenger receptor class B type I: formation, function, and localization in diverse cells and tissues. Reaven E, etal., J Lipid Res. 2004 Mar;45(3):513-28. Epub 2003 Dec 1.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. The role of scavenger receptor class B type I (SR-BI) in lipid trafficking. defining the rules for lipid traders. Rhainds D and Brissette L, Int J Biochem Cell Biol. 2004 Jan;36(1):39-77.
19. Acute aflatoxin B1 - Induced hepatotoxicity alters gene expression and disrupts lipid and lipoprotein metabolism in rats. Rotimi OA, etal., Toxicol Rep. 2017 Jul 24;4:408-414. doi: 10.1016/j.toxrep.2017.07.006. eCollection 2017.
20. Role of class B scavenger receptor type I in phagocytosis of apoptotic rat spermatogenic cells by Sertoli cells. Shiratsuchi A, etal., J Biol Chem 1999 Feb 26;274(9):5901-8.
21. Lipoprotein enhancement of ovarian theca-interstitial cell steroidogenesis: relative contribution of scavenger receptor class B (type I) and adenosine 5'-triphosphate- binding cassette (type A1) transporter in high-density lipoprotein-cholesterol transport and androgen synthesis. Wu Q, etal., Endocrinology 2003 Jun;144(6):2437-45.
22. Identification and expression of scavenger receptor SR-BI in endothelial cells and smooth muscle cells of rat aorta in vitro and in vivo. Yeh YC, etal., Atherosclerosis 2002 Mar;161(1):95-103.
23. Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice. Zhang S, etal., Circulation. 2005 Jun 28;111(25):3457-64. Epub 2005 Jun 20.
Additional References at PubMed
PMID:8753864   PMID:9148942   PMID:9211901   PMID:9254056   PMID:10221589   PMID:10559220   PMID:10579331   PMID:10764676   PMID:10829064   PMID:11208913   PMID:11240025   PMID:11278646  
PMID:11792700   PMID:12202492   PMID:12477932   PMID:12493702   PMID:12562842   PMID:12651854   PMID:14652019   PMID:14694755   PMID:14718538   PMID:14729860   PMID:15140193   PMID:15206959  
PMID:15210842   PMID:15210959   PMID:15489334   PMID:16297529   PMID:16298471   PMID:16339487   PMID:16530182   PMID:16530456   PMID:16584836   PMID:17241464   PMID:17897319   PMID:17905649  
PMID:18079677   PMID:18175806   PMID:19041881   PMID:19087225   PMID:19122200   PMID:19136670   PMID:20458337   PMID:21481393   PMID:22767607   PMID:23197320   PMID:23482569   PMID:25701869  
PMID:25817199   PMID:26567857   PMID:26965621   PMID:27155079   PMID:27881715   PMID:27934803   PMID:28669731   PMID:31344978  


Genomics

Comparative Map Data
Scarb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21231,296,143 - 31,362,649 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,296,156 - 31,362,647 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1232,468,363 - 32,534,776 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,079,673 - 33,146,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,131,509 - 32,197,925 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,694,952 - 36,761,445 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,694,960 - 36,761,455 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01238,572,152 - 38,638,465 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,390,183 - 32,457,661 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11232,253,570 - 32,321,047 (+)NCBI
Celera1232,988,597 - 33,054,666 (+)NCBICelera
Cytogenetic Map12q15NCBI
SCARB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812124,776,856 - 124,863,864 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12124,776,856 - 124,882,668 (-)EnsemblGRCh38hg38GRCh38
GRCh3712125,261,402 - 125,348,410 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612123,828,127 - 123,914,472 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412123,787,055 - 123,873,214NCBI
Celera12124,862,283 - 124,949,187 (-)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12122,224,152 - 122,310,029 (-)NCBIHuRef
CHM1_112125,083,775 - 125,169,604 (-)NCBICHM1_1
T2T-CHM13v2.012124,782,134 - 124,869,001 (-)NCBIT2T-CHM13v2.0
Scarb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395125,354,151 - 125,418,082 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5125,354,151 - 125,418,158 (-)EnsemblGRCm39 Ensembl
GRCm385125,277,087 - 125,341,094 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5125,277,087 - 125,341,094 (-)EnsemblGRCm38mm10GRCm38
MGSCv375125,757,460 - 125,821,444 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365125,566,069 - 125,630,053 (-)NCBIMGSCv36mm8
Celera5122,296,944 - 122,361,197 (-)NCBICelera
Cytogenetic Map5G1.1NCBI
cM Map564.11NCBI
Scarb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554824,813,955 - 4,837,392 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554824,813,502 - 4,836,479 (+)NCBIChiLan1.0ChiLan1.0
SCARB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan112132,782,925 - 132,944,486 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012122,293,803 - 122,455,314 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112126,651,077 - 126,698,506 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12126,659,532 - 126,694,767 (-)Ensemblpanpan1.1panPan2
SCARB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1265,035,797 - 5,122,383 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl265,049,407 - 5,121,468 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,195,714 - 5,282,186 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0265,282,168 - 5,368,989 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,295,032 - 5,368,981 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,217,039 - 5,303,430 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0265,308,627 - 5,394,876 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0265,260,548 - 5,347,101 (+)NCBIUU_Cfam_GSD_1.0
Scarb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118158,927,028 - 158,948,613 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936558530,828 - 552,892 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936558530,828 - 555,098 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCARB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1428,301,294 - 28,393,568 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11428,301,421 - 28,393,568 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21430,050,898 - 30,093,735 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCARB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111120,134,485 - 120,223,512 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11120,134,874 - 120,216,904 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037125,058,937 - 125,145,319 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scarb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474723,973,648 - 24,010,820 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474723,970,782 - 24,010,683 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Scarb1
241 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir455rno-miR-455-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23045399
Mir125arno-miR-125a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23045399
Mir125arno-miR-125a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23045399

Predicted Target Of
Summary Value
Count of predictions:776
Count of miRNA genes:242
Interacting mature miRNAs:283
Transcripts:ENSRNOT00000001299, ENSRNOT00000001301, ENSRNOT00000064276
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)122423477731894213Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122860752637691617Rat

Markers in Region
RH130563  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21231,338,775 - 31,338,990 (+)MAPPERmRatBN7.2
Rnor_6.01236,737,576 - 36,737,790NCBIRnor6.0
Rnor_5.01238,614,596 - 38,614,810UniSTSRnor5.0
RGSC_v3.41232,433,792 - 32,434,006UniSTSRGSC3.4
Celera1233,030,797 - 33,031,011UniSTS
RH 3.4 Map12567.91UniSTS
Cytogenetic Map12q15-q16UniSTS
RH134480  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21231,362,360 - 31,362,548 (-)MAPPERmRatBN7.2
mRatBN7.21231,362,360 - 31,362,548 (+)MAPPERmRatBN7.2
mRatBN7.2333,061,973 - 33,062,160 (+)MAPPERmRatBN7.2
Rnor_6.0332,805,794 - 32,805,980NCBIRnor6.0
Rnor_6.01236,761,157 - 36,761,344NCBIRnor6.0
Rnor_5.01238,638,177 - 38,638,364UniSTSRnor5.0
Rnor_5.0337,970,526 - 37,970,712UniSTSRnor5.0
RGSC_v3.41232,457,373 - 32,457,560UniSTSRGSC3.4
RGSC_v3.4329,564,155 - 29,564,341UniSTSRGSC3.4
Celera331,275,513 - 31,275,699UniSTS
Celera1233,054,378 - 33,054,565UniSTS
RH 3.4 Map12549.3UniSTS
Cytogenetic Map12q15-q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1 2
Medium 3 26 56 41 19 41 2 3 74 25 39 11 2
Low 17 6 8 10 6
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000001299   ⟹   ENSRNOP00000001299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1231,296,251 - 31,362,647 (+)Ensembl
Rnor_6.0 Ensembl1236,695,052 - 36,761,443 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000001301   ⟹   ENSRNOP00000001301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1231,335,515 - 31,359,274 (+)Ensembl
Rnor_6.0 Ensembl1236,734,372 - 36,760,752 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000064276   ⟹   ENSRNOP00000060874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1231,296,251 - 31,362,647 (+)Ensembl
Rnor_6.0 Ensembl1236,694,960 - 36,761,455 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110392   ⟹   ENSRNOP00000085701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1231,296,156 - 31,359,274 (+)Ensembl
RefSeq Acc Id: NM_031541   ⟹   NP_113729
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21231,296,156 - 31,362,649 (+)NCBI
Rnor_6.01236,694,957 - 36,761,445 (+)NCBI
Rnor_5.01238,572,152 - 38,638,465 (+)NCBI
RGSC_v3.41232,390,183 - 32,457,661 (+)RGD
Celera1232,988,597 - 33,054,666 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598269   ⟹   XP_017453758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21231,296,167 - 31,362,649 (+)NCBI
Rnor_6.01236,694,952 - 36,761,445 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089099   ⟹   XP_038945027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21231,296,144 - 31,362,649 (+)NCBI
RefSeq Acc Id: XM_039089100   ⟹   XP_038945028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21231,296,143 - 31,362,649 (+)NCBI
RefSeq Acc Id: NP_113729   ⟸   NM_031541
- UniProtKB: P97943 (UniProtKB/Swiss-Prot),   A6J0X1 (UniProtKB/TrEMBL),   Q6SR89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453758   ⟸   XM_017598269
- Peptide Label: isoform X3
- UniProtKB: G3V636 (UniProtKB/TrEMBL),   A6J0X0 (UniProtKB/TrEMBL),   Q6B4I7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001299   ⟸   ENSRNOT00000001299
RefSeq Acc Id: ENSRNOP00000001301   ⟸   ENSRNOT00000001301
RefSeq Acc Id: ENSRNOP00000060874   ⟸   ENSRNOT00000064276
RefSeq Acc Id: XP_038945028   ⟸   XM_039089100
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038945027   ⟸   XM_039089099
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000085701   ⟸   ENSRNOT00000110392

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97943-F1-model_v2 AlphaFold P97943 1-509 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698602
Promoter ID:EPDNEW_R9127
Type:initiation region
Name:Scarb1_1
Description:scavenger receptor class B, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01236,695,033 - 36,695,093EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2302 AgrOrtholog
BioCyc Gene G2FUF-19380 BioCyc
Ensembl Genes ENSRNOG00000000981 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001299 ENTREZGENE
  ENSRNOT00000001299.8 UniProtKB/TrEMBL
  ENSRNOT00000001301.7 UniProtKB/TrEMBL
  ENSRNOT00000064276.4 UniProtKB/TrEMBL
  ENSRNOT00000110392 ENTREZGENE
  ENSRNOT00000110392.1 UniProtKB/TrEMBL
InterPro CD36/SCARB1/SNMP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CD36_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25073 ENTREZGENE
PANTHER PTHR11923 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCAVENGER RECEPTOR CLASS B MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CD36 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Scarb1 PhenoGen
PRINTS CD36ANTIGEN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CD36FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000981 RatGTEx
UniProt A0A8I6A220_RAT UniProtKB/TrEMBL
  A0A8L2QSW8_RAT UniProtKB/TrEMBL
  A6J0X0 ENTREZGENE, UniProtKB/TrEMBL
  A6J0X1 ENTREZGENE, UniProtKB/TrEMBL
  F8WFG6_RAT UniProtKB/TrEMBL
  G3V636 ENTREZGENE, UniProtKB/TrEMBL
  P97943 ENTREZGENE
  Q6B4I7 ENTREZGENE, UniProtKB/TrEMBL
  Q6SR89 ENTREZGENE, UniProtKB/TrEMBL
  SCRB1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Scarb1  scavenger receptor class B, member 1      Symbol and Name updated 629477 APPROVED
2003-03-17 Scarb1  scavenger receptor class B, member 1  Cd36l1  CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1  Symbol and Name updated to reflect Human and Mouse nomenclature 61478 PROVISIONAL
2001-06-12 Srb1  Scavanger receptor class B type 1      Symbol withdrawn, duplicate entry of Cd36l1 (RGD:2302) 62408 WITHDRAWN
2001-06-12 Cd36l1  CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1      Name updated 62408 APPROVED