Scarb1 (scavenger receptor class B, member 1)

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Gene: Scarb1 (scavenger receptor class B, member 1) Rattus norvegicus

Analyze

Symbol:

Scarb1

Name:

scavenger receptor class B, member 1

RGD ID:

2302

Description:

Enables identical protein binding activity and phosphatidylserine binding activity. Involved in several processes, including androgen biosynthetic process; recognition of apoptotic cell; and regulation of phagocytosis. Located in cell surface and microvillus membrane. Orthologous to human SCARB1 (scavenger receptor class B member 1); PARTICIPATES IN retinol metabolic pathway; reverse cholesterol transport pathway; bile acid transport pathway; INTERACTS WITH (+)-schisandrin B; (+)-taxifolin; (E)-thiamethoxam.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1; CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; Cd36l1; scavanger receptor class B type 1; scavenger receptor class B member 1; scavenger receptor class B type I; SR-B1; SR-BI; Srb1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SCARB1 (scavenger receptor class B member 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Scarb1 (scavenger receptor class B, member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Scarb1 (scavenger receptor class B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SCARB1 (scavenger receptor class B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SCARB1 (scavenger receptor class B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Scarb1 (scavenger receptor class B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SCARB1 (scavenger receptor class B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SCARB1 (scavenger receptor class B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Scarb1 (scavenger receptor class B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SCARB1 (scavenger receptor class B member 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Scarb1 (scavenger receptor class B, member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	scarb1 (scavenger receptor class B, member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scav-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10345	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	scav-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG3829	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG31741	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	CG40006	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG7227	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	crq	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	dsb	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	emp	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ninaD	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	santa-maria	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	pes	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	scav-4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	scav-5	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	scav-6	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG2736	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	scarb1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	12	31,296,143 - 31,362,649 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	31,296,156 - 31,362,647 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	32,468,363 - 32,534,776 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	12	33,079,673 - 33,146,089 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	12	32,131,509 - 32,197,925 (+)	NCBI	Rnor_WKY
Rnor_6.0	12	36,694,952 - 36,761,445 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	36,694,960 - 36,761,455 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	38,572,152 - 38,638,465 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	32,390,183 - 32,457,661 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	32,253,570 - 32,321,047 (+)	NCBI
Celera	12	32,988,597 - 33,054,666 (+)	NCBI		Celera
Cytogenetic Map	12	q15	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Mammary Neoplasms (ISO)

cannabis abuse (ISO)

carcinoma (ISO)

Cocaine-Related Disorders (ISO)

Coronary Disease (ISO)

Dyslipidemias (ISO)

end stage renal disease (ISO)

Experimental Mammary Neoplasms (ISO)

Follicular Cyst (ISO)

genetic disease (ISO)

hepatitis C (ISO)

Hypercholesterolemia (ISO)

non-alcoholic fatty liver disease (ISO)

phencyclidine abuse (ISO)

renal cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(+)-schisandrin B (EXP)

(+)-taxifolin (EXP)

(1->4)-beta-D-glucan (ISO)

(E)-thiamethoxam (EXP)

(S)-nicotine (EXP,ISO)

1,2-dichloroethane (ISO)

1-naphthyl isothiocyanate (ISO)

14-Deoxy-11,12-didehydroandrographolide (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-methoxyethanol (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

4-methylimidazole (EXP)

7,12-dimethyltetraphene (EXP)

8-Br-cAMP (ISO)

9-cis-retinoic acid (ISO)

acetylsalicylic acid (ISO)

aconitine (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

all-trans-retinyl palmitate (EXP)

allethrin (EXP)

aluminium oxide (ISO)

ammonium chloride (EXP)

androgen antagonist (EXP)

Aroclor 1254 (EXP)

arotinoid acid (ISO)

arsane (ISO)

arsenic atom (ISO)

atorvastatin calcium (ISO)

atrazine (EXP,ISO)

Bardoxolone methyl (ISO)

benzo[a]pyrene (ISO)

beta-carotene (ISO)

bifenthrin (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

Bisphenol B (EXP)

bromocriptine (EXP)

bucladesine (EXP,ISO)

buspirone (EXP)

Butylbenzyl phthalate (EXP)

caffeine (EXP)

carbon nanotube (ISO)

chenodeoxycholic acid (ISO)

CHIR 99021 (ISO)

chlordecone (ISO)

chloroquine (EXP,ISO)

cholesterol (ISO)

cholic acid (ISO)

choline (ISO)

cisplatin (ISO)

clofibrate (EXP,ISO)

clofibric acid (EXP)

cobalt dichloride (ISO)

cocaine (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cortisol (ISO)

coumestrol (ISO)

curcumin (ISO)

cyclosporin A (ISO)

cyhalothrin (EXP)

cypermethrin (EXP)

cyproconazole (ISO)

DDE (EXP)

DDT (EXP)

decabromodiphenyl ether (EXP)

deoxycholic acid (ISO)

dexamethasone (EXP,ISO)

Di-n-hexyl phthalate (EXP)

diazinon (ISO)

dibenziodolium (ISO)

dibutyl phthalate (EXP,ISO)

dicrotophos (ISO)

Dicyclohexyl phthalate (EXP)

diethyl maleate (ISO)

diethyl phthalate (EXP)

diheptyl phthalate (EXP)

diisobutyl phthalate (EXP)

Diisodecyl phthalate (EXP)

diisononyl phthalate (EXP)

Dimethyl phthalate (EXP)

diosgenin (EXP)

dipentyl phthalate (EXP)

disodium selenite (ISO)

diuron (EXP)

dorsomorphin (ISO)

Enterolactone (ISO)

entinostat (ISO)

epoxiconazole (ISO)

ethanol (EXP,ISO)

ezetimibe (ISO)

fenofibrate (ISO)

fenvalerate (EXP)

flavonoids (EXP)

folic acid (ISO)

fructose (EXP)

genistein (ISO)

glafenine (EXP)

glycochenodeoxycholic acid (ISO)

glycocholic acid (ISO)

glycodeoxycholic acid (ISO)

GW 3965 (ISO)

GW 4064 (ISO)

hexaconazole (ISO)

high-density lipoprotein cholesterol (ISO)

hydrogen peroxide (ISO)

inulin (ISO)

iron trichloride (ISO)

kojic acid (ISO)

L-ascorbic acid (ISO)

L-ascorbic acid 2-phosphate (ISO)

L-methionine (ISO)

lead diacetate (ISO)

lead(0) (ISO)

lead(2+) (ISO)

leflunomide (EXP)

lipopolysaccharide (EXP,ISO)

lithocholic acid (ISO)

losartan (ISO)

lovastatin (ISO)

mercury atom (ISO)

mercury(0) (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

methyltestosterone (ISO)

Mezerein (ISO)

mifepristone (ISO)

mono(2-ethylhexyl) phthalate (EXP,ISO)

monocrotophos (EXP)

monosodium L-glutamate (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-nitrosodiethylamine (EXP)

N-tosyl-L-phenylalanyl chloromethyl ketone (ISO)

nefazodone (ISO)

nickel atom (ISO)

nicotine (EXP,ISO)

nicotinic acid (EXP,ISO)

obeticholic acid (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

paraquat (EXP)

pentachlorophenol (ISO)

perfluorododecanoic acid (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

perfluoroundecanoic acid (EXP)

phencyclidine (ISO)

phenobarbital (ISO)

phenytoin (ISO)

PhIP (EXP)

pioglitazone (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

potassium dichromate (EXP)

pregnenolone 16alpha-carbonitrile (EXP)

progesterone (ISO)

propiconazole (ISO)

resveratrol (EXP,ISO)

rifampicin (ISO)

rimonabant (ISO)

ritonavir (ISO)

Ro 31-8220 (ISO)

rotenone (EXP,ISO)

saccharin (ISO)

SB 431542 (ISO)

Se-methyl-L-selenocysteine (ISO)

Se-methylselenocysteine (ISO)

selenomethionine (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

simvastatin (EXP,ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

Sodium salicylate (ISO)

sucrose (EXP)

sulfadimethoxine (ISO)

sulpiride (EXP)

temozolomide (ISO)

testosterone enanthate (EXP)

tetrachloromethane (EXP)

thiamethoxam (EXP)

thioacetamide (EXP)

tin(II) chloride (anhydrous) (ISO)

titanium dioxide (ISO)

topotecan (EXP)

tributylstannane (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

triphenylstannane (EXP)

triptonide (ISO)

troglitazone (ISO)

undecane (EXP)

valproic acid (ISO)

vecuronium bromide (ISO)

vinclozolin (EXP)

XAV939 (ISO)

zinc dichloride (ISO)

ziram (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

androgen biosynthetic process (IDA)

blood vessel endothelial cell migration (ISO)

carotenoid transport (ISO)

cholesterol catabolic process (ISO)

cholesterol efflux (IBA,ISO)

cholesterol homeostasis (ISO)

cholesterol import (IBA,ISO)

cholesterol transport (ISO)

detection of lipopolysaccharide (ISO)

endothelial cell proliferation (ISO)

high-density lipoprotein particle clearance (ISO,ISS)

high-density lipoprotein particle remodeling (ISO)

intestinal lipid absorption (ISO)

lipid transport (IEA,IMP)

lipopolysaccharide transport (ISO)

lipopolysaccharide-mediated signaling pathway (IEA)

low-density lipoprotein particle clearance (ISO)

phagocytosis, recognition (IMP)

phospholipid transport (ISO)

plasma lipoprotein particle clearance (IBA)

positive regulation of cholesterol storage (ISO,ISS)

positive regulation of nitric-oxide synthase activity (ISO)

positive regulation of triglyceride biosynthetic process (ISO)

recognition of apoptotic cell (IBA,IDA,ISO,ISS)

regulation of phagocytosis (IDA,TAS)

regulation of phosphatidylcholine catabolic process (ISO)

reverse cholesterol transport (ISO,ISS)

steroid biosynthetic process (TAS)

transcytosis (ISO)

triglyceride homeostasis (ISO)

vitamin transmembrane transport (ISO)

Cellular Component

apical plasma membrane (ISO)

basolateral plasma membrane (ISO)

caveola (IBA,ISO)

cell surface (IDA,ISO)

cytoplasm (IBA,ISO)

intracellular membrane-bounded organelle (ISO)

lysosome (ISO)

membrane (ISO)

microvillus membrane (IDA)

plasma membrane (IEA,ISO,ISS)

Molecular Function

amyloid-beta binding (ISO)

apolipoprotein A-I binding (ISO)

apolipoprotein binding (ISO)

high-density lipoprotein particle binding (ISO)

high-density lipoprotein particle receptor activity (ISO,ISS)

identical protein binding (IPI)

lipid binding (IBA)

lipid transporter activity (TAS)

lipopolysaccharide binding (ISO)

lipopolysaccharide immune receptor activity (ISO)

low-density lipoprotein particle binding (IBA,ISO,ISS)

phosphatidylserine binding (IDA,TAS)

protein binding (ISO)

scavenger receptor activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

bile acid transport pathway (IEA)

hepatitis C pathway (IEA)

phagocytosis pathway (IEA)

retinol metabolic pathway (ISO)

reverse cholesterol transport pathway (ISO,TAS)

References

References - curated

#	Reference Title	Reference Citation
1.	Hormonal regulation of adrenal microvillar channel formation.	Azhar S, etal., J Lipid Res. 2002 Jun;43(6):861-71.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids.	Harrison EH Biochim Biophys Acta. 2012 Jan;1821(1):70-7. Epub 2011 Jun 12.
4.	Characterization and chromosomal localization of rat scavenger receptor class B type I, a high density lipoprotein receptor with a putative leucine zipper domain and peroxisomal targeting sequence.	Johnson MS, etal., Endocrinology 1998 Jan;139(1):72-80.
5.	Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular sertoli cells.	Kawasaki Y, etal., J Biol Chem 2002 Jul 26;277(30):27559-66. Epub 2002 May 16.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Cloning, characterization, and cellular distribution of rat scavenger receptor class B type I (SRBI) in the ovary.	Mizutani T, etal., Biochem Biophys Res Commun 1997 May 19;234(2):499-505.
8.	Comparative effect of fish oil feeding and other dietary fatty acids on plasma lipoproteins, biliary lipids, and hepatic expression of proteins involved in reverse cholesterol transport in the rat.	Morgado N, etal., Ann Nutr Metab. 2005 Nov-Dec;49(6):397-406. Epub 2005 Oct 14.
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	Reverse cholesterol transport and cholesterol efflux in atherosclerosis.	Ohashi R, etal., QJM. 2005 Dec;98(12):845-56. Epub 2005 Oct 28.
11.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
12.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
13.	Dimerization of the scavenger receptor class B type I: formation, function, and localization in diverse cells and tissues.	Reaven E, etal., J Lipid Res. 2004 Mar;45(3):513-28. Epub 2003 Dec 1.
14.	GOA pipeline	RGD automated data pipeline
15.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
17.	The role of scavenger receptor class B type I (SR-BI) in lipid trafficking. defining the rules for lipid traders.	Rhainds D and Brissette L, Int J Biochem Cell Biol. 2004 Jan;36(1):39-77.
18.	Role of class B scavenger receptor type I in phagocytosis of apoptotic rat spermatogenic cells by Sertoli cells.	Shiratsuchi A, etal., J Biol Chem 1999 Feb 26;274(9):5901-8.
19.	Lipoprotein enhancement of ovarian theca-interstitial cell steroidogenesis: relative contribution of scavenger receptor class B (type I) and adenosine 5'-triphosphate- binding cassette (type A1) transporter in high-density lipoprotein-cholesterol transport and androgen synthesis.	Wu Q, etal., Endocrinology 2003 Jun;144(6):2437-45.
20.	Identification and expression of scavenger receptor SR-BI in endothelial cells and smooth muscle cells of rat aorta in vitro and in vivo.	Yeh YC, etal., Atherosclerosis 2002 Mar;161(1):95-103.
21.	Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice.	Zhang S, etal., Circulation. 2005 Jun 28;111(25):3457-64. Epub 2005 Jun 20.

Additional References at PubMed

PMID:8753864	PMID:9148942	PMID:9211901	PMID:9254056	PMID:10221589	PMID:10559220	PMID:10579331	PMID:10764676	PMID:10829064	PMID:11208913	PMID:11240025	PMID:11278646
PMID:11792700	PMID:12202492	PMID:12477932	PMID:12493702	PMID:12562842	PMID:12651854	PMID:14652019	PMID:14694755	PMID:14718538	PMID:14729860	PMID:15140193	PMID:15206959
PMID:15210842	PMID:15210959	PMID:15489334	PMID:16297529	PMID:16298471	PMID:16339487	PMID:16530182	PMID:16530456	PMID:16584836	PMID:17241464	PMID:17897319	PMID:17905649
PMID:18079677	PMID:18175806	PMID:19041881	PMID:19087225	PMID:19122200	PMID:19136670	PMID:19878707	PMID:20458337	PMID:21481393	PMID:22767607	PMID:23197320	PMID:23482569
PMID:25701869	PMID:25817199	PMID:26567857	PMID:26965621	PMID:27155079	PMID:27881715	PMID:27934803	PMID:28669731	PMID:31344978

Genomics

Comparative Map Data

Scarb1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	12	31,296,143 - 31,362,649 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	31,296,156 - 31,362,647 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	32,468,363 - 32,534,776 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	12	33,079,673 - 33,146,089 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	12	32,131,509 - 32,197,925 (+)	NCBI	Rnor_WKY
Rnor_6.0	12	36,694,952 - 36,761,445 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	36,694,960 - 36,761,455 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	38,572,152 - 38,638,465 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	32,390,183 - 32,457,661 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	32,253,570 - 32,321,047 (+)	NCBI
Celera	12	32,988,597 - 33,054,666 (+)	NCBI		Celera
Cytogenetic Map	12	q15	NCBI

SCARB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	124,776,856 - 124,863,864 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	12	124,776,856 - 124,882,668 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	125,261,402 - 125,348,410 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	123,828,127 - 123,914,472 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	123,787,055 - 123,873,214	NCBI
Celera	12	124,862,283 - 124,949,187 (-)	NCBI		Celera
Cytogenetic Map	12	q24.31	NCBI
HuRef	12	122,224,152 - 122,310,029 (-)	NCBI		HuRef
CHM1_1	12	125,083,775 - 125,169,604 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	124,782,134 - 124,869,001 (-)	NCBI		T2T-CHM13v2.0

Scarb1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	125,354,151 - 125,418,158 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	125,354,151 - 125,418,158 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	125,277,087 - 125,341,094 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	125,277,087 - 125,341,094 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	125,757,460 - 125,821,444 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	125,566,069 - 125,630,053 (-)	NCBI		MGSCv36	mm8
Celera	5	122,296,944 - 122,361,197 (-)	NCBI		Celera
Cytogenetic Map	5	G1.1	NCBI
cM Map	5	64.11	NCBI

Scarb1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	4,813,955 - 4,837,392 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955482	4,813,502 - 4,836,479 (+)	NCBI	ChiLan1.0	ChiLan1.0

SCARB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	12	132,782,925 - 132,944,486 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	122,293,803 - 122,455,314 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	126,651,077 - 126,698,506 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	126,659,532 - 126,694,767 (-)	Ensembl	panpan1.1		panPan2

SCARB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	5,035,797 - 5,122,383 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	5,049,407 - 5,121,468 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	5,195,714 - 5,282,186 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	5,282,168 - 5,368,989 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	5,295,032 - 5,368,981 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	5,217,039 - 5,303,430 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	5,308,627 - 5,394,876 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	5,260,548 - 5,347,101 (+)	NCBI		UU_Cfam_GSD_1.0

Scarb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	158,927,028 - 158,948,613 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936558	530,828 - 552,892 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936558	530,828 - 555,098 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SCARB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	28,301,294 - 28,393,568 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	28,301,421 - 28,393,568 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	30,050,898 - 30,093,735 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SCARB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	120,134,485 - 120,223,512 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	120,134,874 - 120,216,904 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	125,058,937 - 125,145,319 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Scarb1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	23,973,648 - 24,010,820 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	23,970,782 - 24,010,683 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Scarb1
241 total Variants

miRNA Target Status

Confirmed Target Of

miRNA Gene	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
Mir455	rno-miR-455-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	23045399
Mir125a	rno-miR-125a-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	23045399
Mir125a	rno-miR-125a-3p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	23045399

Predicted Target Of

	Summary Value
Count of predictions:	776
Count of miRNA genes:	242
Interacting mature miRNAs:	283
Transcripts:	ENSRNOT00000001299, ENSRNOT00000001301, ENSRNOT00000064276
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598855	Bp294	Blood pressure QTL 294	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	1	34851688	Rat
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
1300157	Rf21	Renal function QTL 21	4.4		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	12	9318216	32103380	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	10474137	46669029	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	10474137	46669029	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	45055165	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	12351619	46669029	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	12812385	46669029	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	12812385	46669029	Rat
1549902	Bp269	Blood pressure QTL 269			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	13182736	46669029	Rat
1549912	Bp268	Blood pressure QTL 268			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	13182736	46669029	Rat
2302060	Pia37	Pristane induced arthritis QTL 37	6.1	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	13198157	46669029	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	13635523	35682913	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	15550826	38478808	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	15872653	32974238	Rat
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	19144362	46669029	Rat
737822	Alc10	Alcohol consumption QTL 10	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	19610870	40218516	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610870	42828880	Rat
61324	Eae5	Experimental allergic encephalomyelitis QTL 5	14		nervous system integrity trait (VT:0010566)	percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)	12	19610870	46669029	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610889	35682913	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	19835789	38193007	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	20328819	46669029	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	24139202	36638073	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	24234777	31894213	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	28064433	40130419	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	28064433	45899022	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	28064433	46669029	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	28064557	40218380	Rat
631829	Alc6	Alcohol consumption QTL 6	4.7		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	28607526	37691617	Rat

Markers in Region

RH130563

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	31,338,775 - 31,338,990 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	36,737,576 - 36,737,790	NCBI	Rnor6.0
Rnor_5.0	12	38,614,596 - 38,614,810	UniSTS	Rnor5.0
RGSC_v3.4	12	32,433,792 - 32,434,006	UniSTS	RGSC3.4
Celera	12	33,030,797 - 33,031,011	UniSTS
RH 3.4 Map	12	567.91	UniSTS
Cytogenetic Map	12	q15-q16	UniSTS

RH134480

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	31,362,360 - 31,362,548 (-)	MAPPER	mRatBN7.2
mRatBN7.2	12	31,362,360 - 31,362,548 (+)	MAPPER	mRatBN7.2
mRatBN7.2	3	33,061,973 - 33,062,160 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	32,805,794 - 32,805,980	NCBI	Rnor6.0
Rnor_6.0	12	36,761,157 - 36,761,344	NCBI	Rnor6.0
Rnor_5.0	12	38,638,177 - 38,638,364	UniSTS	Rnor5.0
Rnor_5.0	3	37,970,526 - 37,970,712	UniSTS	Rnor5.0
RGSC_v3.4	12	32,457,373 - 32,457,560	UniSTS	RGSC3.4
RGSC_v3.4	3	29,564,155 - 29,564,341	UniSTS	RGSC3.4
Celera	3	31,275,513 - 31,275,699	UniSTS
Celera	12	33,054,378 - 33,054,565	UniSTS
RH 3.4 Map	12	549.3	UniSTS
Cytogenetic Map	12	q15-q16	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High			1								2
Medium	3	26	56	41	19	41	2	3	74	25	39	11	2
Low		17					6	8		10			6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598269	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089100	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB002151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC118429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF071495	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY451993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY682846	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY682847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC076504	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D89655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000228	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U76205	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000001299 ⟹ ENSRNOP00000001299

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	31,296,251 - 31,362,647 (+)	Ensembl
Rnor_6.0 Ensembl	12	36,695,052 - 36,761,443 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000001301 ⟹ ENSRNOP00000001301

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	31,335,515 - 31,359,274 (+)	Ensembl
Rnor_6.0 Ensembl	12	36,734,372 - 36,760,752 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000064276 ⟹ ENSRNOP00000060874

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	31,296,251 - 31,362,647 (+)	Ensembl
Rnor_6.0 Ensembl	12	36,694,960 - 36,761,455 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000110392 ⟹ ENSRNOP00000085701

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	31,296,156 - 31,359,274 (+)	Ensembl

RefSeq Acc Id:

NM_031541 ⟹ NP_113729

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	12	31,296,156 - 31,362,649 (+)	NCBI
Rnor_6.0	12	36,694,957 - 36,761,445 (+)	NCBI
Rnor_5.0	12	38,572,152 - 38,638,465 (+)	NCBI
RGSC_v3.4	12	32,390,183 - 32,457,661 (+)	RGD
Celera	12	32,988,597 - 33,054,666 (+)	RGD

Sequence:

show sequence

GGAATCCCGCGCCGAACACGGGGGCGGGCTGCCCGGGCCATGGCGCATAAAACCTCTGGCCACC
TGCAGGGCTACTGCTGCTCTGGCCACTGTCAGGCACACACCTTGCTGCTCGGTTTCTGTCATCT
CTGTGGCCTCCGTCGCCTCTGTCGCCGTCCCCTTCAGGTCCTGAGCCCAGCGACTCTCGGCCGC
GCACGCGGACATGGGCGTCAGCTCCAGGGCACGCTGGGTGGCCTTGGGGCTGGGCGTTCTAGGG
CTGCTGTGTGCTGCGCTCGGCGTTATCATGATTCTCATGGTGCCCTCGCTCATCAAGCAGCAGG
TGCTCAAGAATGTCCGCATAGACCCCAGCAGCCTGTCCTTTGGGATGTGGAAGGAGATCCCTGT
TCCCTTCTACTTGTCCGTCTACTTCTTCGAGGTGGTCAACCCCAGCGAGGTCCTAAATGGCCAG
AAGCCAGTAGTCCGGGAGCGCGGACCCTATGTCTACAGGGAGTTCAGACAAAAGGTTAACATCA
CCTTCAATGACAATGACACGGTGTCCTACATAGAGAACCGAAGCCTTCGTTTCCAGCCAGACAG
GTCCCAGGGCTCAGAGAGTGACTACATTGTACTGCCTAACATCCTGGTCCTGGGAGGGGCAGTG
ATGATGGAGGACAAGCCCACAAGCCTGAAGCTGCTAATGACCTTGGGGTTGGTCACCATGGGCC
AGCGGGCCTTTATGAACCGCACGGTTGGTGAGATCCTGTGGGGCTACGAAGATCCCTTTGTGAA
TTTCCTCAGCAAATATTTCCCAGACATGTTCCCCATCAAAGGCAAATTTGGCCTGTTCGTTGGG
ATGAACGACTCGAGTTCTGGCGTCTTCACCGTCTTCACAGGTGTCCAGAATTTCAGCAAGATCC
ATCTGGTGGATAAGTGGAACGGCCTCAGCGAGGTCAACTATTGGCATTCGGAACAGTGCAACAT
GATCAATGGTACTGCCGGGCAGATGTGGGCACCATTCATGACACCCGAATCCTCACTGGAATTC
TTCAGCCCAGAAGCCTGCAGATCTATGAAGCTCACCTACCAGGAATCAAGGGTGTTCGAAGGCA
TCCCCACTTATCGCTTCACGGCCCCCGATACTTTGTTTGCCAACGGGTCCGTCTACCCACCTAA
TGAAGGCTTCTGCCCGTGCCGCGAGTCCGGCATTCAGAATGTCAGCACCTGCAGGTTTGGTGCG
CCCCTGTTTCTCTCCCAGCCCCACTTCTACAATGCTGACCCCGTGCTGTCAGAAGCTGTTCTTG
GTCTGAACCCTGACCCAAAGGAGCATTCCTTGTTCCTAGACATCCACCCGGTCACTGGGATCCC
CATGAACTGTTCCGTGAAGATGCAGCTGAGTCTGTACATCAAATCCGTCAAGGGCGTCGGGCAA
ACAGGGAAGATCGAGCCAGTAGTCCTGCCATTGCTGTGGTTCGAACAGAGCGGGATGATGGGTG
GCAAGACCCTGAACACGTTCTACACGCAGCTGGTGCTGATGCCCCAGGTTCTTCACTACGCGCA
GTATGTGCTGCTGGGGCTTGGAGGCCTCCTGCTTCTGGTGCCCATCATTTACCAACTGCGCAGC
CAGGAGAAATGCTTTTTATTTTGGAGTGGTAGTAAAAAGGGCTCGCAGGATAAGGAGGCCATGC
AGGCCTACTCTGAGTCTCTGATGTCACCAGCTGCCAAGGGCACGGTACTGCAAGAAGCCAAGCT
GTAGGGCCCAGAAGACACCACGAGCCCCCCAAACCTGATAGCTTGGTCAGACCAGCCGCCCAGT
CCCTACACCCCACTTCTCGAGGACTCTCTCAGCGGACAACCCGCCAGTGCCACGTCCTGAGCCC
CCAGATGTCACACTGTCCACACGGCACATAGTGTGCGGAAACACTCAGGGACCAGGGACAGACC
CGCTGCTGAGTAGAGCCTGTTGGGCCACAGGCGACCTCTTCTAAGTGACCTGTGAGCCAGGCTG
TGGGAACTGTAGCTGCCCCTCCTGTAGGAGCTGGCGCCGCCGGGGCTCCTGACTTTCTCCGTCT
TTCTCCAGCAGGCTGAAAGCCTTAGTTCCCACAGAGGACACAGATCTGTCACTCCTAGGGGCTG
GGCAAACATCGGCCTCTTGCGTCACGGCTGGACAAGCAGTTCCAGATCCTGACCAGTCTGCACA
CACACTCTGGCGCTGTATCTGGCCCTTCTCCTACAGTCTCTGCTGTCACCTGAACACTGAATTG
GCCACTGTAAGTGGCAGCGGTGGCAGGCCCCCTCAGGGTCCTTATTTTTCAGGCGTGGGGTCAA
AGAGAGAGGTGTGGGCCGTCTACCCCTGGCACCTAGTATATCTCACCAGAGGGTAGGGTATACA
GAGGCCCAGCGTCCCACAATCGACCCCTTTTTTTTCTACTGGAAGAGAAATTTTATCGTCTTTT
GAAAGAAAGTCATGACTGAAGCAATAAACCTTTTCACAAATTCAAAAAAAAAAAAAAAAAAAAA
A

hide sequence

RefSeq Acc Id:

XM_017598269 ⟹ XP_017453758

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	12	31,296,167 - 31,362,649 (+)	NCBI
Rnor_6.0	12	36,694,952 - 36,761,445 (+)	NCBI

Sequence:

show sequence

TAGCCGGAATCCCGCGCCGAACACGGGGGCGGGCTGCCCGGGCCATGGCGCATAAAACCTCTGG
CCACCTGCAGGGCTACTGCTGCTCTGGCCACTGTCAGGCACACACCTTGCTGCTCGGTTTCTGT
CATCTCTGTGGCCTCCGTCGCCTCTGTCGCCGTCCCCTTCAGGTCCTGAGCCCAGCGACTCTCG
GCCGCGCACGCGGACATGGGCGTCAGCTCCAGGGCACGCTGGGTGGCCTTGGGGCTGGGCGTTC
TAGGGCTGCTGTGTGCTGCGCTCGGCGTTATCATGATTCTCATGGTGCCCTCGCTCATCAAGCA
GCAGGTGCTCAAGAATGTCCGCATAGACCCCAGCAGCCTGTCCTTTGGGATGTGGAAGGAGATC
CCTGTTCCCTTCTACTTGTCCGTCTACTTCTTCGAGGTGGTCAACCCCAGCGAGGTCCTAAATG
GCCAGAAGCCAGTAGTCCGGGAGCGCGGACCCTATGTCTACAGGGAGTTCAGACAAAAGGTTAA
CATCACCTTCAATGACAATGACACGGTGTCCTACATAGAGAACCGAAGCCTTCGTTTCCAGCCA
GACAGGTCCCAGGGCTCAGAGAGTGACTACATTGTACTGCCTAACATCCTGGTCCTGGGAGGGG
CAGTGATGATGGAGGACAAGCCCACAAGCCTGAAGCTGCTAATGACCTTGGGGTTGGTCACCAT
GGGCCAGCGGGCCTTTATGAACCGCACGGTTGGTGAGATCCTGTGGGGCTACGAAGATCCCTTT
GTGAATTTCCTCAGCAAATATTTCCCAGACATGTTCCCCATCAAAGGCAAATTTGGCCTGTTCG
TTGGGATGAACGACTCGAGTTCTGGCGTCTTCACCGTCTTCACAGGTGTCCAGAATTTCAGCAA
GATCCATCTGGTGGATAAGTGGAACGGCCTCAGCGAGGTCAACTATTGGCATTCGGAACAGTGC
AACATGATCAATGGTACTGCCGGGCAGATGTGGGCACCATTCATGACACCCGAATCCTCACTGG
AATTCTTCAGCCCAGAAGCCTGCAGATCTATGAAGCTCACCTACCAGGAATCAAGGGTGTTCGA
AGGCATCCCCACTTATCGCTTCACGGCCCCCGATACTTTGTTTGCCAACGGGTCCGTCTACCCA
CCTAATGAAGGCTTCTGCCCGTGCCGCGAGTCCGGCATTCAGAATGTCAGCACCTGCAGGTTTG
GTGCGCCCCTGTTTCTCTCCCAGCCCCACTTCTACAATGCTGACCCCGTGCTGTCAGAAGCTGT
TCTTGGTCTGAACCCTGACCCAAAGGAGCATTCCTTGTTCCTAGACATCCACCCGGTCACTGGG
ATCCCCATGAACTGTTCCGTGAAGATGCAGCTGAGTCTGTACATCAAATCCGTCAAGGGCGTCG
GGCAAACAGGGAAGATCGAGCCAGTAGTCCTGCCATTGCTGTGGTTCGAACAGAGCGGGATGAT
GGGTGGCAAGACCCTGAACACGTTCTACACGCAGCTGGTGCTGATGCCCCAGGTTCTTCACTAC
GCGCAGTATGTGCTGCTGGGGCTTGGAGGCCTCCTGCTTCTGGTGCCCATCATTTACCAACTGC
GCAGCCAGGGCCCAGAAGACACCACGAGCCCCCCAAACCTGATAGCTTGGTCAGACCAGCCGCC
CAGTCCCTACACCCCACTTCTCGAGGACTCTCTCAGCGGACAACCCGCCAGTGCCACGTCCTGA
GCCCCCAGATGTCACACTGTCCACACGGCACATAGTGTGCGGAAACACTCAGGGACCAGGGACA
GACCCGCTGCTGAGTAGAGCCTGTTGGGCCACAGGCGACCTCTTCTAAGTGACCTGTGAGCCAG
GCTGTGGGAACTGTAGCTGCCCCTCCTGTAGGAGCTGGCGCCGCCGGGGCTCCTGACTTTCTCC
GTCTTTCTCCAGCAGGCTGAAAGCCTTAGTTCCCACAGAGGACACAGATCTGTCACTCCTAGGG
GCTGGGCAAACATCGGCCTCTTGCGTCACGGCTGGACAAGCAGTTCCAGATCCTGACCAGTCTG
CACACACACTCTGGCGCTGTATCTGGCCCTTCTCCTACAGTCTCTGCTGTCACCTGAACACTGA
ATTGGCCACTGTAAGTGGCAGCGGTGGCAGGCCCCCTCAGGGTCCTTATTTTTCAGGCGTGGGG
TCAAAGAGAGAGGTGTGGGCCGTCTACCCCTGGCACCTAGTATATCTCACCAGAGGGTAGGGTA
TACAGAGGCCCAGCGTCCCACAATCGACCCCTTTTTTTCTACTGGAAGAGAAATTTTATCGTCT
TTTGAAAGAAAGTCATGACTGAAGCAATAAACCTTTTCACAAATTCAA

hide sequence

RefSeq Acc Id:

XM_039089099 ⟹ XP_038945027

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	12	31,296,144 - 31,362,649 (+)	NCBI

RefSeq Acc Id:

XM_039089100 ⟹ XP_038945028

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	12	31,296,143 - 31,362,649 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_113729	(Get FASTA)	NCBI Sequence Viewer
	XP_017453758	(Get FASTA)	NCBI Sequence Viewer
	XP_038945027	(Get FASTA)	NCBI Sequence Viewer
	XP_038945028	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB19203	(Get FASTA)	NCBI Sequence Viewer
	AAC23892	(Get FASTA)	NCBI Sequence Viewer
	AAH76504	(Get FASTA)	NCBI Sequence Viewer
	AAR18387	(Get FASTA)	NCBI Sequence Viewer
	AAT85566	(Get FASTA)	NCBI Sequence Viewer
	AAT85567	(Get FASTA)	NCBI Sequence Viewer
	BAA14004	(Get FASTA)	NCBI Sequence Viewer
	BAA74541	(Get FASTA)	NCBI Sequence Viewer
	EDM13559	(Get FASTA)	NCBI Sequence Viewer
	EDM13560	(Get FASTA)	NCBI Sequence Viewer
	P97943	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_113729 ⟸ NM_031541

- UniProtKB:

P97943 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MGVSSRARWVALGLGVLGLLCAALGVIMILMVPSLIKQQVLKNVRIDPSSLSFGMWKEIPVPFY
LSVYFFEVVNPSEVLNGQKPVVRERGPYVYREFRQKVNITFNDNDTVSYIENRSLRFQPDRSQG
SESDYIVLPNILVLGGAVMMEDKPTSLKLLMTLGLVTMGQRAFMNRTVGEILWGYEDPFVNFLS
KYFPDMFPIKGKFGLFVGMNDSSSGVFTVFTGVQNFSKIHLVDKWNGLSEVNYWHSEQCNMING
TAGQMWAPFMTPESSLEFFSPEACRSMKLTYQESRVFEGIPTYRFTAPDTLFANGSVYPPNEGF
CPCRESGIQNVSTCRFGAPLFLSQPHFYNADPVLSEAVLGLNPDPKEHSLFLDIHPVTGIPMNC
SVKMQLSLYIKSVKGVGQTGKIEPVVLPLLWFEQSGMMGGKTLNTFYTQLVLMPQVLHYAQYVL
LGLGGLLLLVPIIYQLRSQEKCFLFWSGSKKGSQDKEAMQAYSESLMSPAAKGTVLQEAKL

hide sequence

RefSeq Acc Id:	XP_017453758 ⟸ XM_017598269
- Peptide Label:	isoform X3
- UniProtKB:	G3V636 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGVSSRARWVALGLGVLGLLCAALGVIMILMVPSLIKQQVLKNVRIDPSSLSFGMWKEIPVPFY LSVYFFEVVNPSEVLNGQKPVVRERGPYVYREFRQKVNITFNDNDTVSYIENRSLRFQPDRSQG SESDYIVLPNILVLGGAVMMEDKPTSLKLLMTLGLVTMGQRAFMNRTVGEILWGYEDPFVNFLS KYFPDMFPIKGKFGLFVGMNDSSSGVFTVFTGVQNFSKIHLVDKWNGLSEVNYWHSEQCNMING TAGQMWAPFMTPESSLEFFSPEACRSMKLTYQESRVFEGIPTYRFTAPDTLFANGSVYPPNEGF CPCRESGIQNVSTCRFGAPLFLSQPHFYNADPVLSEAVLGLNPDPKEHSLFLDIHPVTGIPMNC SVKMQLSLYIKSVKGVGQTGKIEPVVLPLLWFEQSGMMGGKTLNTFYTQLVLMPQVLHYAQYVL LGLGGLLLLVPIIYQLRSQGPEDTTSPPNLIAWSDQPPSPYTPLLEDSLSGQPASATS hide sequence

RefSeq Acc Id:

ENSRNOP00000001299 ⟸ ENSRNOT00000001299

RefSeq Acc Id:

ENSRNOP00000001301 ⟸ ENSRNOT00000001301

RefSeq Acc Id:

ENSRNOP00000060874 ⟸ ENSRNOT00000064276

RefSeq Acc Id:	XP_038945028 ⟸ XM_039089100
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038945027 ⟸ XM_039089099
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000085701 ⟸ ENSRNOT00000110392

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P97943-F1-model_v2	AlphaFold	P97943	1-509	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698602

Promoter ID:

EPDNEW_R9127

Type:

initiation region

Name:

Scarb1_1

Description:

scavenger receptor class B, member 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	36,695,033 - 36,695,093	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2302	AgrOrtholog
BioCyc Gene	G2FUF-19380	BioCyc
Ensembl Genes	ENSRNOG00000000981	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000001299	ENTREZGENE
	ENSRNOP00000001299.4	UniProtKB/TrEMBL
	ENSRNOP00000001301.6	UniProtKB/TrEMBL
	ENSRNOP00000060874.2	UniProtKB/TrEMBL
	ENSRNOP00000085701	ENTREZGENE
	ENSRNOP00000085701.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001299	ENTREZGENE
	ENSRNOT00000001299.8	UniProtKB/TrEMBL
	ENSRNOT00000001301.7	UniProtKB/TrEMBL
	ENSRNOT00000064276.4	UniProtKB/TrEMBL
	ENSRNOT00000110392	ENTREZGENE
	ENSRNOT00000110392.1	UniProtKB/TrEMBL
InterPro	CD36/SCARB1/SNMP1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CD36_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25073	UniProtKB/Swiss-Prot
NCBI Gene	25073	ENTREZGENE
PANTHER	PTHR11923	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SCAVENGER RECEPTOR CLASS B MEMBER 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	CD36	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Scarb1	PhenoGen
PRINTS	CD36ANTIGEN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CD36FAMILY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A220_RAT	UniProtKB/TrEMBL
	A0A8L2QSW8_RAT	UniProtKB/TrEMBL
	F8WFG6_RAT	UniProtKB/TrEMBL
	G3V636	ENTREZGENE, UniProtKB/TrEMBL
	P97943	ENTREZGENE
	Q6SR89_RAT	UniProtKB/TrEMBL
	SCRB1_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2003-04-09	Scarb1	scavenger receptor class B, member 1			Symbol and Name updated	629477	APPROVED
2003-03-17	Scarb1	scavenger receptor class B, member 1	Cd36l1	CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1	Symbol and Name updated to reflect Human and Mouse nomenclature	61478	PROVISIONAL
2001-06-12	Srb1	Scavanger receptor class B type 1			Symbol withdrawn, duplicate entry of Cd36l1 (RGD:2302)	62408	WITHDRAWN
2001-06-12	Cd36l1	CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1			Name updated	62408	APPROVED

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Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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RGD Manual Annotations

Imported Annotations - KEGG (archival)