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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2302
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scarb1
Name: scavenger receptor class B, member 1
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scarb1affects expressionISOSCARB1 (Homo sapiens)6480464CTDAspirin affects the expression of SCARB1 mRNAPMID:16816107
Scarb1affects expressionISOScarb1 (Mus musculus)6480464CTDAspirin affects the expression of SCARB1 proteinPMID:16816107
Scarb1decreases expressionISOSCARB1 (Homo sapiens)6480464CTDAspirin results in decreased expression of SCARB1 mRNAPMID:15037193
Scarb1increases expressionISOSCARB1 (Homo sapiens)6480464CTDAspirin results in increased expression of SCARB1 mRNA; Aspirin results in increased expression of SCARB1 proteinPMID:20137092
Scarb1multiple interactionsISOSCARB1 (Homo sapiens)6480464CTD[Aspirin co-treated with Fenofibrate] results in increased expression of SCARB1 protein; Aspirin inhibits the reaction [Niacin results in increased expression of SCARB1 mRNA]; Aspirin results in decreased expression of and results in decreased activity of SCARB1 protein; Aspirin results in increased expression of and results in increased activity of SCARB1 proteinPMID:15037193 PMID:16816107
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