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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2302
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scarb1
Name: scavenger receptor class B, member 1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scarb1increases abundanceISOScarb1 (Mus musculus)6480464CTDSCARB1 protein results in increased abundance of ProgesteronePMID:20404351
Scarb1increases expressionISOScarb1 (Mus musculus)6480464CTDProgesterone results in increased expression of SCARB1 mRNAPMID:19000923
Scarb1multiple interactionsISOScarb1 (Mus musculus)6480464CTD[Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]PMID:20404351
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