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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2302
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scarb1
Name: scavenger receptor class B, member 1
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scarb1decreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of SCARB1 mRNA; Diethylhexyl Phthalate results in decreased expression of SCARB1 proteinPMID:16690193 PMID:26472102 PMID:29325824 PMID:33983380 PMID:34438493 PMID:36198370
Scarb1multiple interactionsEXP 6480464CTDtaxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SCARB1 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SCARB1 protein]PMID:36198370
Scarb1decreases expressionISOScarb1 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of SCARB1 mRNAPMID:19245819
Scarb1increases expressionISOScarb1 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of SCARB1 mRNAPMID:19000923
Scarb1multiple interactionsISOSCARB1 (Homo sapiens)6480464CTD[Diethylhexyl Phthalate results in increased abundance of 2-ethyl-5-carboxypentyl phthalate] which results in increased expression of SCARB1 mRNAPMID:34438493
Scarb1multiple interactionsISOScarb1 (Mus musculus)6480464CTD[Diethylhexyl Phthalate affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of SCARB1 mRNAPMID:29718165
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