Eln (elastin) - Rat Genome Database

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Gene: Eln (elastin) Rattus norvegicus
Analyze
Symbol: Eln
Name: elastin
RGD ID: 67394
Description: Enables extracellular matrix constituent conferring elasticity. Involved in several processes, including cellular response to L-ascorbic acid; cellular response to growth factor stimulus; and cellular response to lipid. Located in extracellular matrix and extracellular space. Used to study abdominal aortic aneurysm. Biomarker of autosomal recessive polycystic kidney disease; bladder neck obstruction; congenital diaphragmatic hernia; liver cirrhosis; and silicosis. Human ortholog(s) of this gene implicated in several diseases, including Williams-Beuren syndrome; aortic disease (multiple); autoimmune disease (multiple); cutis laxa (multiple); and retinal disease (multiple). Orthologous to human ELN (elastin); INTERACTS WITH 1,2-dimethylhydrazine; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: RATTREL11; TREL11; TRELA; Trela26; Tropoelastin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21221,968,544 - 22,011,929 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1221,968,544 - 22,011,928 (+)Ensembl
Rnor_6.01224,978,478 - 25,021,864 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,978,483 - 25,021,863 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,978,748 - 27,022,485 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,033,657 - 23,077,043 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11222,892,500 - 22,934,907 (+)NCBI
Celera1223,732,827 - 23,776,213 (+)NCBICelera
RH 3.4 Map12345.7RGD
RH 3.4 Map12344.2RGD
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IDA,ISO)
Anetoderma  (ISO)
aortic aneurysm  (ISO)
aortic valve disease  (ISS)
aortic valve stenosis  (ISO)
atrioventricular septal defect  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
autosomal dominant cutis laxa  (ISO)
autosomal dominant cutis laxa 1  (ISO)
autosomal recessive polycystic kidney disease  (IEP)
bladder neck obstruction  (IEP)
Buschke-Ollendorff syndrome  (ISO)
chronic obstructive pulmonary disease  (ISO)
congenital diaphragmatic hernia  (IEP)
cutis laxa  (ISO)
dermatitis herpetiformis  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
essential hypertension  (ISS)
exfoliation syndrome  (ISO)
Experimental Diabetes Mellitus  (IEP)
facioscapulohumeral muscular dystrophy  (ISO)
genetic disease  (ISO)
Hypertelorism  (ISO)
hypertension  (ISO)
intestinal volvulus  (ISO)
intracranial aneurysm  (ISO)
Kawasaki disease  (ISO)
Kuhnt-Junius degeneration  (ISO)
Lichen Sclerosus et Atrophicus  (ISO)
liver cirrhosis  (IEP)
macular degeneration  (ISO)
melanoma  (ISO)
Myocardial Ischemia  (ISO)
Neurodevelopmental Disorders  (ISO)
photosensitivity disease  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
polyarteritis nodosa  (ISO)
polymyositis  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
primary open angle glaucoma  (ISO)
pseudoxanthoma elasticum  (ISO)
psoriasis  (ISO)
pterygium  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
silicosis  (IEP)
Sunburn  (ISO)
Supravalvar Aortic Stenosis, Eisenberg Type  (ISO)
supravalvular aortic stenosis  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
thoracic aortic aneurysm  (ISO)
thromboangiitis obliterans  (ISO)
Urinary Incontinence, Stress  (IEP)
varicose veins  (ISO)
Volvulus Of Midgut  (ISO)
Williams-Beuren syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP,ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (EXP,ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
beta-aminopropionitrile  (EXP)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
C60 fullerene  (EXP)
calcitriol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroprene  (EXP)
choline  (ISO)
clothianidin  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
cycloheximide  (EXP)
D-penicillamine  (ISO)
dexamethasone  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
enilconazole  (EXP)
fenamidone  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
furan  (EXP)
griseofulvin  (ISO)
hydralazine  (EXP)
hydrogen sulfide  (ISO)
isoprenaline  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
losartan  (EXP)
mifepristone  (EXP)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
okadaic acid  (EXP)
ozone  (EXP)
palbociclib  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
radicicol  (ISO)
rotenone  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
tetrachloromethane  (EXP)
tetrathiomolybdate(2-)  (EXP)
thiacloprid  (EXP)
titanium dioxide  (EXP,ISO)
Trapidil  (EXP)
tremolite asbestos  (ISO)
triclosan  (ISO)
triptonide  (ISO)
Y-27632  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

References

References - curated
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6. Berk JL, etal., Am J Physiol. 1996 Dec;271(6 Pt 1):L939-48.
7. Bernstein EF, etal., J Invest Dermatol. 1994 Aug;103(2):182-6.
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14. DiCamillo SJ, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L232-43. Epub 2006 Feb 10.
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16. Ewart AK, etal., J Clin Invest. 1994 Mar;93(3):1071-7.
17. Farrell AM, etal., J Eur Acad Dermatol Venereol. 2001 May;15(3):212-7.
18. Feinmesser M, etal., Am J Dermatopathol. 2002 Apr;24(2):108-17.
19. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Gillot JM, etal., J Rheumatol. 1997 Apr;24(4):677-82.
21. Giro MG, etal., J Invest Dermatol. 1992 Aug;99(2):129-37.
22. GOA data from the GO Consortium
23. Gray MA, etal., Urology. 2008 Jun;71(6):1214-9. doi: 10.1016/j.urology.2007.11.054. Epub 2008 Feb 15.
24. Guarino N, etal., J Pediatr Surg. 2002 Sep;37(9):1253-7.
25. Hadj-Rabia S, etal., Orphanet J Rare Dis. 2013 Feb 25;8:36. doi: 10.1186/1750-1172-8-36.
26. Hernandez MR Invest Ophthalmol Vis Sci. 1992 Sep;33(10):2891-903.
27. Hong YJ, etal., J Korean Med Sci. 2012 May;27(5):484-8. doi: 10.3346/jkms.2012.27.5.484. Epub 2012 Apr 25.
28. Kamino H, etal., J Cutan Pathol. 2009 Aug;36(8):845-52. doi: 10.1111/j.1600-0560.2008.01170.x. Epub 2008 Nov 19.
29. Kelleher CM, etal., Am J Respir Cell Mol Biol. 2005 Oct;33(4):355-62. Epub 2005 Aug 4.
30. Kondo N, etal., Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1101-5. doi: 10.1167/iovs.07-1145.
31. Kostrominova TY and Brooks SV, Age (Dordr). 2013 Dec;35(6):2203-14. doi: 10.1007/s11357-013-9514-2. Epub 2013 Jan 27.
32. Kothapalli CR and Ramamurthi A, Tissue Eng Part A. 2009 Jan;15(1):103-13. doi: 10.1089/ten.tea.2007.0390.
33. Kotzot D, etal., Eur J Pediatr. 1995 Jun;154(6):477-82.
34. Krex D, etal., Cerebrovasc Dis. 2004;18(2):104-10. Epub 2004 Jun 22.
35. Kuang PP and Goldstein RH, Am J Physiol Cell Physiol. 2005 Sep;289(3):C766-73. Epub 2005 Apr 6.
36. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
37. Lemack GE, etal., Neurourol Urodyn 1999;18(1):55-68.
38. Lima LH, etal., Ophthalmic Genet. 2011 Jun;32(2):80-2. doi: 10.3109/13816810.2010.544362. Epub 2011 Mar 10.
39. Lin G, etal., Cytotherapy. 2010;12(1):88-95. doi: 10.3109/14653240903350265.
40. Liu B, etal., Am J Physiol. 1993 Nov;265(5 Pt 1):L430-7.
41. Liu P, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2008 Aug;28(8):1354-7.
42. Mariani TJ, etal., Am J Pathol. 1995 Oct;147(4):988-1000.
43. McGowan SE, etal., Am J Respir Cell Mol Biol. 1997 Jul;17(1):25-35.
44. Metcalfe K, etal., Eur J Hum Genet. 2000 Dec;8(12):955-63.
45. MGD data from the GO Consortium
46. NCBI rat LocusLink and RefSeq merged data July 26, 2002
47. Netland PA, etal., Ophthalmology. 1995 Jun;102(6):878-86.
48. Ng K, etal., Am J Physiol Renal Physiol. 2011 Jun;300(6):F1431-6. doi: 10.1152/ajprenal.00079.2011. Epub 2011 Apr 6.
49. Nicoloff G, etal., Gen Pharmacol. 2000 Aug;35(2):83-7.
50. Noguchi A, etal., Pediatr Res. 1990 Oct;28(4):379-82.
51. Ogata T, etal., J Vasc Surg. 2005 Jun;41(6):1036-42.
52. Oikarinen AI, etal., J Am Acad Dermatol. 1984 Jul;11(1):64-72.
53. OMIM Disease Annotation Pipeline
54. Pellicoro A, etal., Hepatology. 2012 Jun;55(6):1965-75. doi: 10.1002/hep.25567. Epub 2012 Apr 18.
55. Pierce RA, etal., Biochemistry 1990 Oct 16;29(41):9677-83.
56. Pierce RA, etal., Genomics 1992 Apr;12(4):651-8.
57. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
58. RGD automated import pipeline for gene-chemical interactions
59. Rodriguez-Revenga L, etal., Arch Dermatol. 2004 Sep;140(9):1135-9.
60. Schroder A, etal., J Urol. 2013 Jun;189(6):2377-84. doi: 10.1016/j.juro.2012.12.110. Epub 2013 Jan 9.
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62. Sephel GC, etal., J Invest Dermatol. 1989 Jul;93(1):147-53.
63. Sivaprasad S, etal., Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3046-51.
64. Szabo Z, etal., J Med Genet. 2006 Mar;43(3):255-8. Epub 2005 Aug 5.
65. Tanaka K, etal., Mol Vis. 2011;17:2751-8. Epub 2011 Oct 22.
66. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
67. Urban Z, etal., J Invest Dermatol. 2005 Jun;124(6):1193-9.
68. Wang IJ, etal., Am J Pathol. 2000 Oct;157(4):1269-76.
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Additional References at PubMed
PMID:2768256   PMID:2913947   PMID:2971041   PMID:7534784   PMID:10424889   PMID:11889128   PMID:12477932   PMID:12679320   PMID:12882762   PMID:12890646   PMID:14614988   PMID:15489334  
PMID:15668357   PMID:16005428   PMID:17099216   PMID:18441095   PMID:18614015   PMID:18757743   PMID:20736890   PMID:21363967   PMID:21606336   PMID:21729992   PMID:21769453   PMID:22205540  
PMID:22435995   PMID:22718481   PMID:23648172   PMID:24440697   PMID:25218173   PMID:25970707   PMID:26075500   PMID:27559042   PMID:28257481   PMID:29242152   PMID:30720050   PMID:30914253  
PMID:32160810   PMID:32630068   PMID:32794252   PMID:33558588   PMID:33761588  


Genomics

Comparative Map Data
Eln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21221,968,544 - 22,011,929 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1221,968,544 - 22,011,928 (+)Ensembl
Rnor_6.01224,978,478 - 25,021,864 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,978,483 - 25,021,863 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,978,748 - 27,022,485 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,033,657 - 23,077,043 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11222,892,500 - 22,934,907 (+)NCBI
Celera1223,732,827 - 23,776,213 (+)NCBICelera
RH 3.4 Map12345.7RGD
RH 3.4 Map12344.2RGD
Cytogenetic Map12q12NCBI
ELN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl774,027,789 - 74,069,907 (+)EnsemblGRCh38hg38GRCh38
GRCh38774,027,772 - 74,069,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37773,442,503 - 73,484,237 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,080,363 - 73,122,173 (+)NCBINCBI36hg18NCBI36
Build 34772,887,168 - 72,927,681NCBI
Celera768,923,491 - 68,963,674 (+)NCBI
Cytogenetic Map7q11.23NCBI
HuRef769,326,571 - 69,367,012 (+)NCBIHuRef
CHM1_1773,587,503 - 73,629,630 (+)NCBICHM1_1
CRA_TCAGchr7v2772,775,191 - 72,817,309 (+)NCBI
Eln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,731,449 - 134,776,300 (-)NCBIGRCm39mm39
GRCm39 Ensembl5134,731,447 - 134,776,177 (-)Ensembl
GRCm385134,702,595 - 134,747,368 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,702,593 - 134,747,323 (-)EnsemblGRCm38mm10GRCm38
MGSCv375135,178,466 - 135,223,124 (-)NCBIGRCm37mm9NCBIm37
MGSCv365134,987,223 - 135,031,881 (-)NCBImm8
Celera5131,710,617 - 131,755,279 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.76NCBI
Eln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545613,788,992 - 13,818,836 (-)NCBIChiLan1.0ChiLan1.0
ELN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1781,177,699 - 81,218,306 (+)NCBIpanpan1.1PanPan1.1panPan2
ELN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,299,524 - 6,331,425 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,300,727 - 6,331,325 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha67,997,308 - 8,029,192 (-)NCBI
ROS_Cfam_1.066,114,552 - 6,146,504 (-)NCBI
UMICH_Zoey_3.166,104,697 - 6,136,585 (-)NCBI
UNSW_CanFamBas_1.066,052,537 - 6,084,439 (-)NCBI
UU_Cfam_GSD_1.066,216,223 - 6,248,126 (-)NCBI
Eln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344130,871,544 - 130,901,273 (-)NCBI
SpeTri2.0NW_0049365433,135,169 - 3,165,023 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ELN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl311,214,073 - 11,244,897 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1311,214,194 - 11,245,891 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,929,464 - 10,935,434 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ELN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,999,164 - 9,048,703 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660707,474,714 - 7,540,034 (+)NCBIVero_WHO_p1.0
Eln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474013,856,932 - 13,886,266 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D12Wox14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,003,428 - 22,003,586 (+)MAPPERmRatBN7.2
Rnor_6.01225,013,364 - 25,013,521NCBIRnor6.0
Rnor_5.01227,013,985 - 27,014,142UniSTSRnor5.0
RGSC_v3.41223,068,543 - 23,068,700UniSTSRGSC3.4
Celera1223,767,713 - 23,767,870UniSTS
Cytogenetic Map12q12UniSTS
D12Mgh12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,996,586 - 21,996,726 (+)MAPPERmRatBN7.2
Rnor_6.01225,006,522 - 25,006,661NCBIRnor6.0
Rnor_5.01227,007,143 - 27,007,282UniSTSRnor5.0
RGSC_v3.41223,061,700 - 23,061,840RGDRGSC3.4
RGSC_v3.41223,061,701 - 23,061,840UniSTSRGSC3.4
RGSC_v3.11222,920,521 - 22,920,661RGD
Celera1223,760,871 - 23,761,010UniSTS
RH 3.4 Map12344.2UniSTS
Cytogenetic Map12q12UniSTS
D12Mgh13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,003,411 - 22,003,550 (+)MAPPERmRatBN7.2
Rnor_6.01225,013,347 - 25,013,485NCBIRnor6.0
Rnor_5.01227,013,968 - 27,014,106UniSTSRnor5.0
RGSC_v3.41223,068,525 - 23,068,664RGDRGSC3.4
RGSC_v3.41223,068,526 - 23,068,664UniSTSRGSC3.4
RGSC_v3.11222,927,346 - 22,927,485RGD
Celera1223,767,696 - 23,767,834UniSTS
Cytogenetic Map12q12UniSTS
D8Arb9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,003,421 - 22,003,625 (+)MAPPERmRatBN7.2
Rnor_6.01225,013,357 - 25,013,560NCBIRnor6.0
Rnor_5.01227,013,978 - 27,014,181UniSTSRnor5.0
RGSC_v3.41223,068,535 - 23,068,739RGDRGSC3.4
RGSC_v3.41223,068,536 - 23,068,739UniSTSRGSC3.4
RGSC_v3.11222,927,356 - 22,927,560RGD
Celera1223,767,706 - 23,767,909UniSTS
Cytogenetic Map12q12UniSTS
D12Hmgc2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,996,720 - 21,996,983 (+)MAPPERmRatBN7.2
Rnor_6.01225,006,656 - 25,006,918NCBIRnor6.0
Rnor_5.01227,007,277 - 27,007,539UniSTSRnor5.0
RGSC_v3.41223,061,835 - 23,062,097UniSTSRGSC3.4
RGSC_v3.41223,061,379 - 23,063,057RGDRGSC3.4
Celera1223,761,005 - 23,761,267UniSTS
RH 3.4 Map12343.61UniSTS
RH 3.4 Map12343.61RGD
Cytogenetic Map12q12UniSTS
RH94685  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,011,328 - 22,011,545 (+)MAPPERmRatBN7.2
Rnor_6.01225,021,264 - 25,021,480NCBIRnor6.0
Rnor_5.01227,021,885 - 27,022,101UniSTSRnor5.0
RGSC_v3.41223,076,443 - 23,076,659UniSTSRGSC3.4
Celera1223,775,613 - 23,775,829UniSTS
Cytogenetic Map12q12UniSTS
BI274506  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,979,263 - 21,979,424 (+)MAPPERmRatBN7.2
Rnor_6.01224,989,198 - 24,989,358NCBIRnor6.0
Rnor_5.01226,989,468 - 26,989,628UniSTSRnor5.0
RGSC_v3.41223,044,377 - 23,044,537UniSTSRGSC3.4
Celera1223,743,547 - 23,743,707UniSTS
RH 3.4 Map12345.6UniSTS
Cytogenetic Map12q12UniSTS
Eln  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,986,223 - 21,986,921 (+)MAPPERmRatBN7.2
Rnor_6.01224,996,157 - 24,996,854NCBIRnor6.0
Rnor_5.01226,996,620 - 26,997,317UniSTSRnor5.0
RGSC_v3.41223,051,336 - 23,052,033UniSTSRGSC3.4
Celera1223,750,506 - 23,751,203UniSTS
Cytogenetic Map12q12UniSTS
Eln  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,010,235 - 22,011,026 (+)MAPPERmRatBN7.2
Rnor_6.01225,020,171 - 25,020,961NCBIRnor6.0
Rnor_5.01227,020,792 - 27,021,582UniSTSRnor5.0
Celera1223,774,520 - 23,775,310UniSTS
Cytogenetic Map12q12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)121961087024139202Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
631521Pia12Pristane induced arthritis QTL 128.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)122025941723672083Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:333
Count of miRNA genes:76
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000001995, ENSRNOT00000032780, ENSRNOT00000040069
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 10 1 2
Medium 2 27 22 14 11 14 4 7 41 27 34 9 4
Low 1 6 35 27 8 27 4 4 33 8 6 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000032780   ⟹   ENSRNOP00000030301
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,968,544 - 22,011,928 (+)Ensembl
Rnor_6.0 Ensembl1224,989,298 - 25,021,863 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000040069   ⟹   ENSRNOP00000045102
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,968,544 - 22,011,928 (+)Ensembl
Rnor_6.0 Ensembl1224,978,483 - 25,020,907 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109651   ⟹   ENSRNOP00000096516
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,968,544 - 22,011,928 (+)Ensembl
RefSeq Acc Id: NM_012722   ⟹   NP_036854
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21221,968,544 - 22,011,929 (+)NCBI
Rnor_6.01224,978,478 - 25,021,864 (+)NCBI
Rnor_5.01226,978,748 - 27,022,485 (+)NCBI
RGSC_v3.41223,033,657 - 23,077,043 (+)RGD
Celera1223,732,827 - 23,776,213 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036854   ⟸   NM_012722
- Peptide Label: precursor
- UniProtKB: Q99372 (UniProtKB/Swiss-Prot),   D4A9U4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000030301   ⟸   ENSRNOT00000032780
RefSeq Acc Id: ENSRNOP00000045102   ⟸   ENSRNOT00000040069
RefSeq Acc Id: ENSRNOP00000096516   ⟸   ENSRNOT00000109651

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698567
Promoter ID:EPDNEW_R9091
Type:multiple initiation site
Name:Eln_1
Description:elastin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01224,978,470 - 24,978,530EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:67394 AgrOrtholog
Ensembl Genes ENSRNOG00000001469 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000030301 UniProtKB/TrEMBL
  ENSRNOP00000045102 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032780 UniProtKB/TrEMBL
  ENSRNOT00000040069 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7097661 IMAGE-MGC_LOAD
InterPro Tropoelastin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25043 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94768 IMAGE-MGC_LOAD
NCBI Gene 25043 ENTREZGENE
PANTHER PTHR24018 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eln PhenoGen
TIGR TC204140
UniProt A0A0G2JST5_RAT UniProtKB/TrEMBL
  D4A9U4 ENTREZGENE, UniProtKB/TrEMBL
  ELN_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q5RKH4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Eln  elastin      Symbol and Name updated 629477 APPROVED
2003-03-12 Eln  elastin  Trela  Tropoelastin  Data Merged 628472 PROVISIONAL
2002-06-10 Eln        Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Trela  Tropoelastin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression overexpression modifies bladder elasticity and function in transgenic mice 731206