Eln (elastin) - Rat Genome Database

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Gene: Eln (elastin) Rattus norvegicus
Analyze
Symbol: Eln
Name: elastin
RGD ID: 67394
Description: Enables extracellular matrix constituent conferring elasticity. Involved in several processes, including cellular response to L-ascorbic acid; cellular response to copper ion; and cellular response to lipid. Located in extracellular space. Used to study abdominal aortic aneurysm. Biomarker of autosomal recessive polycystic kidney disease; bladder neck obstruction; congenital diaphragmatic hernia; liver cirrhosis; and silicosis. Human ortholog(s) of this gene implicated in several diseases, including Williams-Beuren syndrome; aortic disease (multiple); autoimmune disease (multiple); cutis laxa (multiple); and retinal disease (multiple). Orthologous to human ELN (elastin); INTERACTS WITH 1,2-dimethylhydrazine; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: RATTREL11; TREL11; TRELA; Trela26; Tropoelastin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,604,983 - 27,648,413 (+)NCBIGRCr8
mRatBN7.21221,968,544 - 22,011,929 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,968,544 - 22,011,928 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,109,255 - 23,152,934 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,721,589 - 23,765,283 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,789,694 - 22,833,151 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,978,478 - 25,021,864 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,978,483 - 25,021,863 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,978,748 - 27,022,485 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,033,657 - 23,077,043 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,892,500 - 22,934,907 (+)NCBI
Celera1223,732,827 - 23,776,213 (+)NCBICelera
RH 3.4 Map12344.2RGD
RH 3.4 Map12345.7RGD
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IDA,ISO)
Anetoderma  (ISO)
aortic aneurysm  (ISO)
aortic valve disease  (ISS)
aortic valve stenosis  (ISO)
atrioventricular septal defect  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
autosomal dominant cutis laxa  (ISO)
autosomal dominant cutis laxa 1  (ISO)
autosomal recessive polycystic kidney disease  (IEP)
bladder neck obstruction  (IEP)
Buschke-Ollendorff syndrome  (ISO)
chronic obstructive pulmonary disease  (ISO)
congenital diaphragmatic hernia  (IEP)
cutis laxa  (ISO)
dermatitis herpetiformis  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
essential hypertension  (ISS)
exfoliation syndrome  (ISO)
Experimental Diabetes Mellitus  (IEP)
facioscapulohumeral muscular dystrophy  (ISO)
gastrointestinal carcinoma  (ISO)
genetic disease  (ISO)
Hypertelorism  (ISO)
hypertension  (ISO)
inguinal hernia  (ISO)
intestinal volvulus  (ISO)
intracranial aneurysm  (ISO)
Kawasaki disease  (ISO)
Kuhnt-Junius degeneration  (ISO)
Lichen Sclerosus et Atrophicus  (ISO)
liver cirrhosis  (IEP)
macular degeneration  (ISO)
melanoma  (ISO)
Myocardial Ischemia  (ISO)
Neurodevelopmental Disorders  (ISO)
photosensitivity disease  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
polyarteritis nodosa  (ISO)
polymyositis  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
primary open angle glaucoma  (ISO)
pseudoxanthoma elasticum  (ISO)
psoriasis  (ISO)
pterygium  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
silicosis  (IEP)
Stroke  (ISO)
Sunburn  (ISO)
Supravalvar Aortic Stenosis, Eisenberg Type  (ISO)
supravalvular aortic stenosis  (ISO,ISS)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
thoracic aortic aneurysm  (ISO)
thromboangiitis obliterans  (ISO)
Urinary Incontinence, Stress  (IEP)
varicose veins  (ISO)
Volvulus Of Midgut  (ISO)
Williams-Beuren syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP,ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
17beta-estradiol  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
beta-aminopropionitrile  (EXP)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroprene  (EXP)
choline  (ISO)
clothianidin  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
cycloheximide  (EXP)
D-penicillamine  (ISO)
dexamethasone  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
enilconazole  (EXP)
ethylparaben  (ISO)
fenamidone  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
furan  (EXP)
griseofulvin  (ISO)
hydralazine  (EXP)
hydrogen sulfide  (ISO)
inulin  (ISO)
isoprenaline  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
losartan  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
mifepristone  (EXP)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
okadaic acid  (EXP)
ozone  (EXP,ISO)
palbociclib  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
radicicol  (ISO)
rotenone  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP)
tetrathiomolybdate(2-)  (EXP)
thiacloprid  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
Trapidil  (EXP)
tremolite asbestos  (ISO)
triclosan  (ISO)
triptonide  (ISO)
Y-27632  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Inhibition of transforming growth factor beta worsens elastin degradation in a murine model of Kawasaki disease. Alvira CM, etal., Am J Pathol. 2011 Mar;178(3):1210-20. doi: 10.1016/j.ajpath.2010.11.054.
2. Immunochemical identification of abnormal constituents in the dermis of pseudoxanthoma elasticum patients. Baccarani-Contri M, etal., Eur J Histochem. 1994;38(2):111-23.
3. Alteration of the extracellular matrix of smooth muscle cells by ascorbate treatment. Barone LM, etal., Biochim Biophys Acta. 1985 Jun 18;840(2):245-54.
4. Differential expression of lysyl oxidases LOXL1 and LOX during growth and aging suggests specific roles in elastin and collagen fiber remodeling in rat aorta. Behmoaras J, etal., Rejuvenation Res. 2008 Oct;11(5):883-9. doi: 10.1089/rej.2008.0760.
5. Hypoxia suppresses elastin repair by rat lung fibroblasts. Berk JL, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L931-6. Epub 2005 Jul 29.
6. Effect of okadaic acid on elastin gene expression in interstitial lung fibroblasts. Berk JL, etal., Am J Physiol. 1996 Dec;271(6 Pt 1):L939-48.
7. Enhanced elastin and fibrillin gene expression in chronically photodamaged skin. Bernstein EF, etal., J Invest Dermatol. 1994 Aug;103(2):182-6.
8. Dermatitis herpetiformis--an autoimmune disease due to cross-reaction between dietary glutenin and dermal elastin? Bodvarsson S, etal., Scand J Immunol. 1993 Dec;38(6):546-50.
9. Elastin degradation in systemic vasculitis. Bokarewa M, etal., Pathol Biol (Paris). 1996 Apr;44(4):254-8.
10. Role of elastin in spontaneously hypertensive rat small mesenteric artery remodelling. Briones AM, etal., J Physiol. 2003 Oct 1;552(Pt 1):185-95. Epub 2003 Jul 4.
11. Transcriptional regulation of tropoelastin expression in rat lung fibroblasts: changes with age and hyperoxia. Bruce MC and Honaker CE, Am J Physiol. 1998 Jun;274(6 Pt 1):L940-50.
12. Basic fibroblast growth factor decreases elastin gene transcription in aortic smooth muscle cells. Carreras I, etal., J Cell Biochem. 2002;85(3):592-600.
13. Abnormalities of serum antielastin antibodies in connective tissue diseases. Colburn KK, etal., J Investig Med. 2003 Mar;51(2):104-9.
14. Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts. DiCamillo SJ, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L232-43. Epub 2006 Feb 10.
15. Skin elastic fibers in Williams syndrome. Dridi SM, etal., Am J Med Genet. 1999 Nov 19;87(2):134-8.
16. Supravalvular aortic stenosis associated with a deletion disrupting the elastin gene. Ewart AK, etal., J Clin Invest. 1994 Mar;93(3):1071-7.
17. Alterations in fibrillin as well as collagens I and III and elastin occur in vulval lichen sclerosus. Farrell AM, etal., J Eur Acad Dermatol Venereol. 2001 May;15(3):212-7.
18. Relationship of tumorigenic malignant melanomas to dermal elastin: an expression of tumor/stromal interaction that may be related to prognosis. Feinmesser M, etal., Am J Dermatopathol. 2002 Apr;24(2):108-17.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Elastase derived elastin peptides: putative autoimmune targets in giant cell arteritis. Gillot JM, etal., J Rheumatol. 1997 Apr;24(4):677-82.
21. Buschke-Ollendorff syndrome associated with elevated elastin production by affected skin fibroblasts in culture. Giro MG, etal., J Invest Dermatol. 1992 Aug;99(2):129-37.
22. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
23. Time-dependent alterations of select genes in streptozotocin-induced diabetic rat bladder. Gray MA, etal., Urology. 2008 Jun;71(6):1214-9. doi: 10.1016/j.urology.2007.11.054. Epub 2008 Feb 15.
24. Effect of mechanical ventilation on the pulmonary expression and production of elastin in nitrofen-induced diaphragmatic hernia in rats. Guarino N, etal., J Pediatr Surg. 2002 Sep;37(9):1253-7.
25. Twenty patients including 7 probands with autosomal dominant cutis laxa confirm clinical and molecular homogeneity. Hadj-Rabia S, etal., Orphanet J Rare Dis. 2013 Feb 25;8:36. doi: 10.1186/1750-1172-8-36.
26. Ultrastructural immunocytochemical analysis of elastin in the human lamina cribrosa. Changes in elastic fibers in primary open-angle glaucoma. Hernandez MR Invest Ophthalmol Vis Sci. 1992 Sep;33(10):2891-903.
27. Serum elastin-derived peptides and anti-elastin antibody in patients with systemic sclerosis. Hong YJ, etal., J Korean Med Sci. 2012 May;27(5):484-8. doi: 10.3346/jkms.2012.27.5.484. Epub 2012 Apr 25.
28. The use of elastin immunostain improves the evaluation of melanomas associated with nevi. Kamino H, etal., J Cutan Pathol. 2009 Aug;36(8):845-52. doi: 10.1111/j.1600-0560.2008.01170.x. Epub 2008 Nov 19.
29. A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease. Kelleher CM, etal., Am J Respir Cell Mol Biol. 2005 Oct;33(4):355-62. Epub 2005 Aug 4.
30. Elastin gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. Kondo N, etal., Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1101-5. doi: 10.1167/iovs.07-1145.
31. Age-related changes in structure and extracellular matrix protein expression levels in rat tendons. Kostrominova TY and Brooks SV, Age (Dordr). 2013 Dec;35(6):2203-14. doi: 10.1007/s11357-013-9514-2. Epub 2013 Jan 27.
32. Biomimetic regeneration of elastin matrices using hyaluronan and copper ion cues. Kothapalli CR and Ramamurthi A, Tissue Eng Part A. 2009 Jan;15(1):103-13. doi: 10.1089/ten.tea.2007.0390.
33. Phenotype of the Williams-Beuren syndrome associated with hemizygosity at the elastin locus. Kotzot D, etal., Eur J Pediatr. 1995 Jun;154(6):477-82.
34. Extended single nucleotide polymorphism and haplotype analysis of the elastin gene in Caucasians with intracranial aneurysms provides evidence for racially/ethnically based differences. Krex D, etal., Cerebrovasc Dis. 2004;18(2):104-10. Epub 2004 Jun 22.
35. Regulation of elastin gene transcription by proteasome dysfunction. Kuang PP and Goldstein RH, Am J Physiol Cell Physiol. 2005 Sep;289(3):C766-73. Epub 2005 Apr 6.
36. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
37. Altered bladder function in transgenic mice expressing rat elastin. Lemack GE, etal., Neurourol Urodyn 1999;18(1):55-68.
38. Elastin rs2301995 polymorphism is not associated with polypoidal choroidal vasculopathy in caucasians. Lima LH, etal., Ophthalmic Genet. 2011 Jun;32(2):80-2. doi: 10.3109/13816810.2010.544362. Epub 2011 Mar 10.
39. Treatment of stress urinary incontinence with adipose tissue-derived stem cells. Lin G, etal., Cytotherapy. 2010;12(1):88-95. doi: 10.3109/14653240903350265.
40. Retinoic acid increases elastin in neonatal rat lung fibroblast cultures. Liu B, etal., Am J Physiol. 1993 Nov;265(5 Pt 1):L430-7.
41. [Expressions of fibrillin-1, elastin and matrix metalloproteinase-1 and -9 in chronic actinic dermatitis in elderly patients]. Liu P, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2008 Aug;28(8):1354-7.
42. Increased elastin production in experimental granulomatous lung disease. Mariani TJ, etal., Am J Pathol. 1995 Oct;147(4):988-1000.
43. Exogenous and endogenous transforming growth factors-beta influence elastin gene expression in cultured lung fibroblasts. McGowan SE, etal., Am J Respir Cell Mol Biol. 1997 Jul;17(1):25-35.
44. Elastin: mutational spectrum in supravalvular aortic stenosis. Metcalfe K, etal., Eur J Hum Genet. 2000 Dec;8(12):955-63.
45. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
46. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
47. Elastosis of the lamina cribrosa in pseudoexfoliation syndrome with glaucoma. Netland PA, etal., Ophthalmology. 1995 Jun;102(6):878-86.
48. Aortic stiffness is associated with vascular calcification and remodeling in a chronic kidney disease rat model. Ng K, etal., Am J Physiol Renal Physiol. 2011 Jun;300(6):F1431-6. doi: 10.1152/ajprenal.00079.2011. Epub 2011 Apr 6.
49. An association of anti-elastin IgA antibodies with development of retinopathy in diabetic children. Nicoloff G, etal., Gen Pharmacol. 2000 Aug;35(2):83-7.
50. Developmental changes of tropoelastin synthesis by rat pulmonary fibroblasts and effects of dexamethasone. Noguchi A, etal., Pediatr Res. 1990 Oct;28(4):379-82.
51. Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. Ogata T, etal., J Vasc Surg. 2005 Jun;41(6):1036-42.
52. Anetoderma: biochemical and ultrastructural demonstration of an elastin defect in the skin of three patients. Oikarinen AI, etal., J Am Acad Dermatol. 1984 Jul;11(1):64-72.
53. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
54. Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis. Pellicoro A, etal., Hepatology. 2012 Jun;55(6):1965-75. doi: 10.1002/hep.25567. Epub 2012 Apr 18.
55. Heterogeneity of rat tropoelastin mRNA revealed by cDNA cloning. Pierce RA, etal., Biochemistry 1990 Oct 16;29(41):9677-83.
56. Elements of the rat tropoelastin gene associated with alternative splicing. Pierce RA, etal., Genomics 1992 Apr;12(4):651-8.
57. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
58. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
59. A novel elastin gene mutation resulting in an autosomal dominant form of cutis laxa. Rodriguez-Revenga L, etal., Arch Dermatol. 2004 Sep;140(9):1135-9.
60. Rapamycin attenuates bladder hypertrophy during long-term outlet obstruction in vivo: tissue, matrix and mechanistic insights. Schroder A, etal., J Urol. 2013 Jun;189(6):2377-84. doi: 10.1016/j.juro.2012.12.110. Epub 2013 Jan 9.
61. Elastase digestion of normal and pseudoxanthoma elasticum lesional skin elastins. Schwartz E, etal., Exp Mol Pathol. 1991 Oct;55(2):190-5.
62. Heterogeneity of elastin expression in cutis laxa fibroblast strains. Sephel GC, etal., J Invest Dermatol. 1989 Jul;93(1):147-53.
63. Serum elastin-derived peptides in age-related macular degeneration. Sivaprasad S, etal., Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3046-51.
64. Aortic aneurysmal disease and cutis laxa caused by defects in the elastin gene. Szabo Z, etal., J Med Genet. 2006 Mar;43(3):255-8. Epub 2005 Aug 5.
65. Analysis of candidate genes for age-related macular degeneration subtypes in the Japanese population. Tanaka K, etal., Mol Vis. 2011;17:2751-8. Epub 2011 Oct 22.
66. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
67. Autosomal dominant cutis laxa with severe lung disease: synthesis and matrix deposition of mutant tropoelastin. Urban Z, etal., J Invest Dermatol. 2005 Jun;124(6):1193-9.
68. Mechanism of abnormal elastin gene expression in the pinguecular part of pterygia. Wang IJ, etal., Am J Pathol. 2000 Oct;157(4):1269-76.
69. Elastic fibers reconstructed using adenovirus-mediated expression of tropoelastin and tested in the elastase model of abdominal aortic aneurysm in rats. Xiong J, etal., J Vasc Surg. 2008 Oct;48(4):965-73. doi: 10.1016/j.jvs.2008.04.016. Epub 2008 Jun 30.
70. Elastic tissue changes in skin following PUVA therapy. Zelickson AS, etal., J Am Acad Dermatol. 1980 Aug;3(2):186-92.
71. Cutis laxa arising from frameshift mutations in exon 30 of the elastin gene (ELN). Zhang MC, etal., J Biol Chem. 1999 Jan 8;274(2):981-6.
Additional References at PubMed
PMID:2768256   PMID:2913947   PMID:2971041   PMID:7534784   PMID:10424889   PMID:11889128   PMID:12477932   PMID:12679320   PMID:12882762   PMID:12890646   PMID:14614988   PMID:15489334  
PMID:15668357   PMID:16005428   PMID:17099216   PMID:18441095   PMID:18614015   PMID:18757743   PMID:20736890   PMID:21363967   PMID:21606336   PMID:21729992   PMID:21769453   PMID:22205540  
PMID:22435995   PMID:22718481   PMID:23648172   PMID:24440697   PMID:25218173   PMID:25970707   PMID:26075500   PMID:27559042   PMID:28257481   PMID:29242152   PMID:30720050   PMID:30914253  
PMID:32160810   PMID:32630068   PMID:32794252   PMID:33558588   PMID:33761588   PMID:38508328  


Genomics

Comparative Map Data
Eln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,604,983 - 27,648,413 (+)NCBIGRCr8
mRatBN7.21221,968,544 - 22,011,929 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,968,544 - 22,011,928 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,109,255 - 23,152,934 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,721,589 - 23,765,283 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,789,694 - 22,833,151 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,978,478 - 25,021,864 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,978,483 - 25,021,863 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,978,748 - 27,022,485 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,033,657 - 23,077,043 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,892,500 - 22,934,907 (+)NCBI
Celera1223,732,827 - 23,776,213 (+)NCBICelera
RH 3.4 Map12344.2RGD
RH 3.4 Map12345.7RGD
Cytogenetic Map12q12NCBI
ELN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38774,028,173 - 74,069,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl774,027,789 - 74,069,907 (+)EnsemblGRCh38hg38GRCh38
GRCh37773,442,503 - 73,484,237 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,080,363 - 73,122,173 (+)NCBINCBI36Build 36hg18NCBI36
Build 34772,887,168 - 72,927,681NCBI
Celera768,923,491 - 68,963,674 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef769,326,571 - 69,367,012 (+)NCBIHuRef
CHM1_1773,587,503 - 73,629,630 (+)NCBICHM1_1
T2T-CHM13v2.0775,231,309 - 75,273,042 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,775,191 - 72,817,309 (+)NCBI
Eln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,731,449 - 134,776,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,731,447 - 134,776,177 (-)EnsemblGRCm39 Ensembl
GRCm385134,702,595 - 134,747,368 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,702,593 - 134,747,323 (-)EnsemblGRCm38mm10GRCm38
MGSCv375135,178,466 - 135,223,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365134,987,223 - 135,031,881 (-)NCBIMGSCv36mm8
Celera5131,710,617 - 131,755,279 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.76NCBI
Eln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545613,788,992 - 13,818,836 (-)NCBIChiLan1.0ChiLan1.0
ELN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2690,829,914 - 90,871,930 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17139,094,545 - 139,136,568 (-)NCBINHGRI_mPanPan1
PanPan1.1781,177,699 - 81,218,306 (+)NCBIpanpan1.1PanPan1.1panPan2
ELN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,299,524 - 6,331,425 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,300,727 - 6,331,325 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha67,997,308 - 8,029,192 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.066,114,552 - 6,146,504 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl66,114,583 - 6,146,603 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.166,104,697 - 6,136,585 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.066,052,537 - 6,084,439 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,216,223 - 6,248,126 (-)NCBIUU_Cfam_GSD_1.0
Eln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344130,871,544 - 130,901,273 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365433,135,169 - 3,165,023 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ELN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl311,214,205 - 11,244,897 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1311,214,194 - 11,245,891 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,929,464 - 10,935,434 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ELN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,999,164 - 9,048,703 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660707,474,714 - 7,540,034 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474013,856,932 - 13,886,266 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eln
321 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:333
Count of miRNA genes:76
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000001995, ENSRNOT00000032780, ENSRNOT00000040069
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)121961087024139202Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
631521Pia12Pristane induced arthritis QTL 128.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)122025941723672083Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat

Markers in Region
D12Wox14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,003,428 - 22,003,586 (+)MAPPERmRatBN7.2
Rnor_6.01225,013,364 - 25,013,521NCBIRnor6.0
Rnor_5.01227,013,985 - 27,014,142UniSTSRnor5.0
RGSC_v3.41223,068,543 - 23,068,700UniSTSRGSC3.4
Celera1223,767,713 - 23,767,870UniSTS
Cytogenetic Map12q12UniSTS
D12Mgh12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,996,586 - 21,996,726 (+)MAPPERmRatBN7.2
Rnor_6.01225,006,522 - 25,006,661NCBIRnor6.0
Rnor_5.01227,007,143 - 27,007,282UniSTSRnor5.0
RGSC_v3.41223,061,700 - 23,061,840RGDRGSC3.4
RGSC_v3.41223,061,701 - 23,061,840UniSTSRGSC3.4
RGSC_v3.11222,920,521 - 22,920,661RGD
Celera1223,760,871 - 23,761,010UniSTS
RH 3.4 Map12344.2UniSTS
Cytogenetic Map12q12UniSTS
D12Mgh13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,003,411 - 22,003,550 (+)MAPPERmRatBN7.2
Rnor_6.01225,013,347 - 25,013,485NCBIRnor6.0
Rnor_5.01227,013,968 - 27,014,106UniSTSRnor5.0
RGSC_v3.41223,068,525 - 23,068,664RGDRGSC3.4
RGSC_v3.41223,068,526 - 23,068,664UniSTSRGSC3.4
RGSC_v3.11222,927,346 - 22,927,485RGD
Celera1223,767,696 - 23,767,834UniSTS
Cytogenetic Map12q12UniSTS
D8Arb9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,003,421 - 22,003,625 (+)MAPPERmRatBN7.2
Rnor_6.01225,013,357 - 25,013,560NCBIRnor6.0
Rnor_5.01227,013,978 - 27,014,181UniSTSRnor5.0
RGSC_v3.41223,068,535 - 23,068,739RGDRGSC3.4
RGSC_v3.41223,068,536 - 23,068,739UniSTSRGSC3.4
RGSC_v3.11222,927,356 - 22,927,560RGD
Celera1223,767,706 - 23,767,909UniSTS
Cytogenetic Map12q12UniSTS
D12Hmgc2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,996,720 - 21,996,983 (+)MAPPERmRatBN7.2
Rnor_6.01225,006,656 - 25,006,918NCBIRnor6.0
Rnor_5.01227,007,277 - 27,007,539UniSTSRnor5.0
RGSC_v3.41223,061,835 - 23,062,097UniSTSRGSC3.4
RGSC_v3.41223,061,379 - 23,063,057RGDRGSC3.4
Celera1223,761,005 - 23,761,267UniSTS
RH 3.4 Map12343.61UniSTS
RH 3.4 Map12343.61RGD
Cytogenetic Map12q12UniSTS
RH94685  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,011,328 - 22,011,545 (+)MAPPERmRatBN7.2
Rnor_6.01225,021,264 - 25,021,480NCBIRnor6.0
Rnor_5.01227,021,885 - 27,022,101UniSTSRnor5.0
RGSC_v3.41223,076,443 - 23,076,659UniSTSRGSC3.4
Celera1223,775,613 - 23,775,829UniSTS
Cytogenetic Map12q12UniSTS
BI274506  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,979,263 - 21,979,424 (+)MAPPERmRatBN7.2
Rnor_6.01224,989,198 - 24,989,358NCBIRnor6.0
Rnor_5.01226,989,468 - 26,989,628UniSTSRnor5.0
RGSC_v3.41223,044,377 - 23,044,537UniSTSRGSC3.4
Celera1223,743,547 - 23,743,707UniSTS
RH 3.4 Map12345.6UniSTS
Cytogenetic Map12q12UniSTS
Eln  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,986,223 - 21,986,921 (+)MAPPERmRatBN7.2
Rnor_6.01224,996,157 - 24,996,854NCBIRnor6.0
Rnor_5.01226,996,620 - 26,997,317UniSTSRnor5.0
RGSC_v3.41223,051,336 - 23,052,033UniSTSRGSC3.4
Celera1223,750,506 - 23,751,203UniSTS
Cytogenetic Map12q12UniSTS
Eln  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,010,235 - 22,011,026 (+)MAPPERmRatBN7.2
Rnor_6.01225,020,171 - 25,020,961NCBIRnor6.0
Rnor_5.01227,020,792 - 27,021,582UniSTSRnor5.0
Celera1223,774,520 - 23,775,310UniSTS
Cytogenetic Map12q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 10 1 2
Medium 2 27 22 14 11 14 4 7 41 27 34 9 4
Low 1 6 35 27 8 27 4 4 33 8 6 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000032780   ⟹   ENSRNOP00000030301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,968,544 - 22,011,928 (+)Ensembl
Rnor_6.0 Ensembl1224,989,298 - 25,021,863 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000040069   ⟹   ENSRNOP00000045102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,968,544 - 22,011,928 (+)Ensembl
Rnor_6.0 Ensembl1224,978,483 - 25,020,907 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109651   ⟹   ENSRNOP00000096516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,968,544 - 22,011,928 (+)Ensembl
RefSeq Acc Id: NM_012722   ⟹   NP_036854
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,605,027 - 27,648,413 (+)NCBI
mRatBN7.21221,968,544 - 22,011,929 (+)NCBI
Rnor_6.01224,978,478 - 25,021,864 (+)NCBI
Rnor_5.01226,978,748 - 27,022,485 (+)NCBI
RGSC_v3.41223,033,657 - 23,077,043 (+)RGD
Celera1223,732,827 - 23,776,213 (+)RGD
Sequence:
RefSeq Acc Id: XM_063271069   ⟹   XP_063127139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,604,983 - 27,648,413 (+)NCBI
RefSeq Acc Id: XM_063271071   ⟹   XP_063127141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,604,983 - 27,648,413 (+)NCBI
RefSeq Acc Id: XM_063271072   ⟹   XP_063127142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,604,983 - 27,648,413 (+)NCBI
RefSeq Acc Id: XM_063271073   ⟹   XP_063127143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,604,983 - 27,648,413 (+)NCBI
RefSeq Acc Id: XM_063271074   ⟹   XP_063127144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,604,983 - 27,648,413 (+)NCBI
RefSeq Acc Id: XM_063271075   ⟹   XP_063127145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,604,983 - 27,648,413 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036854   ⟸   NM_012722
- Peptide Label: precursor
- UniProtKB: Q99372 (UniProtKB/Swiss-Prot),   Q5RKH4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000030301   ⟸   ENSRNOT00000032780
RefSeq Acc Id: ENSRNOP00000045102   ⟸   ENSRNOT00000040069
RefSeq Acc Id: ENSRNOP00000096516   ⟸   ENSRNOT00000109651
RefSeq Acc Id: XP_063127139   ⟸   XM_063271069
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JST5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127142   ⟸   XM_063271072
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063127141   ⟸   XM_063271071
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063127143   ⟸   XM_063271073
- Peptide Label: isoform X4
- UniProtKB: D4A9U4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127144   ⟸   XM_063271074
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063127145   ⟸   XM_063271075
- Peptide Label: isoform X6
- UniProtKB: A0A8I6APE9 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99372-F1-model_v2 AlphaFold Q99372 1-870 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698567
Promoter ID:EPDNEW_R9091
Type:multiple initiation site
Name:Eln_1
Description:elastin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01224,978,470 - 24,978,530EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:67394 AgrOrtholog
BioCyc Gene G2FUF-19584 BioCyc
Ensembl Genes ENSRNOG00000001469 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00065001486 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000032780 ENTREZGENE
  ENSRNOT00000032780.8 UniProtKB/TrEMBL
  ENSRNOT00000040069.7 UniProtKB/TrEMBL
  ENSRNOT00000109651.1 UniProtKB/TrEMBL
  ENSRNOT00065001981 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7097661 IMAGE-MGC_LOAD
InterPro Tropoelastin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25043 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94768 IMAGE-MGC_LOAD
NCBI Gene 25043 ENTREZGENE
PANTHER ELASTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24018 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eln PhenoGen
PRINTS TROPOELASTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001469 RatGTEx
  ENSRNOG00065001486 RatGTEx
TIGR TC204140
UniProt A0A0G2JST5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APE9 ENTREZGENE, UniProtKB/TrEMBL
  A6J0H3_RAT UniProtKB/TrEMBL
  A6J0H4_RAT UniProtKB/TrEMBL
  A6J0H5_RAT UniProtKB/TrEMBL
  A6J0H6_RAT UniProtKB/TrEMBL
  D4A9U4 ENTREZGENE, UniProtKB/TrEMBL
  ELN_RAT UniProtKB/Swiss-Prot
  Q5RKH4 ENTREZGENE
  Q99372 ENTREZGENE
UniProt Secondary Q5RKH4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Eln  elastin      Symbol and Name updated 629477 APPROVED
2003-03-12 Eln  elastin  Trela  Tropoelastin  Data merged from RGD:3902 628472 PROVISIONAL
2002-06-10 Eln        Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Trela  Tropoelastin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression overexpression modifies bladder elasticity and function in transgenic mice 731206